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Protein
Submitted name:

Tuberin

Gene

Tsc2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-1632852. Macroautophagy.
R-MMU-165181. Inhibition of TSC complex formation by PKB.
R-MMU-198323. AKT phosphorylates targets in the cytosol.
R-MMU-380972. Energy dependent regulation of mTOR by LKB1-AMPK.
R-MMU-5628897. TP53 Regulates Metabolic Genes.

Names & Taxonomyi

Protein namesi
Submitted name:
TuberinImported
Submitted name:
Tuberous sclerosis 2Imported
Gene namesi
Name:Tsc2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:102548. Tsc2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Expressioni

Gene expression databases

BgeeiENSMUSG00000002496.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000094986.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1467 – 1694228Rap-GAPInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG3687. Eukaryota.
ENOG410XPFJ. LUCA.
GeneTreeiENSGT00760000119182.
HOVERGENiHBG018005.
KOiK07207.
OMAiLGTPRPN.
OrthoDBiEOG091G00O2.
TreeFamiTF324484.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000331. Rap_GAP_dom.
IPR003913. Tuberin.
IPR018515. Tuberin-type_domain.
IPR024584. Tuberin_N.
[Graphical view]
PANTHERiPTHR10063:SF1. PTHR10063:SF1. 4 hits.
PfamiPF11864. DUF3384. 1 hit.
PF02145. Rap_GAP. 1 hit.
PF03542. Tuberin. 1 hit.
[Graphical view]
PRINTSiPR01431. TUBERIN.
SUPFAMiSSF111347. SSF111347. 1 hit.
SSF48371. SSF48371. 1 hit.
PROSITEiPS50085. RAPGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TT21-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKPTSKDSG LKEKFKILLG LGTSRPNPRC AEGKQTEFII TSEILRELSG
60 70 80 90 100
ECGLNNRIRM IGQICDVAKT KKLEEHAVEA LWKAVSDLLQ PERPPEARHA
110 120 130 140 150
VLTLLKAIVQ GQGDRLGVLR ALFFKVIKDY PSNEDLHERL EVFKALTDNG
160 170 180 190 200
RHITYLEEEL AEFVLQWMDV GLSSEFLLVL VNLVKFNSCY LDEYIASMVH
210 220 230 240 250
MICLLCIRTV SSVDIEVSLQ VLDAVVCYNC LPAESLPLFI ITLCRTINVK
260 270 280 290 300
ELCEPCWKLM RNLLGTHLGH SAIYNMCRIM EDRSYMEDAP LLRGAVFFVG
310 320 330 340 350
MALWGAHRLY SLKNSPTSVL PSFYEAMTCP NEVVSYEIVL SITRLIKKYR
360 370 380 390 400
KELQAVTWDI LLDIIERLLQ QLQNLDSPEL KTIVHDLLTT VEELCDQNEF
410 420 430 440 450
HGSQERYYEL VESYADQRPE SSLLNLISYR AQSIHPAKDG WIQNLQLLME
460 470 480 490 500
RFFRNECRSA VRIKVLDVLS FVLLINRQFY EEELINSVVI SQLSHIPEDK
510 520 530 540 550
DHQVRKLATQ LLVDLAEGCH THHFNSLLDI IEKVMARSLS PPPELEERDL
560 570 580 590 600
AMHSASLEDV KTAVLGLLVI LQTKLYTLPA SHATRVYESL ISHIQLHYKH
610 620 630 640 650
GYSLPIASSI RLQAFDFLLL LRADSLHRLG LPNKDGVVRF SPYCLCDCME
660 670 680 690 700
LDRASEKKAS GPLSPPTGPP SPVPMGPAVR LGYLPYSLLF RVLLQCLKQE
710 720 730 740 750
SDWKVLKLVL SRLPESLRYK VLIFTSPCSV DQLSSALCSM LSAPKTLERL
760 770 780 790 800
RGTPEGFSRT DLHLAVVPVL TALISYHNYL DKTRQREMVY CLEQGLIYRC
810 820 830 840 850
ASQCVVALAI CSVEMPDIII KALPVLVVKL THISATASMA IPLLEFLSTL
860 870 880 890 900
ARLPHLYRNF AAEQYASVFA ISLPYTNPSK FNQYIVCLAH HVIAMWFIRC
910 920 930 940 950
RLPFRKDFVP YITKGLRSNV LLSFDDTPEK DSFRARSTSL NERPKSRIQT
960 970 980 990 1000
SLTSASLGSA DENSMAQADD NLKNLHLELT ETCLDMMARY VFSNFTAVPK
1010 1020 1030 1040 1050
RSPVGEFLLA GGRTKTWLVG NKLVTVTTSV GTGTRSLLGL DSGDLQGGSD
1060 1070 1080 1090 1100
SSSDPSTHVR QTKEAPAKLE SQAGQQVSRG ARDRVRSMSG GHGLRVGVLD
1110 1120 1130 1140 1150
TSAPYSPGGS ASLGPQTAVA AKPEKPPAGA QLPTAEKTNL AAYVPLLTQG
1160 1170 1180 1190 1200
WAEILVRRPT GNTSWLMSLE NPLSPFSSDI NNMPLQELSN ALMAAERFKE
1210 1220 1230 1240 1250
HRDTALYKSL SVPAAGTAKP PTLPRSNTDS AMVLEEGSPG ETQVPVEPPE
1260 1270 1280 1290 1300
LEDFEAALGT DRHCQRPDTY SRSSSASSQE EKSHLEELAA GGIPIERAIS
1310 1320 1330 1340 1350
SEGARPAVDL SFQPSQPLSK SSSSPELQTL QDILGDLGDK IDIGRLSPEA
1360 1370 1380 1390 1400
KVRSQSGILD GEAATWSATG EESRITVPPE GPLPSSSPRS PSGLRPRGYT
1410 1420 1430 1440 1450
ISDSAPSRRG KRVERDNFKS RAAASSAEKV PGINPSFVFL QLYHSPFFGD
1460 1470 1480 1490 1500
ESNKPILLPN ESFERSVQLL DQIPSYDTHK IAVLYVGEGQ SSSELAILSN
1510 1520 1530 1540 1550
EHGSYRYTEF LTGLGRLIEL KDCQPDKVYL GGLDVCGEDG QFTYCWHDDI
1560 1570 1580 1590 1600
MQAVFHIATL MPTKDVDKHR CDKKRHLGND FVSIIYNDSG EDFKLGTIKG
1610 1620 1630 1640 1650
QFNFVHVIIT PLDYKCNLLT LQCRKDMEGL VDTSVAKIVS DRNLSFVARQ
1660 1670 1680 1690 1700
MALHANMASQ VHHSRSNPTD IYPSKWIARL RHIKRLRQRI REEVHYSNPS
1710 1720 1730 1740
LPLMHPPAHT KAPAQAPEAT PTYETGQRKR LISSVDDFTE FV
Length:1,742
Mass (Da):194,099
Last modified:October 1, 2003 - v1
Checksum:i0515487278578EF2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC132367 Genomic DNA. No translation available.
BC052449 mRNA. Translation: AAH52449.1.
BC060701 mRNA. Translation: AAH60701.1.
RefSeqiNP_001034452.1. NM_001039363.2.
NP_001273643.1. NM_001286714.1.
NP_001273645.1. NM_001286716.1.
NP_001273647.1. NM_001286718.1.
UniGeneiMm.30435.

Genome annotation databases

EnsembliENSMUST00000097373; ENSMUSP00000094986; ENSMUSG00000002496.
GeneIDi22084.
KEGGimmu:22084.
UCSCiuc008axa.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC132367 Genomic DNA. No translation available.
BC052449 mRNA. Translation: AAH52449.1.
BC060701 mRNA. Translation: AAH60701.1.
RefSeqiNP_001034452.1. NM_001039363.2.
NP_001273643.1. NM_001286714.1.
NP_001273645.1. NM_001286716.1.
NP_001273647.1. NM_001286718.1.
UniGeneiMm.30435.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000094986.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000097373; ENSMUSP00000094986; ENSMUSG00000002496.
GeneIDi22084.
KEGGimmu:22084.
UCSCiuc008axa.2. mouse.

Organism-specific databases

CTDi7249.
MGIiMGI:102548. Tsc2.

Phylogenomic databases

eggNOGiKOG3687. Eukaryota.
ENOG410XPFJ. LUCA.
GeneTreeiENSGT00760000119182.
HOVERGENiHBG018005.
KOiK07207.
OMAiLGTPRPN.
OrthoDBiEOG091G00O2.
TreeFamiTF324484.

Enzyme and pathway databases

ReactomeiR-MMU-1632852. Macroautophagy.
R-MMU-165181. Inhibition of TSC complex formation by PKB.
R-MMU-198323. AKT phosphorylates targets in the cytosol.
R-MMU-380972. Energy dependent regulation of mTOR by LKB1-AMPK.
R-MMU-5628897. TP53 Regulates Metabolic Genes.

Miscellaneous databases

ChiTaRSiTsc2. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000002496.

Family and domain databases

Gene3Di1.25.10.10. 3 hits.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000331. Rap_GAP_dom.
IPR003913. Tuberin.
IPR018515. Tuberin-type_domain.
IPR024584. Tuberin_N.
[Graphical view]
PANTHERiPTHR10063:SF1. PTHR10063:SF1. 4 hits.
PfamiPF11864. DUF3384. 1 hit.
PF02145. Rap_GAP. 1 hit.
PF03542. Tuberin. 1 hit.
[Graphical view]
PRINTSiPR01431. TUBERIN.
SUPFAMiSSF111347. SSF111347. 1 hit.
SSF48371. SSF48371. 1 hit.
PROSITEiPS50085. RAPGAP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ7TT21_MOUSE
AccessioniPrimary (citable) accession number: Q7TT21
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: September 7, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.