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Protein
Submitted name:

ATP-binding cassette sub-family G member 8

Gene

Abcg8

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Keywords - Ligandi

ATP-bindingUniRule annotationImported, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
ATP-binding cassette sub-family G member 8Imported
Submitted name:
Abcg8 proteinImported
Gene namesi
Name:Abcg8Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1914720. Abcg8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei416 – 43621HelicalSequence analysisAdd
BLAST
Transmembranei448 – 46720HelicalSequence analysisAdd
BLAST
Transmembranei527 – 55226HelicalSequence analysisAdd
BLAST
Transmembranei564 – 58926HelicalSequence analysisAdd
BLAST
Transmembranei640 – 65920HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035246.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 313267ABC transporterInterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 ABC transporter domain.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0061. Eukaryota.
COG1131. LUCA.
GeneTreeiENSGT00740000114855.
HOVERGENiHBG050444.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01061. ABC2_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TSR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEKTKEETQ LWNGTVLQDA SGLQDSLFSS ESDNSLYFTY SGQSNTLEVR
60 70 80 90 100
DLTYQVDIAS QVPWFEQLAQ FKIPWRSHSS QDSCELGIRN LSFKVRSGQM
110 120 130 140 150
LAIIGSSGCG RASLLDVITG RGHGGKMKSG QIWINGQPST PQLVRKCVAH
160 170 180 190 200
VRQHDQLLPN LTVRETLAFI AQMRLPRTFS QAQRDKRVED VIAELRLRQC
210 220 230 240 250
ANTRVGNTYV RGVSGGERRR VSIGVQLLWN PGILILDEPT SGLDSFTAHN
260 270 280 290 300
LVTTLSRLAK GNRLVLISLH QPRSDIFRLF DLVLLMTSGT PIYLGAAQQM
310 320 330 340 350
VQYFTSIGHP CPRYSNPADF YVDLTSIDRR SKEREVATVE KAQSLAALFL
360 370 380 390 400
EKVQGFDDFL WKAEAKELNT STHTVSLTLT QDTDCGTAVE LPGMIEQFST
410 420 430 440 450
LIRRQISNDF RDLPTLLIHG SEACLMSLII GFLYYGHGAK QLSFMDTAAL
460 470 480 490 500
LFMIGALIPF NVILDVVSKC HSERSMLYYE LEDGLYTAGP YFFAKILGEL
510 520 530 540 550
PEHCAYVIIY AMPIYWLTNL RPVPELFLLH FLLVWLVVFC CRTMALAASA
560 570 580 590 600
MLPTFHMSSF FCNALYNSFY LTAGFMINLD NLWIVPAWIS KLSFLRWCFS
610 620 630 640 650
GLMQIQFNGH LYTTQIGNFT FSILGDTMIS AMDLNSHPLY AIYLIVIGIS
660 670
YGFLFLYYLS LKLIKQKSIQ DW
Length:672
Mass (Da):75,868
Last modified:October 1, 2003 - v1
Checksum:iCAB720502EA8FE21
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC165360 Genomic DNA. No translation available.
BC138484 mRNA. Translation: AAI38485.1.
BC145293 mRNA. Translation: AAI45294.1.
AY196216 mRNA. Translation: AAO45096.1.
RefSeqiXP_006524889.1. XM_006524826.2.
UniGeneiMm.26581.

Genome annotation databases

EnsembliENSMUST00000171915; ENSMUSP00000126675; ENSMUSG00000024254.
GeneIDi67470.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC165360 Genomic DNA. No translation available.
BC138484 mRNA. Translation: AAI38485.1.
BC145293 mRNA. Translation: AAI45294.1.
AY196216 mRNA. Translation: AAO45096.1.
RefSeqiXP_006524889.1. XM_006524826.2.
UniGeneiMm.26581.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000035246.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000171915; ENSMUSP00000126675; ENSMUSG00000024254.
GeneIDi67470.

Organism-specific databases

CTDi64241.
MGIiMGI:1914720. Abcg8.

Phylogenomic databases

eggNOGiKOG0061. Eukaryota.
COG1131. LUCA.
GeneTreeiENSGT00740000114855.
HOVERGENiHBG050444.

Miscellaneous databases

SOURCEiSearch...

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR013525. ABC_2_trans.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01061. ABC2_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Primary Roles of FXR and ABCG5/ABCG8 in Cholesterol Gallstone Susceptibility: Evidence from a Cross of PERA/Ei and I/Ln Inbred Mice."
    Wittenburg H., Lyons M.A., Li R., Churchill G.A., Carey M.C., Paigen B.
    Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: PERA/EiImported.
    Tissue: LiverImported.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: BrainImported.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  4. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ7TSR6_MOUSE
AccessioniPrimary (citable) accession number: Q7TSR6
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: May 11, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.