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Protein

Elongator complex protein 1

Gene

Elp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a scaffold protein that may assemble active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK).By similarity
Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4. Involved in cell migration. Involved in neurogenesis (PubMed:19185337). Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (PubMed:19185337).2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Elongator complex protein 1
Short name:
ELP1
Alternative name(s):
IkappaB kinase complex-associated protein
Short name:
IKK complex-associated protein
Gene namesi
Name:Elp1
Synonyms:Ikap, Ikbkap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1914544 Ikbkap

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002839951 – 1333Elongator complex protein 1Add BLAST1333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei805PhosphoserineBy similarity1
Modified residuei1172PhosphoserineBy similarity1
Modified residuei1175PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ7TT37
MaxQBiQ7TT37
PaxDbiQ7TT37
PeptideAtlasiQ7TT37
PRIDEiQ7TT37

PTM databases

iPTMnetiQ7TT37
PhosphoSitePlusiQ7TT37

Expressioni

Tissue specificityi

Widely expressed with highest levels in brain.1 Publication

Developmental stagei

Expressed at embryonic days 7, 11, 15 and 17 with the highest expression at embryonic day 11.1 Publication

Gene expression databases

BgeeiENSMUSG00000028431
GenevisibleiQ7TT37 MM

Interactioni

Subunit structurei

Interacts preferentially with MAP3K14/NIK followed by IKK-alpha and IKK-beta. Component of the RNA polymerase II elongator complex (Elongator), which consists of ELP1, STIP1/ELP2, ELP3, ELP4, ELP5 and ELP6. Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit. Interacts with ELP3 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi230947, 3 interactors
IntActiQ7TT37, 1 interactor
MINTiQ7TT37
STRINGi10090.ENSMUSP00000030140

Structurei

3D structure databases

ProteinModelPortaliQ7TT37
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ELP1/IKA1 family.Curated

Phylogenomic databases

eggNOGiKOG1920 Eukaryota
COG5290 LUCA
GeneTreeiENSGT00390000013344
HOVERGENiHBG019038
InParanoidiQ7TT37
KOiK11373
OMAiKVRVWNR
OrthoDBiEOG091G01A5
PhylomeDBiQ7TT37
TreeFamiTF300402

Family and domain databases

InterProiView protein in InterPro
IPR006849 Elp1
PANTHERiPTHR12747 PTHR12747, 1 hit
PfamiView protein in Pfam
PF04762 IKI3, 1 hit
PIRSFiPIRSF017233 IKAP, 1 hit

Sequencei

Sequence statusi: Complete.

Q7TT37-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRNLKLHRTL EFRDIQAPGK PQCFCLRAEQ GTVLIGSERG LTEVDPVRRE
60 70 80 90 100
VKTEISLVAE GFLPEDGSGC IVGIQDLLDQ ESVCVATASG DVIVCNLSTQ
110 120 130 140 150
QLECVGSVAS GISVMSWSPD QELLLLATAQ QTLIMMTKDF EVIAEEQIHQ
160 170 180 190 200
DDFGEGKFVT VGWGSKQTQF HGSEGRPTAF PVQLPENALP WDDRRPHITW
210 220 230 240 250
RGDGQYFAVS VVCRQTEARK IRVWNREFAL QSTSESVPGL GPALAWKPSG
260 270 280 290 300
SLIASTQDKP NQQDVVFFEK NGLLHGHFTL PFLKDEVKVN DLLWNADSSV
310 320 330 340 350
LAIWLEDLPK EDSSTLKSYV QLWTVGNYHW YLKQSLPFST TGKNQIVSLL
360 370 380 390 400
WDPVTPCRLH VLCTGWRYLC CDWHWTTDRS SGNSANDLAN VAVIDGNRVL
410 420 430 440 450
VTVFRQTVVP PPMCTYRLLI PHPVNQVIFS AHLGNDLAVL DASNQISVYK
460 470 480 490 500
CGDKPNMDST VKLGAVGGNG FKVPLTTPHL EKRYSIQFGN NEEEEEEEVN
510 520 530 540 550
ALQLSFLTWV EDDTFLAISY SHSSSQSIIH HLTVTHSEVD EEQGQLDVSS
560 570 580 590 600
SVTVDGVVIG LCCCSKTKSL AVQLADGQVL KYLWESPSLA VEPWKNSEGI
610 620 630 640 650
PVRFVHPCTQ MEVATIGGEE CVLGLTDRCR FFINDTEVAS NITSFAVCDD
660 670 680 690 700
FLLVTTHSHT CQVFSLSGAS LKMLQAALSG SHEASGEILR KVERGSRIVT
710 720 730 740 750
VVPQDTKLIL QMPRGNLEVV HHRALVLAQI RKWLDKLMFK EAFECMRKLR
760 770 780 790 800
INLNLIHDHN PKVFLENVET FVKQIDSVNH INLFFTELRE EDVTKTMYPP
810 820 830 840 850
PITKSVQVST HPDGKKLDLI CDAMRAAMEA INPRKFCLSI LTSHVKKTTP
860 870 880 890 900
ELEIVLQKVQ ELQGNLPFDP ESVSVEEALK YLLLLVDVNE LFNHSLGTYD
910 920 930 940 950
FNLVLMVAEK SQKDPKEYLP FLNTLKKMET NYQRFTIDKY LKRYEKALGH
960 970 980 990 1000
LSKCGPEYFT ECLNLIKDKN LYKEALKLYR PDSPQYQAVS MAYGEHLMQE
1010 1020 1030 1040 1050
HLYEPAGLVF ARCGAQEKAL EAFLACGSWQ QALCVAAQLQ MSKDKVAGLA
1060 1070 1080 1090 1100
RTLAGKLVEQ RKHSEAATVL EQYAQDYEEA VLLLLEGSAW EEALRLVYKY
1110 1120 1130 1140 1150
DRVDIIETSV KPSILEAQKN YMDFLDSETA TFIRHKNRLQ VVRALRRQAP
1160 1170 1180 1190 1200
QVHVDHEVAH GPESDLFSET SSIMSGSEMS GRYSHSNSRI SARSSKNRRK
1210 1220 1230 1240 1250
AERKKHSLKE GSPLEGLALL EALSEVVQSV EKLKDEVRAI LKVLFLFEFE
1260 1270 1280 1290 1300
EQAKELQRAF ESTLQLMERA VPEIWTPAGQ QSSTTPVLGP SSTANSITAS
1310 1320 1330
YQQQKTCVPA LDAGVYMPPK MDPRSQWKLS LLE
Length:1,333
Mass (Da):149,584
Last modified:March 1, 2004 - v2
Checksum:iC40E0098DD4DF63C
GO

Sequence cautioni

The sequence AAL36025 differs from that shown. Reason: Frameshift at position 498.Curated
The sequence AAO15309 differs from that shown. Reason: Frameshift at several positions.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti42T → P in AAO15309 (Ref. 3) Curated1
Sequence conflicti120D → G in BAE27720 (PubMed:16141072).Curated1
Sequence conflicti215 – 216QT → HS in AAO15309 (Ref. 3) Curated2
Sequence conflicti221I → V in AAL40925 (PubMed:11722848).Curated1
Sequence conflicti346I → V in AAL40925 (PubMed:11722848).Curated1
Sequence conflicti346I → V in AAO15309 (Ref. 3) Curated1
Sequence conflicti582Y → I in AAL36025 (PubMed:11747609).Curated1
Sequence conflicti634 – 635ND → LV in AAL36025 (PubMed:11747609).Curated2
Sequence conflicti649D → A in AAL40925 (PubMed:11722848).Curated1
Sequence conflicti663V → G in AAL36025 (PubMed:11747609).Curated1
Sequence conflicti663V → G in AAL40925 (PubMed:11722848).Curated1
Sequence conflicti663V → G in AAO15309 (Ref. 3) Curated1
Sequence conflicti693 – 694ER → VW in AAL36025 (PubMed:11747609).Curated2
Sequence conflicti773K → F in AAL36025 (PubMed:11747609).Curated1
Sequence conflicti1110V → I in AAL36025 (PubMed:11747609).Curated1
Sequence conflicti1110V → I in AAL40925 (PubMed:11722848).Curated1
Sequence conflicti1110V → I in AAO15309 (Ref. 3) Curated1
Sequence conflicti1159A → G in BAB23291 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF367244 mRNA Translation: AAL36025.1 Frameshift.
AF387811 mRNA Translation: AAL40925.1
AF140786 mRNA Translation: AAO15309.1 Frameshift.
AK004402 mRNA Translation: BAB23291.1
AK076152 mRNA Translation: BAC36221.1
AK035944 mRNA Translation: BAC29252.1
AK147153 mRNA Translation: BAE27720.1
AL807762, AL929577 Genomic DNA Translation: CAM25708.1
AL929577, AL807762 Genomic DNA Translation: CAM24766.1
BC052387 mRNA Translation: AAH52387.2
BC054468 mRNA Translation: AAH54468.1
CCDSiCCDS38765.1
RefSeqiNP_080355.2, NM_026079.3
UniGeneiMm.282743

Genome annotation databases

EnsembliENSMUST00000030140; ENSMUSP00000030140; ENSMUSG00000028431
GeneIDi230233
KEGGimmu:230233
UCSCiuc012del.1 mouse

Similar proteinsi

Entry informationi

Entry nameiELP1_MOUSE
AccessioniPrimary (citable) accession number: Q7TT37
Secondary accession number(s): Q3UHY6
, Q7TQH1, Q8C6B3, Q8CBI3, Q8CH82, Q8VHU5, Q8VHV9, Q9CT81
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: March 1, 2004
Last modified: March 28, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health