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Protein

Adhesion G protein-coupled receptor A3

Gene

Adgra3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Orphan receptor that may have a role in planar cell polarity pathway.By similarity

Miscellaneous

Most adhesion GPCRs proteins undergo autoproteolysis at the GPS domain. ADGRA3 is predicted non-cleavable because of the lack of a consensus catalytic triad sequence within GPS domain.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Protein family/group databases

MEROPSiP02.950

Names & Taxonomyi

Protein namesi
Recommended name:
Adhesion G protein-coupled receptor A3
Alternative name(s):
G-protein coupled receptor 125
Gene namesi
Name:Adgra3
Synonyms:Gpr125
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1917943 Adgra3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 747ExtracellularCuratedAdd BLAST720
Transmembranei748 – 768Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini769 – 785CytoplasmicCuratedAdd BLAST17
Transmembranei786 – 806Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini807 – 815ExtracellularCurated9
Transmembranei816 – 836Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini837 – 865CytoplasmicCuratedAdd BLAST29
Transmembranei866 – 886Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini887 – 908ExtracellularCuratedAdd BLAST22
Transmembranei909 – 929Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini930 – 985CytoplasmicCuratedAdd BLAST56
Transmembranei986 – 1006Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini1007 – 1013ExtracellularCurated7
Transmembranei1014 – 1034Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini1035 – 1310CytoplasmicCuratedAdd BLAST276

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000001290128 – 1310Adhesion G protein-coupled receptor A3Add BLAST1283

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi87N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi195N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi253 ↔ 313PROSITE-ProRule annotation
Glycosylationi290N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi321N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi422N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi442N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi581N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi641N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi676N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi717N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi810N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ7TT36
PaxDbiQ7TT36
PRIDEiQ7TT36

PTM databases

iPTMnetiQ7TT36
PhosphoSitePlusiQ7TT36

Expressioni

Tissue specificityi

Expressed by spermatogonial progenitor cells located within the outer cell layer of the seminiferous tubule and by multipotent adult spermatogonial-derived stem cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000029090
CleanExiMM_GPR125
GenevisibleiQ7TT36 MM

Interactioni

Subunit structurei

Interacts (via PDZ-binding motif) with DLG1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000030971

Structurei

3D structure databases

ProteinModelPortaliQ7TT36
SMRiQ7TT36
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 70LRRNTAdd BLAST43
Repeati71 – 92LRR 1Add BLAST22
Repeati95 – 116LRR 2Add BLAST22
Repeati119 – 140LRR 3Add BLAST22
Repeati143 – 164LRR 4Add BLAST22
Domaini176 – 226LRRCTAdd BLAST51
Domaini231 – 329Ig-likeAdd BLAST99
Domaini687 – 738GPSPROSITE-ProRule annotationAdd BLAST52

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1308 – 1310PDZ-bindingSequence analysis3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi44 – 48Poly-Ala5
Compositional biasi1109 – 1112Poly-Ala4

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
KOG4237 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00860000133701
HOGENOMiHOG000112767
HOVERGENiHBG051777
InParanoidiQ7TT36
KOiK08462
OMAiANFSDKM
OrthoDBiEOG091G03GB
TreeFamiTF331206

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.80.10.10, 1 hit
4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR000203 GPS
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF01825 GPS, 1 hit
PF07679 I-set, 1 hit
PF13855 LRR_8, 1 hit
SMARTiView protein in SMART
SM00303 GPS, 1 hit
SM00409 IG, 1 hit
SM00369 LRR_TYP, 4 hits
SM00082 LRRCT, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
SSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
PS50221 GPS, 1 hit
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 4 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TT36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPPPPLLLL PLALLALLWG GERGAAALPA GCKHDGRARG TGRAAAAAEG
60 70 80 90 100
KVVCSSLELA QVLPPDTLPN RTVTLILSNN KISELKNGSF SGLSLLERLD
110 120 130 140 150
LRNNLISRIA PGAFWGLSSL KRLDLTNNRI GCLNADVFRG LTNLVRLNLS
160 170 180 190 200
GNLFTSLSQG TFDYLGSLRS LEFQTEYLLC DCNILWMHRW VKERNITVRD
210 220 230 240 250
TRCVYPKSLQ AQPVTGVKQE LLTCDPPLEL PSFYMTPSHR QVVFEGDSLP
260 270 280 290 300
FQCMASYIDQ DMQVLWYQDG RIVETDESQG IFVEKSMIHN CSLIASALTI
310 320 330 340 350
SNIQAGSTGN WGCHVQTKRG NNTRTVDIVV LESSAQYCPP ERVVNNKGDF
360 370 380 390 400
RWPRTLAGIT AYLQCTRNTH SSGIYPGSAQ DERKAWRRCD RGGFWADDDY
410 420 430 440 450
SRCQYANDVT RVLYMFNQMP LNLTNAVATA RQLLAYTVEA ANFSDKMDVI
460 470 480 490 500
FVAEMIEKFG RFTREEKSKE LGDVMVDVAS NIMLADERVL WLAQREAKAC
510 520 530 540 550
SRIVQCLQRI ATHRLASGAH VYSTYSPNIA LEAYVIKAAG FTGMTCSVFQ
560 570 580 590 600
KVAASDRAGL SDYGRRDPDG NLDKQLSFKC NVSSTFSSLA LKNTIMEASI
610 620 630 640 650
QLPSSLLSPK HKREARAADD ALYKLQLIAF RNGKLFPATG NSTKLADDGK
660 670 680 690 700
RRTVVTPVIL TKIDGATVDT HHIPVNVTLR RIAHGADAVA AQWDFDLLNG
710 720 730 740 750
QGGWKSDGCC ILYSDENITT IQCGSLGNYA VLMDLTGTEL YTPAASLLHP
760 770 780 790 800
VVYTTAITLL LCLLAVIISY MYHHSLIRIS LKSWHMLVNL CFHILLTCVV
810 820 830 840 850
FVGGITQTRN ASVCQAVGII LHYSTLATVL WVGVTARNIY KQVTKKAKRC
860 870 880 890 900
QDPDEPPAPP RPMLRFYLIG GGIPIIVCGI TAAANIKNYG SRPSAPYCWM
910 920 930 940 950
AWEPSLGAFY GPASFITFVN CMYFLSIFIQ LKRHPERKYE LKEPTEEQQR
960 970 980 990 1000
LAANENGEIN HQDSMSLSLI STSTLENEHS FQSQLLGASL TLLLYVILWM
1010 1020 1030 1040 1050
FGAMAVSLYY PLDLVFSFFF GATCLSFSAF MMVHHCINRE DVRLAWIMMC
1060 1070 1080 1090 1100
CPGRSSYSVQ VNVQPPNSSA TNGEAPKCTN SSAESSCTNK SASSFKNSSQ
1110 1120 1130 1140 1150
GCKLTNLQAA AAQYHSNALP VNATPQLDNS LTEHSMDNDI KMHVAPLDVQ
1160 1170 1180 1190 1200
FRTNVHPSRH HKNRSKGHRA SRLTVLREYA YDVPTSVEGS VQNGLPKSRP
1210 1220 1230 1240 1250
GSNEGHSRSR RAYLAYRERQ YNPPQQDSSD ACSTLPKSSR NVEKPVSTSS
1260 1270 1280 1290 1300
KKDAPRKPAA ADLESQQKSY GLNLAVQNGP VKSNGQEGPL LATDVTGNVR
1310
TGLWKHETTV
Length:1,310
Mass (Da):144,697
Last modified:July 27, 2011 - v3
Checksum:i688D8D44059F0142
GO

Sequence cautioni

The sequence AAH52391 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30A → P in AAH52391 (PubMed:15489334).Curated1
Sequence conflicti1070A → T in AAH19649 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC102501 Genomic DNA No translation available.
AC130666 Genomic DNA No translation available.
BC019649 mRNA Translation: AAH19649.1
BC052391 mRNA Translation: AAH52391.1 Different initiation.
BC058251 mRNA Translation: AAH58251.1
CCDSiCCDS51500.1
RefSeqiNP_598672.1, NM_133911.1
UniGeneiMm.272974

Genome annotation databases

EnsembliENSMUST00000030971; ENSMUSP00000030971; ENSMUSG00000029090
GeneIDi70693
KEGGimmu:70693
UCSCiuc008xjz.2 mouse

Similar proteinsi

Entry informationi

Entry nameiAGRA3_MOUSE
AccessioniPrimary (citable) accession number: Q7TT36
Secondary accession number(s): E9QK56, Q6PE67, Q8VE71
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 27, 2011
Last modified: April 25, 2018
This is version 129 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health