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Q7TSN5

- GP151_RAT

UniProt

Q7TSN5 - GP151_RAT

Protein

Probable G-protein coupled receptor 151

Gene

Gpr151

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Orphan receptor.

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable G-protein coupled receptor 151
    Alternative name(s):
    GPCR-2037
    Gene namesi
    Name:Gpr151
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 18

    Organism-specific databases

    RGDi727873. Gpr151.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 421421Probable G-protein coupled receptor 151PRO_0000069634Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi114 ↔ 190PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ7TSN5.

    PTM databases

    PhosphoSiteiQ7TSN5.

    Expressioni

    Tissue specificityi

    Exclusively expressed in neurons of the habenular complex. The expression is particularly prominent in the medial habenular nucleus, whereas the lateral habenular nucleus exhibited a lower level of expression.

    Gene expression databases

    GenevestigatoriQ7TSN5.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000043810.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7TSN5.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4444ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini66 – 749CytoplasmicSequence Analysis
    Topological domaini96 – 12227ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini144 – 15613CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini178 – 20427ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini226 – 25833CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini280 – 28910ExtracellularSequence Analysis
    Topological domaini311 – 421111CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei45 – 6521Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei75 – 9521Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei123 – 14321Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei157 – 17721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei205 – 22521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei259 – 27921Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei290 – 31021Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG288736.
    GeneTreeiENSGT00640000091572.
    HOGENOMiHOG000112774.
    HOVERGENiHBG051787.
    InParanoidiQ7TSN5.
    KOiK08435.
    OMAiCKSSDWF.
    OrthoDBiEOG74FF0X.
    PhylomeDBiQ7TSN5.
    TreeFamiTF332591.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7TSN5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKATLAVFA DSDSSNMNES FAHLHFAGGY LPSDSKGWRT IIPSLLAAVC    50
    LVGFVGNLCV IGLLLHGVWK RKPSMIHSLI LNLSLADISL LLFSAPVRAT 100
    AYVKGVWDLG WFVCKSSDWF THMCMAAKSL TFVVVAKVCF MYASDPAKPV 150
    GTHNCTIWSL LGAIWVVASL LPLPEWFFST TRHHAGVEMC LVDVPAVAAE 200
    FMSLFGKLYP LLVFCLPLLL AGFYFWRAYN QCKIRCAKTQ NLRNQMRSKQ 250
    LTVMLLSTAV TSALLWLPEW IAWLWVWHLK AGGPMPPQGF IALSQVLMFS 300
    ISTVNPLIFL MMSEEFKAGL KGIWKWMITR KPVVTSEVQE VPAGNIETLP 350
    GKAPSPETQT CIPDTDRCGS PDSSKETTDK VMVPILPDVE QFWHERDVGP 400
    SAQDNDPIPW EHEGQETKGC N 421
    Length:421
    Mass (Da):46,724
    Last modified:October 1, 2003 - v1
    Checksum:i5ADAE6CA69828512
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ564168 mRNA. Translation: CAD91897.1.
    RefSeqiNP_853664.1. NM_181633.2.
    UniGeneiRn.57350.

    Genome annotation databases

    EnsembliENSRNOT00000043544; ENSRNOP00000043810; ENSRNOG00000027103.
    GeneIDi307475.
    KEGGirno:307475.
    UCSCiRGD:727873. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ564168 mRNA. Translation: CAD91897.1 .
    RefSeqi NP_853664.1. NM_181633.2.
    UniGenei Rn.57350.

    3D structure databases

    ProteinModelPortali Q7TSN5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000043810.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q7TSN5.

    Proteomic databases

    PRIDEi Q7TSN5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000043544 ; ENSRNOP00000043810 ; ENSRNOG00000027103 .
    GeneIDi 307475.
    KEGGi rno:307475.
    UCSCi RGD:727873. rat.

    Organism-specific databases

    CTDi 134391.
    RGDi 727873. Gpr151.

    Phylogenomic databases

    eggNOGi NOG288736.
    GeneTreei ENSGT00640000091572.
    HOGENOMi HOG000112774.
    HOVERGENi HBG051787.
    InParanoidi Q7TSN5.
    KOi K08435.
    OMAi CKSSDWF.
    OrthoDBi EOG74FF0X.
    PhylomeDBi Q7TSN5.
    TreeFami TF332591.

    Miscellaneous databases

    NextBioi 657422.
    PROi Q7TSN5.

    Gene expression databases

    Genevestigatori Q7TSN5.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a novel orphan G protein-coupled receptor (GPCR-2037): in situ hybridization reveals high mRNA expression in rat brain restricted to neurons of the habenular complex."
      Berthold M., Collin M., Sejlitz T., Meister B., Lind P.
      Brain Res. Mol. Brain Res. 120:22-29(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Brain.

    Entry informationi

    Entry nameiGP151_RAT
    AccessioniPrimary (citable) accession number: Q7TSN5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3