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Unreviewed, UniProtKB/TrEMBL Q7TST7 (Q7TST7_MOUSE)

Last modified January 19, 2010. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information

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Names and origin

Protein namesSubmitted name:
    Protein kinase C-zeta 2 EMBL BAC76975.1
Gene names
Name: Prkcz MGI 97602
Synonyms: Prkcz2 EMBL BAC76975.1
OrganismMus musculus (Mouse) EMBL BAC76975.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length409 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein. Spearmint SPM000961

Sequence similarities

Belongs to the protein kinase superfamily.

Contains 1 AGC-kinase C-terminal domain.

Contains 1 protein kinase domain.

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Ontologies

Keywords
   LigandATP-binding RuleBase RU000304V2 Spearmint SPM000961
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase RuleBase RU000305V3 Spearmint SPM000961
Transferase
Gene Ontology (GO)
   Biological processactin cytoskeleton reorganization

Inferred from electronic annotation. Source: Compara

activation of phospholipase D activity

Inferred from electronic annotation. Source: Compara

activation of protein kinase B activity

Inferred from electronic annotation. Source: Compara

insulin receptor signaling pathway

Inferred from electronic annotation. Source: Compara

long-term memory

Inferred from electronic annotation. Source: Compara

membrane depolarization

Inferred from electronic annotation. Source: Compara

membrane hyperpolarization

Inferred from electronic annotation. Source: Compara

negative regulation of apoptosis

Inferred from electronic annotation. Source: Compara

negative regulation of hydrolase activity

Inferred from electronic annotation. Source: Compara

negative regulation of insulin receptor signaling pathway

Inferred from electronic annotation. Source: Compara

negative regulation of peptidyl-tyrosine phosphorylation

Inferred from electronic annotation. Source: Compara

negative regulation of protein complex assembly

Inferred from electronic annotation. Source: Compara

peptidyl-serine phosphorylation

Inferred from electronic annotation. Source: Compara

positive regulation of cell proliferation

Inferred from electronic annotation. Source: Compara

positive regulation of cell-matrix adhesion

Inferred from electronic annotation. Source: Compara

positive regulation of glucose import

Inferred from electronic annotation. Source: Compara

positive regulation of protein transport

Inferred from electronic annotation. Source: Compara

positive regulation of synaptic transmission

Inferred from electronic annotation. Source: Compara

protein heterooligomerization

Inferred from electronic annotation. Source: Compara

vesicle transport along microtubule

Inferred from electronic annotation. Source: Compara

   Cellular componentcytosol

Inferred from electronic annotation. Source: Compara

filamentous actin

Inferred from electronic annotation. Source: Compara

membrane raft

Inferred from electronic annotation. Source: Compara

microsome

Inferred from electronic annotation. Source: Compara

perinuclear region of cytoplasm

Inferred from electronic annotation. Source: Compara

plasma membrane

Inferred from electronic annotation. Source: Compara

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phospholipase binding

Inferred from electronic annotation. Source: Compara

potassium channel regulator activity

Inferred from electronic annotation. Source: Compara

protein kinase binding

Inferred from electronic annotation. Source: Compara

protein serine/threonine kinase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

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Sequences

Sequence LengthMass (Da)Tools
Q7TST7-1 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 628DD31702F040DE

FASTA40946,543
        10         20         30         40         50         60 
MDSVMPSQEP PVDGKNDGVD LPSEETDGIA YISSSRKHDN IKDDSEDLKP VIDGVDGIKI 

        70         80         90        100        110        120 
SQGLGLQDFD LIRVIGRGSY AKVLLVRLKK NDQIYAMKVV KKELVHDDED IDWVQTEKHV 

       130        140        150        160        170        180 
FEQASSNPFL VGLHSCFQTT SRLFLVIEYV NGGDLMFHMQ RQRKLPEEHA RFYAAEICIA 

       190        200        210        220        230        240 
LNFLHERGII YRDLKLDNVL LDADGHIKLT DYGMCKEGLG PGDTTSTFCG TPNYIAPEIL 

       250        260        270        280        290        300 
RGEEYGFSVD WWALGVLMFE MMAGRSPFDI ITDNPDMNTE DYLFQVILEK PIRIPRFLSV 

       310        320        330        340        350        360 
KASHVLKGFL NKDPKERLGC RPQTGFSDIK SHAFFRSIDW DLLEKKQTLP PFQPQITDDY 

       370        380        390        400 
GLDNFDTQFT SEPVQLTPDD EDVIKRIDQS EFEGFEYINP LLLSAEESV

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References

[1]"PKC zeta II, a small molecule of protein kinase C zeta, specifically expressed in the mouse brain."
Hirai T., Niino Y.S., Chida K.
Neurosci. Lett. 348:151-154(2003) [PubMed: 12932816] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Brain EMBL BAC76975.1.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB110830 mRNA. Translation: BAC76975.1.
IPIIPI00828578.
UniGeneMm.28561

3D structure databases

HSSPHSSP built from PDB template 1MRY based on UniProtKB P31751.
SMRQ7TST7. Positions 64-401.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ7TST7.

Genome annotation databases

EnsemblENSMUST00000030922; ENSMUSP00000030922; ENSMUSG00000029053; Mus musculus. [Genome view]
ENSMUST00000103178; ENSMUSP00000099467; ENSMUSG00000029053; Mus musculus. [Genome view]

Organism-specific databases

MGIMGI:97602. Prkcz.

Phylogenomic databases

HOVERGENQ7TST7.
InParanoidQ7TST7.

Gene expression databases

ArrayExpressQ7TST7.
BgeeQ7TST7.
GenevestigatorQ7TST7.

Family and domain databases

InterProIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR015745. PKC.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR017442. Se/Thr_prot_kinase-like_dom.
IPR008271. Ser/Thr_prot_kinase_AS.
IPR002290. Ser/Thr_prot_kinase_dom.
[Graphical view]
PANTHERPTHR22985:SF86. PKC. 1 hit.
PfamPF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
SMARTSM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
PROSITEPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

SOURCESearch...

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Entry information

Entry nameQ7TST7_MOUSE
AccessionPrimary (citable) accession number: Q7TST7
Entry history
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: January 19, 2010
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequences · References · Cross-references · Entry information