Q7TSN6 (GP151_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable G-protein coupled receptor 151 protein

Alternative name(s):
G-protein coupled receptor PGR7
GPCR-2037

Gene names

Name:	Gpr151
Synonyms:	Pgr7

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	422 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location

Cell membrane; Multi-pass membrane protein Potential.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 422	422	Probable G-protein coupled receptor 151 protein		PRO_0000069633
Regions
	Topological domain	1 – 45	45	Extracellular Potential
	Transmembrane	46 – 66	21	Helical; Name=1; Potential
	Topological domain	67 – 76	10	Cytoplasmic Potential
	Transmembrane	77 – 97	21	Helical; Name=2; Potential
	Topological domain	98 – 123	26	Extracellular Potential
	Transmembrane	124 – 144	21	Helical; Name=3; Potential
	Topological domain	145 – 157	13	Cytoplasmic Potential
	Transmembrane	158 – 178	21	Helical; Name=4; Potential
	Topological domain	179 – 205	27	Extracellular Potential
	Transmembrane	206 – 226	21	Helical; Name=5; Potential
	Topological domain	227 – 259	33	Cytoplasmic Potential
	Transmembrane	260 – 280	21	Helical; Name=6; Potential
	Topological domain	281 – 290	10	Extracellular Potential
	Transmembrane	291 – 311	21	Helical; Name=7; Potential
	Topological domain	312 – 422	111	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	14	1	N-linked (GlcNAc...) Potential
	Glycosylation	19	1	N-linked (GlcNAc...) Potential
	Disulfide bond	115 ↔ 191		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7TSN6 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 06F6F2FB2127793F	FASTA	422	46,826
	10 20 30 40 50 60 MGKAMLRAGF ADTNSSNMNE SFARLHFAGG YLPSDSKDWR TIIPSLLMAV CLVGLVGNLC 70 80 90 100 110 120 VIGILLHGVW KRKPSTIHSL ILNLSLADFS LLLFSAPVRA AAYSKGVWDL GWFICKSSDW 130 140 150 160 170 180 FTHVCMAAKS LTFVVVAKAC FAYASDPAKQ ESIHSRTIWS VLAGIWVVAS LLPLPEWLFS 190 200 210 220 230 240 TTRRHAGVEM CLVDVPAVAE EFMSMFGKLY PLLVFCLPLL LAGVYFWRAY DQCKTRCTKT 250 260 270 280 290 300 RNLRDQMRSK QLTVMLLSTA IISALLWLPE WIAWLWVWHV KAGGPMPPQG FIALSQVLMF 310 320 330 340 350 360 FTSTANPLIF LVMSEEFKAG LKGLWKWMIT RKPAVTSEVQ EAPAGNTEAL PGKAPSPETQ 370 380 390 400 410 420 TCILDTDGRG SPDDSKEKSG KVVAPILPDV EQFWHERDAV PSAQDNDPIP WEHEGQETEG CN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of a novel orphan G protein-coupled receptor (GPCR-2037): in situ hybridization reveals high mRNA expression in rat brain restricted to neurons of the habenular complex." Berthold M., Collin M., Sejlitz T., Meister B., Lind P. Brain Res. Mol. Brain Res. 120:22-29(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c. Tissue: Brain.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"Molecular cloning of a novel G-protein-coupled receptor." Ignatov A., Schaller H.C. Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-422. Strain: C3H/He.
[4]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 102-422. Strain: C57BL/6J. Tissue: Head.
[5]	"The G protein-coupled receptor repertoires of human and mouse." Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A. Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 45-158.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ564167 mRNA. Translation: CAD91896.1. BC120520 mRNA. Translation: AAI20521.1. BC120526 mRNA. Translation: AAI20527.1. AY351677 mRNA. Translation: AAQ62568.1. AK048591 mRNA. Translation: BAC33383.1. AY255533 mRNA. Translation: AAO85045.1.
IPI	IPI00337877.
RefSeq	NP_853521.1. NM_181543.1.
UniGene	Mm.186779.
3D structure databases
ProteinModelPortal	Q7TSN6.
SMR	Q7TSN6. Positions 45-324.
ModBase	Search...
PTM databases
PhosphoSite	Q7TSN6.
Proteomic databases
PRIDE	Q7TSN6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000054738; ENSMUSP00000058887; ENSMUSG00000042816.
GeneID	240239.
KEGG	mmu:240239.
UCSC	uc008eua.1. mouse.
Organism-specific databases
CTD	134391.
MGI	MGI:2441887. Gpr151.
Phylogenomic databases
eggNOG	NOG288736.
GeneTree	ENSGT00640000091572.
HOGENOM	HOG000112774.
HOVERGEN	HBG051787.
InParanoid	Q0VBS2.
KO	K08435.
OMA	FGKLYPL.
OrthoDB	EOG4N5VX8.
Gene expression databases
Bgee	Q7TSN6.
CleanEx	MM_GPR151.
Genevestigator	Q7TSN6.
GermOnline	ENSMUSG00000042816. Mus musculus.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	384518.
SOURCE	Search...

Entry information

Entry name

GP151_MOUSE

Accession

Primary (citable) accession number: Q7TSN6
Secondary accession number(s): Q0VBS2, Q80UD8, Q8BX88

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2004
Last sequence update:	October 1, 2003
Last modified:	May 1, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program