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Protein

T-box transcription factor TBX3

Gene

Tbx3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. Acts as a negative regulator of PML function in cellular senescence (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi107 – 220114T-box; first partPROSITE-ProRule annotationAdd
BLAST
DNA bindingi241 – 30565T-box; second partPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
T-box transcription factor TBX3
Short name:
T-box protein 3
Gene namesi
Name:Tbx3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi735203. Tbx3.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 743743T-box transcription factor TBX3PRO_0000184430Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei371 – 3711PhosphoserineBy similarity
Modified residuei434 – 4341PhosphoserineCombined sources
Modified residuei440 – 4401PhosphoserineBy similarity
Modified residuei707 – 7071PhosphoserineCombined sources
Modified residuei738 – 7381PhosphoserineBy similarity
Modified residuei740 – 7401PhosphoserineBy similarity
Modified residuei742 – 7421PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ7TST9.
PRIDEiQ7TST9.

PTM databases

iPTMnetiQ7TST9.

Expressioni

Gene expression databases

ExpressionAtlasiQ7TST9. baseline and differential.
GenevisibleiQ7TST9. RN.

Interactioni

Subunit structurei

Interacts with PML.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011552.

Structurei

3D structure databases

ProteinModelPortaliQ7TST9.
SMRiQ7TST9. Positions 100-305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 T-box DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3585. Eukaryota.
ENOG410XSTS. LUCA.
GeneTreeiENSGT00760000118897.
HOGENOMiHOG000038046.
HOVERGENiHBG000412.
InParanoidiQ7TST9.
KOiK10177.
OMAiPSQFAMG.
OrthoDBiEOG7W9RV1.
PhylomeDBiQ7TST9.
TreeFamiTF106341.

Family and domain databases

Gene3Di2.60.40.820. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR022582. TBX.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERiPTHR11267. PTHR11267. 2 hits.
PfamiPF00907. T-box. 1 hit.
PF12598. TBX. 1 hit.
[Graphical view]
PRINTSiPR00937. TBOX.
SMARTiSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiPS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TST9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSMRDPVI PGTSMAYHPF LPHRAPDFAM SAVLGHQPPF FPALTLPPNG
60 70 80 90 100
AAALSLPGAL AKPIMDQLVG AAETGIPFSS LGPQAHLRPL KTMEPEEDVE
110 120 130 140 150
DDPKVHLEAK ELWDQFHKRG TEMVITKSGR RMFPPFKVRC SGLDKKAKYI
160 170 180 190 200
LLMDIIAADD CRYKFHNSRW MVAGKADPEM PKRMYIHPDS PATGEQWMSK
210 220 230 240 250
VVTFHKLKLT NNISDKHGFT LAFPSDHATW QGNYSFGTQT ILNSMHKYQP
260 270 280 290 300
RFHIVRANDI LKLPYSTFRT YLFPETEFIA VTAYQNDKIT QLKIDNNPFA
310 320 330 340 350
KGFRDTGNGR REKRKQLTLQ SMRVFDERHK KETGTSDESS SEQAAFNCFA
360 370 380 390 400
QASSPAVSTV GTSNLKDLCP SEAESDAEAE SKEEHGPEAC DTAKISTTTA
410 420 430 440 450
EEPGRDKGSP ATRAQLFPAE PSRARDTARL DKASPDSRHS PATISSSTRV
460 470 480 490 500
PGADEHRSPG REGPVSAKVD EARALPAKDA FAPLSVQTDA TAHLTQGPLP
510 520 530 540 550
GLGFAPGLAG QQFFNGHPLF LHPGQFAMGG AFSSMAAGMG PLLATVSGAS
560 570 580 590 600
TGVSGLDSTA MASAAAAQGL SGASAATLPF HLQQHVLASQ GLAMSPFGSL
610 620 630 640 650
FPYPYTYMAA AAAASSAAAS SSVHRHPFLN LNSMRPRLRY SPYSIPVPVP
660 670 680 690 700
DSSSLLATAL PSMASAAGPL DGKSAVLAAS PASVAVDSGS ELNSRSSTLS
710 720 730 740
SGSVSLSPKL CSEKEAATSE LQSIQRLVSG LEAKPDRSCS GSP
Length:743
Mass (Da):79,335
Last modified:October 1, 2003 - v1
Checksum:iA1D3C92A1F0ECAFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY289619 mRNA. Translation: AAP43504.1.
RefSeqiNP_853669.1. NM_181638.1.
XP_006249477.1. XM_006249415.2.
XP_006249478.1. XM_006249416.2.
XP_006249479.1. XM_006249417.2.
UniGeneiRn.162144.

Genome annotation databases

EnsembliENSRNOT00000011552; ENSRNOP00000011552; ENSRNOG00000008706.
GeneIDi353305.
KEGGirno:353305.
UCSCiRGD:735203. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY289619 mRNA. Translation: AAP43504.1.
RefSeqiNP_853669.1. NM_181638.1.
XP_006249477.1. XM_006249415.2.
XP_006249478.1. XM_006249416.2.
XP_006249479.1. XM_006249417.2.
UniGeneiRn.162144.

3D structure databases

ProteinModelPortaliQ7TST9.
SMRiQ7TST9. Positions 100-305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011552.

PTM databases

iPTMnetiQ7TST9.

Proteomic databases

PaxDbiQ7TST9.
PRIDEiQ7TST9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000011552; ENSRNOP00000011552; ENSRNOG00000008706.
GeneIDi353305.
KEGGirno:353305.
UCSCiRGD:735203. rat.

Organism-specific databases

CTDi6926.
RGDi735203. Tbx3.

Phylogenomic databases

eggNOGiKOG3585. Eukaryota.
ENOG410XSTS. LUCA.
GeneTreeiENSGT00760000118897.
HOGENOMiHOG000038046.
HOVERGENiHBG000412.
InParanoidiQ7TST9.
KOiK10177.
OMAiPSQFAMG.
OrthoDBiEOG7W9RV1.
PhylomeDBiQ7TST9.
TreeFamiTF106341.

Miscellaneous databases

PROiQ7TST9.

Gene expression databases

ExpressionAtlasiQ7TST9. baseline and differential.
GenevisibleiQ7TST9. RN.

Family and domain databases

Gene3Di2.60.40.820. 1 hit.
InterProiIPR008967. p53-like_TF_DNA-bd.
IPR022582. TBX.
IPR001699. TF_T-box.
IPR018186. TF_T-box_CS.
[Graphical view]
PANTHERiPTHR11267. PTHR11267. 2 hits.
PfamiPF00907. T-box. 1 hit.
PF12598. TBX. 1 hit.
[Graphical view]
PRINTSiPR00937. TBOX.
SMARTiSM00425. TBOX. 1 hit.
[Graphical view]
SUPFAMiSSF49417. SSF49417. 1 hit.
PROSITEiPS01283. TBOX_1. 1 hit.
PS01264. TBOX_2. 1 hit.
PS50252. TBOX_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Tbx3 is a regulator of apoptosis and cell growth in rat bladder epithelial cells."
    Ito A., Asamoto M., Hokaiwado N., Inaguma S., Takahashi S., Shirai T.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Fischer 344.
    Tissue: Urinary bladder.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-434 AND SER-707, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiTBX3_RAT
AccessioniPrimary (citable) accession number: Q7TST9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: October 1, 2003
Last modified: June 8, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.