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Q7TSP5

- VTCN1_MOUSE

UniProt

Q7TSP5 - VTCN1_MOUSE

Protein

V-set domain containing T-cell activation inhibitor 1

Gene

Vtcn1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.By similarity3 Publications

    GO - Molecular functioni

    1. receptor binding Source: MGI

    GO - Biological processi

    1. immune system process Source: UniProtKB-KW
    2. interferon-gamma secretion Source: MGI
    3. interleukin-4 secretion Source: MGI
    4. negative regulation of T cell activation Source: MGI
    5. positive regulation of interleukin-2 secretion Source: MGI
    6. positive regulation of T cell proliferation Source: MGI
    7. response to protozoan Source: MGI

    Keywords - Biological processi

    Adaptive immunity, Immunity

    Protein family/group databases

    MEROPSiI43.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    V-set domain containing T-cell activation inhibitor 1
    Alternative name(s):
    B7 homolog 4
    Short name:
    B7-H4
    Immune costimulatory protein B7-H4
    Protein B7S1
    T cell costimulatory molecule B7x
    Gene namesi
    Name:Vtcn1Imported
    Synonyms:B7h4By similarity
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:3039619. Vtcn1.

    Subcellular locationi

    Cell membrane 3 Publications; Lipid-anchorGPI-anchor 3 Publications
    Note: Expressed at the cell surface. A soluble form has also been detected.3 Publications

    GO - Cellular componenti

    1. anchored component of membrane Source: UniProtKB-KW
    2. external side of plasma membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Mice mount mildy augmented T-helper 1 responses and display slightly lowered parasitic burdens upon Leishmania major infection.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 257233V-set domain containing T-cell activation inhibitor 1Sequence AnalysisPRO_0000339238Add
    BLAST
    Propeptidei258 – 28326Removed in mature formSequence AnalysisPRO_0000339239Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi56 ↔ 130PROSITE-ProRule annotation
    Disulfide bondi168 ↔ 225PROSITE-ProRule annotation
    Glycosylationi216 – 2161N-linked (GlcNAc...)Sequence Analysis
    Lipidationi257 – 2571GPI-anchor amidated glycineSequence Analysis

    Post-translational modificationi

    N-glycosylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

    Proteomic databases

    PRIDEiQ7TSP5.

    Expressioni

    Tissue specificityi

    Expressed on the surface of professional antigen-presenting cells (at protein level). Widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus.3 Publications

    Inductioni

    Down-regulated upon activation of B-cells.1 Publication

    Gene expression databases

    BgeeiQ7TSP5.
    GenevestigatoriQ7TSP5.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7TSP5.
    SMRiQ7TSP5. Positions 35-241.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 144110Ig-like V-type 1Sequence AnalysisAdd
    BLAST
    Domaini153 – 24189Ig-like V-type 2Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the immunoglobulin superfamily. BTN/MOG family.By similarity
    Contains 2 Ig-like V-type (immunoglobulin-like) domains.Sequence Analysis

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG87575.
    GeneTreeiENSGT00700000104325.
    HOGENOMiHOG000139645.
    HOVERGENiHBG097943.
    InParanoidiQ7TSP5.
    KOiK06747.
    OMAiSQVDQGA.
    OrthoDBiEOG7FBRH9.
    PhylomeDBiQ7TSP5.
    TreeFamiTF331083.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7TSP5-1 [UniParc]FASTAAdd to Basket

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    MASLGQIIFW SIINIIIILA GAIALIIGFG ISGKHFITVT TFTSAGNIGE    50
    DGTLSCTFEP DIKLNGIVIQ WLKEGIKGLV HEFKEGKDDL SQQHEMFRGR 100
    TAVFADQVVV GNASLRLKNV QLTDAGTYTC YIRTSKGKGN ANLEYKTGAF 150
    SMPEINVDYN ASSESLRCEA PRWFPQPTVA WASQVDQGAN FSEVSNTSFE 200
    LNSENVTMKV VSVLYNVTIN NTYSCMIEND IAKATGDIKV TDSEVKRRSQ 250
    LQLLNSGPSP CVFSSAFVAG WALLSLSCCL MLR 283
    Length:283
    Mass (Da):30,875
    Last modified:October 1, 2003 - v1
    Checksum:i7E2F174618578519
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti134 – 1341T → S in AAH32925. (PubMed:15489334)Curated
    Sequence conflicti263 – 2631F → S in AAH32925. (PubMed:15489334)Curated
    Sequence conflicti268 – 2681V → A in AAP88965. (PubMed:12818166)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY280973 mRNA. Translation: AAP37284.1.
    AY322147 mRNA. Translation: AAP88965.1.
    AY346099 mRNA. Translation: AAQ24205.1.
    AK143276 mRNA. Translation: BAE25330.1.
    AK145664 mRNA. Translation: BAE26576.1.
    BC032925 mRNA. Translation: AAH32925.1.
    CCDSiCCDS17677.1.
    RefSeqiNP_848709.2. NM_178594.3.
    UniGeneiMm.137467.

    Genome annotation databases

    EnsembliENSMUST00000054791; ENSMUSP00000057721; ENSMUSG00000051076.
    GeneIDi242122.
    KEGGimmu:242122.
    UCSCiuc008qqx.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY280973 mRNA. Translation: AAP37284.1 .
    AY322147 mRNA. Translation: AAP88965.1 .
    AY346099 mRNA. Translation: AAQ24205.1 .
    AK143276 mRNA. Translation: BAE25330.1 .
    AK145664 mRNA. Translation: BAE26576.1 .
    BC032925 mRNA. Translation: AAH32925.1 .
    CCDSi CCDS17677.1.
    RefSeqi NP_848709.2. NM_178594.3.
    UniGenei Mm.137467.

    3D structure databases

    ProteinModelPortali Q7TSP5.
    SMRi Q7TSP5. Positions 35-241.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I43.001.

    Proteomic databases

    PRIDEi Q7TSP5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000054791 ; ENSMUSP00000057721 ; ENSMUSG00000051076 .
    GeneIDi 242122.
    KEGGi mmu:242122.
    UCSCi uc008qqx.2. mouse.

    Organism-specific databases

    CTDi 79679.
    MGIi MGI:3039619. Vtcn1.

    Phylogenomic databases

    eggNOGi NOG87575.
    GeneTreei ENSGT00700000104325.
    HOGENOMi HOG000139645.
    HOVERGENi HBG097943.
    InParanoidi Q7TSP5.
    KOi K06747.
    OMAi SQVDQGA.
    OrthoDBi EOG7FBRH9.
    PhylomeDBi Q7TSP5.
    TreeFami TF331083.

    Miscellaneous databases

    NextBioi 385239.
    PROi Q7TSP5.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q7TSP5.
    Genevestigatori Q7TSP5.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "B7-H4, a molecule of the B7 family, negatively regulates T cell immunity."
      Sica G.L., Choi I.-H., Zhu G., Tamada K., Wang S.-D., Tamura H., Chapoval A.I., Flies D.B., Bajorath J., Chen L.
      Immunity 18:849-861(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Strain: BALB/cImported.
      Tissue: Spleen1 Publication.
    2. "B7S1, a novel B7 family member that negatively regulates T cell activation."
      Prasad D.V.R., Richards S., Mai X.M., Dong C.
      Immunity 18:863-873(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, INDUCTION, GPI-ANCHOR.
    3. "B7x: a widely expressed B7 family member that inhibits T cell activation."
      Zang X., Loke P., Kim J., Murphy K., Waitz R., Allison J.P.
      Proc. Natl. Acad. Sci. U.S.A. 100:10388-10392(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Strain: FVB/NImported.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6JImported.
      Tissue: BlastocystImported and OviductImported.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: UterusImported.
    6. Cited for: DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiVTCN1_MOUSE
    AccessioniPrimary (citable) accession number: Q7TSP5
    Secondary accession number(s): Q7TPH5, Q8K091
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 96 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3