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Protein

V-set domain containing T-cell activation inhibitor 1

Gene

Vtcn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.By similarity3 Publications

GO - Molecular functioni

  • receptor binding Source: MGI

GO - Biological processi

  • adaptive immune response Source: UniProtKB-KW
  • interferon-gamma secretion Source: MGI
  • interleukin-4 secretion Source: MGI
  • negative regulation of T cell activation Source: MGI
  • positive regulation of interleukin-2 secretion Source: MGI
  • positive regulation of T cell proliferation Source: MGI
  • response to protozoan Source: MGI
Complete GO annotation...

Keywords - Biological processi

Adaptive immunity, Immunity

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
V-set domain containing T-cell activation inhibitor 1
Alternative name(s):
B7 homolog 4
Short name:
B7-H4
Immune costimulatory protein B7-H4
Protein B7S1
T cell costimulatory molecule B7x
Gene namesi
Name:Vtcn1Imported
Synonyms:B7h4By similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:3039619. Vtcn1.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • external side of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice mount mildy augmented T-helper 1 responses and display slightly lowered parasitic burdens upon Leishmania major infection.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000033923825 – 257V-set domain containing T-cell activation inhibitor 1Sequence analysisAdd BLAST233
PropeptideiPRO_0000339239258 – 283Removed in mature formSequence analysisAdd BLAST26

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi56 ↔ 130PROSITE-ProRule annotation
Disulfide bondi168 ↔ 225PROSITE-ProRule annotation
Glycosylationi216N-linked (GlcNAc...)Sequence analysis1
Lipidationi257GPI-anchor amidated glycineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiQ7TSP5.
PaxDbiQ7TSP5.
PRIDEiQ7TSP5.

PTM databases

PhosphoSitePlusiQ7TSP5.

Expressioni

Tissue specificityi

Expressed on the surface of professional antigen-presenting cells (at protein level). Widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus.3 Publications

Inductioni

Down-regulated upon activation of B-cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000051076.
GenevisibleiQ7TSP5. MM.

Interactioni

GO - Molecular functioni

  • receptor binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057721.

Structurei

3D structure databases

ProteinModelPortaliQ7TSP5.
SMRiQ7TSP5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 144Ig-like V-type 1Sequence analysisAdd BLAST110
Domaini153 – 241Ig-like V-type 2Sequence analysisAdd BLAST89

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. BTN/MOG family.By similarity
Contains 2 Ig-like V-type (immunoglobulin-like) domains.Sequence analysis

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IKB5. Eukaryota.
ENOG4111T2B. LUCA.
GeneTreeiENSGT00700000104325.
HOGENOMiHOG000139645.
HOVERGENiHBG097943.
InParanoidiQ7TSP5.
KOiK06747.
OMAiVDQGANF.
OrthoDBiEOG091G0IEZ.
PhylomeDBiQ7TSP5.
TreeFamiTF331083.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TSP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLGQIIFW SIINIIIILA GAIALIIGFG ISGKHFITVT TFTSAGNIGE
60 70 80 90 100
DGTLSCTFEP DIKLNGIVIQ WLKEGIKGLV HEFKEGKDDL SQQHEMFRGR
110 120 130 140 150
TAVFADQVVV GNASLRLKNV QLTDAGTYTC YIRTSKGKGN ANLEYKTGAF
160 170 180 190 200
SMPEINVDYN ASSESLRCEA PRWFPQPTVA WASQVDQGAN FSEVSNTSFE
210 220 230 240 250
LNSENVTMKV VSVLYNVTIN NTYSCMIEND IAKATGDIKV TDSEVKRRSQ
260 270 280
LQLLNSGPSP CVFSSAFVAG WALLSLSCCL MLR
Length:283
Mass (Da):30,875
Last modified:October 1, 2003 - v1
Checksum:i7E2F174618578519
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti134T → S in AAH32925 (PubMed:15489334).Curated1
Sequence conflicti263F → S in AAH32925 (PubMed:15489334).Curated1
Sequence conflicti268V → A in AAP88965 (PubMed:12818166).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY280973 mRNA. Translation: AAP37284.1.
AY322147 mRNA. Translation: AAP88965.1.
AY346099 mRNA. Translation: AAQ24205.1.
AK143276 mRNA. Translation: BAE25330.1.
AK145664 mRNA. Translation: BAE26576.1.
BC032925 mRNA. Translation: AAH32925.1.
CCDSiCCDS17677.1.
RefSeqiNP_848709.2. NM_178594.3.
UniGeneiMm.137467.

Genome annotation databases

EnsembliENSMUST00000054791; ENSMUSP00000057721; ENSMUSG00000051076.
GeneIDi242122.
KEGGimmu:242122.
UCSCiuc008qqx.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY280973 mRNA. Translation: AAP37284.1.
AY322147 mRNA. Translation: AAP88965.1.
AY346099 mRNA. Translation: AAQ24205.1.
AK143276 mRNA. Translation: BAE25330.1.
AK145664 mRNA. Translation: BAE26576.1.
BC032925 mRNA. Translation: AAH32925.1.
CCDSiCCDS17677.1.
RefSeqiNP_848709.2. NM_178594.3.
UniGeneiMm.137467.

3D structure databases

ProteinModelPortaliQ7TSP5.
SMRiQ7TSP5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057721.

Protein family/group databases

MEROPSiI43.001.

PTM databases

PhosphoSitePlusiQ7TSP5.

Proteomic databases

EPDiQ7TSP5.
PaxDbiQ7TSP5.
PRIDEiQ7TSP5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054791; ENSMUSP00000057721; ENSMUSG00000051076.
GeneIDi242122.
KEGGimmu:242122.
UCSCiuc008qqx.2. mouse.

Organism-specific databases

CTDi79679.
MGIiMGI:3039619. Vtcn1.

Phylogenomic databases

eggNOGiENOG410IKB5. Eukaryota.
ENOG4111T2B. LUCA.
GeneTreeiENSGT00700000104325.
HOGENOMiHOG000139645.
HOVERGENiHBG097943.
InParanoidiQ7TSP5.
KOiK06747.
OMAiVDQGANF.
OrthoDBiEOG091G0IEZ.
PhylomeDBiQ7TSP5.
TreeFamiTF331083.

Miscellaneous databases

PROiQ7TSP5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051076.
GenevisibleiQ7TSP5. MM.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVTCN1_MOUSE
AccessioniPrimary (citable) accession number: Q7TSP5
Secondary accession number(s): Q7TPH5, Q8K091
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.