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Protein

Kinesin-like protein KIF15

Gene

Kif15

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Plus-end directed kinesin-like motor enzyme involved in mitotic spindle assembly.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi109 – 1168ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Motor protein

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF15
Alternative name(s):
Kinesin-like protein 2
Gene namesi
Name:Kif15
Synonyms:Klp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi727790. Kif15.

Subcellular locationi

  • Cytoplasm By similarity
  • Cytoplasmcytoskeletonspindle 1 Publication

  • Note: Colocalizes with TPX2 in mitosis (By similarity). Detected during the interphase in the cytoplasm as finely punctuate pattern and irregularly shaped dots. Localizes at the spindle poles and microtubules prior to anaphase. Localizes at the central spindle at anaphase. Localizes at the sites of invaginating cell membranes, a position that corresponds to the location of the contractile actomyosin ring of dividing cells. Colocalizes with actin in interphase. Colocalizes in dendrites and in growth cone of axons with microtubules.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13851385Kinesin-like protein KIF15PRO_0000328686Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1007 – 10071N6-acetyllysineBy similarity
Modified residuei1167 – 11671PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ7TSP2.
PRIDEiQ7TSP2.

PTM databases

PhosphoSiteiQ7TSP2.

Expressioni

Tissue specificityi

Expressed in sympathetic neurons.1 Publication

Developmental stagei

Expressed in brain at 17 dpc and in cerebellum at 19 dpc.1 Publication

Interactioni

Subunit structurei

Interacts with MKI67 and TPX2.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030707.

Structurei

3D structure databases

ProteinModelPortaliQ7TSP2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 363338Kinesin motorPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili368 – 13851018Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KLP2 subfamily.PROSITE-ProRule annotation
Contains 1 kinesin motor domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4280. Eukaryota.
COG5059. LUCA.
HOGENOMiHOG000113225.
HOVERGENiHBG062662.
InParanoidiQ7TSP2.
KOiK10400.
PhylomeDBiQ7TSP2.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR031794. HMMR_C.
IPR027640. Kinesin-like_fam.
IPR024658. Kinesin-like_KLP2.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 4 hits.
PfamiPF15908. HMMR_C. 1 hit.
PF00225. Kinesin. 1 hit.
PF12711. Kinesin-relat_1. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TSP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPGCKSELR NVTNSHSNQP SNEDDAIKVF VRIRPAEEGA RSADGEQSLC
60 70 80 90 100
LSVLSQTALR LHSNPDPKTF VFDYVAGMDT TQESVFSTVA KSIVESCMSG
110 120 130 140 150
YNGTIFAYGQ TGSGKTFTMM GPSDSDNFSH NLRGVIPRSF EYLFSLIDRE
160 170 180 190 200
KEKAGAGKSF LCKCSFIEVY NEQIYDLLDS ASVGLYLREH IKKGVFVVGA
210 220 230 240 250
VEQVVASAAE AYQVLSRGWR NRRVASTSMN RESSRSHAVF TITIESMEKS
260 270 280 290 300
SEAVNIRTSL LNLVDLAGSE RQKDTHAEGM RLKEAGNINR SLSCLGQVIT
310 320 330 340 350
ALVDVGNGKQ RHVCYRDSKL TFLLRDSLGG NAKTAIIANV HPGSRCFGET
360 370 380 390 400
LSTLNFAQRA KLIKNKAVVN EDTQGNVSQL QAEVKRLREQ LSQFTSGQLT
410 420 430 440 450
PGSSLARDKE KANYMEYFLE AMLFFKKSEQ EKKSLVEKIT QLEDLTLKKE
460 470 480 490 500
KFIQSNKMIV KFREDQIMRL ERLQKEARGS FLPEEQDRLL SELRDEIRTL
510 520 530 540 550
REQVEHHPRL AKYAMENHSL REENRKLKLL APVKRAHELD AQAIARLEQA
560 570 580 590 600
FSEVSSTETN DKGLQGLPPK AIKEPSFFTS TEKLKVQLLQ IQTELNNSKQ
610 620 630 640 650
EYEEFKELTR KKQLELESEL QSLQKANLNL ENLLEATKVC KRQEVSQLNK
660 670 680 690 700
IHAETLKIIT TPTKAYQLCS RLVPKSSPEV GSFGFLRSQS APDNDILNEP
710 720 730 740 750
VPPEMSEQAL EAISEELRTV QEQLSVLQVK LDEEEHKNLK LQQNVDRLEH
760 770 780 790 800
HSTQMQELFS SERSDWSKQQ QDYLTQLSDL EKQLQDAQTK NDFLKCEVHD
810 820 830 840 850
LRIVLNSADK ELSLVKLEYS TFKESQEKEL SQLSERHVQV QLQLDNARLE
860 870 880 890 900
NEKLLESQAC LQDSYDNLQE VMKFEVDQLS KNLQNCKQEN ETLKSDLHNL
910 920 930 940 950
VELFEAEKER NNKLSLQFEE DKENSSKEIL KALETVRQEK QEEMARCEKQ
960 970 980 990 1000
MAKVQELEES LLAAENVVSC LEKSRESDKE LVTNLMNQIQ ELRTSAGEKS
1010 1020 1030 1040 1050
EAIDTLKQEL QDISCKYTAA VADKEESKEL IRRQEVDILE LKETLRLRIL
1060 1070 1080 1090 1100
SEDIERDMLC EDLAHATEQL NMLTEASKKH SGLLQSAQEE LTKKEALIQE
1110 1120 1130 1140 1150
LQHKLNQEKE EVEQKKSEYN LKMKQLEHVM GSAPEYPQSP KTPPHFQTHL
1160 1170 1180 1190 1200
AKLLETQEQE IEDGRASKMS LQHLVTKLNE DREVKNAEIL RMKDQLCEME
1210 1220 1230 1240 1250
NLRLESQQLR ERTWLLQTQL DDMKRQGESS SQSRPDSQQL KNEYEEEIIR
1260 1270 1280 1290 1300
ERLAKNKLIE EMLKMKTDLE EVQSALDSKE KFCHRMSEEV ERTRTLESRA
1310 1320 1330 1340 1350
FQEKEQLRSK LEEMYEERER TCQEMEMLRK QLEFLAEENG KLIGHQNLHQ
1360 1370 1380
KIQYVVRLKK ENIRLAEETE KLRAENVFLK ERKKE
Length:1,385
Mass (Da):159,540
Last modified:October 1, 2003 - v1
Checksum:iA640E2250DA6A0F6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti473 – 4731L → R in AAP44512 (PubMed:14618103).Curated
Sequence conflicti562 – 5621K → I in AAP44512 (PubMed:14618103).Curated
Sequence conflicti835 – 8351E → D in AAP44512 (PubMed:14618103).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY291580 mRNA. Translation: AAP44512.1.
AY291581 mRNA. Translation: AAP44513.1.
RefSeqiNP_853666.1. NM_181635.2.
UniGeneiRn.45205.

Genome annotation databases

GeneIDi353302.
KEGGirno:353302.
UCSCiRGD:727790. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY291580 mRNA. Translation: AAP44512.1.
AY291581 mRNA. Translation: AAP44513.1.
RefSeqiNP_853666.1. NM_181635.2.
UniGeneiRn.45205.

3D structure databases

ProteinModelPortaliQ7TSP2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030707.

PTM databases

PhosphoSiteiQ7TSP2.

Proteomic databases

PaxDbiQ7TSP2.
PRIDEiQ7TSP2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi353302.
KEGGirno:353302.
UCSCiRGD:727790. rat.

Organism-specific databases

CTDi56992.
RGDi727790. Kif15.

Phylogenomic databases

eggNOGiKOG4280. Eukaryota.
COG5059. LUCA.
HOGENOMiHOG000113225.
HOVERGENiHBG062662.
InParanoidiQ7TSP2.
KOiK10400.
PhylomeDBiQ7TSP2.

Miscellaneous databases

PROiQ7TSP2.

Family and domain databases

Gene3Di3.40.850.10. 1 hit.
InterProiIPR031794. HMMR_C.
IPR027640. Kinesin-like_fam.
IPR024658. Kinesin-like_KLP2.
IPR001752. Kinesin_motor_dom.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24115. PTHR24115. 4 hits.
PfamiPF15908. HMMR_C. 1 hit.
PF00225. Kinesin. 1 hit.
PF12711. Kinesin-relat_1. 1 hit.
[Graphical view]
PRINTSiPR00380. KINESINHEAVY.
SMARTiSM00129. KISc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS50067. KINESIN_MOTOR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Expression of the mitotic kinesin Kif15 in postmitotic neurons: implications for neuronal migration and development."
    Buster D.W., Baird D.H., Yu W., Solowska J.M., Chauviere M., Mazurek A., Kress M., Baas P.W.
    J. Neurocytol. 32:79-96(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiKIF15_RAT
AccessioniPrimary (citable) accession number: Q7TSP2
Secondary accession number(s): Q7TN17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: October 1, 2003
Last modified: June 8, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.