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Protein

V-set domain containing T-cell activation inhibitor 1

Gene

Vtcn1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.By similarity3 Publications

GO - Molecular functioni

  • signaling receptor binding Source: MGI

GO - Biological processi

  • adaptive immune response Source: UniProtKB-KW
  • interferon-gamma secretion Source: MGI
  • interleukin-4 secretion Source: MGI
  • negative regulation of apoptotic process Source: MGI
  • negative regulation of T cell activation Source: MGI
  • negative regulation of T cell proliferation Source: MGI
  • positive regulation of interleukin-2 secretion Source: MGI
  • positive regulation of T cell proliferation Source: MGI
  • response to protozoan Source: MGI

Keywordsi

Biological processAdaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
V-set domain containing T-cell activation inhibitor 1
Alternative name(s):
B7 homolog 4
Short name:
B7-H4
Immune costimulatory protein B7-H4
Protein B7S1
T cell costimulatory molecule B7x
Gene namesi
Name:Vtcn1Imported
Synonyms:B7h4By similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:3039619 Vtcn1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice mount mildy augmented T-helper 1 responses and display slightly lowered parasitic burdens upon Leishmania major infection.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000033923825 – 257V-set domain containing T-cell activation inhibitor 1Sequence analysisAdd BLAST233
PropeptideiPRO_0000339239258 – 283Removed in mature formSequence analysisAdd BLAST26

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi56 ↔ 130PROSITE-ProRule annotation
Disulfide bondi168 ↔ 225PROSITE-ProRule annotation
Glycosylationi216N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi257GPI-anchor amidated glycineSequence analysis1

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

EPDiQ7TSP5
PaxDbiQ7TSP5
PRIDEiQ7TSP5

PTM databases

PhosphoSitePlusiQ7TSP5

Expressioni

Tissue specificityi

Expressed on the surface of professional antigen-presenting cells (at protein level). Widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus.3 Publications

Inductioni

Down-regulated upon activation of B-cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000051076
GenevisibleiQ7TSP5 MM

Interactioni

GO - Molecular functioni

  • signaling receptor binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000057721

Structurei

3D structure databases

ProteinModelPortaliQ7TSP5
SMRiQ7TSP5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 144Ig-like V-type 1Sequence analysisAdd BLAST110
Domaini153 – 241Ig-like V-type 2Sequence analysisAdd BLAST89

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. BTN/MOG family.By similarity

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IKB5 Eukaryota
ENOG4111T2B LUCA
GeneTreeiENSGT00700000104325
HOGENOMiHOG000139645
HOVERGENiHBG097943
InParanoidiQ7TSP5
KOiK06747
OMAiRCEAPRW
OrthoDBiEOG091G0IEZ
PhylomeDBiQ7TSP5
TreeFamiTF331083

Family and domain databases

Gene3Di2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SUPFAMiSSF48726 SSF48726, 2 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TSP5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLGQIIFW SIINIIIILA GAIALIIGFG ISGKHFITVT TFTSAGNIGE
60 70 80 90 100
DGTLSCTFEP DIKLNGIVIQ WLKEGIKGLV HEFKEGKDDL SQQHEMFRGR
110 120 130 140 150
TAVFADQVVV GNASLRLKNV QLTDAGTYTC YIRTSKGKGN ANLEYKTGAF
160 170 180 190 200
SMPEINVDYN ASSESLRCEA PRWFPQPTVA WASQVDQGAN FSEVSNTSFE
210 220 230 240 250
LNSENVTMKV VSVLYNVTIN NTYSCMIEND IAKATGDIKV TDSEVKRRSQ
260 270 280
LQLLNSGPSP CVFSSAFVAG WALLSLSCCL MLR
Length:283
Mass (Da):30,875
Last modified:October 1, 2003 - v1
Checksum:i7E2F174618578519
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti134T → S in AAH32925 (PubMed:15489334).Curated1
Sequence conflicti263F → S in AAH32925 (PubMed:15489334).Curated1
Sequence conflicti268V → A in AAP88965 (PubMed:12818166).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY280973 mRNA Translation: AAP37284.1
AY322147 mRNA Translation: AAP88965.1
AY346099 mRNA Translation: AAQ24205.1
AK143276 mRNA Translation: BAE25330.1
AK145664 mRNA Translation: BAE26576.1
BC032925 mRNA Translation: AAH32925.1
CCDSiCCDS17677.1
RefSeqiNP_848709.2, NM_178594.3
UniGeneiMm.137467

Genome annotation databases

EnsembliENSMUST00000054791; ENSMUSP00000057721; ENSMUSG00000051076
GeneIDi242122
KEGGimmu:242122
UCSCiuc008qqx.2 mouse

Similar proteinsi

Entry informationi

Entry nameiVTCN1_MOUSE
AccessioniPrimary (citable) accession number: Q7TSP5
Secondary accession number(s): Q7TPH5, Q8K091
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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