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Protein

Inositol polyphosphate multikinase

Gene

Ipmk

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol 1,4,5-trisphosphate (Ins(1,4,5)P3) and inositol 1,3,4,6-tetrakisphosphate (Ins(1,3,4,6)P4) (By similarity).By similarity

Catalytic activityi

2 ATP + 1D-myo-inositol 1,4,5-trisphosphate = 2 ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • inositol-1,4,5-trisphosphate 3-kinase activity Source: MGI
  • inositol-1,4,5-trisphosphate 6-kinase activity Source: UniProtKB-EC
  • inositol tetrakisphosphate 3-kinase activity Source: MGI

GO - Biological processi

  • inositol phosphate biosynthetic process Source: MGI
  • neural tube formation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.1.151. 3474.
ReactomeiR-MMU-1855191. Synthesis of IPs in the nucleus.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol polyphosphate multikinase (EC:2.7.1.151)
Alternative name(s):
Inositol 1,3,4,6-tetrakisphosphate 5-kinase
Gene namesi
Name:Ipmk
Synonyms:Impk
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1916968. Ipmk.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000668712 – 396Inositol polyphosphate multikinaseAdd BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei19PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ7TT16.
PRIDEiQ7TT16.

PTM databases

iPTMnetiQ7TT16.
PhosphoSitePlusiQ7TT16.

Expressioni

Gene expression databases

BgeeiENSMUSG00000060733.
CleanExiMM_IPMK.
ExpressionAtlasiQ7TT16. baseline and differential.
GenevisibleiQ7TT16. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078240.

Structurei

3D structure databases

ProteinModelPortaliQ7TT16.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni123 – 131Substrate bindingBy similarity9

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi300 – 310Nuclear localization signalAdd BLAST11

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1620. Eukaryota.
ENOG410YHQ3. LUCA.
GeneTreeiENSGT00390000014381.
HOGENOMiHOG000116306.
HOVERGENiHBG052124.
InParanoidiQ7TT16.
KOiK00915.
PhylomeDBiQ7TT16.
TreeFamiTF321442.

Family and domain databases

InterProiIPR005522. IPK.
[Graphical view]
PANTHERiPTHR12400. PTHR12400. 2 hits.
PfamiPF03770. IPK. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7TT16-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAEPPALRL RPPGSTGDSP PVPRLLGGCV PLSHQVAGHM YGKDKVGILQ
60 70 80 90 100
HPDGTVLKQL QPPPRGPREL EFYTMVYAAD CADAVLLELR KHLPKYYGVW
110 120 130 140 150
SPPTAPNDVY LKLEDVTHKF NKPCIMDVKI GRKSYDPFAS SEKIQQQVSK
160 170 180 190 200
YPLMEEIGFL VLGMRVYHLH SDSYETQNQH YGRGLTKETL KEGVSKFFHN
210 220 230 240 250
GFCLRKDAIA ASIQKVEKIL QWFENQKQLN FYASSLLFVY EGSSQPATTK
260 270 280 290 300
ANDRTLAGRF LSKGPLTDAD GLECNNNFHL FGAPPNGMSV GKSLSKAYSR
310 320 330 340 350
HRKLYAKKHQ SQTSLKVETL EQDNGWRSMS QEHLNGNVLA QLEKVFYHLP
360 370 380 390
AGRPEIPEAE VRMIDFAHVF PSNTVDEGYV YGLKHLIAVL RSILDS
Length:396
Mass (Da):44,453
Last modified:October 1, 2003 - v1
Checksum:i5A91EED2E601E977
GO
Isoform 2 (identifier: Q7TT16-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     194-216: VSKFFHNGFCLRKDAIAASIQKV → EPWSGAAAAVSKMALTRFSSPLE
     217-396: Missing.

Note: No experimental confirmation available.
Show »
Length:216
Mass (Da):24,013
Checksum:i1C11D7AE13498B09
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56V → D in BAC29655 (PubMed:16141072).Curated1
Sequence conflicti121N → I in BAC29655 (PubMed:16141072).Curated1
Sequence conflicti204L → I in BAC29655 (PubMed:16141072).Curated1
Sequence conflicti207D → G in BAC29655 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010923194 – 216VSKFF…SIQKV → EPWSGAAAAVSKMALTRFSS PLE in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_010924217 – 396Missing in isoform 2. 1 PublicationAdd BLAST180

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010523 mRNA. Translation: BAB27004.1.
AK036084 mRNA. Translation: BAC29300.1.
AK036978 mRNA. Translation: BAC29655.1.
BC052463 mRNA. Translation: AAH52463.1.
CCDSiCCDS23918.1. [Q7TT16-1]
RefSeqiNP_081460.1. NM_027184.1. [Q7TT16-1]
UniGeneiMm.245867.

Genome annotation databases

EnsembliENSMUST00000079252; ENSMUSP00000078240; ENSMUSG00000060733. [Q7TT16-1]
ENSMUST00000118381; ENSMUSP00000113083; ENSMUSG00000060733. [Q7TT16-2]
ENSMUST00000147277; ENSMUSP00000120073; ENSMUSG00000060733. [Q7TT16-2]
GeneIDi69718.
KEGGimmu:69718.
UCSCiuc007for.1. mouse. [Q7TT16-2]
uc007fos.1. mouse. [Q7TT16-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010523 mRNA. Translation: BAB27004.1.
AK036084 mRNA. Translation: BAC29300.1.
AK036978 mRNA. Translation: BAC29655.1.
BC052463 mRNA. Translation: AAH52463.1.
CCDSiCCDS23918.1. [Q7TT16-1]
RefSeqiNP_081460.1. NM_027184.1. [Q7TT16-1]
UniGeneiMm.245867.

3D structure databases

ProteinModelPortaliQ7TT16.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000078240.

PTM databases

iPTMnetiQ7TT16.
PhosphoSitePlusiQ7TT16.

Proteomic databases

PaxDbiQ7TT16.
PRIDEiQ7TT16.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000079252; ENSMUSP00000078240; ENSMUSG00000060733. [Q7TT16-1]
ENSMUST00000118381; ENSMUSP00000113083; ENSMUSG00000060733. [Q7TT16-2]
ENSMUST00000147277; ENSMUSP00000120073; ENSMUSG00000060733. [Q7TT16-2]
GeneIDi69718.
KEGGimmu:69718.
UCSCiuc007for.1. mouse. [Q7TT16-2]
uc007fos.1. mouse. [Q7TT16-1]

Organism-specific databases

CTDi253430.
MGIiMGI:1916968. Ipmk.

Phylogenomic databases

eggNOGiKOG1620. Eukaryota.
ENOG410YHQ3. LUCA.
GeneTreeiENSGT00390000014381.
HOGENOMiHOG000116306.
HOVERGENiHBG052124.
InParanoidiQ7TT16.
KOiK00915.
PhylomeDBiQ7TT16.
TreeFamiTF321442.

Enzyme and pathway databases

BRENDAi2.7.1.151. 3474.
ReactomeiR-MMU-1855191. Synthesis of IPs in the nucleus.

Miscellaneous databases

PROiQ7TT16.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000060733.
CleanExiMM_IPMK.
ExpressionAtlasiQ7TT16. baseline and differential.
GenevisibleiQ7TT16. MM.

Family and domain databases

InterProiIPR005522. IPK.
[Graphical view]
PANTHERiPTHR12400. PTHR12400. 2 hits.
PfamiPF03770. IPK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIPMK_MOUSE
AccessioniPrimary (citable) accession number: Q7TT16
Secondary accession number(s): Q8BZ11, Q8BZA8, Q9CWM9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.