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Protein

Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial

Gene

Pdpr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Decreases the sensitivity of PDP1 to magnesium ions, and this inhibition is reversed by the polyamine spermine.By similarity

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-204174. Regulation of pyruvate dehydrogenase (PDH) complex.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial
Short name:
PDPr
Gene namesi
Name:Pdpr
Synonyms:Kiaa1990
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2442188. Pdpr.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
  • mitochondrial matrix Source: UniProtKB-SubCell
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 9393MitochondrionSequence analysisAdd
BLAST
Chaini94 – 878785Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrialPRO_0000328741Add
BLAST

Proteomic databases

EPDiQ7TSQ8.
MaxQBiQ7TSQ8.
PaxDbiQ7TSQ8.
PRIDEiQ7TSQ8.

PTM databases

iPTMnetiQ7TSQ8.
PhosphoSiteiQ7TSQ8.

Expressioni

Gene expression databases

BgeeiQ7TSQ8.
ExpressionAtlasiQ7TSQ8. baseline and differential.
GenevisibleiQ7TSQ8. MM.

Interactioni

Subunit structurei

Heterodimer of a catalytic (PDP1) and a regulatory (PDPR) subunit.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046639.

Structurei

3D structure databases

ProteinModelPortaliQ7TSQ8.
SMRiQ7TSQ8. Positions 11-419, 456-816.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvT family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2844. Eukaryota.
COG0404. LUCA.
GeneTreeiENSGT00530000063120.
HOGENOMiHOG000251716.
HOVERGENiHBG103854.
InParanoidiQ7TSQ8.
KOiK17509.
OMAiLVNCPES.
OrthoDBiEOG7W1533.
PhylomeDBiQ7TSQ8.
TreeFamiTF314735.

Family and domain databases

Gene3Di2.40.30.110. 1 hit.
3.30.1360.120. 2 hits.
3.50.50.60. 3 hits.
InterProiIPR006076. FAD-dep_OxRdtase.
IPR023753. FAD/NAD-binding_dom.
IPR032503. FAO_M.
IPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR029043. GcvT/YgfZ_C.
IPR027266. TrmE/GcvT_dom1.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
PF16350. FAO_M. 1 hit.
PF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
[Graphical view]
SUPFAMiSSF101790. SSF101790. 1 hit.
SSF51905. SSF51905. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TSQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLYRLLSIVQ RQRTSPGWQT WSSARSSTST AEAHSIALPA QAQVVICGGG
60 70 80 90 100
IMGTSVAYHL SKMGWQDIVL LEQGRLAAGS TRFCAGILST ARHSSVEQKM
110 120 130 140 150
ANYSNKLYHQ LEQETGIQTG YLRTGSISLA QTQDRLISLK RINSRLNVVG
160 170 180 190 200
IPSEIISPKK VAELHPLLNV HDLVGAMYVP EDAVVSSADV ALALASAASQ
210 220 230 240 250
NGVQIYDRTS VLHVLIKKGQ VTGVETDKGQ IECQYFVNCA GQWAYELGLS
260 270 280 290 300
NEEPLSIPLH ACEHFYLLTR PWDTPLQSNT PTIVDADGRI YIRNWQGGIL
310 320 330 340 350
SGGFEKNPKP IFTEGKNQLE IQNLREDWDH FEPLLSSLLR RMPALETLEI
360 370 380 390 400
LKLVNCPETF TPDMKCIMGE SPVVQGYFVL AGMNSAGLSL GGGAGKFLAE
410 420 430 440 450
WMVYGYPSEN VWELDLQRFG ALQSSRTFLR HRVMEVMPLI YDLKVPRWDF
460 470 480 490 500
QTGRQLRTSP LYDRLDAQGA RWMEKHGFER PKYFVPPNKD LLALEQSKTF
510 520 530 540 550
YKPDWFDIVE SEVKCCKEAV CVIDMSSFTK FEITSTGDEA LESLQYLFCN
560 570 580 590 600
DLDVPVGHIV HTGMLNEYGG YENDCSIARL TKRSFFMISP TDQQVHCWAW
610 620 630 640 650
LNKYLPKDSN LLLEDVTWKY TALNLIGPRA VDVLSELSYA PMTPDHFPTL
660 670 680 690 700
FCKEMSVGYA NGIRVMSMTH TGEPGFMLYI PIEYALHVYN EVMSVGQKYG
710 720 730 740 750
IRNAGYYALR SLRIEKFFAF WGQDLNTLTT PLECGGESRV KLEKGIDFIG
760 770 780 790 800
RDALLQQKQT GVYKRLAMFI LDDHDTDLDL WPWWGEPIYR NGKYAGKTTS
810 820 830 840 850
SAYSYTLERH VCLGYVHNFS EDSGEEQVVT TDFINRGEYE IDIAGHRFQA
860 870
KAKLYPVTSF FTHKRRKDDV ELSDFHGK
Length:878
Mass (Da):99,230
Last modified:October 1, 2003 - v1
Checksum:i16A8C9ED77613525
GO

Sequence cautioni

The sequence BAC98282.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti438 – 4381P → H in BAC98282 (PubMed:14621295).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY223867 mRNA. Translation: AAP20649.1.
AK129472 mRNA. Translation: BAC98282.1. Different initiation.
BC120745 mRNA. Translation: AAI20746.1.
BC125425 mRNA. Translation: AAI25426.1.
CCDSiCCDS22670.1.
RefSeqiNP_938050.1. NM_198308.1.
XP_006531147.1. XM_006531084.2.
UniGeneiMm.28350.
Mm.370024.

Genome annotation databases

EnsembliENSMUST00000039333; ENSMUSP00000046639; ENSMUSG00000033624.
GeneIDi319518.
KEGGimmu:319518.
UCSCiuc009nlw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY223867 mRNA. Translation: AAP20649.1.
AK129472 mRNA. Translation: BAC98282.1. Different initiation.
BC120745 mRNA. Translation: AAI20746.1.
BC125425 mRNA. Translation: AAI25426.1.
CCDSiCCDS22670.1.
RefSeqiNP_938050.1. NM_198308.1.
XP_006531147.1. XM_006531084.2.
UniGeneiMm.28350.
Mm.370024.

3D structure databases

ProteinModelPortaliQ7TSQ8.
SMRiQ7TSQ8. Positions 11-419, 456-816.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000046639.

PTM databases

iPTMnetiQ7TSQ8.
PhosphoSiteiQ7TSQ8.

Proteomic databases

EPDiQ7TSQ8.
MaxQBiQ7TSQ8.
PaxDbiQ7TSQ8.
PRIDEiQ7TSQ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039333; ENSMUSP00000046639; ENSMUSG00000033624.
GeneIDi319518.
KEGGimmu:319518.
UCSCiuc009nlw.1. mouse.

Organism-specific databases

CTDi55066.
MGIiMGI:2442188. Pdpr.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2844. Eukaryota.
COG0404. LUCA.
GeneTreeiENSGT00530000063120.
HOGENOMiHOG000251716.
HOVERGENiHBG103854.
InParanoidiQ7TSQ8.
KOiK17509.
OMAiLVNCPES.
OrthoDBiEOG7W1533.
PhylomeDBiQ7TSQ8.
TreeFamiTF314735.

Enzyme and pathway databases

ReactomeiR-MMU-204174. Regulation of pyruvate dehydrogenase (PDH) complex.

Miscellaneous databases

PROiQ7TSQ8.
SOURCEiSearch...

Gene expression databases

BgeeiQ7TSQ8.
ExpressionAtlasiQ7TSQ8. baseline and differential.
GenevisibleiQ7TSQ8. MM.

Family and domain databases

Gene3Di2.40.30.110. 1 hit.
3.30.1360.120. 2 hits.
3.50.50.60. 3 hits.
InterProiIPR006076. FAD-dep_OxRdtase.
IPR023753. FAD/NAD-binding_dom.
IPR032503. FAO_M.
IPR013977. GCV_T_C.
IPR006222. GCV_T_N.
IPR029043. GcvT/YgfZ_C.
IPR027266. TrmE/GcvT_dom1.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
PF16350. FAO_M. 1 hit.
PF01571. GCV_T. 1 hit.
PF08669. GCV_T_C. 1 hit.
[Graphical view]
SUPFAMiSSF101790. SSF101790. 1 hit.
SSF51905. SSF51905. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "An alternatively spliced form of a gene encoding pyruvate dehydrogenase phosphatase regulatory subunit."
    Jang J.S., Ackerman S.L.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Nagase T., Ohara O., Koga H.
    DNA Res. 10:167-180(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Lung, Spleen and Testis.

Entry informationi

Entry nameiPDPR_MOUSE
AccessioniPrimary (citable) accession number: Q7TSQ8
Secondary accession number(s): Q6ZPF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: October 1, 2003
Last modified: June 8, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.