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Q7TSY8

- SGOL2_MOUSE

UniProt

Q7TSY8 - SGOL2_MOUSE

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Protein

Shugoshin-like 2

Gene

Sgol2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation. Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments.2 Publications

GO - Biological processi

  1. female meiotic division Source: MGI
  2. male meiosis Source: MGI
  3. meiotic sister chromatid cohesion, centromeric Source: MGI
  4. positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric Source: MGI
  5. protein localization Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition, Meiosis

Enzyme and pathway databases

ReactomeiREACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_207679. Separation of Sister Chromatids.

Names & Taxonomyi

Protein namesi
Recommended name:
Shugoshin-like 2
Alternative name(s):
Shugoshin-2
Short name:
Sgo2
Gene namesi
Name:Sgol2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1098767. Sgol2.

Subcellular locationi

Nucleus By similarity. Chromosomecentromere. Chromosomecentromerekinetochore
Note: Centromeric localization requires the presence of BUB1 and AUKRB. During meiosis I, accumulates at centromeres during diplotene, and colocalizes differentially with the cohesin subunits RAD21 and REC8 at metaphase I centromeres. SGO2 and RAD21 change their relative distributions during telophase I when sister-kinetochore association is lost. During meiosis II, it shows a striking tension-dependent redistribution within centromeres throughout chromosome congression during prometaphase II, as it does during mitosis.

GO - Cellular componenti

  1. chromosome, centromeric region Source: UniProtKB
  2. condensed chromosome, centromeric region Source: MGI
  3. condensed nuclear chromosome, centromeric region Source: MGI
  4. kinetochore Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice develop normally and survive to adulthood without any apparent alteration. However, both males and females are infertile. This defect appears cytologically as complete loss of centromere cohesion at metaphase II, leading to single chromatids, and physiologically as formation of aneuploid gametes that gave rise to infertility.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11641164Shugoshin-like 2PRO_0000055440Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1042 – 10421PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ7TSY8.
PaxDbiQ7TSY8.
PRIDEiQ7TSY8.

PTM databases

PhosphoSiteiQ7TSY8.

Expressioni

Tissue specificityi

Ubiquitously expressed in proliferating cells. Highly expressed in the testis and oocytes.1 Publication

Gene expression databases

BgeeiQ7TSY8.
CleanExiMM_SGOL2.
GenevestigatoriQ7TSY8.

Interactioni

Subunit structurei

Interacts with PPP2CA. Part of an astrin (SPAG5)-kinastrin (SKAP) complex containing KNSTRN, SPAG5, PLK1, DYNLL1 and SGOL2 By similarity.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Mad2l1Q9Z1B53EBI-2552468,EBI-2552918

Protein-protein interaction databases

BioGridi212920. 16 interactions.
IntActiQ7TSY8. 17 interactions.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili62 – 11352Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the shugoshin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG25773.
GeneTreeiENSGT00390000016383.
HOGENOMiHOG000154309.
HOVERGENiHBG093950.
InParanoidiQ7TSY8.
KOiK11581.
OMAiKVNRKTE.
OrthoDBiEOG790G02.
PhylomeDBiQ7TSY8.
TreeFamiTF350100.

Family and domain databases

InterProiIPR026706. SGOL2.
[Graphical view]
PANTHERiPTHR21577:SF2. PTHR21577:SF2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7TSY8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEYPGIKVDT VTSGIQRRVK GRIAKTNLNV SLASKIKAKI LNNSSIFKIS
60 70 80 90 100
LKHNNRALAR ALSKEKENSR RITTEKMQLQ KEVEKLNFEN TFLRLKLNTL
110 120 130 140 150
NKKLVEIESH VSNDLLTAIE ISSLSEFHQG SFLLSATKKQ RNSKQCKPAH
160 170 180 190 200
LPYARVLLTS ENDDDDGADD KWQTKCNNRT ISKTSPDSTS SVSRQPSSLH
210 220 230 240 250
QCNLKAFPPK EDNQKTCGSG HLEHTSSVDI LPNESHSDQS PKSSLSEMKT
260 270 280 290 300
APSPSLRREK LSHGNVTMRK KCVSSTPDIL YVTDLDHQPT SSPGSNWNNE
310 320 330 340 350
IHGHTNETSN NTQRNAECFL DLPSESSSEP DAKRMELVQK NTDSFHFQKT
360 370 380 390 400
VYDAADMELT ATDIGKIVAV SKSKKNQNKK KADCRKETFR KVKGASSDKK
410 420 430 440 450
RESSKRECKD GSEVGAEEEA DAARAERGAG VLDGRGDSEE PNCISSTEQP
460 470 480 490 500
SQVNTQKKRT LQNSSDQENI QNTKRRQTYT TDEQEETNPF SRHSVKFLQD
510 520 530 540 550
GKFDLCQKTL HHNLSKPSRQ TFVIRKSEKD NLFPNQEDKD TISENLEVTN
560 570 580 590 600
EFHIDDLSIE ANENVCDHET QTMLDLKKSV SAQQNQTKIN KTKQKINRRT
610 620 630 640 650
KIISVMSQVY EDNDKDIHVL EKDNFPFHTQ ANKETTSGNL ESSKEFESPL
660 670 680 690 700
LFTRDNGSLR DCKTQNVLDL HKQIPDLYPD RNESQISKIP RQKVNRKTEV
710 720 730 740 750
ISGVKCFSND QGVHCSEKDK SLLLQKDKDF PGTLKDLSEF DTPAFCNKDS
760 770 780 790 800
AKSCDYKSEM LLGLKKHDPN MQPACQDDSK AGKKLRQKVN RKTEIISKIT
810 820 830 840 850
QIHENDRGST HDSLNKKLCQ KVNISKIISQ MNQIYETINE DGNGFKSSIK
860 870 880 890 900
DCEDIKSCDF GEINSNKKEN YDPIQDPCTL VKKTKRKGSC KAGSSLAGAK
910 920 930 940 950
NRCGLQLTDS SQVQSVPLDS GLRHHPNEAD SGPGEQTNLP KMQKQSAGRS
960 970 980 990 1000
LGDAFSVSLG KEGSRPAKAV SKMTPKSKKR KLPLGCSPET HGTVEITPNT
1010 1020 1030 1040 1050
DLAKAVDSQQ TEKENYLEKE KIAKRKPDFC TKVLKPLSET CSSNIKNSSL
1060 1070 1080 1090 1100
DSMCKSSLPL SISSRKTLML EESSSLESTC IFQVGDAAHE KITTGTRNPH
1110 1120 1130 1140 1150
HRTQKSTPGS RTSLVLVDTS SVSDTNPANP ENESEGQSSH PMRRKRQCVP
1160
LNLTEPSLRS KMRR
Length:1,164
Mass (Da):130,277
Last modified:October 1, 2003 - v1
Checksum:i64BCDCE5738576D6
GO

Sequence cautioni

The sequence AAH23855.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti78 – 781Q → R in BAB30980. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC023855 mRNA. Translation: AAH23855.1. Sequence problems.
BC044797 mRNA. Translation: AAH44797.1.
BC052742 mRNA. Translation: AAH52742.1.
AK017868 mRNA. Translation: BAB30980.1.
AK042448 mRNA. Translation: BAC31263.1.
CCDSiCCDS35574.1.
RefSeqiNP_001171338.1. NM_001177867.1.
NP_950172.1. NM_199007.2.
UniGeneiMm.32800.

Genome annotation databases

EnsembliENSMUST00000027202; ENSMUSP00000027202; ENSMUSG00000026039.
GeneIDi68549.
KEGGimmu:68549.
UCSCiuc007bbk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC023855 mRNA. Translation: AAH23855.1 . Sequence problems.
BC044797 mRNA. Translation: AAH44797.1 .
BC052742 mRNA. Translation: AAH52742.1 .
AK017868 mRNA. Translation: BAB30980.1 .
AK042448 mRNA. Translation: BAC31263.1 .
CCDSi CCDS35574.1.
RefSeqi NP_001171338.1. NM_001177867.1.
NP_950172.1. NM_199007.2.
UniGenei Mm.32800.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 212920. 16 interactions.
IntActi Q7TSY8. 17 interactions.

PTM databases

PhosphoSitei Q7TSY8.

Proteomic databases

MaxQBi Q7TSY8.
PaxDbi Q7TSY8.
PRIDEi Q7TSY8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027202 ; ENSMUSP00000027202 ; ENSMUSG00000026039 .
GeneIDi 68549.
KEGGi mmu:68549.
UCSCi uc007bbk.2. mouse.

Organism-specific databases

CTDi 151246.
MGIi MGI:1098767. Sgol2.

Phylogenomic databases

eggNOGi NOG25773.
GeneTreei ENSGT00390000016383.
HOGENOMi HOG000154309.
HOVERGENi HBG093950.
InParanoidi Q7TSY8.
KOi K11581.
OMAi KVNRKTE.
OrthoDBi EOG790G02.
PhylomeDBi Q7TSY8.
TreeFami TF350100.

Enzyme and pathway databases

Reactomei REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_207679. Separation of Sister Chromatids.

Miscellaneous databases

NextBioi 327428.
PROi Q7TSY8.
SOURCEi Search...

Gene expression databases

Bgeei Q7TSY8.
CleanExi MM_SGOL2.
Genevestigatori Q7TSY8.

Family and domain databases

InterProi IPR026706. SGOL2.
[Graphical view ]
PANTHERi PTHR21577:SF2. PTHR21577:SF2. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6 and FVB/N.
    Tissue: Brain and Mammary tumor.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-593.
    Strain: C57BL/6J.
    Tissue: Thymus.
  3. Lubec G., Kang S.U., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 95-103; 259-269; 579-588 AND 1056-1065, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6 and OF1.
    Tissue: Brain and Hippocampus.
  4. "Mammalian SGO2 appears at the inner centromere domain and redistributes depending on tension across centromeres during meiosis II and mitosis."
    Gomez R., Valdeolmillos A., Parra M.T., Viera A., Carreiro C., Roncal F., Rufas J.S., Barbero J.L., Suja J.A.
    EMBO Rep. 8:173-180(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  5. Cited for: DISRUPTION PHENOTYPE, FUNCTION.
  6. "Unified mode of centromeric protection by shugoshin in mammalian oocytes and somatic cells."
    Lee J., Kitajima T.S., Tanno Y., Yoshida K., Morita T., Miyano T., Miyake M., Watanabe Y.
    Nat. Cell Biol. 10:42-52(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiSGOL2_MOUSE
AccessioniPrimary (citable) accession number: Q7TSY8
Secondary accession number(s): Q811I4
, Q8C9C4, Q8CGJ4, Q9CS55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Shugoshin is Japanese for guardian spirit (as it is known to be a protector of centromeric cohesin).

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3