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Q7TSN5 (GP151_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable G-protein coupled receptor 151
Alternative name(s):
GPCR-2037
Gene names
Name:Gpr151
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length421 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Orphan receptor.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Exclusively expressed in neurons of the habenular complex. The expression is particularly prominent in the medial habenular nucleus, whereas the lateral habenular nucleus exhibited a lower level of expression.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 421421Probable G-protein coupled receptor 151
PRO_0000069634

Regions

Topological domain1 – 4444Extracellular Potential
Transmembrane45 – 6521Helical; Name=1; Potential
Topological domain66 – 749Cytoplasmic Potential
Transmembrane75 – 9521Helical; Name=2; Potential
Topological domain96 – 12227Extracellular Potential
Transmembrane123 – 14321Helical; Name=3; Potential
Topological domain144 – 15613Cytoplasmic Potential
Transmembrane157 – 17721Helical; Name=4; Potential
Topological domain178 – 20427Extracellular Potential
Transmembrane205 – 22521Helical; Name=5; Potential
Topological domain226 – 25833Cytoplasmic Potential
Transmembrane259 – 27921Helical; Name=6; Potential
Topological domain280 – 28910Extracellular Potential
Transmembrane290 – 31021Helical; Name=7; Potential
Topological domain311 – 421111Cytoplasmic Potential

Amino acid modifications

Glycosylation181N-linked (GlcNAc...) Potential
Disulfide bond114 ↔ 190 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7TSN5 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 5ADAE6CA69828512

FASTA42146,724
        10         20         30         40         50         60 
MGKATLAVFA DSDSSNMNES FAHLHFAGGY LPSDSKGWRT IIPSLLAAVC LVGFVGNLCV 

        70         80         90        100        110        120 
IGLLLHGVWK RKPSMIHSLI LNLSLADISL LLFSAPVRAT AYVKGVWDLG WFVCKSSDWF 

       130        140        150        160        170        180 
THMCMAAKSL TFVVVAKVCF MYASDPAKPV GTHNCTIWSL LGAIWVVASL LPLPEWFFST 

       190        200        210        220        230        240 
TRHHAGVEMC LVDVPAVAAE FMSLFGKLYP LLVFCLPLLL AGFYFWRAYN QCKIRCAKTQ 

       250        260        270        280        290        300 
NLRNQMRSKQ LTVMLLSTAV TSALLWLPEW IAWLWVWHLK AGGPMPPQGF IALSQVLMFS 

       310        320        330        340        350        360 
ISTVNPLIFL MMSEEFKAGL KGIWKWMITR KPVVTSEVQE VPAGNIETLP GKAPSPETQT 

       370        380        390        400        410        420 
CIPDTDRCGS PDSSKETTDK VMVPILPDVE QFWHERDVGP SAQDNDPIPW EHEGQETKGC 


N 

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References

[1]"Cloning of a novel orphan G protein-coupled receptor (GPCR-2037): in situ hybridization reveals high mRNA expression in rat brain restricted to neurons of the habenular complex."
Berthold M., Collin M., Sejlitz T., Meister B., Lind P.
Brain Res. Mol. Brain Res. 120:22-29(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AJ564168 mRNA. Translation: CAD91897.1.
RefSeqNP_853664.1. NM_181633.2.
UniGeneRn.57350.

3D structure databases

ProteinModelPortalQ7TSN5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000043810.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ7TSN5.

Proteomic databases

PRIDEQ7TSN5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000043544; ENSRNOP00000043810; ENSRNOG00000027103.
GeneID307475.
KEGGrno:307475.
UCSCRGD:727873. rat.

Organism-specific databases

CTD134391.
RGD727873. Gpr151.

Phylogenomic databases

eggNOGNOG288736.
GeneTreeENSGT00640000091572.
HOGENOMHOG000112774.
HOVERGENHBG051787.
InParanoidQ7TSN5.
KOK08435.
OMACKSSDWF.
OrthoDBEOG74FF0X.
PhylomeDBQ7TSN5.
TreeFamTF332591.

Gene expression databases

GenevestigatorQ7TSN5.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio657422.
PROQ7TSN5.

Entry information

Entry nameGP151_RAT
AccessionPrimary (citable) accession number: Q7TSN5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2003
Last modified: April 16, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries