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Protein

RNA exonuclease 1 homolog

Gene

Rexo1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Seems to have no detectable effect on transcription elongation in vitro.By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Names & Taxonomyi

Protein namesi
Recommended name:
RNA exonuclease 1 homolog (EC:3.1.-.-)
Alternative name(s):
Transcription elongation factor B polypeptide 3-binding protein 1
Gene namesi
Name:Rexo1
Synonyms:Kiaa1138, Tceb3bp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1914182. Rexo1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12131213RNA exonuclease 1 homologPRO_0000239233Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei277 – 2771PhosphoserineCombined sources
Modified residuei279 – 2791PhosphoserineCombined sources
Modified residuei353 – 3531PhosphoserineCombined sources
Modified residuei514 – 5141PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ7TT28.
MaxQBiQ7TT28.
PaxDbiQ7TT28.
PRIDEiQ7TT28.

PTM databases

iPTMnetiQ7TT28.
PhosphoSiteiQ7TT28.

Expressioni

Gene expression databases

BgeeiQ7TT28.
CleanExiMM_REXO1.
ExpressionAtlasiQ7TT28. baseline and differential.
GenevisibleiQ7TT28. MM.

Interactioni

Subunit structurei

Interacts with TCEA2 and TCEB3.By similarity

Protein-protein interaction databases

IntActiQ7TT28. 1 interaction.
STRINGi10090.ENSMUSP00000049705.

Structurei

3D structure databases

ProteinModelPortaliQ7TT28.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1052 – 1201150ExonucleaseAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili83 – 11230Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi365 – 43167Lys-richAdd
BLAST
Compositional biasi535 – 58349Ser-richAdd
BLAST

Sequence similaritiesi

Belongs to the REXO1/REXO3 family.Curated
Contains 1 exonuclease domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2248. Eukaryota.
COG0847. LUCA.
GeneTreeiENSGT00840000129821.
HOGENOMiHOG000039979.
HOVERGENiHBG090644.
InParanoidiQ7TT28.
KOiK14570.
OMAiELEQRRY.
OrthoDBiEOG73RB9W.
PhylomeDBiQ7TT28.
TreeFamiTF350172.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR031736. EloA-BP1.
IPR013520. Exonuclease_RNaseT/DNA_pol3.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF15870. EloA-BP1. 1 hit.
[Graphical view]
SMARTiSM00479. EXOIII. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7TT28-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLRSTGFFRS IDCPYWAGAP GGPCRRPYCH FRHRGARGPG APGSGGAASP
60 70 80 90 100
ASGLGYDPYN PELPQPPVQR ENGALGQGDG MLELELVNQA IEAVRGEVEL
110 120 130 140 150
EQRRYQELLE TARGHSAGPS ALAPCSPATS IDDDDTFSLA LTYTPGGLLS
160 170 180 190 200
PDAAYQPTPL AVPAEPGHKY SLAPSDRSQG RAAGGAGALE YVPKAVGQPR
210 220 230 240 250
RCGRPVSGGK YVVDSSKPST DLEYDPLSNY SARHLGRASA RDERATKRPR
260 270 280 290 300
GSRGAEPYTP ALKKPCDPFG GCEARFSDSE DDVTSPPKAD VSSPKAGADP
310 320 330 340 350
ESKAPGKPVS KEGREHEDGG LRGTKEMAVQ YDVEDLGQPP KAPDTVSVVK
360 370 380 390 400
PGSPARASQD ARVPKEGKAK KKKSGTSASL SHKDKVRKKD KKKEKDPARP
410 420 430 440 450
RGKEKVCTDK KKLPASNPRG KAQGPEGTKK KPSSATTVAS SGKGGSGRPS
460 470 480 490 500
STGPQDSGPG PHAPLAWKAG SAKKMSSGKL VERKARSLDE GAPQDTPKLK
510 520 530 540 550
KRALSHAELF GDESEEEDSS LGAGAPRVWP PTLPSLSSDS ESDSDSSLGL
560 570 580 590 600
DETKVPKRLK AAPPASPVPP SPLSSSSSSS GASQCAEEDV DYSALEKEVD
610 620 630 640 650
FDVDPMEECL RIFNESTSVK TEDKGRLARQ PPKEKAEEKT HAGLTTLFPG
660 670 680 690 700
QKRRVSHLCK PGKESEAPKR TPVAPPARPP TAQEVCYRRA QLAQRDSASW
710 720 730 740 750
LQAAPRPTER LSSVHISAPG EKRRIAHVPN PRLAAAPTGA KRALSASSSQ
760 770 780 790 800
ASHGPEPGSQ PLKTRTLSGM ASKTTTTVTP KRIAHSPSLQ SLKKPVIPKE
810 820 830 840 850
FGGKVPTVVR QRYLNLFIEE CLKFCSSNQE AIEKALNEEK VAYDRSPSKN
860 870 880 890 900
IYLNVAVNTL KKLRGLVPNT VPNLSKASGR RVVSHEVVLG GKLAAKTSFS
910 920 930 940 950
LSRPSSPRVE ELKGTALYSR LREYLLTQEQ LKENGYPFPH PERPGGAIIF
960 970 980 990 1000
TAEEKKPKDP SCRICCRCGT EYLVSSSGRC VRSEECYYHW GRLRRNRVAG
1010 1020 1030 1040 1050
GWETQYMCCS AAVGSVGCQV AKQHVQDGRK ENLEGFVRTF QKELPEDAHA
1060 1070 1080 1090 1100
GVFALDCEMS YTTYGLELTR VTVVDTDMQV VYDTFVKPDN EVVDYNTRFS
1110 1120 1130 1140 1150
GVTEADLVDT SITLRDVQAV LLSMFSADTI LIGHSLESDL LALKVIHGTV
1160 1170 1180 1190 1200
VDTSVLFPHR LGLPYKRSLR NLMADYLRQI IQDNVDGHSS SEDASACMHL
1210
VIWKIREDAK TKR
Length:1,213
Mass (Da):130,790
Last modified:October 1, 2003 - v1
Checksum:i2ECFAAA7A1B54363
GO
Isoform 2 (identifier: Q7TT28-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-679: Missing.
     680-735: PTAQEVCYRR...AHVPNPRLAA → MSFHTPSPVP...CTHVPCPPSA
     875-876: SK → STFLYFLLE

Note: May be due to an intron retention. No experimental confirmation available.
Show »
Length:537
Mass (Da):59,622
Checksum:i6EB5893FEF4DC385
GO

Sequence cautioni

The sequence BAD32386.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti187 – 1871G → S in AAH69964 (PubMed:15489334).Curated
Sequence conflicti284 – 2841T → A in AAH69964 (PubMed:15489334).Curated
Sequence conflicti347 – 3471S → P in AAH69964 (PubMed:15489334).Curated
Sequence conflicti394 – 3941E → K in AAH39623 (PubMed:15489334).Curated
Sequence conflicti394 – 3941E → K in AAH69964 (PubMed:15489334).Curated
Sequence conflicti569 – 5691P → L in BAD32386 (PubMed:15368895).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 679679Missing in isoform 2. 1 PublicationVSP_019121Add
BLAST
Alternative sequencei680 – 73556PTAQE…PRLAA → MSFHTPSPVPRPPLRCEMRV LLTLNDRSFLVLRSSVMGLL SSCTHVPCPPSA in isoform 2. 1 PublicationVSP_019122Add
BLAST
Alternative sequencei875 – 8762SK → STFLYFLLE in isoform 2. 1 PublicationVSP_019123

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173108 mRNA. Translation: BAD32386.1. Different initiation.
AK006228 mRNA. Translation: BAB24471.1.
AK144769 mRNA. Translation: BAE26057.1.
BC039623 mRNA. Translation: AAH39623.1.
BC052424 mRNA. Translation: AAH52424.1.
BC069964 mRNA. Translation: AAH69964.1.
CCDSiCCDS24025.1. [Q7TT28-1]
RefSeqiNP_080128.2. NM_025852.3. [Q7TT28-1]
UniGeneiMm.1116.

Genome annotation databases

EnsembliENSMUST00000057910; ENSMUSP00000049705; ENSMUSG00000047417. [Q7TT28-1]
GeneIDi66932.
KEGGimmu:66932.
UCSCiuc007gdq.1. mouse. [Q7TT28-2]
uc007gds.1. mouse. [Q7TT28-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173108 mRNA. Translation: BAD32386.1. Different initiation.
AK006228 mRNA. Translation: BAB24471.1.
AK144769 mRNA. Translation: BAE26057.1.
BC039623 mRNA. Translation: AAH39623.1.
BC052424 mRNA. Translation: AAH52424.1.
BC069964 mRNA. Translation: AAH69964.1.
CCDSiCCDS24025.1. [Q7TT28-1]
RefSeqiNP_080128.2. NM_025852.3. [Q7TT28-1]
UniGeneiMm.1116.

3D structure databases

ProteinModelPortaliQ7TT28.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ7TT28. 1 interaction.
STRINGi10090.ENSMUSP00000049705.

PTM databases

iPTMnetiQ7TT28.
PhosphoSiteiQ7TT28.

Proteomic databases

EPDiQ7TT28.
MaxQBiQ7TT28.
PaxDbiQ7TT28.
PRIDEiQ7TT28.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057910; ENSMUSP00000049705; ENSMUSG00000047417. [Q7TT28-1]
GeneIDi66932.
KEGGimmu:66932.
UCSCiuc007gdq.1. mouse. [Q7TT28-2]
uc007gds.1. mouse. [Q7TT28-1]

Organism-specific databases

CTDi57455.
MGIiMGI:1914182. Rexo1.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2248. Eukaryota.
COG0847. LUCA.
GeneTreeiENSGT00840000129821.
HOGENOMiHOG000039979.
HOVERGENiHBG090644.
InParanoidiQ7TT28.
KOiK14570.
OMAiELEQRRY.
OrthoDBiEOG73RB9W.
PhylomeDBiQ7TT28.
TreeFamiTF350172.

Miscellaneous databases

ChiTaRSiRexo1. mouse.
NextBioi323057.
PROiQ7TT28.
SOURCEiSearch...

Gene expression databases

BgeeiQ7TT28.
CleanExiMM_REXO1.
ExpressionAtlasiQ7TT28. baseline and differential.
GenevisibleiQ7TT28. MM.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
InterProiIPR031736. EloA-BP1.
IPR013520. Exonuclease_RNaseT/DNA_pol3.
IPR012337. RNaseH-like_dom.
[Graphical view]
PfamiPF15870. EloA-BP1. 1 hit.
[Graphical view]
SMARTiSM00479. EXOIII. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Fetal brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6J and Czech II.
    Tissue: Lung and Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Brain and Mammary tumor.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-277; SER-279; SER-353 AND SER-514, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brown adipose tissue, Kidney, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiREXO1_MOUSE
AccessioniPrimary (citable) accession number: Q7TT28
Secondary accession number(s): Q3UMP1
, Q69ZR0, Q6NSQ6, Q6PI95, Q9DA29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: October 1, 2003
Last modified: May 11, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.