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Protein

Lysosome-associated membrane glycoprotein 3

Gene

Lamp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in dendritic cell function and in adaptive immunity.By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Lysosome-associated membrane glycoprotein 3
Short name:
LAMP-3
Short name:
Lysosomal-associated membrane protein 3
Alternative name(s):
DC-lysosome-associated membrane glycoprotein
Short name:
DC LAMP
CD_antigen: CD208
Gene namesi
Name:Lamp3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2441659. Lamp3.

Subcellular locationi

  • Lysosome membrane By similarity; Single-pass type I membrane protein Sequence analysis
  • Cytoplasmic vesicle membrane By similarity; Single-pass type I membrane protein Sequence analysis

  • Note: During dendritic cell maturation, detected on cytoplasmic vesicles (the MHC II compartment) that contain MHC II proteins, LAMP1, LAMP2 and LAMP3. Detected on lysosomes in mature dendritic cells.By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 376LumenalSequence analysisAdd BLAST355
Transmembranei377 – 397HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini398 – 411CytoplasmicPROSITE-ProRule annotationAdd BLAST14

GO - Cellular componenti

  • alveolar lamellar body membrane Source: MGI
  • early endosome Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • lysosomal membrane Source: MGI
  • lysosome Source: MGI
  • perinuclear region of cytoplasm Source: MGI
  • plasma membrane Source: MGI
  • vesicle Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000022369722 – 411Lysosome-associated membrane glycoprotein 3Add BLAST390

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi227N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi232 ↔ 269PROSITE-ProRule annotation
Disulfide bondi334 ↔ 371PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ7TST5.
PaxDbiQ7TST5.
PeptideAtlasiQ7TST5.
PRIDEiQ7TST5.

PTM databases

iPTMnetiQ7TST5.
PhosphoSitePlusiQ7TST5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000041247.
CleanExiMM_LAMP3.
GenevisibleiQ7TST5. MM.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080556.

Structurei

3D structure databases

ProteinModelPortaliQ7TST5.
SMRiQ7TST5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LAMP family.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4818. Eukaryota.
ENOG410XQ96. LUCA.
GeneTreeiENSGT00530000063068.
HOGENOMiHOG000004835.
HOVERGENiHBG081889.
InParanoidiQ7TST5.
KOiK06562.
OMAiFEDDHFG.
OrthoDBiEOG091G09EV.
PhylomeDBiQ7TST5.
TreeFamiTF316339.

Family and domain databases

InterProiIPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiPS51407. LAMP_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TST5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGQISAVAV LFLSLTVILH GYQIREKEFP KARGYLQYTA TSAEQITTKP
60 70 80 90 100
LLQLINQRSH ITLASRFKDD YIQMAAETSA IENTAHITMK TVTPVTTKSL
110 120 130 140 150
PPISSASYTF VRSNNAHMTA SSTDDTIGSG SIAHLPVPTT RASLAIVNYI
160 170 180 190 200
TGRATQLGGQ TTLPKTFFTA SHKSTTNQRP TLSTNVLGTS TPTHKDRSTT
210 220 230 240 250
SPVPLVPRPT LVTWSSPAKI GTYEVLNGSR LCIKAEMGLA LIVQEKDLDS
260 270 280 290 300
ATQRYFNIDP SLTHASGKCD SQKSNLFLNF QGGSVNITFT KEENLYYISE
310 320 330 340 350
VGAYLTISNT EKTYQGKKNT LMMFETVVGH SFKCVSEQSI QLSAQLQMKT
360 370 380 390 400
MNIHLQAFDF EGDSFGNVNE CLSDYTVVLP MVAIIVVVIC VVGLSVYKIR
410
QRHQSSAYQR I
Length:411
Mass (Da):45,129
Last modified:October 1, 2003 - v1
Checksum:iFC7D6F16485A02ED
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti75A → G in BAC25713 (PubMed:16141072).Curated1
Sequence conflicti109T → S in BAC25713 (PubMed:16141072).Curated1
Sequence conflicti195 – 196KD → TG in BAC25713 (PubMed:16141072).Curated2
Sequence conflicti248L → W in BAC25713 (PubMed:16141072).Curated1
Sequence conflicti257N → H in BAC25713 (PubMed:16141072).Curated1
Sequence conflicti268K → N in BAC25713 (PubMed:16141072).Curated1
Sequence conflicti272Q → H in BAC25713 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ510130 mRNA. Translation: CAD52824.1.
AK028039 mRNA. Translation: BAC25713.1.
CCDSiCCDS37285.1.
RefSeqiNP_796330.2. NM_177356.3.
UniGeneiMm.258059.
Mm.295252.

Genome annotation databases

EnsembliENSMUST00000081880; ENSMUSP00000080556; ENSMUSG00000041247.
GeneIDi239739.
KEGGimmu:239739.
UCSCiuc007ypb.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ510130 mRNA. Translation: CAD52824.1.
AK028039 mRNA. Translation: BAC25713.1.
CCDSiCCDS37285.1.
RefSeqiNP_796330.2. NM_177356.3.
UniGeneiMm.258059.
Mm.295252.

3D structure databases

ProteinModelPortaliQ7TST5.
SMRiQ7TST5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000080556.

PTM databases

iPTMnetiQ7TST5.
PhosphoSitePlusiQ7TST5.

Proteomic databases

MaxQBiQ7TST5.
PaxDbiQ7TST5.
PeptideAtlasiQ7TST5.
PRIDEiQ7TST5.

Protocols and materials databases

DNASUi239739.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000081880; ENSMUSP00000080556; ENSMUSG00000041247.
GeneIDi239739.
KEGGimmu:239739.
UCSCiuc007ypb.1. mouse.

Organism-specific databases

CTDi27074.
MGIiMGI:2441659. Lamp3.

Phylogenomic databases

eggNOGiKOG4818. Eukaryota.
ENOG410XQ96. LUCA.
GeneTreeiENSGT00530000063068.
HOGENOMiHOG000004835.
HOVERGENiHBG081889.
InParanoidiQ7TST5.
KOiK06562.
OMAiFEDDHFG.
OrthoDBiEOG091G09EV.
PhylomeDBiQ7TST5.
TreeFamiTF316339.

Miscellaneous databases

PROiQ7TST5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000041247.
CleanExiMM_LAMP3.
GenevisibleiQ7TST5. MM.

Family and domain databases

InterProiIPR002000. Lysosome-assoc_membr_glycop.
[Graphical view]
PANTHERiPTHR11506. PTHR11506. 1 hit.
PfamiPF01299. Lamp. 1 hit.
[Graphical view]
PRINTSiPR00336. LYSASSOCTDMP.
PROSITEiPS51407. LAMP_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLAMP3_MOUSE
AccessioniPrimary (citable) accession number: Q7TST5
Secondary accession number(s): Q8C1F6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.