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Q7TSN5

- GP151_RAT

UniProt

Q7TSN5 - GP151_RAT

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Protein

Probable G-protein coupled receptor 151

Gene

Gpr151

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 151
Alternative name(s):
GPCR-2037
Gene namesi
Name:Gpr151
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 18

Organism-specific databases

RGDi727873. Gpr151.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4444ExtracellularSequence AnalysisAdd
BLAST
Transmembranei45 – 6521Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini66 – 749CytoplasmicSequence Analysis
Transmembranei75 – 9521Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini96 – 12227ExtracellularSequence AnalysisAdd
BLAST
Transmembranei123 – 14321Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini144 – 15613CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei157 – 17721Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini178 – 20427ExtracellularSequence AnalysisAdd
BLAST
Transmembranei205 – 22521Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini226 – 25833CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei259 – 27921Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini280 – 28910ExtracellularSequence Analysis
Transmembranei290 – 31021Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini311 – 421111CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 421421Probable G-protein coupled receptor 151PRO_0000069634Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi18 – 181N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi114 ↔ 190PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ7TSN5.

PTM databases

PhosphoSiteiQ7TSN5.

Expressioni

Tissue specificityi

Exclusively expressed in neurons of the habenular complex. The expression is particularly prominent in the medial habenular nucleus, whereas the lateral habenular nucleus exhibited a lower level of expression.

Gene expression databases

GenevestigatoriQ7TSN5.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000043810.

Structurei

3D structure databases

ProteinModelPortaliQ7TSN5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG288736.
GeneTreeiENSGT00640000091572.
HOGENOMiHOG000112774.
HOVERGENiHBG051787.
InParanoidiQ7TSN5.
KOiK08435.
OMAiCKSSDWF.
OrthoDBiEOG74FF0X.
PhylomeDBiQ7TSN5.
TreeFamiTF332591.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TSN5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKATLAVFA DSDSSNMNES FAHLHFAGGY LPSDSKGWRT IIPSLLAAVC
60 70 80 90 100
LVGFVGNLCV IGLLLHGVWK RKPSMIHSLI LNLSLADISL LLFSAPVRAT
110 120 130 140 150
AYVKGVWDLG WFVCKSSDWF THMCMAAKSL TFVVVAKVCF MYASDPAKPV
160 170 180 190 200
GTHNCTIWSL LGAIWVVASL LPLPEWFFST TRHHAGVEMC LVDVPAVAAE
210 220 230 240 250
FMSLFGKLYP LLVFCLPLLL AGFYFWRAYN QCKIRCAKTQ NLRNQMRSKQ
260 270 280 290 300
LTVMLLSTAV TSALLWLPEW IAWLWVWHLK AGGPMPPQGF IALSQVLMFS
310 320 330 340 350
ISTVNPLIFL MMSEEFKAGL KGIWKWMITR KPVVTSEVQE VPAGNIETLP
360 370 380 390 400
GKAPSPETQT CIPDTDRCGS PDSSKETTDK VMVPILPDVE QFWHERDVGP
410 420
SAQDNDPIPW EHEGQETKGC N
Length:421
Mass (Da):46,724
Last modified:October 1, 2003 - v1
Checksum:i5ADAE6CA69828512
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ564168 mRNA. Translation: CAD91897.1.
RefSeqiNP_853664.1. NM_181633.2.
UniGeneiRn.57350.

Genome annotation databases

EnsembliENSRNOT00000043544; ENSRNOP00000043810; ENSRNOG00000027103.
GeneIDi307475.
KEGGirno:307475.
UCSCiRGD:727873. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ564168 mRNA. Translation: CAD91897.1 .
RefSeqi NP_853664.1. NM_181633.2.
UniGenei Rn.57350.

3D structure databases

ProteinModelPortali Q7TSN5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000043810.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q7TSN5.

Proteomic databases

PRIDEi Q7TSN5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000043544 ; ENSRNOP00000043810 ; ENSRNOG00000027103 .
GeneIDi 307475.
KEGGi rno:307475.
UCSCi RGD:727873. rat.

Organism-specific databases

CTDi 134391.
RGDi 727873. Gpr151.

Phylogenomic databases

eggNOGi NOG288736.
GeneTreei ENSGT00640000091572.
HOGENOMi HOG000112774.
HOVERGENi HBG051787.
InParanoidi Q7TSN5.
KOi K08435.
OMAi CKSSDWF.
OrthoDBi EOG74FF0X.
PhylomeDBi Q7TSN5.
TreeFami TF332591.

Miscellaneous databases

NextBioi 657422.
PROi Q7TSN5.

Gene expression databases

Genevestigatori Q7TSN5.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning of a novel orphan G protein-coupled receptor (GPCR-2037): in situ hybridization reveals high mRNA expression in rat brain restricted to neurons of the habenular complex."
    Berthold M., Collin M., Sejlitz T., Meister B., Lind P.
    Brain Res. Mol. Brain Res. 120:22-29(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiGP151_RAT
AccessioniPrimary (citable) accession number: Q7TSN5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3