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Q7TSY8

- SGOL2_MOUSE

UniProt

Q7TSY8 - SGOL2_MOUSE

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Protein
Shugoshin-like 2
Gene
Sgol2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I. Has a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis. May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation. Essential for recruiting KIF2C to the inner centromere and for correcting defective kinetochore attachments.2 Publications

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. female meiotic division Source: MGI
  2. male meiosis Source: MGI
  3. meiotic sister chromatid cohesion, centromeric Source: MGI
  4. positive regulation of maintenance of meiotic sister chromatid cohesion, centromeric Source: MGI
  5. protein localization Source: MGI
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition, Meiosis

Enzyme and pathway databases

ReactomeiREACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_207679. Separation of Sister Chromatids.

Names & Taxonomyi

Protein namesi
Recommended name:
Shugoshin-like 2
Alternative name(s):
Shugoshin-2
Short name:
Sgo2
Gene namesi
Name:Sgol2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:1098767. Sgol2.

Subcellular locationi

Nucleus By similarity. Chromosomecentromere. Chromosomecentromerekinetochore
Note: Centromeric localization requires the presence of BUB1 and AUKRB. During meiosis I, accumulates at centromeres during diplotene, and colocalizes differentially with the cohesin subunits RAD21 and REC8 at metaphase I centromeres. SGO2 and RAD21 change their relative distributions during telophase I when sister-kinetochore association is lost. During meiosis II, it shows a striking tension-dependent redistribution within centromeres throughout chromosome congression during prometaphase II, as it does during mitosis.2 Publications

GO - Cellular componenti

  1. chromosome, centromeric region Source: UniProtKB
  2. condensed chromosome kinetochore Source: UniProtKB-SubCell
  3. condensed chromosome, centromeric region Source: MGI
  4. condensed nuclear chromosome, centromeric region Source: MGI
  5. kinetochore Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Centromere, Chromosome, Kinetochore, Nucleus

Pathology & Biotechi

Disruption phenotypei

Mice develop normally and survive to adulthood without any apparent alteration. However, both males and females are infertile. This defect appears cytologically as complete loss of centromere cohesion at metaphase II, leading to single chromatids, and physiologically as formation of aneuploid gametes that gave rise to infertility.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 11641164Shugoshin-like 2
PRO_0000055440Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1042 – 10421Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ7TSY8.
PRIDEiQ7TSY8.

PTM databases

PhosphoSiteiQ7TSY8.

Expressioni

Tissue specificityi

Ubiquitously expressed in proliferating cells. Highly expressed in the testis and oocytes.1 Publication

Gene expression databases

BgeeiQ7TSY8.
CleanExiMM_SGOL2.
GenevestigatoriQ7TSY8.

Interactioni

Subunit structurei

Interacts with PPP2CA. Part of an astrin (SPAG5)-kinastrin (SKAP) complex containing KNSTRN, SPAG5, PLK1, DYNLL1 and SGOL2 By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
Mad2l1Q9Z1B53EBI-2552468,EBI-2552918

Protein-protein interaction databases

BioGridi212920. 16 interactions.
IntActiQ7TSY8. 17 interactions.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili62 – 11352 Reviewed prediction
Add
BLAST

Sequence similaritiesi

Belongs to the shugoshin family.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG25773.
GeneTreeiENSGT00390000016383.
HOGENOMiHOG000154309.
HOVERGENiHBG093950.
InParanoidiQ7TSY8.
KOiK11581.
OMAiKVNRKTE.
OrthoDBiEOG790G02.
PhylomeDBiQ7TSY8.
TreeFamiTF350100.

Family and domain databases

InterProiIPR026706. SGOL2.
[Graphical view]
PANTHERiPTHR21577:SF2. PTHR21577:SF2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7TSY8-1 [UniParc]FASTAAdd to Basket

« Hide

MEYPGIKVDT VTSGIQRRVK GRIAKTNLNV SLASKIKAKI LNNSSIFKIS     50
LKHNNRALAR ALSKEKENSR RITTEKMQLQ KEVEKLNFEN TFLRLKLNTL 100
NKKLVEIESH VSNDLLTAIE ISSLSEFHQG SFLLSATKKQ RNSKQCKPAH 150
LPYARVLLTS ENDDDDGADD KWQTKCNNRT ISKTSPDSTS SVSRQPSSLH 200
QCNLKAFPPK EDNQKTCGSG HLEHTSSVDI LPNESHSDQS PKSSLSEMKT 250
APSPSLRREK LSHGNVTMRK KCVSSTPDIL YVTDLDHQPT SSPGSNWNNE 300
IHGHTNETSN NTQRNAECFL DLPSESSSEP DAKRMELVQK NTDSFHFQKT 350
VYDAADMELT ATDIGKIVAV SKSKKNQNKK KADCRKETFR KVKGASSDKK 400
RESSKRECKD GSEVGAEEEA DAARAERGAG VLDGRGDSEE PNCISSTEQP 450
SQVNTQKKRT LQNSSDQENI QNTKRRQTYT TDEQEETNPF SRHSVKFLQD 500
GKFDLCQKTL HHNLSKPSRQ TFVIRKSEKD NLFPNQEDKD TISENLEVTN 550
EFHIDDLSIE ANENVCDHET QTMLDLKKSV SAQQNQTKIN KTKQKINRRT 600
KIISVMSQVY EDNDKDIHVL EKDNFPFHTQ ANKETTSGNL ESSKEFESPL 650
LFTRDNGSLR DCKTQNVLDL HKQIPDLYPD RNESQISKIP RQKVNRKTEV 700
ISGVKCFSND QGVHCSEKDK SLLLQKDKDF PGTLKDLSEF DTPAFCNKDS 750
AKSCDYKSEM LLGLKKHDPN MQPACQDDSK AGKKLRQKVN RKTEIISKIT 800
QIHENDRGST HDSLNKKLCQ KVNISKIISQ MNQIYETINE DGNGFKSSIK 850
DCEDIKSCDF GEINSNKKEN YDPIQDPCTL VKKTKRKGSC KAGSSLAGAK 900
NRCGLQLTDS SQVQSVPLDS GLRHHPNEAD SGPGEQTNLP KMQKQSAGRS 950
LGDAFSVSLG KEGSRPAKAV SKMTPKSKKR KLPLGCSPET HGTVEITPNT 1000
DLAKAVDSQQ TEKENYLEKE KIAKRKPDFC TKVLKPLSET CSSNIKNSSL 1050
DSMCKSSLPL SISSRKTLML EESSSLESTC IFQVGDAAHE KITTGTRNPH 1100
HRTQKSTPGS RTSLVLVDTS SVSDTNPANP ENESEGQSSH PMRRKRQCVP 1150
LNLTEPSLRS KMRR 1164
Length:1,164
Mass (Da):130,277
Last modified:October 1, 2003 - v1
Checksum:i64BCDCE5738576D6
GO

Sequence cautioni

The sequence AAH23855.1 differs from that shown. Reason: Contaminating sequence. Potential poly-A sequence.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti78 – 781Q → R in BAB30980. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC023855 mRNA. Translation: AAH23855.1. Sequence problems.
BC044797 mRNA. Translation: AAH44797.1.
BC052742 mRNA. Translation: AAH52742.1.
AK017868 mRNA. Translation: BAB30980.1.
AK042448 mRNA. Translation: BAC31263.1.
CCDSiCCDS35574.1.
RefSeqiNP_001171338.1. NM_001177867.1.
NP_950172.1. NM_199007.2.
UniGeneiMm.32800.

Genome annotation databases

EnsembliENSMUST00000027202; ENSMUSP00000027202; ENSMUSG00000026039.
GeneIDi68549.
KEGGimmu:68549.
UCSCiuc007bbk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC023855 mRNA. Translation: AAH23855.1 . Sequence problems.
BC044797 mRNA. Translation: AAH44797.1 .
BC052742 mRNA. Translation: AAH52742.1 .
AK017868 mRNA. Translation: BAB30980.1 .
AK042448 mRNA. Translation: BAC31263.1 .
CCDSi CCDS35574.1.
RefSeqi NP_001171338.1. NM_001177867.1.
NP_950172.1. NM_199007.2.
UniGenei Mm.32800.

3D structure databases

ModBasei Search...

Protein-protein interaction databases

BioGridi 212920. 16 interactions.
IntActi Q7TSY8. 17 interactions.

PTM databases

PhosphoSitei Q7TSY8.

Proteomic databases

PaxDbi Q7TSY8.
PRIDEi Q7TSY8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000027202 ; ENSMUSP00000027202 ; ENSMUSG00000026039 .
GeneIDi 68549.
KEGGi mmu:68549.
UCSCi uc007bbk.2. mouse.

Organism-specific databases

CTDi 151246.
MGIi MGI:1098767. Sgol2.

Phylogenomic databases

eggNOGi NOG25773.
GeneTreei ENSGT00390000016383.
HOGENOMi HOG000154309.
HOVERGENi HBG093950.
InParanoidi Q7TSY8.
KOi K11581.
OMAi KVNRKTE.
OrthoDBi EOG790G02.
PhylomeDBi Q7TSY8.
TreeFami TF350100.

Enzyme and pathway databases

Reactomei REACT_198961. Resolution of Sister Chromatid Cohesion.
REACT_207679. Separation of Sister Chromatids.

Miscellaneous databases

NextBioi 327428.
PROi Q7TSY8.
SOURCEi Search...

Gene expression databases

Bgeei Q7TSY8.
CleanExi MM_SGOL2.
Genevestigatori Q7TSY8.

Family and domain databases

InterProi IPR026706. SGOL2.
[Graphical view ]
PANTHERi PTHR21577:SF2. PTHR21577:SF2. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6 and FVB/N.
    Tissue: Brain and Mammary tumor.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-593.
    Strain: C57BL/6J.
    Tissue: Thymus.
  3. Lubec G., Kang S.U., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 95-103; 259-269; 579-588 AND 1056-1065, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6 and OF1.
    Tissue: Brain and Hippocampus.
  4. "Mammalian SGO2 appears at the inner centromere domain and redistributes depending on tension across centromeres during meiosis II and mitosis."
    Gomez R., Valdeolmillos A., Parra M.T., Viera A., Carreiro C., Roncal F., Rufas J.S., Barbero J.L., Suja J.A.
    EMBO Rep. 8:173-180(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  5. Cited for: DISRUPTION PHENOTYPE, FUNCTION.
  6. "Unified mode of centromeric protection by shugoshin in mammalian oocytes and somatic cells."
    Lee J., Kitajima T.S., Tanno Y., Yoshida K., Morita T., Miyano T., Miyake M., Watanabe Y.
    Nat. Cell Biol. 10:42-52(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiSGOL2_MOUSE
AccessioniPrimary (citable) accession number: Q7TSY8
Secondary accession number(s): Q811I4
, Q8C9C4, Q8CGJ4, Q9CS55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 1, 2003
Last modified: September 3, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Shugoshin is Japanese for guardian spirit (as it is known to be a protector of centromeric cohesin).

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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