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Q7TST5 (LAMP3_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysosome-associated membrane glycoprotein 3

Short name=LAMP-3
Short name=Lysosomal-associated membrane protein 3
Alternative name(s):
DC-lysosome-associated membrane glycoprotein
Short name=DC LAMP
CD_antigen=CD208
Gene names
Name:Lamp3
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length411 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in dendritic cell function and in adaptive immunity By similarity.

Subunit structure

Monomer By similarity.

Subcellular location

Lysosome membrane; Single-pass type I membrane protein By similarity. Cytoplasmic vesicle membrane; Single-pass type I membrane protein By similarity. Note: During dendritic cell maturation, detected on cytoplasmic vesicles (the MHC II compartment) that contain MHC II proteins, LAMP1, LAMP2 and LAMP3. Detected on lysosomes in mature dendritic cells By similarity.

Sequence similarities

Belongs to the LAMP family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 411390Lysosome-associated membrane glycoprotein 3
PRO_0000223697

Regions

Topological domain22 – 376355Lumenal Potential
Transmembrane377 – 39721Helical; Potential
Topological domain398 – 41114Cytoplasmic Potential

Amino acid modifications

Glycosylation2271N-linked (GlcNAc...) Potential
Disulfide bond232 ↔ 269 By similarity
Disulfide bond334 ↔ 371 By similarity

Experimental info

Sequence conflict751A → G in BAC25713. Ref.2
Sequence conflict1091T → S in BAC25713. Ref.2
Sequence conflict195 – 1962KD → TG in BAC25713. Ref.2
Sequence conflict2481L → W in BAC25713. Ref.2
Sequence conflict2571N → H in BAC25713. Ref.2
Sequence conflict2681K → N in BAC25713. Ref.2
Sequence conflict2721Q → H in BAC25713. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q7TST5 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: FC7D6F16485A02ED

FASTA41145,129
        10         20         30         40         50         60 
MPGQISAVAV LFLSLTVILH GYQIREKEFP KARGYLQYTA TSAEQITTKP LLQLINQRSH 

        70         80         90        100        110        120 
ITLASRFKDD YIQMAAETSA IENTAHITMK TVTPVTTKSL PPISSASYTF VRSNNAHMTA 

       130        140        150        160        170        180 
SSTDDTIGSG SIAHLPVPTT RASLAIVNYI TGRATQLGGQ TTLPKTFFTA SHKSTTNQRP 

       190        200        210        220        230        240 
TLSTNVLGTS TPTHKDRSTT SPVPLVPRPT LVTWSSPAKI GTYEVLNGSR LCIKAEMGLA 

       250        260        270        280        290        300 
LIVQEKDLDS ATQRYFNIDP SLTHASGKCD SQKSNLFLNF QGGSVNITFT KEENLYYISE 

       310        320        330        340        350        360 
VGAYLTISNT EKTYQGKKNT LMMFETVVGH SFKCVSEQSI QLSAQLQMKT MNIHLQAFDF 

       370        380        390        400        410 
EGDSFGNVNE CLSDYTVVLP MVAIIVVVIC VVGLSVYKIR QRHQSSAYQR I 

« Hide

References

« Hide 'large scale' references
[1]"Murine CD208/DC-LAMP is associated with the surfactant secretory organelles in type II pneumocytes."
Salaun B.P.A., de Saint-Vis B.M., Clair-Moninot V.A., Pin J.J., Dubois-Barthelemy C., Kissenpfennig A., Peronne C., Mattei M.-G., Davoust J., Kleijmeer M.J., Lebecque S.J.E.
Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Lung.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ510130 mRNA. Translation: CAD52824.1.
AK028039 mRNA. Translation: BAC25713.1.
RefSeqNP_796330.2. NM_177356.3.
UniGeneMm.258059.
Mm.295252.

3D structure databases

ProteinModelPortalQ7TST5.
SMRQ7TST5. Positions 219-373.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ7TST5.

Proteomic databases

PaxDbQ7TST5.
PRIDEQ7TST5.

Protocols and materials databases

DNASU239739.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000081880; ENSMUSP00000080556; ENSMUSG00000041247.
GeneID239739.
KEGGmmu:239739.
UCSCuc007ypb.1. mouse.

Organism-specific databases

CTD27074.
MGIMGI:2441659. Lamp3.

Phylogenomic databases

eggNOGNOG288611.
GeneTreeENSGT00530000063068.
HOGENOMHOG000004835.
HOVERGENHBG081889.
InParanoidQ7TST5.
KOK06562.
OMAYYISEVG.
OrthoDBEOG7ZD1VH.
PhylomeDBQ7TST5.
TreeFamTF316339.

Gene expression databases

BgeeQ7TST5.
CleanExMM_LAMP3.
GenevestigatorQ7TST5.

Family and domain databases

InterProIPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERPTHR11506. PTHR11506. 1 hit.
PfamPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSPR00336. LYSASSOCTDMP.
PROSITEPS51407. LAMP_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio384259.
PROQ7TST5.
SOURCESearch...

Entry information

Entry nameLAMP3_MOUSE
AccessionPrimary (citable) accession number: Q7TST5
Secondary accession number(s): Q8C1F6
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: October 1, 2003
Last modified: April 16, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot