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Protein

Nucleus accumbens-associated protein 1

Gene

Nacc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. Involved in the acute behavioral and neurological responses to cocaine and amphetamines.2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleus accumbens-associated protein 1
Short name:
NAC-1
Alternative name(s):
BTB/POZ domain-containing protein 14B
Gene namesi
Name:Nacc1
Synonyms:Btbd14b, Nac1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1914080. Nacc1.

Subcellular locationi

  • Nucleus
  • Cytoplasm

  • Note: Distribution in the cytoplasm is dependent on phosphorylation.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice are viable with no obvious developmental or physiological impairments. In addition, they do not display alterations in chronic responses to cocaine and amphetamine administration, but do however display significantly diminished acute behavioral and neurochemical responses to these drugs.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 514514Nucleus accumbens-associated protein 1PRO_0000274042Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki167 – 167Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei187 – 1871PhosphoserineBy similarity
Modified residuei245 – 2451Phosphoserine; by PKCBy similarity
Modified residuei492 – 4921PhosphoserineCombined sources
Modified residuei496 – 4961PhosphoserineCombined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ7TSZ8.
MaxQBiQ7TSZ8.
PaxDbiQ7TSZ8.
PRIDEiQ7TSZ8.

PTM databases

PhosphoSiteiQ7TSZ8.

Expressioni

Tissue specificityi

Ubiquitously expressed with higher expression in the brain, kidney and liver, and at lower levels in heart, lung and testes.1 Publication

Gene expression databases

BgeeiQ7TSZ8.
GenevisibleiQ7TSZ8. MM.

Interactioni

Subunit structurei

Homooligomer; mediated by the BTB domain. Interacts with HDAC3 and HDAC4. Interacts (via BTB domain) with CUL3, PSMD7 AND RCOR1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Sall4Q8BX224EBI-5691985,EBI-2312582

Protein-protein interaction databases

BioGridi211748. 18 interactions.
DIPiDIP-29930N.
IntActiQ7TSZ8. 5 interactions.
STRINGi10090.ENSMUSP00000001975.

Structurei

3D structure databases

ProteinModelPortaliQ7TSZ8.
SMRiQ7TSZ8. Positions 2-123.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 9465BTBPROSITE-ProRule annotationAdd
BLAST
Domaini360 – 45798BENPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 BEN domain.PROSITE-ProRule annotation
Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119063.
HOGENOMiHOG000231834.
HOVERGENiHBG052875.
InParanoidiQ7TSZ8.
KOiK10486.
OMAiNMGDQFL.
OrthoDBiEOG7WT419.
PhylomeDBiQ7TSZ8.
TreeFamiTF331184.

Family and domain databases

InterProiIPR018379. BEN_domain.
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF10523. BEN. 1 hit.
PF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM01025. BEN. 1 hit.
SM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS51457. BEN. 1 hit.
PS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TSZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQTLQMEIP NFGNSILECL NEQRLQGLYC DVSVVVKGHA FKAHRAVLAA
60 70 80 90 100
SSSYFRDLFN SSRSAVVELP AAVQPQSFQQ ILTFCYTGRL SMNMGDQFLL
110 120 130 140 150
IYTAGFLQIQ EIMEKGTEFF LKVSSPSCDS QGLHPEEAPS SEPQSPVAQT
160 170 180 190 200
LGWPACSTPL PLVSRVKTEQ ELDSVQCTPM AKRLWDSSQK EAGGSGGNNG
210 220 230 240 250
SRKMAKFSTP DLALNRMPQP LSMATATAAV AVVAVGGCVS GPSMSERTSP
260 270 280 290 300
GTSSAYTSDS PSSYHNEEDE EEDAGEEGTD EQYRQICNMY TMYSMLNVGQ
310 320 330 340 350
TAEKVEALPE QVVLESRSRI RVRQDLASLP AELINQIGNR CHPKLYDEGD
360 370 380 390 400
PSEKLELVTG TNVYITRAQL MNCHVSAGTR HKVLLRRLLA SFFDRNTLAN
410 420 430 440 450
SCGTGIRSST NDPRRKPLDS RVLHAVKYYC QNFAPNFKES EMNAIAADMC
460 470 480 490 500
TNARRVVRKS WLPKTKPLHL VEGDNYSSFI SDTCKIEPDM MSMEHSFETA
510
SHDGEAGPSA EVLQ
Length:514
Mass (Da):56,537
Last modified:October 1, 2003 - v1
Checksum:iC83C23891B097626
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti401 – 4011S → R in BAB28558 (PubMed:16141072).Curated
Sequence conflicti403 – 4031G → V in AAH48157 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012935 mRNA. Translation: BAB28558.1.
BC048157 mRNA. Translation: AAH48157.1.
BC052706 mRNA. Translation: AAH52706.1.
BC054800 mRNA. Translation: AAH54800.1.
CCDSiCCDS22475.1.
RefSeqiNP_080064.3. NM_025788.3.
XP_006531355.1. XM_006531292.1.
XP_006531356.1. XM_006531293.2.
XP_006531357.1. XM_006531294.2.
UniGeneiMm.289698.

Genome annotation databases

EnsembliENSMUST00000001975; ENSMUSP00000001975; ENSMUSG00000001910.
GeneIDi66830.
KEGGimmu:66830.
UCSCiuc009mmu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012935 mRNA. Translation: BAB28558.1.
BC048157 mRNA. Translation: AAH48157.1.
BC052706 mRNA. Translation: AAH52706.1.
BC054800 mRNA. Translation: AAH54800.1.
CCDSiCCDS22475.1.
RefSeqiNP_080064.3. NM_025788.3.
XP_006531355.1. XM_006531292.1.
XP_006531356.1. XM_006531293.2.
XP_006531357.1. XM_006531294.2.
UniGeneiMm.289698.

3D structure databases

ProteinModelPortaliQ7TSZ8.
SMRiQ7TSZ8. Positions 2-123.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211748. 18 interactions.
DIPiDIP-29930N.
IntActiQ7TSZ8. 5 interactions.
STRINGi10090.ENSMUSP00000001975.

PTM databases

PhosphoSiteiQ7TSZ8.

Proteomic databases

EPDiQ7TSZ8.
MaxQBiQ7TSZ8.
PaxDbiQ7TSZ8.
PRIDEiQ7TSZ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000001975; ENSMUSP00000001975; ENSMUSG00000001910.
GeneIDi66830.
KEGGimmu:66830.
UCSCiuc009mmu.2. mouse.

Organism-specific databases

CTDi112939.
MGIiMGI:1914080. Nacc1.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119063.
HOGENOMiHOG000231834.
HOVERGENiHBG052875.
InParanoidiQ7TSZ8.
KOiK10486.
OMAiNMGDQFL.
OrthoDBiEOG7WT419.
PhylomeDBiQ7TSZ8.
TreeFamiTF331184.

Miscellaneous databases

ChiTaRSiNacc1. mouse.
NextBioi322761.
PROiQ7TSZ8.
SOURCEiSearch...

Gene expression databases

BgeeiQ7TSZ8.
GenevisibleiQ7TSZ8. MM.

Family and domain databases

InterProiIPR018379. BEN_domain.
IPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF10523. BEN. 1 hit.
PF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM01025. BEN. 1 hit.
SM00225. BTB. 1 hit.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS51457. BEN. 1 hit.
PS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  3. "The mouse Nac1 gene, encoding a cocaine-regulated bric-a-brac tramtrac broad complex/pox virus and zinc finger protein, is regulated by AP1."
    Mackler S.A., Homan Y.X., Korutla L., Conti A.C., Blendy J.A.
    Neuroscience 121:355-361(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, ALTERNATIVE SPLICING.
  4. "A BTB/POZ protein, NAC-1, is related to tumor recurrence and is essential for tumor growth and survival."
    Nakayama K., Nakayama N., Davidson B., Sheu J.-J.C., Jinawath N., Santillan A., Salani R., Bristow R.E., Morin P.J., Kurman R.J., Wang T.-L., Shih I.-M.
    Proc. Natl. Acad. Sci. U.S.A. 103:18739-18744(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. "Requirement for the POZ/BTB protein NAC1 in acute but not chronic psychomotor stimulant response."
    Mackler S., Pacchioni A., Degnan R., Homan Y., Conti A.C., Kalivas P., Blendy J.A.
    Behav. Brain Res. 187:48-55(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-492 AND SER-496, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain and Kidney.

Entry informationi

Entry nameiNACC1_MOUSE
AccessioniPrimary (citable) accession number: Q7TSZ8
Secondary accession number(s): Q80X97, Q9CZ72
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: October 1, 2003
Last modified: May 11, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.