Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q7TSL3

- FBX11_RAT

UniProt

Q7TSL3 - FBX11_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

F-box only protein 11

Gene

Fbxo11

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53LOG.By similarity

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri749 – 82072UBR-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ubiquitin-protein transferase activity Source: InterPro
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box only protein 11
Gene namesi
Name:Fbxo11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 6

Organism-specific databases

RGDi727935. Fbxo11.

Subcellular locationi

Nucleus By similarity. Chromosome By similarity

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 843843F-box only protein 11PRO_0000119892Add
BLAST

Proteomic databases

PaxDbiQ7TSL3.

PTM databases

PhosphoSiteiQ7TSL3.

Expressioni

Gene expression databases

GenevestigatoriQ7TSL3.

Interactioni

Subunit structurei

Component of the SCF(FBXO11) complex consisting of CUL1, RBX1, SKP1 and FBXO11. Interacts with p53/TP53, BCL6 and DTL (when not phosphorylated). Interacts with PRDM1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021998.

Structurei

3D structure databases

ProteinModelPortaliQ7TSL3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini69 – 11547F-boxPROSITE-ProRule annotationAdd
BLAST
Repeati311 – 33323PbH1 1Add
BLAST
Repeati334 – 35623PbH1 2Add
BLAST
Repeati357 – 37923PbH1 3Add
BLAST
Repeati380 – 40223PbH1 4Add
BLAST
Repeati403 – 42523PbH1 5Add
BLAST
Repeati426 – 44823PbH1 6Add
BLAST
Repeati449 – 47123PbH1 7Add
BLAST
Repeati472 – 49423PbH1 8Add
BLAST
Repeati495 – 51723PbH1 9Add
BLAST
Repeati518 – 54023PbH1 10Add
BLAST
Repeati541 – 56323PbH1 11Add
BLAST
Repeati564 – 58623PbH1 12Add
BLAST
Repeati587 – 60923PbH1 13Add
BLAST
Repeati610 – 63223PbH1 14Add
BLAST
Repeati633 – 65523PbH1 15Add
BLAST
Repeati656 – 67823PbH1 16Add
BLAST
Repeati679 – 70123PbH1 17Add
BLAST
Repeati702 – 72423PbH1 18Add
BLAST
Repeati725 – 74622PbH1 19Add
BLAST

Sequence similaritiesi

Contains 1 F-box domain.PROSITE-ProRule annotation
Contains 19 PbH1 repeats.Curated
Contains 1 UBR-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri749 – 82072UBR-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG12793.
GeneTreeiENSGT00530000063425.
HOGENOMiHOG000020584.
HOVERGENiHBG051565.
InParanoidiQ7TSL3.
KOiK10297.
OMAiGLYVTDY.
OrthoDBiEOG73803Z.
PhylomeDBiQ7TSL3.

Family and domain databases

Gene3Di2.160.20.10. 4 hits.
InterProiIPR006633. Carb-bd_sugar_hydrolysis-dom.
IPR001810. F-box_dom.
IPR007742. NosD_dom.
IPR022441. Para_beta_helix_rpt-2.
IPR006626. PbH1.
IPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
IPR003126. Znf_N-recognin.
[Graphical view]
PfamiPF12937. F-box-like. 1 hit.
PF05048. NosD. 1 hit.
PF02207. zf-UBR. 1 hit.
[Graphical view]
SMARTiSM00722. CASH. 3 hits.
SM00256. FBOX. 1 hit.
SM00710. PbH1. 19 hits.
[Graphical view]
SUPFAMiSSF51126. SSF51126. 3 hits.
SSF81383. SSF81383. 1 hit.
TIGRFAMsiTIGR03804. para_beta_helix. 4 hits.
PROSITEiPS50181. FBOX. 1 hit.
PS51157. ZF_UBR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TSL3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVAEESGPGA QNSPYQLRRK TLLPKRTACP TKNSMEGAST STTENFGHRA
60 70 80 90 100
KRARVSGKSQ DLSAAPAEQY LQEKLPDEVV LKIFSYLLEQ DLCRAACVCK
110 120 130 140 150
RFSELANDPI LWKRLYMEVF EYTRPMMHPE PGKFYQINPE EYEHPNPWKE
160 170 180 190 200
SFQQLYKGAH VKPGFAEHFY SNPARYKGRE NMLYYDTIED ALGGVQEAHF
210 220 230 240 250
DGLIFVHSGI YTDEWIYIES PITMIGAAPG KVADKVIIEN TRDSTFVFME
260 270 280 290 300
GSEDAYVGYM TIRFNPDDKS AQHHNAHHCL EITVNCSPII DHCIIRSTCT
310 320 330 340 350
VGSAVCVSGQ GACPTIKHCN ISDCENVGLY ITDHAQGIYE DNEISNNALA
360 370 380 390 400
GIWVKNHGNP IIRRNHIHHG RDVGVFTFDH GMGYFESCNI HRNRIAGFEV
410 420 430 440 450
KAYANPTVVR CEIHHGQTGG IYVHEKGRGQ FIENKIYANN FAGVWITSNS
460 470 480 490 500
DPTIRGNSIF NGNQGGVYIF GDGRGLIEGN DIYGNALAGI QIRTNSCPIV
510 520 530 540 550
RHNKIHDGQH GGIYVHEKGQ GVIEENEVYS NTLAGVWVTT GSTPVLRRNR
560 570 580 590 600
IHSGKQVGVY FYDNGHGVLE DNDIYNHMYS GVQIRTGSNP KIRRNKIWGG
610 620 630 640 650
QNGGILVYNS GLGCIEDNEI FDNAMAGVWI KTDSNPTLRR NKIHDGRDGG
660 670 680 690 700
ICIFNGGRGL LEENDIFRNA QAGVLISTNS HPVLRKNRIF DGFAAGIEIT
710 720 730 740 750
NHATATLEGN QIFNNRFGGL FLASGVNVTM KDNKIMNNQD AIEKAVSRGQ
760 770 780 790 800
CLYKISSYTS YPMHDFYRCH TCNTTDRNAI CVNCIKKCHQ GHDVEFIRHD
810 820 830 840
RFFCDCGAGT LSNPCTLAGE PTHDTDTLYD SAPPIESNTL QHN
Length:843
Mass (Da):94,042
Last modified:October 1, 2003 - v1
Checksum:i0C2498C81F96EB42
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY274810 mRNA. Translation: AAP42075.1.
RefSeqiNP_853662.1. NM_181631.2.
UniGeneiRn.36585.

Genome annotation databases

EnsembliENSRNOT00000021998; ENSRNOP00000021998; ENSRNOG00000016396.
GeneIDi301674.
KEGGirno:301674.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY274810 mRNA. Translation: AAP42075.1 .
RefSeqi NP_853662.1. NM_181631.2.
UniGenei Rn.36585.

3D structure databases

ProteinModelPortali Q7TSL3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000021998.

PTM databases

PhosphoSitei Q7TSL3.

Proteomic databases

PaxDbi Q7TSL3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000021998 ; ENSRNOP00000021998 ; ENSRNOG00000016396 .
GeneIDi 301674.
KEGGi rno:301674.

Organism-specific databases

CTDi 80204.
RGDi 727935. Fbxo11.

Phylogenomic databases

eggNOGi NOG12793.
GeneTreei ENSGT00530000063425.
HOGENOMi HOG000020584.
HOVERGENi HBG051565.
InParanoidi Q7TSL3.
KOi K10297.
OMAi GLYVTDY.
OrthoDBi EOG73803Z.
PhylomeDBi Q7TSL3.

Enzyme and pathway databases

UniPathwayi UPA00143 .

Miscellaneous databases

NextBioi 649071.
PROi Q7TSL3.

Gene expression databases

Genevestigatori Q7TSL3.

Family and domain databases

Gene3Di 2.160.20.10. 4 hits.
InterProi IPR006633. Carb-bd_sugar_hydrolysis-dom.
IPR001810. F-box_dom.
IPR007742. NosD_dom.
IPR022441. Para_beta_helix_rpt-2.
IPR006626. PbH1.
IPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
IPR003126. Znf_N-recognin.
[Graphical view ]
Pfami PF12937. F-box-like. 1 hit.
PF05048. NosD. 1 hit.
PF02207. zf-UBR. 1 hit.
[Graphical view ]
SMARTi SM00722. CASH. 3 hits.
SM00256. FBOX. 1 hit.
SM00710. PbH1. 19 hits.
[Graphical view ]
SUPFAMi SSF51126. SSF51126. 3 hits.
SSF81383. SSF81383. 1 hit.
TIGRFAMsi TIGR03804. para_beta_helix. 4 hits.
PROSITEi PS50181. FBOX. 1 hit.
PS51157. ZF_UBR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Shan Y.X., Ye G.M., Guo Z.K., Huang C.Q., Pan J., Yu L.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiFBX11_RAT
AccessioniPrimary (citable) accession number: Q7TSL3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3