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Q7TST5

- LAMP3_MOUSE

UniProt

Q7TST5 - LAMP3_MOUSE

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Protein
Lysosome-associated membrane glycoprotein 3
Gene
Lamp3
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May play a role in dendritic cell function and in adaptive immunity By similarity.

GO - Biological processi

  1. immune system process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 3
Short name:
LAMP-3
Short name:
Lysosomal-associated membrane protein 3
Alternative name(s):
DC-lysosome-associated membrane glycoprotein
Short name:
DC LAMP
CD_antigen: CD208
Gene namesi
Name:Lamp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:2441659. Lamp3.

Subcellular locationi

Lysosome membrane; Single-pass type I membrane protein By similarity. Cytoplasmic vesicle membrane; Single-pass type I membrane protein By similarity
Note: During dendritic cell maturation, detected on cytoplasmic vesicles (the MHC II compartment) that contain MHC II proteins, LAMP1, LAMP2 and LAMP3. Detected on lysosomes in mature dendritic cells By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 376355Lumenal Reviewed prediction
Add
BLAST
Transmembranei377 – 39721Helical; Reviewed prediction
Add
BLAST
Topological domaini398 – 41114Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. alveolar lamellar body membrane Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. lysosomal membrane Source: MGI
  4. lysosome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121 Reviewed prediction
Add
BLAST
Chaini22 – 411390Lysosome-associated membrane glycoprotein 3
PRO_0000223697Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi227 – 2271N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi232 ↔ 269 By similarity
Disulfide bondi334 ↔ 371 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ7TST5.
PaxDbiQ7TST5.
PRIDEiQ7TST5.

PTM databases

PhosphoSiteiQ7TST5.

Expressioni

Gene expression databases

BgeeiQ7TST5.
CleanExiMM_LAMP3.
GenevestigatoriQ7TST5.

Interactioni

Subunit structurei

Monomer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ7TST5.
SMRiQ7TST5. Positions 219-373.

Family & Domainsi

Sequence similaritiesi

Belongs to the LAMP family.

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG288611.
GeneTreeiENSGT00530000063068.
HOGENOMiHOG000004835.
HOVERGENiHBG081889.
InParanoidiQ7TST5.
KOiK06562.
OMAiYYISEVG.
OrthoDBiEOG7ZD1VH.
PhylomeDBiQ7TST5.
TreeFamiTF316339.

Family and domain databases

InterProiIPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiPS51407. LAMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TST5-1 [UniParc]FASTAAdd to Basket

« Hide

MPGQISAVAV LFLSLTVILH GYQIREKEFP KARGYLQYTA TSAEQITTKP    50
LLQLINQRSH ITLASRFKDD YIQMAAETSA IENTAHITMK TVTPVTTKSL 100
PPISSASYTF VRSNNAHMTA SSTDDTIGSG SIAHLPVPTT RASLAIVNYI 150
TGRATQLGGQ TTLPKTFFTA SHKSTTNQRP TLSTNVLGTS TPTHKDRSTT 200
SPVPLVPRPT LVTWSSPAKI GTYEVLNGSR LCIKAEMGLA LIVQEKDLDS 250
ATQRYFNIDP SLTHASGKCD SQKSNLFLNF QGGSVNITFT KEENLYYISE 300
VGAYLTISNT EKTYQGKKNT LMMFETVVGH SFKCVSEQSI QLSAQLQMKT 350
MNIHLQAFDF EGDSFGNVNE CLSDYTVVLP MVAIIVVVIC VVGLSVYKIR 400
QRHQSSAYQR I 411
Length:411
Mass (Da):45,129
Last modified:October 1, 2003 - v1
Checksum:iFC7D6F16485A02ED
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti75 – 751A → G in BAC25713. 1 Publication
Sequence conflicti109 – 1091T → S in BAC25713. 1 Publication
Sequence conflicti195 – 1962KD → TG in BAC25713. 1 Publication
Sequence conflicti248 – 2481L → W in BAC25713. 1 Publication
Sequence conflicti257 – 2571N → H in BAC25713. 1 Publication
Sequence conflicti268 – 2681K → N in BAC25713. 1 Publication
Sequence conflicti272 – 2721Q → H in BAC25713. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ510130 mRNA. Translation: CAD52824.1.
AK028039 mRNA. Translation: BAC25713.1.
CCDSiCCDS37285.1.
RefSeqiNP_796330.2. NM_177356.3.
UniGeneiMm.258059.
Mm.295252.

Genome annotation databases

EnsembliENSMUST00000081880; ENSMUSP00000080556; ENSMUSG00000041247.
GeneIDi239739.
KEGGimmu:239739.
UCSCiuc007ypb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ510130 mRNA. Translation: CAD52824.1 .
AK028039 mRNA. Translation: BAC25713.1 .
CCDSi CCDS37285.1.
RefSeqi NP_796330.2. NM_177356.3.
UniGenei Mm.258059.
Mm.295252.

3D structure databases

ProteinModelPortali Q7TST5.
SMRi Q7TST5. Positions 219-373.
ModBasei Search...

PTM databases

PhosphoSitei Q7TST5.

Proteomic databases

MaxQBi Q7TST5.
PaxDbi Q7TST5.
PRIDEi Q7TST5.

Protocols and materials databases

DNASUi 239739.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000081880 ; ENSMUSP00000080556 ; ENSMUSG00000041247 .
GeneIDi 239739.
KEGGi mmu:239739.
UCSCi uc007ypb.1. mouse.

Organism-specific databases

CTDi 27074.
MGIi MGI:2441659. Lamp3.

Phylogenomic databases

eggNOGi NOG288611.
GeneTreei ENSGT00530000063068.
HOGENOMi HOG000004835.
HOVERGENi HBG081889.
InParanoidi Q7TST5.
KOi K06562.
OMAi YYISEVG.
OrthoDBi EOG7ZD1VH.
PhylomeDBi Q7TST5.
TreeFami TF316339.

Miscellaneous databases

NextBioi 384259.
PROi Q7TST5.
SOURCEi Search...

Gene expression databases

Bgeei Q7TST5.
CleanExi MM_LAMP3.
Genevestigatori Q7TST5.

Family and domain databases

InterProi IPR002000. Lysosome-assoc_membr_glycop.
[Graphical view ]
PANTHERi PTHR11506. PTHR11506. 1 hit.
Pfami PF01299. Lamp. 1 hit.
[Graphical view ]
PRINTSi PR00336. LYSASSOCTDMP.
PROSITEi PS51407. LAMP_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Murine CD208/DC-LAMP is associated with the surfactant secretory organelles in type II pneumocytes."
    Salaun B.P.A., de Saint-Vis B.M., Clair-Moninot V.A., Pin J.J., Dubois-Barthelemy C., Kissenpfennig A., Peronne C., Mattei M.-G., Davoust J., Kleijmeer M.J., Lebecque S.J.E.
    Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Lung.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Lung.

Entry informationi

Entry nameiLAMP3_MOUSE
AccessioniPrimary (citable) accession number: Q7TST5
Secondary accession number(s): Q8C1F6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi