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Q7TST5

- LAMP3_MOUSE

UniProt

Q7TST5 - LAMP3_MOUSE

Protein

Lysosome-associated membrane glycoprotein 3

Gene

Lamp3

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    May play a role in dendritic cell function and in adaptive immunity.By similarity

    GO - Biological processi

    1. immune system process Source: UniProtKB-KW

    Keywords - Biological processi

    Adaptive immunity, Immunity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysosome-associated membrane glycoprotein 3
    Short name:
    LAMP-3
    Short name:
    Lysosomal-associated membrane protein 3
    Alternative name(s):
    DC-lysosome-associated membrane glycoprotein
    Short name:
    DC LAMP
    CD_antigen: CD208
    Gene namesi
    Name:Lamp3
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:2441659. Lamp3.

    Subcellular locationi

    Lysosome membrane PROSITE-ProRule annotation; Single-pass type I membrane protein PROSITE-ProRule annotation. Cytoplasmic vesicle membrane By similarity; Single-pass type I membrane protein PROSITE-ProRule annotation
    Note: During dendritic cell maturation, detected on cytoplasmic vesicles (the MHC II compartment) that contain MHC II proteins, LAMP1, LAMP2 and LAMP3. Detected on lysosomes in mature dendritic cells By similarity.By similarity

    GO - Cellular componenti

    1. alveolar lamellar body membrane Source: MGI
    2. integral component of membrane Source: UniProtKB-KW
    3. lysosomal membrane Source: MGI
    4. lysosome Source: MGI

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Lysosome, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 411390Lysosome-associated membrane glycoprotein 3PRO_0000223697Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi227 – 2271N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi232 ↔ 269PROSITE-ProRule annotation
    Disulfide bondi334 ↔ 371PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ7TST5.
    PaxDbiQ7TST5.
    PRIDEiQ7TST5.

    PTM databases

    PhosphoSiteiQ7TST5.

    Expressioni

    Gene expression databases

    BgeeiQ7TST5.
    CleanExiMM_LAMP3.
    GenevestigatoriQ7TST5.

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ7TST5.
    SMRiQ7TST5. Positions 219-373.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 376355LumenalSequence AnalysisAdd
    BLAST
    Topological domaini398 – 41114CytoplasmicPROSITE-ProRule annotationAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei377 – 39721HelicalPROSITE-ProRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LAMP family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG288611.
    GeneTreeiENSGT00530000063068.
    HOGENOMiHOG000004835.
    HOVERGENiHBG081889.
    InParanoidiQ7TST5.
    KOiK06562.
    OMAiYYISEVG.
    OrthoDBiEOG7ZD1VH.
    PhylomeDBiQ7TST5.
    TreeFamiTF316339.

    Family and domain databases

    InterProiIPR002000. Lysosome-assoc_membr_glycop.
    [Graphical view]
    PANTHERiPTHR11506. PTHR11506. 1 hit.
    PfamiPF01299. Lamp. 1 hit.
    [Graphical view]
    PRINTSiPR00336. LYSASSOCTDMP.
    PROSITEiPS51407. LAMP_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7TST5-1 [UniParc]FASTAAdd to Basket

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    MPGQISAVAV LFLSLTVILH GYQIREKEFP KARGYLQYTA TSAEQITTKP    50
    LLQLINQRSH ITLASRFKDD YIQMAAETSA IENTAHITMK TVTPVTTKSL 100
    PPISSASYTF VRSNNAHMTA SSTDDTIGSG SIAHLPVPTT RASLAIVNYI 150
    TGRATQLGGQ TTLPKTFFTA SHKSTTNQRP TLSTNVLGTS TPTHKDRSTT 200
    SPVPLVPRPT LVTWSSPAKI GTYEVLNGSR LCIKAEMGLA LIVQEKDLDS 250
    ATQRYFNIDP SLTHASGKCD SQKSNLFLNF QGGSVNITFT KEENLYYISE 300
    VGAYLTISNT EKTYQGKKNT LMMFETVVGH SFKCVSEQSI QLSAQLQMKT 350
    MNIHLQAFDF EGDSFGNVNE CLSDYTVVLP MVAIIVVVIC VVGLSVYKIR 400
    QRHQSSAYQR I 411
    Length:411
    Mass (Da):45,129
    Last modified:October 1, 2003 - v1
    Checksum:iFC7D6F16485A02ED
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti75 – 751A → G in BAC25713. (PubMed:16141072)Curated
    Sequence conflicti109 – 1091T → S in BAC25713. (PubMed:16141072)Curated
    Sequence conflicti195 – 1962KD → TG in BAC25713. (PubMed:16141072)Curated
    Sequence conflicti248 – 2481L → W in BAC25713. (PubMed:16141072)Curated
    Sequence conflicti257 – 2571N → H in BAC25713. (PubMed:16141072)Curated
    Sequence conflicti268 – 2681K → N in BAC25713. (PubMed:16141072)Curated
    Sequence conflicti272 – 2721Q → H in BAC25713. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ510130 mRNA. Translation: CAD52824.1.
    AK028039 mRNA. Translation: BAC25713.1.
    CCDSiCCDS37285.1.
    RefSeqiNP_796330.2. NM_177356.3.
    UniGeneiMm.258059.
    Mm.295252.

    Genome annotation databases

    EnsembliENSMUST00000081880; ENSMUSP00000080556; ENSMUSG00000041247.
    GeneIDi239739.
    KEGGimmu:239739.
    UCSCiuc007ypb.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ510130 mRNA. Translation: CAD52824.1 .
    AK028039 mRNA. Translation: BAC25713.1 .
    CCDSi CCDS37285.1.
    RefSeqi NP_796330.2. NM_177356.3.
    UniGenei Mm.258059.
    Mm.295252.

    3D structure databases

    ProteinModelPortali Q7TST5.
    SMRi Q7TST5. Positions 219-373.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q7TST5.

    Proteomic databases

    MaxQBi Q7TST5.
    PaxDbi Q7TST5.
    PRIDEi Q7TST5.

    Protocols and materials databases

    DNASUi 239739.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000081880 ; ENSMUSP00000080556 ; ENSMUSG00000041247 .
    GeneIDi 239739.
    KEGGi mmu:239739.
    UCSCi uc007ypb.1. mouse.

    Organism-specific databases

    CTDi 27074.
    MGIi MGI:2441659. Lamp3.

    Phylogenomic databases

    eggNOGi NOG288611.
    GeneTreei ENSGT00530000063068.
    HOGENOMi HOG000004835.
    HOVERGENi HBG081889.
    InParanoidi Q7TST5.
    KOi K06562.
    OMAi YYISEVG.
    OrthoDBi EOG7ZD1VH.
    PhylomeDBi Q7TST5.
    TreeFami TF316339.

    Miscellaneous databases

    NextBioi 384259.
    PROi Q7TST5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q7TST5.
    CleanExi MM_LAMP3.
    Genevestigatori Q7TST5.

    Family and domain databases

    InterProi IPR002000. Lysosome-assoc_membr_glycop.
    [Graphical view ]
    PANTHERi PTHR11506. PTHR11506. 1 hit.
    Pfami PF01299. Lamp. 1 hit.
    [Graphical view ]
    PRINTSi PR00336. LYSASSOCTDMP.
    PROSITEi PS51407. LAMP_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Murine CD208/DC-LAMP is associated with the surfactant secretory organelles in type II pneumocytes."
      Salaun B.P.A., de Saint-Vis B.M., Clair-Moninot V.A., Pin J.J., Dubois-Barthelemy C., Kissenpfennig A., Peronne C., Mattei M.-G., Davoust J., Kleijmeer M.J., Lebecque S.J.E.
      Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Lung.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Lung.

    Entry informationi

    Entry nameiLAMP3_MOUSE
    AccessioniPrimary (citable) accession number: Q7TST5
    Secondary accession number(s): Q8C1F6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2006
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3