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Q7TST7

- Q7TST7_MOUSE

UniProt

Q7TST7 - Q7TST7_MOUSE

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Protein
Submitted name:

Protein kinase C-zeta 2

Gene

Prkcz

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.SAAS annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein kinase activity Source: MGI
  3. protein serine/threonine kinase activity Source: UniProtKB-KW
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. microtubule cytoskeleton organization Source: MGI
  2. neuron projection extension Source: MGI
  3. protein localization to plasma membrane Source: MGI
  4. protein phosphorylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Protein kinase C-zeta 2Imported
Gene namesi
Name:PrkczImported
Synonyms:Prkcz2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:97602. Prkcz.

Subcellular locationi

GO - Cellular componenti

  1. apical cortex Source: MGI
  2. apical plasma membrane Source: MGI
  3. axon hillock Source: MGI
  4. cell cortex Source: MGI
  5. cytoplasm Source: MGI
  6. microtubule organizing center Source: MGI
  7. nuclear envelope Source: MGI
  8. nuclear matrix Source: MGI
  9. nucleus Source: MGI
  10. plasma membrane Source: MGI
  11. protein complex Source: MGI
  12. tight junction Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ7TST7.

Structurei

3D structure databases

ProteinModelPortaliQ7TST7.
SMRiQ7TST7. Positions 64-401.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains AGC-kinase C-terminal domain.SAAS annotation

Phylogenomic databases

HOVERGENiHBG108317.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR012233. PKC_zeta.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERiPTHR24357:SF60. PTHR24357:SF60. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
SMARTiSM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TST7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDSVMPSQEP PVDGKNDGVD LPSEETDGIA YISSSRKHDN IKDDSEDLKP
60 70 80 90 100
VIDGVDGIKI SQGLGLQDFD LIRVIGRGSY AKVLLVRLKK NDQIYAMKVV
110 120 130 140 150
KKELVHDDED IDWVQTEKHV FEQASSNPFL VGLHSCFQTT SRLFLVIEYV
160 170 180 190 200
NGGDLMFHMQ RQRKLPEEHA RFYAAEICIA LNFLHERGII YRDLKLDNVL
210 220 230 240 250
LDADGHIKLT DYGMCKEGLG PGDTTSTFCG TPNYIAPEIL RGEEYGFSVD
260 270 280 290 300
WWALGVLMFE MMAGRSPFDI ITDNPDMNTE DYLFQVILEK PIRIPRFLSV
310 320 330 340 350
KASHVLKGFL NKDPKERLGC RPQTGFSDIK SHAFFRSIDW DLLEKKQTLP
360 370 380 390 400
PFQPQITDDY GLDNFDTQFT SEPVQLTPDD EDVIKRIDQS EFEGFEYINP

LLLSAEESV
Length:409
Mass (Da):46,543
Last modified:October 1, 2003 - v1
Checksum:i628DD31702F040DE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB110830 mRNA. Translation: BAC76975.1.
UniGeneiMm.28561.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB110830 mRNA. Translation: BAC76975.1 .
UniGenei Mm.28561.

3D structure databases

ProteinModelPortali Q7TST7.
SMRi Q7TST7. Positions 64-401.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:97602. Prkcz.

Phylogenomic databases

HOVERGENi HBG108317.

Miscellaneous databases

SOURCEi Search...

Gene expression databases

Genevestigatori Q7TST7.

Family and domain databases

InterProi IPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR012233. PKC_zeta.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
PANTHERi PTHR24357:SF60. PTHR24357:SF60. 1 hit.
Pfami PF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view ]
SMARTi SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "PKC zeta II, a small molecule of protein kinase C zeta, specifically expressed in the mouse brain."
    Hirai T., Niino Y.S., Chida K.
    Neurosci. Lett. 348:151-154(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BrainImported.

Entry informationi

Entry nameiQ7TST7_MOUSE
AccessioniPrimary (citable) accession number: Q7TST7
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)