Q7TSN5 (GP151_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable G-protein coupled receptor 151

Alternative name(s):
GPCR-2037

Gene names

Name:

Gpr151

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	421 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Orphan receptor.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Exclusively expressed in neurons of the habenular complex. The expression is particularly prominent in the medial habenular nucleus, whereas the lateral habenular nucleus exhibited a lower level of expression.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	G-protein coupled receptor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 421	421	Probable G-protein coupled receptor 151		PRO_0000069634
Regions
	Topological domain	1 – 44	44	Extracellular Potential
	Transmembrane	45 – 65	21	Helical; Name=1; Potential
	Topological domain	66 – 74	9	Cytoplasmic Potential
	Transmembrane	75 – 95	21	Helical; Name=2; Potential
	Topological domain	96 – 122	27	Extracellular Potential
	Transmembrane	123 – 143	21	Helical; Name=3; Potential
	Topological domain	144 – 156	13	Cytoplasmic Potential
	Transmembrane	157 – 177	21	Helical; Name=4; Potential
	Topological domain	178 – 204	27	Extracellular Potential
	Transmembrane	205 – 225	21	Helical; Name=5; Potential
	Topological domain	226 – 258	33	Cytoplasmic Potential
	Transmembrane	259 – 279	21	Helical; Name=6; Potential
	Topological domain	280 – 289	10	Extracellular Potential
	Transmembrane	290 – 310	21	Helical; Name=7; Potential
	Topological domain	311 – 421	111	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	18	1	N-linked (GlcNAc...) Potential
	Disulfide bond	114 ↔ 190		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7TSN5 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 5ADAE6CA69828512	FASTA	421	46,724
	10 20 30 40 50 60 MGKATLAVFA DSDSSNMNES FAHLHFAGGY LPSDSKGWRT IIPSLLAAVC LVGFVGNLCV 70 80 90 100 110 120 IGLLLHGVWK RKPSMIHSLI LNLSLADISL LLFSAPVRAT AYVKGVWDLG WFVCKSSDWF 130 140 150 160 170 180 THMCMAAKSL TFVVVAKVCF MYASDPAKPV GTHNCTIWSL LGAIWVVASL LPLPEWFFST 190 200 210 220 230 240 TRHHAGVEMC LVDVPAVAAE FMSLFGKLYP LLVFCLPLLL AGFYFWRAYN QCKIRCAKTQ 250 260 270 280 290 300 NLRNQMRSKQ LTVMLLSTAV TSALLWLPEW IAWLWVWHLK AGGPMPPQGF IALSQVLMFS 310 320 330 340 350 360 ISTVNPLIFL MMSEEFKAGL KGIWKWMITR KPVVTSEVQE VPAGNIETLP GKAPSPETQT 370 380 390 400 410 420 CIPDTDRCGS PDSSKETTDK VMVPILPDVE QFWHERDVGP SAQDNDPIPW EHEGQETKGC N

References

[1]	"Cloning of a novel orphan G protein-coupled receptor (GPCR-2037): in situ hybridization reveals high mRNA expression in rat brain restricted to neurons of the habenular complex." Berthold M., Collin M., Sejlitz T., Meister B., Lind P. Brain Res. Mol. Brain Res. 120:22-29(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ564168 mRNA. Translation: CAD91897.1.
IPI	IPI00382355.
RefSeq	NP_853664.1. NM_181633.2.
UniGene	Rn.57350.
3D structure databases
ProteinModelPortal	Q7TSN5.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000043810.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q7TSN5.
Proteomic databases
PRIDE	Q7TSN5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000043544; ENSRNOP00000043810; ENSRNOG00000027103.
GeneID	307475.
KEGG	rno:307475.
UCSC	RGD:727873. rat.
Organism-specific databases
CTD	134391.
RGD	727873. Gpr151.
Phylogenomic databases
eggNOG	NOG288736.
GeneTree	ENSGT00640000091572.
HOGENOM	HOG000112774.
HOVERGEN	HBG051787.
InParanoid	Q7TSN5.
KO	K08435.
OMA	FGKLYPL.
OrthoDB	EOG4N5VX8.
Gene expression databases
Genevestigator	Q7TSN5.
Family and domain databases
InterPro	IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	657422.

Entry information

Entry name

GP151_RAT

Accession

Primary (citable) accession number: Q7TSN5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2004
Last sequence update:	October 1, 2003
Last modified:	April 3, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program