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Q7TST7 (Q7TST7_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
Gene names
Name:Prkcz MGI 97602
Synonyms:Prkcz2 EMBL BAC76975.1
OrganismMus musculus (Mouse) EMBL BAC76975.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length409 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein. SAAS SAAS000961

Sequence similarities

Contains 1 AGC-kinase C-terminal domain.

Contains AGC-kinase C-terminal domain. SAAS SAAS000961

Ontologies

Keywords
   LigandATP-binding SAAS SAAS000961 RuleBase RU000304
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase SAAS SAAS000961
Transferase
Gene Ontology (GO)
   Biological_processmicrotubule cytoskeleton organization

Inferred from mutant phenotype PubMed 15882626. Source: MGI

negative regulation of apoptotic process

Inferred from electronic annotation. Source: InterPro

neuron projection extension

Inferred from genetic interaction PubMed 19668197. Source: MGI

positive regulation of NF-kappaB transcription factor activity

Inferred from electronic annotation. Source: InterPro

protein localization to plasma membrane

Inferred from mutant phenotype PubMed 16455755. Source: MGI

protein phosphorylation

Inferred from direct assay PubMed 14730360. Source: MGI

   Cellular_componentapical cortex

Inferred from direct assay PubMed 15950600. Source: MGI

apical plasma membrane

Inferred from direct assay PubMed 20551175. Source: MGI

axon hillock

Inferred from direct assay PubMed 19668197. Source: MGI

cell cortex

Inferred from direct assay PubMed 15950600. Source: MGI

cytoplasm

Inferred from direct assay PubMed 10882525PubMed 12871585PubMed 14730360. Source: MGI

microtubule organizing center

Inferred from genetic interaction PubMed 19668197. Source: MGI

nuclear envelope

Inferred from direct assay PubMed 10882525. Source: MGI

nuclear matrix

Inferred from direct assay PubMed 10882525. Source: MGI

nucleus

Inferred from direct assay PubMed 10882525. Source: MGI

plasma membrane

Inferred from direct assay PubMed 10882525. Source: MGI

protein complex

Inferred from direct assay PubMed 16510873. Source: MGI

tight junction

Inferred from direct assay PubMed 15775979PubMed 15950600. Source: MGI

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein binding

Inferred from physical interaction PubMed 16510873PubMed 19668197. Source: MGI

protein kinase C activity

Inferred from electronic annotation. Source: InterPro

protein kinase activity

Inferred from direct assay PubMed 14730360. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q7TST7 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 628DD31702F040DE

FASTA40946,543
        10         20         30         40         50         60 
MDSVMPSQEP PVDGKNDGVD LPSEETDGIA YISSSRKHDN IKDDSEDLKP VIDGVDGIKI 

        70         80         90        100        110        120 
SQGLGLQDFD LIRVIGRGSY AKVLLVRLKK NDQIYAMKVV KKELVHDDED IDWVQTEKHV 

       130        140        150        160        170        180 
FEQASSNPFL VGLHSCFQTT SRLFLVIEYV NGGDLMFHMQ RQRKLPEEHA RFYAAEICIA 

       190        200        210        220        230        240 
LNFLHERGII YRDLKLDNVL LDADGHIKLT DYGMCKEGLG PGDTTSTFCG TPNYIAPEIL 

       250        260        270        280        290        300 
RGEEYGFSVD WWALGVLMFE MMAGRSPFDI ITDNPDMNTE DYLFQVILEK PIRIPRFLSV 

       310        320        330        340        350        360 
KASHVLKGFL NKDPKERLGC RPQTGFSDIK SHAFFRSIDW DLLEKKQTLP PFQPQITDDY 

       370        380        390        400 
GLDNFDTQFT SEPVQLTPDD EDVIKRIDQS EFEGFEYINP LLLSAEESV 

« Hide

References

[1]"PKC zeta II, a small molecule of protein kinase C zeta, specifically expressed in the mouse brain."
Hirai T., Niino Y.S., Chida K.
Neurosci. Lett. 348:151-154(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Brain EMBL BAC76975.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB110830 mRNA. Translation: BAC76975.1.
UniGeneMm.28561.

3D structure databases

ProteinModelPortalQ7TST7.
SMRQ7TST7. Positions 64-401.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:97602. Prkcz.

Phylogenomic databases

HOVERGENHBG108317.
InParanoidQ7TST7.

Gene expression databases

GenevestigatorQ7TST7.

Family and domain databases

InterProIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR012233. PKC_zeta.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PANTHERPTHR24357:SF60. PTHR24357:SF60. 1 hit.
PfamPF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
SMARTSM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameQ7TST7_MOUSE
AccessionPrimary (citable) accession number: Q7TST7
Entry history
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: June 11, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)