Reviewed, UniProtKB/Swiss-Prot Q7TSV6 (AATC2_MOUSE)

Names and origin

Protein names

Recommended name:
    Putative aspartate aminotransferase, cytoplasmic 2
    EC=2.6.1.1
Alternative name(s):
    Transaminase A-like protein 1
    Glutamate oxaloacetate transaminase 1-like protein 1

Gene names

Name:

Got1l1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	404 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.
Cofactor	Pyridoxal phosphate By similarity.
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Miscellaneous	In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.
Sequence similarities	Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro cellular amino acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	L-aspartate:2-oxoglutarate aminotransferase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7TSV6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7TSV6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     255-404: DEGVGILVVA...IHEAVMLTEG → GLLWVEGREK

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 404	404	Putative aspartate aminotransferase, cytoplasmic 2		PRO_0000333000
Amino acid modifications
	Modified residue	249	1	N6-(pyridoxal phosphate)lysine By similarity
Natural variations
	Alternative sequence	255 – 404	150	DEGVG…MLTEG → GLLWVEGREK in isoform 2.		VSP_033430

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 3BFF5A2D3E790329	FASTA	404	45,458
	10 20 30 40 50 60 MTSLSVFRDV PTAQKLEGSL LKIYRQDGYP SKLFLAYKVC MTEEGHPWVS LVVHKTRLQI 70 80 90 100 110 120 AEDPSLDYEY LPLVGLKSFI QSSLELLFGK HSEAIAEKRV GGVHIVGESG AFQLGAQFLK 130 140 150 160 170 180 TWRKNVKIVC IVSCQKEQCG LIFQDMGFIV YEYSIWNASD LCSDPSMFVE VLQHIPVGSI 190 200 210 220 230 240 LVIGNITDCK FTQNQWTKLM SIIKSKQIFP FFDIPCQGLS TGDLEEDTKI LQYFVSLGLE 250 260 270 280 290 300 FFCSQSLSKN FGIYDEGVGI LVVAALSNQH LLCVLSQLMD YVQALWGNPP ATGARIITSI 310 320 330 340 350 360 LCNPALFGEW KQSLKGVVEN MMLIKEKVKE KLRLLGTPGS WDHITRQSGT HGYLGLTYQQ 370 380 390 400 VEFLVKKKHI YLPKTSRINF TCINARNIDY ITQSIHEAVM LTEG
	Isoform 2. Checksum: 1DB66BEE312B7C95	FASTA	264	29,866
	10 20 30 40 50 60 MTSLSVFRDV PTAQKLEGSL LKIYRQDGYP SKLFLAYKVC MTEEGHPWVS LVVHKTRLQI 70 80 90 100 110 120 AEDPSLDYEY LPLVGLKSFI QSSLELLFGK HSEAIAEKRV GGVHIVGESG AFQLGAQFLK 130 140 150 160 170 180 TWRKNVKIVC IVSCQKEQCG LIFQDMGFIV YEYSIWNASD LCSDPSMFVE VLQHIPVGSI 190 200 210 220 230 240 LVIGNITDCK FTQNQWTKLM SIIKSKQIFP FFDIPCQGLS TGDLEEDTKI LQYFVSLGLE 250 260 FFCSQSLSKN FGIYGLLWVE GREK

References

[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Strain: C57BL/6J. Tissue: Testis.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK006984 mRNA. Translation: BAB24820.1. BC052754 mRNA. Translation: AAH52754.1.
IPI	IPI00469340. IPI00895110.
RefSeq	NP_083950.1.
UniGene	Mm.272794
3D structure databases
HSSP	HSSP built from PDB template 1AJS based on UniProtKB P00503.
ModBase	Search...
Proteomic databases
PRIDE	Q7TSV6.
Genome annotation databases
Ensembl	ENSMUST00000038174; ENSMUSP00000041337; ENSMUSG00000039720; Mus musculus. [Genome view]
GeneID	76615.
KEGG	mmu:76615.
UCSC	uc009lic.1. mouse. uc009lid.1. mouse.
Organism-specific databases
CTD	76615.
MGI	MGI:1923865. Got1l1.
Phylogenomic databases
HOGENOM	Q7TSV6.
HOVERGEN	Q7TSV6.
OMA	INFTCIN.
Gene expression databases
ArrayExpress	Q7TSV6.
Bgee	Q7TSV6.
Genevestigator	Q7TSV6.
Family and domain databases
InterPro	IPR004839. Aminotransferase_I/II. IPR000796. Asp_trans. IPR004838. NHTrfase_class1_PyrdxlP-BS. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11879. Asp_trans. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
PRINTS	PR00799. TRANSAMINASE.
PROSITE	PS00105. AA_TRANSFER_CLASS_1. False negative. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	345462.
SOURCE	Search...

Entry information

Entry name

AATC2_MOUSE

Accession

Primary (citable) accession number: Q7TSV6
Secondary accession number(s): Q9D9F3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	October 1, 2003
Last modified:	November 3, 2009
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)