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Q7TSS2

- UB2Q1_MOUSE

UniProt

Q7TSS2 - UB2Q1_MOUSE

Protein

Ubiquitin-conjugating enzyme E2 Q1

Gene

Ube2q1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 2 (21 Feb 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the covalent attachment of ubiquitin to other proteins.PROSITE-ProRule annotation

    Catalytic activityi

    ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei351 – 3511Glycyl thioester intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. acid-amino acid ligase activity Source: InterPro
    2. ATP binding Source: UniProtKB-KW

    GO - Biological processi

    1. embryo implantation Source: MGI
    2. fertilization Source: MGI
    3. mating behavior Source: MGI
    4. prolactin secretion Source: MGI
    5. protein ubiquitination Source: UniProtKB-UniPathway
    6. reproductive system development Source: MGI
    7. suckling behavior Source: MGI

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin-conjugating enzyme E2 Q1 (EC:6.3.2.19)
    Alternative name(s):
    Ubiquitin carrier protein Q1
    Ubiquitin-protein ligase Q1
    Gene namesi
    Name:Ube2q1
    Synonyms:Ube2q
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1917343. Ube2q1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 422422Ubiquitin-conjugating enzyme E2 Q1PRO_0000223877Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ7TSS2.
    PaxDbiQ7TSS2.
    PRIDEiQ7TSS2.

    PTM databases

    PhosphoSiteiQ7TSS2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ7TSS2.
    BgeeiQ7TSS2.
    CleanExiMM_UBE2Q1.
    GenevestigatoriQ7TSS2.

    Interactioni

    Protein-protein interaction databases

    BioGridi213860. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7TSS2.
    SMRiQ7TSS2. Positions 249-409.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG320521.
    GeneTreeiENSGT00390000018573.
    HOGENOMiHOG000007757.
    HOVERGENiHBG061368.
    InParanoidiQ7TSS2.
    KOiK10582.
    OMAiNQYSLTR.
    OrthoDBiEOG76DTSS.
    PhylomeDBiQ7TSS2.
    TreeFamiTF313338.

    Family and domain databases

    Gene3Di3.10.110.10. 1 hit.
    InterProiIPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view]
    PfamiPF00179. UQ_con. 1 hit.
    [Graphical view]
    SUPFAMiSSF54495. SSF54495. 2 hits.
    PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7TSS2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQQPQPQGQQ QPGPGQQLGV QGAAPGAGGG PGGGPGPGPC LRRELKLLES    50
    IFHRGHERFR IASACLDELS CEFLLAGAGG AGAGAAPGPH LPSRGSVPGD 100
    PVRIHCNITE SYPAVPPIWS VESDDPNLAA VLERLVDIKK GNTLLLQHLK 150
    RIISDLCKLY NLPQHPDVEM LDQPLPAEQC TQEEVSSEDE DEEMPEDTED 200
    LDHYEMKEEE PAEGKKSEDD GIGKENLAIL EKIKKNQRQD YLNGAVSGSV 250
    QATDRLMKEL RDIYRSQSFK GGNYAVELVN DSLYDWNVKL LKVDQDSALH 300
    NDLQILKEKE GADFILLNFS FKDNFPFDPP FVRVVSPVLS GGYVLGGGAI 350
    CMELLTKQGW SSAYSIESVI MQISATLVKG KARVQFGANK SQYSLTRAQQ 400
    SYKSLVQIHE KNGWYTPPKE DG 422
    Length:422
    Mass (Da):46,173
    Last modified:February 21, 2006 - v2
    Checksum:i845897861B36971F
    GO
    Isoform 2 (identifier: Q7TSS2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-169: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:253
    Mass (Da):28,487
    Checksum:i8FB9519FF26585CF
    GO

    Sequence cautioni

    The sequence AAH51487.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAB26217.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti121 – 1211V → G in AAM60815. 1 PublicationCurated
    Sequence conflicti125 – 1262DP → AL in AAM60815. 1 PublicationCurated
    Sequence conflicti139 – 1391K → R in AAM60815. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 169169Missing in isoform 2. 1 PublicationVSP_017297Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY112699 mRNA. Translation: AAM60815.1.
    AK009324 mRNA. Translation: BAB26217.2. Different initiation.
    AK146707 mRNA. Translation: BAE27373.1.
    BC030044 mRNA. Translation: AAH30044.2.
    BC051487 mRNA. Translation: AAH51487.1. Different initiation.
    BC060966 mRNA. Translation: AAH60966.1.
    BC082275 mRNA. Translation: AAH82275.1.
    CCDSiCCDS17517.1. [Q7TSS2-1]
    RefSeqiNP_081591.3. NM_027315.4. [Q7TSS2-1]
    UniGeneiMm.41438.

    Genome annotation databases

    EnsembliENSMUST00000038356; ENSMUSP00000037939; ENSMUSG00000042572. [Q7TSS2-1]
    GeneIDi70093.
    KEGGimmu:70093.
    UCSCiuc008qad.2. mouse. [Q7TSS2-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY112699 mRNA. Translation: AAM60815.1 .
    AK009324 mRNA. Translation: BAB26217.2 . Different initiation.
    AK146707 mRNA. Translation: BAE27373.1 .
    BC030044 mRNA. Translation: AAH30044.2 .
    BC051487 mRNA. Translation: AAH51487.1 . Different initiation.
    BC060966 mRNA. Translation: AAH60966.1 .
    BC082275 mRNA. Translation: AAH82275.1 .
    CCDSi CCDS17517.1. [Q7TSS2-1 ]
    RefSeqi NP_081591.3. NM_027315.4. [Q7TSS2-1 ]
    UniGenei Mm.41438.

    3D structure databases

    ProteinModelPortali Q7TSS2.
    SMRi Q7TSS2. Positions 249-409.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 213860. 1 interaction.

    PTM databases

    PhosphoSitei Q7TSS2.

    Proteomic databases

    MaxQBi Q7TSS2.
    PaxDbi Q7TSS2.
    PRIDEi Q7TSS2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000038356 ; ENSMUSP00000037939 ; ENSMUSG00000042572 . [Q7TSS2-1 ]
    GeneIDi 70093.
    KEGGi mmu:70093.
    UCSCi uc008qad.2. mouse. [Q7TSS2-1 ]

    Organism-specific databases

    CTDi 55585.
    MGIi MGI:1917343. Ube2q1.

    Phylogenomic databases

    eggNOGi NOG320521.
    GeneTreei ENSGT00390000018573.
    HOGENOMi HOG000007757.
    HOVERGENi HBG061368.
    InParanoidi Q7TSS2.
    KOi K10582.
    OMAi NQYSLTR.
    OrthoDBi EOG76DTSS.
    PhylomeDBi Q7TSS2.
    TreeFami TF313338.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    NextBioi 330988.
    PROi Q7TSS2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7TSS2.
    Bgeei Q7TSS2.
    CleanExi MM_UBE2Q1.
    Genevestigatori Q7TSS2.

    Family and domain databases

    Gene3Di 3.10.110.10. 1 hit.
    InterProi IPR000608. UBQ-conjugat_E2.
    IPR016135. UBQ-conjugating_enzyme/RWD.
    [Graphical view ]
    Pfami PF00179. UQ_con. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54495. SSF54495. 2 hits.
    PROSITEi PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation and characterization of the human UBE2Q gene and its murine ortholog."
      Altmann M.E., Schulze E., Adham I.M., Koehler M., Engel W.
      Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: 129/Sv.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 169-422 (ISOFORM 1).
      Tissue: Brain, Mammary gland and Thymus.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 29-422 (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Fetal heart and Tongue.

    Entry informationi

    Entry nameiUB2Q1_MOUSE
    AccessioniPrimary (citable) accession number: Q7TSS2
    Secondary accession number(s): Q3UIY3
    , Q6P913, Q80UT5, Q8K2T0, Q9D7E1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2006
    Last sequence update: February 21, 2006
    Last modified: October 1, 2014
    This is version 88 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3