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Q7TSN6

- GP151_MOUSE

UniProt

Q7TSN6 - GP151_MOUSE

Protein

Probable G-protein coupled receptor 151 protein

Gene

Gpr151

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 151 protein
    Alternative name(s):
    G-protein coupled receptor PGR7
    GPCR-2037
    Gene namesi
    Name:Gpr151
    Synonyms:Pgr7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:2441887. Gpr151.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 422422Probable G-protein coupled receptor 151 proteinPRO_0000069633Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi14 – 141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi19 – 191N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi115 ↔ 191PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ7TSN6.

    PTM databases

    PhosphoSiteiQ7TSN6.

    Expressioni

    Gene expression databases

    BgeeiQ7TSN6.
    CleanExiMM_GPR151.
    GenevestigatoriQ7TSN6.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7TSN6.
    SMRiQ7TSN6. Positions 42-324.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4545ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini67 – 7610CytoplasmicSequence Analysis
    Topological domaini98 – 12326ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini145 – 15713CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini179 – 20527ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini227 – 25933CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini281 – 29010ExtracellularSequence Analysis
    Topological domaini312 – 422111CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei46 – 6621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei77 – 9721Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei124 – 14421Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei158 – 17821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei206 – 22621Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei260 – 28021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei291 – 31121Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG288736.
    GeneTreeiENSGT00640000091572.
    HOGENOMiHOG000112774.
    HOVERGENiHBG051787.
    InParanoidiQ0VBS2.
    KOiK08435.
    OMAiCKSSDWF.
    OrthoDBiEOG74FF0X.
    PhylomeDBiQ7TSN6.
    TreeFamiTF332591.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7TSN6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKAMLRAGF ADTNSSNMNE SFARLHFAGG YLPSDSKDWR TIIPSLLMAV    50
    CLVGLVGNLC VIGILLHGVW KRKPSTIHSL ILNLSLADFS LLLFSAPVRA 100
    AAYSKGVWDL GWFICKSSDW FTHVCMAAKS LTFVVVAKAC FAYASDPAKQ 150
    ESIHSRTIWS VLAGIWVVAS LLPLPEWLFS TTRRHAGVEM CLVDVPAVAE 200
    EFMSMFGKLY PLLVFCLPLL LAGVYFWRAY DQCKTRCTKT RNLRDQMRSK 250
    QLTVMLLSTA IISALLWLPE WIAWLWVWHV KAGGPMPPQG FIALSQVLMF 300
    FTSTANPLIF LVMSEEFKAG LKGLWKWMIT RKPAVTSEVQ EAPAGNTEAL 350
    PGKAPSPETQ TCILDTDGRG SPDDSKEKSG KVVAPILPDV EQFWHERDAV 400
    PSAQDNDPIP WEHEGQETEG CN 422
    Length:422
    Mass (Da):46,826
    Last modified:October 1, 2003 - v1
    Checksum:i06F6F2FB2127793F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ564167 mRNA. Translation: CAD91896.1.
    BC120520 mRNA. Translation: AAI20521.1.
    BC120526 mRNA. Translation: AAI20527.1.
    AY351677 mRNA. Translation: AAQ62568.1.
    AK048591 mRNA. Translation: BAC33383.1.
    AY255533 mRNA. Translation: AAO85045.1.
    CCDSiCCDS29215.1.
    RefSeqiNP_853521.1. NM_181543.1.
    UniGeneiMm.186779.

    Genome annotation databases

    EnsembliENSMUST00000054738; ENSMUSP00000058887; ENSMUSG00000042816.
    GeneIDi240239.
    KEGGimmu:240239.
    UCSCiuc008eua.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ564167 mRNA. Translation: CAD91896.1 .
    BC120520 mRNA. Translation: AAI20521.1 .
    BC120526 mRNA. Translation: AAI20527.1 .
    AY351677 mRNA. Translation: AAQ62568.1 .
    AK048591 mRNA. Translation: BAC33383.1 .
    AY255533 mRNA. Translation: AAO85045.1 .
    CCDSi CCDS29215.1.
    RefSeqi NP_853521.1. NM_181543.1.
    UniGenei Mm.186779.

    3D structure databases

    ProteinModelPortali Q7TSN6.
    SMRi Q7TSN6. Positions 42-324.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q7TSN6.

    Proteomic databases

    PRIDEi Q7TSN6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000054738 ; ENSMUSP00000058887 ; ENSMUSG00000042816 .
    GeneIDi 240239.
    KEGGi mmu:240239.
    UCSCi uc008eua.1. mouse.

    Organism-specific databases

    CTDi 134391.
    MGIi MGI:2441887. Gpr151.

    Phylogenomic databases

    eggNOGi NOG288736.
    GeneTreei ENSGT00640000091572.
    HOGENOMi HOG000112774.
    HOVERGENi HBG051787.
    InParanoidi Q0VBS2.
    KOi K08435.
    OMAi CKSSDWF.
    OrthoDBi EOG74FF0X.
    PhylomeDBi Q7TSN6.
    TreeFami TF332591.

    Miscellaneous databases

    NextBioi 384518.
    PROi Q7TSN6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q7TSN6.
    CleanExi MM_GPR151.
    Genevestigatori Q7TSN6.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a novel orphan G protein-coupled receptor (GPCR-2037): in situ hybridization reveals high mRNA expression in rat brain restricted to neurons of the habenular complex."
      Berthold M., Collin M., Sejlitz T., Meister B., Lind P.
      Brain Res. Mol. Brain Res. 120:22-29(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "Molecular cloning of a novel G-protein-coupled receptor."
      Ignatov A., Schaller H.C.
      Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-422.
      Strain: C3H/He.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 102-422.
      Strain: C57BL/6J.
      Tissue: Head.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 45-158.

    Entry informationi

    Entry nameiGP151_MOUSE
    AccessioniPrimary (citable) accession number: Q7TSN6
    Secondary accession number(s): Q0VBS2, Q80UD8, Q8BX88
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3