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Q7TSN6 (GP151_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable G-protein coupled receptor 151 protein
Alternative name(s):
G-protein coupled receptor PGR7
GPCR-2037
Gene names
Name:Gpr151
Synonyms:Pgr7
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length422 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 422422Probable G-protein coupled receptor 151 protein
PRO_0000069633

Regions

Topological domain1 – 4545Extracellular Potential
Transmembrane46 – 6621Helical; Name=1; Potential
Topological domain67 – 7610Cytoplasmic Potential
Transmembrane77 – 9721Helical; Name=2; Potential
Topological domain98 – 12326Extracellular Potential
Transmembrane124 – 14421Helical; Name=3; Potential
Topological domain145 – 15713Cytoplasmic Potential
Transmembrane158 – 17821Helical; Name=4; Potential
Topological domain179 – 20527Extracellular Potential
Transmembrane206 – 22621Helical; Name=5; Potential
Topological domain227 – 25933Cytoplasmic Potential
Transmembrane260 – 28021Helical; Name=6; Potential
Topological domain281 – 29010Extracellular Potential
Transmembrane291 – 31121Helical; Name=7; Potential
Topological domain312 – 422111Cytoplasmic Potential

Amino acid modifications

Glycosylation141N-linked (GlcNAc...) Potential
Glycosylation191N-linked (GlcNAc...) Potential
Disulfide bond115 ↔ 191 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7TSN6 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 06F6F2FB2127793F

FASTA42246,826
        10         20         30         40         50         60 
MGKAMLRAGF ADTNSSNMNE SFARLHFAGG YLPSDSKDWR TIIPSLLMAV CLVGLVGNLC 

        70         80         90        100        110        120 
VIGILLHGVW KRKPSTIHSL ILNLSLADFS LLLFSAPVRA AAYSKGVWDL GWFICKSSDW 

       130        140        150        160        170        180 
FTHVCMAAKS LTFVVVAKAC FAYASDPAKQ ESIHSRTIWS VLAGIWVVAS LLPLPEWLFS 

       190        200        210        220        230        240 
TTRRHAGVEM CLVDVPAVAE EFMSMFGKLY PLLVFCLPLL LAGVYFWRAY DQCKTRCTKT 

       250        260        270        280        290        300 
RNLRDQMRSK QLTVMLLSTA IISALLWLPE WIAWLWVWHV KAGGPMPPQG FIALSQVLMF 

       310        320        330        340        350        360 
FTSTANPLIF LVMSEEFKAG LKGLWKWMIT RKPAVTSEVQ EAPAGNTEAL PGKAPSPETQ 

       370        380        390        400        410        420 
TCILDTDGRG SPDDSKEKSG KVVAPILPDV EQFWHERDAV PSAQDNDPIP WEHEGQETEG 


CN 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of a novel orphan G protein-coupled receptor (GPCR-2037): in situ hybridization reveals high mRNA expression in rat brain restricted to neurons of the habenular complex."
Berthold M., Collin M., Sejlitz T., Meister B., Lind P.
Brain Res. Mol. Brain Res. 120:22-29(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]"Molecular cloning of a novel G-protein-coupled receptor."
Ignatov A., Schaller H.C.
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-422.
Strain: C3H/He.
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 102-422.
Strain: C57BL/6J.
Tissue: Head.
[5]"The G protein-coupled receptor repertoires of human and mouse."
Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A.
Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 45-158.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ564167 mRNA. Translation: CAD91896.1.
BC120520 mRNA. Translation: AAI20521.1.
BC120526 mRNA. Translation: AAI20527.1.
AY351677 mRNA. Translation: AAQ62568.1.
AK048591 mRNA. Translation: BAC33383.1.
AY255533 mRNA. Translation: AAO85045.1.
RefSeqNP_853521.1. NM_181543.1.
UniGeneMm.186779.

3D structure databases

ProteinModelPortalQ7TSN6.
SMRQ7TSN6. Positions 41-324.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ7TSN6.

Proteomic databases

PRIDEQ7TSN6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000054738; ENSMUSP00000058887; ENSMUSG00000042816.
GeneID240239.
KEGGmmu:240239.
UCSCuc008eua.1. mouse.

Organism-specific databases

CTD134391.
MGIMGI:2441887. Gpr151.

Phylogenomic databases

eggNOGNOG288736.
GeneTreeENSGT00640000091572.
HOGENOMHOG000112774.
HOVERGENHBG051787.
InParanoidQ0VBS2.
KOK08435.
OMACKSSDWF.
OrthoDBEOG74FF0X.
PhylomeDBQ7TSN6.
TreeFamTF332591.

Gene expression databases

BgeeQ7TSN6.
CleanExMM_GPR151.
GenevestigatorQ7TSN6.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio384518.
PROQ7TSN6.
SOURCESearch...

Entry information

Entry nameGP151_MOUSE
AccessionPrimary (citable) accession number: Q7TSN6
Secondary accession number(s): Q0VBS2, Q80UD8, Q8BX88
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2003
Last modified: April 16, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries