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Protein

Nucleus accumbens-associated protein 1

Gene

Nacc1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. Involved in the acute behavioral and neurological responses to cocaine and amphetamines.2 Publications

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleus accumbens-associated protein 1
Short name:
NAC-1
Alternative name(s):
BTB/POZ domain-containing protein 14B
Gene namesi
Name:Nacc1
Synonyms:Btbd14b, Nac1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1914080 Nacc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice are viable with no obvious developmental or physiological impairments. In addition, they do not display alterations in chronic responses to cocaine and amphetamine administration, but do however display significantly diminished acute behavioral and neurochemical responses to these drugs.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002740421 – 514Nucleus accumbens-associated protein 1Add BLAST514

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki167Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki167Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linki182Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei187PhosphoserineBy similarity1
Modified residuei245Phosphoserine; by PKCBy similarity1
Cross-linki304Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki438Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki466Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki485Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei492PhosphoserineCombined sources1
Modified residuei496PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ7TSZ8
MaxQBiQ7TSZ8
PaxDbiQ7TSZ8
PeptideAtlasiQ7TSZ8
PRIDEiQ7TSZ8

PTM databases

iPTMnetiQ7TSZ8
PhosphoSitePlusiQ7TSZ8

Expressioni

Tissue specificityi

Ubiquitously expressed with higher expression in the brain, kidney and liver, and at lower levels in heart, lung and testes.1 Publication

Gene expression databases

BgeeiENSMUSG00000001910
GenevisibleiQ7TSZ8 MM

Interactioni

Subunit structurei

Homooligomer; mediated by the BTB domain. Interacts with HDAC3 and HDAC4. Interacts (via BTB domain) with CUL3, PSMD7 AND RCOR1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Sall4Q8BX224EBI-5691985,EBI-2312582

Protein-protein interaction databases

BioGridi211748, 19 interactors
DIPiDIP-29930N
IntActiQ7TSZ8, 6 interactors
MINTiQ7TSZ8
STRINGi10090.ENSMUSP00000001975

Structurei

3D structure databases

ProteinModelPortaliQ7TSZ8
SMRiQ7TSZ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 94BTBPROSITE-ProRule annotationAdd BLAST65
Domaini360 – 457BENPROSITE-ProRule annotationAdd BLAST98

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119063
HOGENOMiHOG000231834
HOVERGENiHBG052875
InParanoidiQ7TSZ8
KOiK10486
OMAiNMGDQFL
OrthoDBiEOG091G05RI
PhylomeDBiQ7TSZ8
TreeFamiTF331184

Family and domain databases

InterProiView protein in InterPro
IPR018379 BEN_domain
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
PfamiView protein in Pfam
PF10523 BEN, 1 hit
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM01025 BEN, 1 hit
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
PROSITEiView protein in PROSITE
PS51457 BEN, 1 hit
PS50097 BTB, 1 hit

Sequencei

Sequence statusi: Complete.

Q7TSZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQTLQMEIP NFGNSILECL NEQRLQGLYC DVSVVVKGHA FKAHRAVLAA
60 70 80 90 100
SSSYFRDLFN SSRSAVVELP AAVQPQSFQQ ILTFCYTGRL SMNMGDQFLL
110 120 130 140 150
IYTAGFLQIQ EIMEKGTEFF LKVSSPSCDS QGLHPEEAPS SEPQSPVAQT
160 170 180 190 200
LGWPACSTPL PLVSRVKTEQ ELDSVQCTPM AKRLWDSSQK EAGGSGGNNG
210 220 230 240 250
SRKMAKFSTP DLALNRMPQP LSMATATAAV AVVAVGGCVS GPSMSERTSP
260 270 280 290 300
GTSSAYTSDS PSSYHNEEDE EEDAGEEGTD EQYRQICNMY TMYSMLNVGQ
310 320 330 340 350
TAEKVEALPE QVVLESRSRI RVRQDLASLP AELINQIGNR CHPKLYDEGD
360 370 380 390 400
PSEKLELVTG TNVYITRAQL MNCHVSAGTR HKVLLRRLLA SFFDRNTLAN
410 420 430 440 450
SCGTGIRSST NDPRRKPLDS RVLHAVKYYC QNFAPNFKES EMNAIAADMC
460 470 480 490 500
TNARRVVRKS WLPKTKPLHL VEGDNYSSFI SDTCKIEPDM MSMEHSFETA
510
SHDGEAGPSA EVLQ
Length:514
Mass (Da):56,537
Last modified:October 1, 2003 - v1
Checksum:iC83C23891B097626
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti401S → R in BAB28558 (PubMed:16141072).Curated1
Sequence conflicti403G → V in AAH48157 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK012935 mRNA Translation: BAB28558.1
BC048157 mRNA Translation: AAH48157.1
BC052706 mRNA Translation: AAH52706.1
BC054800 mRNA Translation: AAH54800.1
CCDSiCCDS22475.1
RefSeqiNP_080064.3, NM_025788.3
XP_006531355.1, XM_006531292.2
XP_006531356.1, XM_006531293.3
XP_006531357.1, XM_006531294.3
UniGeneiMm.289698

Genome annotation databases

EnsembliENSMUST00000001975; ENSMUSP00000001975; ENSMUSG00000001910
GeneIDi66830
KEGGimmu:66830
UCSCiuc009mmu.2 mouse

Similar proteinsi

Entry informationi

Entry nameiNACC1_MOUSE
AccessioniPrimary (citable) accession number: Q7TSZ8
Secondary accession number(s): Q80X97, Q9CZ72
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: October 1, 2003
Last modified: March 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health