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Protein

Probable G-protein coupled receptor 151 protein

Gene

Gpr151

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 151 protein
Alternative name(s):
G-protein coupled receptor PGR7
GPCR-2037
Gene namesi
Name:Gpr151
Synonyms:Pgr7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:2441887. Gpr151.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4545ExtracellularSequence AnalysisAdd
BLAST
Transmembranei46 – 6621Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini67 – 7610CytoplasmicSequence Analysis
Transmembranei77 – 9721Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini98 – 12326ExtracellularSequence AnalysisAdd
BLAST
Transmembranei124 – 14421Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini145 – 15713CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei158 – 17821Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini179 – 20527ExtracellularSequence AnalysisAdd
BLAST
Transmembranei206 – 22621Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini227 – 25933CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei260 – 28021Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini281 – 29010ExtracellularSequence Analysis
Transmembranei291 – 31121Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini312 – 422111CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 422422Probable G-protein coupled receptor 151 proteinPRO_0000069633Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi14 – 141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi19 – 191N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi115 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ7TSN6.

PTM databases

PhosphoSiteiQ7TSN6.

Expressioni

Gene expression databases

BgeeiQ7TSN6.
CleanExiMM_GPR151.
GenevestigatoriQ7TSN6.

Structurei

3D structure databases

ProteinModelPortaliQ7TSN6.
SMRiQ7TSN6. Positions 42-324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG288736.
GeneTreeiENSGT00640000091572.
HOGENOMiHOG000112774.
HOVERGENiHBG051787.
InParanoidiQ7TSN6.
KOiK08435.
OMAiCKSSDWF.
OrthoDBiEOG74FF0X.
PhylomeDBiQ7TSN6.
TreeFamiTF332591.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TSN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKAMLRAGF ADTNSSNMNE SFARLHFAGG YLPSDSKDWR TIIPSLLMAV
60 70 80 90 100
CLVGLVGNLC VIGILLHGVW KRKPSTIHSL ILNLSLADFS LLLFSAPVRA
110 120 130 140 150
AAYSKGVWDL GWFICKSSDW FTHVCMAAKS LTFVVVAKAC FAYASDPAKQ
160 170 180 190 200
ESIHSRTIWS VLAGIWVVAS LLPLPEWLFS TTRRHAGVEM CLVDVPAVAE
210 220 230 240 250
EFMSMFGKLY PLLVFCLPLL LAGVYFWRAY DQCKTRCTKT RNLRDQMRSK
260 270 280 290 300
QLTVMLLSTA IISALLWLPE WIAWLWVWHV KAGGPMPPQG FIALSQVLMF
310 320 330 340 350
FTSTANPLIF LVMSEEFKAG LKGLWKWMIT RKPAVTSEVQ EAPAGNTEAL
360 370 380 390 400
PGKAPSPETQ TCILDTDGRG SPDDSKEKSG KVVAPILPDV EQFWHERDAV
410 420
PSAQDNDPIP WEHEGQETEG CN
Length:422
Mass (Da):46,826
Last modified:October 1, 2003 - v1
Checksum:i06F6F2FB2127793F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ564167 mRNA. Translation: CAD91896.1.
BC120520 mRNA. Translation: AAI20521.1.
BC120526 mRNA. Translation: AAI20527.1.
AY351677 mRNA. Translation: AAQ62568.1.
AK048591 mRNA. Translation: BAC33383.1.
AY255533 mRNA. Translation: AAO85045.1.
CCDSiCCDS29215.1.
RefSeqiNP_853521.1. NM_181543.1.
UniGeneiMm.186779.

Genome annotation databases

EnsembliENSMUST00000054738; ENSMUSP00000058887; ENSMUSG00000042816.
GeneIDi240239.
KEGGimmu:240239.
UCSCiuc008eua.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ564167 mRNA. Translation: CAD91896.1.
BC120520 mRNA. Translation: AAI20521.1.
BC120526 mRNA. Translation: AAI20527.1.
AY351677 mRNA. Translation: AAQ62568.1.
AK048591 mRNA. Translation: BAC33383.1.
AY255533 mRNA. Translation: AAO85045.1.
CCDSiCCDS29215.1.
RefSeqiNP_853521.1. NM_181543.1.
UniGeneiMm.186779.

3D structure databases

ProteinModelPortaliQ7TSN6.
SMRiQ7TSN6. Positions 42-324.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ7TSN6.

Proteomic databases

PRIDEiQ7TSN6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054738; ENSMUSP00000058887; ENSMUSG00000042816.
GeneIDi240239.
KEGGimmu:240239.
UCSCiuc008eua.1. mouse.

Organism-specific databases

CTDi134391.
MGIiMGI:2441887. Gpr151.

Phylogenomic databases

eggNOGiNOG288736.
GeneTreeiENSGT00640000091572.
HOGENOMiHOG000112774.
HOVERGENiHBG051787.
InParanoidiQ7TSN6.
KOiK08435.
OMAiCKSSDWF.
OrthoDBiEOG74FF0X.
PhylomeDBiQ7TSN6.
TreeFamiTF332591.

Miscellaneous databases

NextBioi384518.
PROiQ7TSN6.
SOURCEiSearch...

Gene expression databases

BgeeiQ7TSN6.
CleanExiMM_GPR151.
GenevestigatoriQ7TSN6.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a novel orphan G protein-coupled receptor (GPCR-2037): in situ hybridization reveals high mRNA expression in rat brain restricted to neurons of the habenular complex."
    Berthold M., Collin M., Sejlitz T., Meister B., Lind P.
    Brain Res. Mol. Brain Res. 120:22-29(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Molecular cloning of a novel G-protein-coupled receptor."
    Ignatov A., Schaller H.C.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 5-422.
    Strain: C3H/He.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 102-422.
    Strain: C57BL/6J.
    Tissue: Head.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 45-158.

Entry informationi

Entry nameiGP151_MOUSE
AccessioniPrimary (citable) accession number: Q7TSN6
Secondary accession number(s): Q0VBS2, Q80UD8, Q8BX88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2003
Last modified: January 7, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.