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Protein
Submitted name:

Leucyl-tRNA synthetase

Gene

Lars

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetaseUniRule annotationImported, Ligase

Keywords - Biological processi

Protein biosynthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Leucyl-tRNA synthetaseImported
Submitted name:
MCG127948Imported
Gene namesi
Name:LarsImported
ORF Names:mCG_127948Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1913808. Lars.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PeptideAtlasiQ7TSZ3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024493.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095197.

Structurei

3D structure databases

SMRiQ7TSZ3. Positions 13-930.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 10585tRNA-synt_1InterPro annotationAdd
BLAST
Domaini189 – 757569tRNA-synt_1InterPro annotationAdd
BLAST
Domaini796 – 912117Anticodon_1InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0437. Eukaryota.
COG0495. LUCA.
HOVERGENiHBG055325.
KOiK01869.
OMAiFYITTCA.
OrthoDBiEOG091G01VH.
PhylomeDBiQ7TSZ3.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TSZ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGRKGTAKV DFLKEIEKEA QQKWEAEKVF EVSASRLEKQ KQSSKGKYFV
60 70 80 90 100
TFPYPYMNGR LHLGHTFSLS KCEFAVGYQR LKGKSCLFPF GLHCTGMPIK
110 120 130 140 150
ACADKLKREI ELYGCPPDFP EEEEEEEESS AKPGDIVVRD KAKGKKSKAA
160 170 180 190 200
AKAGSSKYQW DIMKSLGLSD DDIVKFSEAE HWLDYFPPLA VQDLKTIGLK
210 220 230 240 250
VDWRRSFITT DVNPYYDSFV RWQFLTLRER NKIKFGKRYT IYSPKDGQPC
260 270 280 290 300
MDHDRQTGEG VGPQEYTLVK LKVLEPYPSK LSGLKGKNIF LVAATLRPET
310 320 330 340 350
MFGQTNCWVR PDMKYIGFET ANGDIFICTQ RAARNMSYQG FTKHNGVVPV
360 370 380 390 400
VKELMGEEIL GASLSAPLTC YKVVYVLPML TIKEDKGTGV VTSVPSDSPD
410 420 430 440 450
DLAALRDLKK KQALRTKFGI RDDMVLPFEP VPVLEIPGIG NLPAVTVCDE
460 470 480 490 500
LKIQSQNDRE KLAEAKEKLY LRGFYDGVML VDGFKGQKIQ HVKKTIQKNM
510 520 530 540 550
IDAGDALIYM EPEKQVMSRS ADECVVALCD QWYLDYGDEN WKKQTFQCLK
560 570 580 590 600
NMETFCEESR KNFEASLDWL QEHACSRTYG LGTRLPWDEQ WLIESLSDST
610 620 630 640 650
IYMAFYTVAH LLQGGDLNGQ AESPLGIRPQ QMTKDVWDYV FFKDAPFPKT
660 670 680 690 700
QIPKEKLDQL KQEFEFWYPV DLRASGKDLI PNHLSYYIYN HVAMWPEQSD
710 720 730 740 750
KWPVSVRANG HLLLNSEKMS KSTGNFLTLS QAVDKFSADG MRLALADAGD
760 770 780 790 800
TVEDANFVEA MADAGILRLY TWVEWVKEML ASCSSLRSGP ADSFNDRVFA
810 820 830 840 850
SEMNAGIIKT DQNYEKMMFK EALKTGFFEF QAAKDKYREL ATEGMHRELV
860 870 880 890 900
FRFIEVQTIL LTPFCPHLCE HIWTLLGKPD SIMHASWPVA GPVDESLIRS
910 920 930 940 950
SQYLMEVAHD LRLRLKNYMM PAKGKKTDKQ PAQRPSHCTI YVAKNYPVWQ
960 970 980 990 1000
HITLTTLRSH FEANNGKLPD NKVIASELGS LPELKKYMKK VMPFVAMIKE
1010 1020 1030 1040 1050
NMEKKGPRVL DLELEFDEQA VLMENIVYLT NSLELEHIEV KFASEAEDKV
1060 1070 1080 1090 1100
REECCPGKPL NVFRTEPGVP VSLVNPQPSS GHFSTKIDIR QGDSCESIIR
1110 1120 1130 1140 1150
RLMKTDRGIK DLSKVKLMRF DDPLLGPRRV PVLGREHSEK TLISENAVFH
1160 1170
VDLVSKKVHL TENGLRTDIG DTMVYLVH
Length:1,178
Mass (Da):134,192
Last modified:October 1, 2003 - v1
Checksum:i1186583D5237FFC1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC052715 mRNA. Translation: AAH52715.1.
AK166827 mRNA. Translation: BAE39051.1.
CH466528 Genomic DNA. Translation: EDL10039.1.
RefSeqiNP_598898.2. NM_134137.2.
UniGeneiMm.312170.

Genome annotation databases

GeneIDi107045.
KEGGimmu:107045.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC052715 mRNA. Translation: AAH52715.1.
AK166827 mRNA. Translation: BAE39051.1.
CH466528 Genomic DNA. Translation: EDL10039.1.
RefSeqiNP_598898.2. NM_134137.2.
UniGeneiMm.312170.

3D structure databases

SMRiQ7TSZ3. Positions 13-930.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000095197.

Proteomic databases

PeptideAtlasiQ7TSZ3.

Protocols and materials databases

DNASUi107045.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi107045.
KEGGimmu:107045.

Organism-specific databases

CTDi51520.
MGIiMGI:1913808. Lars.

Phylogenomic databases

eggNOGiKOG0437. Eukaryota.
COG0495. LUCA.
HOVERGENiHBG055325.
KOiK01869.
OMAiFYITTCA.
OrthoDBiEOG091G01VH.
PhylomeDBiQ7TSZ3.

Miscellaneous databases

ChiTaRSiLars. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024493.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR004493. Leu-tRNA-synth_Ia_arc/euk.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 2 hits.
TIGRFAMsiTIGR00395. leuS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ7TSZ3_MOUSE
AccessioniPrimary (citable) accession number: Q7TSZ3
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: September 7, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.