ID GP151_RAT Reviewed; 421 AA. AC Q7TSN5; DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2003, sequence version 1. DT 24-JAN-2024, entry version 114. DE RecName: Full=Probable G-protein coupled receptor 151; DE AltName: Full=GPCR-2037; GN Name=Gpr151; OS Rattus norvegicus (Rat). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Rattus. OX NCBI_TaxID=10116; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC STRAIN=Sprague-Dawley; TISSUE=Brain; RX PubMed=14667573; DOI=10.1016/j.molbrainres.2003.09.013; RA Berthold M., Collin M., Sejlitz T., Meister B., Lind P.; RT "Cloning of a novel orphan G protein-coupled receptor (GPCR-2037): in situ RT hybridization reveals high mRNA expression in rat brain restricted to RT neurons of the habenular complex."; RL Brain Res. Mol. Brain Res. 120:22-29(2003). CC -!- FUNCTION: Orphan receptor. CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. CC -!- TISSUE SPECIFICITY: Exclusively expressed in neurons of the habenular CC complex. The expression is particularly prominent in the medial CC habenular nucleus, whereas the lateral habenular nucleus exhibited a CC lower level of expression. CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family. CC {ECO:0000255|PROSITE-ProRule:PRU00521}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ564168; CAD91897.1; -; mRNA. DR RefSeq; NP_853664.1; NM_181633.2. DR AlphaFoldDB; Q7TSN5; -. DR SMR; Q7TSN5; -. DR STRING; 10116.ENSRNOP00000043810; -. DR GlyCosmos; Q7TSN5; 1 site, No reported glycans. DR GlyGen; Q7TSN5; 1 site. DR PhosphoSitePlus; Q7TSN5; -. DR PaxDb; 10116-ENSRNOP00000043810; -. DR Ensembl; ENSRNOT00000043544.4; ENSRNOP00000043810.3; ENSRNOG00000027103.5. DR Ensembl; ENSRNOT00055031960; ENSRNOP00055025857; ENSRNOG00055018755. DR Ensembl; ENSRNOT00060020639; ENSRNOP00060016255; ENSRNOG00060012167. DR Ensembl; ENSRNOT00065033417; ENSRNOP00065026729; ENSRNOG00065019838. DR GeneID; 307475; -. DR KEGG; rno:307475; -. DR UCSC; RGD:727873; rat. DR AGR; RGD:727873; -. DR CTD; 134391; -. DR RGD; 727873; Gpr151. DR eggNOG; KOG3656; Eukaryota. DR GeneTree; ENSGT01030000234518; -. DR HOGENOM; CLU_053982_0_0_1; -. DR InParanoid; Q7TSN5; -. DR OMA; CTIWSVL; -. DR OrthoDB; 4729702at2759; -. DR PhylomeDB; Q7TSN5; -. DR TreeFam; TF332591; -. DR PRO; PR:Q7TSN5; -. DR Proteomes; UP000002494; Chromosome 18. DR Bgee; ENSRNOG00000027103; Expressed in spleen and 8 other cell types or tissues. DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. DR GO; GO:0004930; F:G protein-coupled receptor activity; ISO:RGD. DR GO; GO:0042802; F:identical protein binding; ISO:RGD. DR GO; GO:0008188; F:neuropeptide receptor activity; IBA:GO_Central. DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISO:RGD. DR GO; GO:0010447; P:response to acidic pH; ISO:RGD. DR CDD; cd15002; 7tmA_GPR151; 1. DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1. DR InterPro; IPR000276; GPCR_Rhodpsn. DR InterPro; IPR017452; GPCR_Rhodpsn_7TM. DR PANTHER; PTHR45695:SF1; G-PROTEIN COUPLED RECEPTOR 151; 1. DR PANTHER; PTHR45695; LEUCOKININ RECEPTOR-RELATED; 1. DR Pfam; PF00001; 7tm_1; 1. DR PRINTS; PR00237; GPCRRHODOPSN. DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1. DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1. PE 2: Evidence at transcript level; KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein; KW Membrane; Receptor; Reference proteome; Transducer; Transmembrane; KW Transmembrane helix. FT CHAIN 1..421 FT /note="Probable G-protein coupled receptor 151" FT /id="PRO_0000069634" FT TOPO_DOM 1..44 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 45..65 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 66..74 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 75..95 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 96..122 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 123..143 FT /note="Helical; Name=3" FT /evidence="ECO:0000255" FT TOPO_DOM 144..156 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 157..177 FT /note="Helical; Name=4" FT /evidence="ECO:0000255" FT TOPO_DOM 178..204 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 205..225 FT /note="Helical; Name=5" FT /evidence="ECO:0000255" FT TOPO_DOM 226..258 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 259..279 FT /note="Helical; Name=6" FT /evidence="ECO:0000255" FT TOPO_DOM 280..289 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 290..310 FT /note="Helical; Name=7" FT /evidence="ECO:0000255" FT TOPO_DOM 311..421 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT REGION 346..381 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 394..421 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 352..367 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT CARBOHYD 18 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 114..190 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521" SQ SEQUENCE 421 AA; 46724 MW; 5ADAE6CA69828512 CRC64; MGKATLAVFA DSDSSNMNES FAHLHFAGGY LPSDSKGWRT IIPSLLAAVC LVGFVGNLCV IGLLLHGVWK RKPSMIHSLI LNLSLADISL LLFSAPVRAT AYVKGVWDLG WFVCKSSDWF THMCMAAKSL TFVVVAKVCF MYASDPAKPV GTHNCTIWSL LGAIWVVASL LPLPEWFFST TRHHAGVEMC LVDVPAVAAE FMSLFGKLYP LLVFCLPLLL AGFYFWRAYN QCKIRCAKTQ NLRNQMRSKQ LTVMLLSTAV TSALLWLPEW IAWLWVWHLK AGGPMPPQGF IALSQVLMFS ISTVNPLIFL MMSEEFKAGL KGIWKWMITR KPVVTSEVQE VPAGNIETLP GKAPSPETQT CIPDTDRCGS PDSSKETTDK VMVPILPDVE QFWHERDVGP SAQDNDPIPW EHEGQETKGC N //