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Q7TST7

- Q7TST7_MOUSE

UniProt

Q7TST7 - Q7TST7_MOUSE

Protein
Submitted name:

Protein kinase C-zeta 2

Gene

Prkcz

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.SAAS annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. protein binding Source: MGI
    3. protein kinase activity Source: MGI
    4. protein serine/threonine kinase activity Source: UniProtKB-KW
    5. zinc ion binding Source: InterPro

    GO - Biological processi

    1. microtubule cytoskeleton organization Source: MGI
    2. neuron projection extension Source: MGI
    3. protein localization to plasma membrane Source: MGI
    4. protein phosphorylation Source: MGI

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinaseSAAS annotation, Transferase

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Protein kinase C-zeta 2Imported
    Gene namesi
    Name:PrkczImported
    Synonyms:Prkcz2Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:97602. Prkcz.

    Subcellular locationi

    GO - Cellular componenti

    1. apical cortex Source: MGI
    2. apical plasma membrane Source: MGI
    3. axon hillock Source: MGI
    4. cell cortex Source: MGI
    5. cytoplasm Source: MGI
    6. microtubule organizing center Source: MGI
    7. nuclear envelope Source: MGI
    8. nuclear matrix Source: MGI
    9. nucleus Source: MGI
    10. plasma membrane Source: MGI
    11. protein complex Source: MGI
    12. tight junction Source: MGI

    Expressioni

    Gene expression databases

    GenevestigatoriQ7TST7.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7TST7.
    SMRiQ7TST7. Positions 64-401.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains AGC-kinase C-terminal domain.SAAS annotation

    Phylogenomic databases

    HOVERGENiHBG108317.
    InParanoidiQ7TST7.

    Family and domain databases

    InterProiIPR000961. AGC-kinase_C.
    IPR011009. Kinase-like_dom.
    IPR012233. PKC_zeta.
    IPR017892. Pkinase_C.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PANTHERiPTHR24357:SF60. PTHR24357:SF60. 1 hit.
    PfamiPF00069. Pkinase. 1 hit.
    PF00433. Pkinase_C. 1 hit.
    [Graphical view]
    SMARTiSM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7TST7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDSVMPSQEP PVDGKNDGVD LPSEETDGIA YISSSRKHDN IKDDSEDLKP    50
    VIDGVDGIKI SQGLGLQDFD LIRVIGRGSY AKVLLVRLKK NDQIYAMKVV 100
    KKELVHDDED IDWVQTEKHV FEQASSNPFL VGLHSCFQTT SRLFLVIEYV 150
    NGGDLMFHMQ RQRKLPEEHA RFYAAEICIA LNFLHERGII YRDLKLDNVL 200
    LDADGHIKLT DYGMCKEGLG PGDTTSTFCG TPNYIAPEIL RGEEYGFSVD 250
    WWALGVLMFE MMAGRSPFDI ITDNPDMNTE DYLFQVILEK PIRIPRFLSV 300
    KASHVLKGFL NKDPKERLGC RPQTGFSDIK SHAFFRSIDW DLLEKKQTLP 350
    PFQPQITDDY GLDNFDTQFT SEPVQLTPDD EDVIKRIDQS EFEGFEYINP 400
    LLLSAEESV 409
    Length:409
    Mass (Da):46,543
    Last modified:October 1, 2003 - v1
    Checksum:i628DD31702F040DE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB110830 mRNA. Translation: BAC76975.1.
    UniGeneiMm.28561.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB110830 mRNA. Translation: BAC76975.1 .
    UniGenei Mm.28561.

    3D structure databases

    ProteinModelPortali Q7TST7.
    SMRi Q7TST7. Positions 64-401.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:97602. Prkcz.

    Phylogenomic databases

    HOVERGENi HBG108317.
    InParanoidi Q7TST7.

    Miscellaneous databases

    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q7TST7.

    Family and domain databases

    InterProi IPR000961. AGC-kinase_C.
    IPR011009. Kinase-like_dom.
    IPR012233. PKC_zeta.
    IPR017892. Pkinase_C.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    PANTHERi PTHR24357:SF60. PTHR24357:SF60. 1 hit.
    Pfami PF00069. Pkinase. 1 hit.
    PF00433. Pkinase_C. 1 hit.
    [Graphical view ]
    SMARTi SM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "PKC zeta II, a small molecule of protein kinase C zeta, specifically expressed in the mouse brain."
      Hirai T., Niino Y.S., Chida K.
      Neurosci. Lett. 348:151-154(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: BrainImported.

    Entry informationi

    Entry nameiQ7TST7_MOUSE
    AccessioniPrimary (citable) accession number: Q7TST7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2003
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)