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Q7TSS2

- UB2Q1_MOUSE

UniProt

Q7TSS2 - UB2Q1_MOUSE

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Protein

Ubiquitin-conjugating enzyme E2 Q1

Gene

Ube2q1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Catalyzes the covalent attachment of ubiquitin to other proteins.PROSITE-ProRule annotation

Catalytic activityi

ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei351 – 3511Glycyl thioester intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. acid-amino acid ligase activity Source: InterPro
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. embryo implantation Source: MGI
  2. fertilization Source: MGI
  3. mating behavior Source: MGI
  4. prolactin secretion Source: MGI
  5. protein ubiquitination Source: UniProtKB-UniPathway
  6. reproductive system development Source: MGI
  7. suckling behavior Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin-conjugating enzyme E2 Q1 (EC:6.3.2.19)
Alternative name(s):
Ubiquitin carrier protein Q1
Ubiquitin-protein ligase Q1
Gene namesi
Name:Ube2q1
Synonyms:Ube2q
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1917343. Ube2q1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Ubiquitin-conjugating enzyme E2 Q1PRO_0000223877Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ7TSS2.
PaxDbiQ7TSS2.
PRIDEiQ7TSS2.

PTM databases

PhosphoSiteiQ7TSS2.

Expressioni

Gene expression databases

BgeeiQ7TSS2.
CleanExiMM_UBE2Q1.
ExpressionAtlasiQ7TSS2. baseline and differential.
GenevestigatoriQ7TSS2.

Interactioni

Protein-protein interaction databases

BioGridi213860. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ7TSS2.
SMRiQ7TSS2. Positions 249-409.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ubiquitin-conjugating enzyme family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG320521.
GeneTreeiENSGT00390000018573.
HOGENOMiHOG000007757.
HOVERGENiHBG061368.
InParanoidiQ7TSS2.
KOiK10582.
OMAiNQYSLTR.
OrthoDBiEOG76DTSS.
PhylomeDBiQ7TSS2.
TreeFamiTF313338.

Family and domain databases

Gene3Di3.10.110.10. 1 hit.
InterProiIPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view]
PfamiPF00179. UQ_con. 1 hit.
[Graphical view]
SUPFAMiSSF54495. SSF54495. 2 hits.
PROSITEiPS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q7TSS2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQQPQPQGQQ QPGPGQQLGV QGAAPGAGGG PGGGPGPGPC LRRELKLLES
60 70 80 90 100
IFHRGHERFR IASACLDELS CEFLLAGAGG AGAGAAPGPH LPSRGSVPGD
110 120 130 140 150
PVRIHCNITE SYPAVPPIWS VESDDPNLAA VLERLVDIKK GNTLLLQHLK
160 170 180 190 200
RIISDLCKLY NLPQHPDVEM LDQPLPAEQC TQEEVSSEDE DEEMPEDTED
210 220 230 240 250
LDHYEMKEEE PAEGKKSEDD GIGKENLAIL EKIKKNQRQD YLNGAVSGSV
260 270 280 290 300
QATDRLMKEL RDIYRSQSFK GGNYAVELVN DSLYDWNVKL LKVDQDSALH
310 320 330 340 350
NDLQILKEKE GADFILLNFS FKDNFPFDPP FVRVVSPVLS GGYVLGGGAI
360 370 380 390 400
CMELLTKQGW SSAYSIESVI MQISATLVKG KARVQFGANK SQYSLTRAQQ
410 420
SYKSLVQIHE KNGWYTPPKE DG
Length:422
Mass (Da):46,173
Last modified:February 21, 2006 - v2
Checksum:i845897861B36971F
GO
Isoform 2 (identifier: Q7TSS2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-169: Missing.

Note: No experimental confirmation available.

Show »
Length:253
Mass (Da):28,487
Checksum:i8FB9519FF26585CF
GO

Sequence cautioni

The sequence AAH51487.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB26217.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti121 – 1211V → G in AAM60815. 1 PublicationCurated
Sequence conflicti125 – 1262DP → AL in AAM60815. 1 PublicationCurated
Sequence conflicti139 – 1391K → R in AAM60815. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 169169Missing in isoform 2. 1 PublicationVSP_017297Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY112699 mRNA. Translation: AAM60815.1.
AK009324 mRNA. Translation: BAB26217.2. Different initiation.
AK146707 mRNA. Translation: BAE27373.1.
BC030044 mRNA. Translation: AAH30044.2.
BC051487 mRNA. Translation: AAH51487.1. Different initiation.
BC060966 mRNA. Translation: AAH60966.1.
BC082275 mRNA. Translation: AAH82275.1.
CCDSiCCDS17517.1. [Q7TSS2-1]
RefSeqiNP_081591.3. NM_027315.4. [Q7TSS2-1]
UniGeneiMm.41438.

Genome annotation databases

EnsembliENSMUST00000038356; ENSMUSP00000037939; ENSMUSG00000042572. [Q7TSS2-1]
GeneIDi70093.
KEGGimmu:70093.
UCSCiuc008qad.2. mouse. [Q7TSS2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY112699 mRNA. Translation: AAM60815.1 .
AK009324 mRNA. Translation: BAB26217.2 . Different initiation.
AK146707 mRNA. Translation: BAE27373.1 .
BC030044 mRNA. Translation: AAH30044.2 .
BC051487 mRNA. Translation: AAH51487.1 . Different initiation.
BC060966 mRNA. Translation: AAH60966.1 .
BC082275 mRNA. Translation: AAH82275.1 .
CCDSi CCDS17517.1. [Q7TSS2-1 ]
RefSeqi NP_081591.3. NM_027315.4. [Q7TSS2-1 ]
UniGenei Mm.41438.

3D structure databases

ProteinModelPortali Q7TSS2.
SMRi Q7TSS2. Positions 249-409.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 213860. 1 interaction.

PTM databases

PhosphoSitei Q7TSS2.

Proteomic databases

MaxQBi Q7TSS2.
PaxDbi Q7TSS2.
PRIDEi Q7TSS2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000038356 ; ENSMUSP00000037939 ; ENSMUSG00000042572 . [Q7TSS2-1 ]
GeneIDi 70093.
KEGGi mmu:70093.
UCSCi uc008qad.2. mouse. [Q7TSS2-1 ]

Organism-specific databases

CTDi 55585.
MGIi MGI:1917343. Ube2q1.

Phylogenomic databases

eggNOGi NOG320521.
GeneTreei ENSGT00390000018573.
HOGENOMi HOG000007757.
HOVERGENi HBG061368.
InParanoidi Q7TSS2.
KOi K10582.
OMAi NQYSLTR.
OrthoDBi EOG76DTSS.
PhylomeDBi Q7TSS2.
TreeFami TF313338.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

NextBioi 330988.
PROi Q7TSS2.
SOURCEi Search...

Gene expression databases

Bgeei Q7TSS2.
CleanExi MM_UBE2Q1.
ExpressionAtlasi Q7TSS2. baseline and differential.
Genevestigatori Q7TSS2.

Family and domain databases

Gene3Di 3.10.110.10. 1 hit.
InterProi IPR000608. UBQ-conjugat_E2.
IPR016135. UBQ-conjugating_enzyme/RWD.
[Graphical view ]
Pfami PF00179. UQ_con. 1 hit.
[Graphical view ]
SUPFAMi SSF54495. SSF54495. 2 hits.
PROSITEi PS50127. UBIQUITIN_CONJUGAT_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of the human UBE2Q gene and its murine ortholog."
    Altmann M.E., Schulze E., Adham I.M., Koehler M., Engel W.
    Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: 129/Sv.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 169-422 (ISOFORM 1).
    Tissue: Brain, Mammary gland and Thymus.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 29-422 (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Fetal heart and Tongue.

Entry informationi

Entry nameiUB2Q1_MOUSE
AccessioniPrimary (citable) accession number: Q7TSS2
Secondary accession number(s): Q3UIY3
, Q6P913, Q80UT5, Q8K2T0, Q9D7E1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: February 21, 2006
Last modified: October 29, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3