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Q7TSL3

- FBX11_RAT

UniProt

Q7TSL3 - FBX11_RAT

Protein

F-box only protein 11

Gene

Fbxo11

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2 and BCL6. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53 By similarity.By similarity

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri749 – 82072UBR-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ubiquitin-protein transferase activity Source: InterPro
    2. zinc ion binding Source: InterPro

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00143.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    F-box only protein 11
    Gene namesi
    Name:Fbxo11
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 6

    Organism-specific databases

    RGDi727935. Fbxo11.

    Subcellular locationi

    Nucleus By similarity. Chromosome By similarity

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chromosome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 843843F-box only protein 11PRO_0000119892Add
    BLAST

    Proteomic databases

    PaxDbiQ7TSL3.

    PTM databases

    PhosphoSiteiQ7TSL3.

    Expressioni

    Gene expression databases

    GenevestigatoriQ7TSL3.

    Interactioni

    Subunit structurei

    Component of the SCF(FBXO11) complex consisting of CUL1, RBX1, SKP1 and FBXO11. Interacts with p53/TP53, BCL6 and DTL (when not phosphorylated) By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000021998.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7TSL3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini69 – 11547F-boxPROSITE-ProRule annotationAdd
    BLAST
    Repeati311 – 33323PbH1 1Add
    BLAST
    Repeati334 – 35623PbH1 2Add
    BLAST
    Repeati357 – 37923PbH1 3Add
    BLAST
    Repeati380 – 40223PbH1 4Add
    BLAST
    Repeati403 – 42523PbH1 5Add
    BLAST
    Repeati426 – 44823PbH1 6Add
    BLAST
    Repeati449 – 47123PbH1 7Add
    BLAST
    Repeati472 – 49423PbH1 8Add
    BLAST
    Repeati495 – 51723PbH1 9Add
    BLAST
    Repeati518 – 54023PbH1 10Add
    BLAST
    Repeati541 – 56323PbH1 11Add
    BLAST
    Repeati564 – 58623PbH1 12Add
    BLAST
    Repeati587 – 60923PbH1 13Add
    BLAST
    Repeati610 – 63223PbH1 14Add
    BLAST
    Repeati633 – 65523PbH1 15Add
    BLAST
    Repeati656 – 67823PbH1 16Add
    BLAST
    Repeati679 – 70123PbH1 17Add
    BLAST
    Repeati702 – 72423PbH1 18Add
    BLAST
    Repeati725 – 74622PbH1 19Add
    BLAST

    Sequence similaritiesi

    Contains 1 F-box domain.PROSITE-ProRule annotation
    Contains 19 PbH1 repeats.Curated
    Contains 1 UBR-type zinc finger.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri749 – 82072UBR-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG12793.
    GeneTreeiENSGT00530000063425.
    HOGENOMiHOG000020584.
    HOVERGENiHBG051565.
    InParanoidiQ7TSL3.
    KOiK10297.
    OMAiGLYVTDY.
    OrthoDBiEOG73803Z.
    PhylomeDBiQ7TSL3.

    Family and domain databases

    Gene3Di2.160.20.10. 4 hits.
    InterProiIPR006633. Carb-bd_sugar_hydrolysis-dom.
    IPR001810. F-box_dom.
    IPR007742. NosD_dom.
    IPR022441. Para_beta_helix_rpt-2.
    IPR006626. PbH1.
    IPR012334. Pectin_lyas_fold.
    IPR011050. Pectin_lyase_fold/virulence.
    IPR003126. Znf_N-recognin.
    [Graphical view]
    PfamiPF12937. F-box-like. 1 hit.
    PF05048. NosD. 1 hit.
    PF02207. zf-UBR. 1 hit.
    [Graphical view]
    SMARTiSM00722. CASH. 3 hits.
    SM00256. FBOX. 1 hit.
    SM00710. PbH1. 19 hits.
    [Graphical view]
    SUPFAMiSSF51126. SSF51126. 3 hits.
    SSF81383. SSF81383. 1 hit.
    TIGRFAMsiTIGR03804. para_beta_helix. 4 hits.
    PROSITEiPS50181. FBOX. 1 hit.
    PS51157. ZF_UBR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7TSL3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVAEESGPGA QNSPYQLRRK TLLPKRTACP TKNSMEGAST STTENFGHRA    50
    KRARVSGKSQ DLSAAPAEQY LQEKLPDEVV LKIFSYLLEQ DLCRAACVCK 100
    RFSELANDPI LWKRLYMEVF EYTRPMMHPE PGKFYQINPE EYEHPNPWKE 150
    SFQQLYKGAH VKPGFAEHFY SNPARYKGRE NMLYYDTIED ALGGVQEAHF 200
    DGLIFVHSGI YTDEWIYIES PITMIGAAPG KVADKVIIEN TRDSTFVFME 250
    GSEDAYVGYM TIRFNPDDKS AQHHNAHHCL EITVNCSPII DHCIIRSTCT 300
    VGSAVCVSGQ GACPTIKHCN ISDCENVGLY ITDHAQGIYE DNEISNNALA 350
    GIWVKNHGNP IIRRNHIHHG RDVGVFTFDH GMGYFESCNI HRNRIAGFEV 400
    KAYANPTVVR CEIHHGQTGG IYVHEKGRGQ FIENKIYANN FAGVWITSNS 450
    DPTIRGNSIF NGNQGGVYIF GDGRGLIEGN DIYGNALAGI QIRTNSCPIV 500
    RHNKIHDGQH GGIYVHEKGQ GVIEENEVYS NTLAGVWVTT GSTPVLRRNR 550
    IHSGKQVGVY FYDNGHGVLE DNDIYNHMYS GVQIRTGSNP KIRRNKIWGG 600
    QNGGILVYNS GLGCIEDNEI FDNAMAGVWI KTDSNPTLRR NKIHDGRDGG 650
    ICIFNGGRGL LEENDIFRNA QAGVLISTNS HPVLRKNRIF DGFAAGIEIT 700
    NHATATLEGN QIFNNRFGGL FLASGVNVTM KDNKIMNNQD AIEKAVSRGQ 750
    CLYKISSYTS YPMHDFYRCH TCNTTDRNAI CVNCIKKCHQ GHDVEFIRHD 800
    RFFCDCGAGT LSNPCTLAGE PTHDTDTLYD SAPPIESNTL QHN 843
    Length:843
    Mass (Da):94,042
    Last modified:October 1, 2003 - v1
    Checksum:i0C2498C81F96EB42
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY274810 mRNA. Translation: AAP42075.1.
    RefSeqiNP_853662.1. NM_181631.2.
    XP_006239792.1. XM_006239730.1.
    UniGeneiRn.36585.

    Genome annotation databases

    EnsembliENSRNOT00000021998; ENSRNOP00000021998; ENSRNOG00000016396.
    GeneIDi301674.
    KEGGirno:301674.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY274810 mRNA. Translation: AAP42075.1 .
    RefSeqi NP_853662.1. NM_181631.2.
    XP_006239792.1. XM_006239730.1.
    UniGenei Rn.36585.

    3D structure databases

    ProteinModelPortali Q7TSL3.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000021998.

    PTM databases

    PhosphoSitei Q7TSL3.

    Proteomic databases

    PaxDbi Q7TSL3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000021998 ; ENSRNOP00000021998 ; ENSRNOG00000016396 .
    GeneIDi 301674.
    KEGGi rno:301674.

    Organism-specific databases

    CTDi 80204.
    RGDi 727935. Fbxo11.

    Phylogenomic databases

    eggNOGi NOG12793.
    GeneTreei ENSGT00530000063425.
    HOGENOMi HOG000020584.
    HOVERGENi HBG051565.
    InParanoidi Q7TSL3.
    KOi K10297.
    OMAi GLYVTDY.
    OrthoDBi EOG73803Z.
    PhylomeDBi Q7TSL3.

    Enzyme and pathway databases

    UniPathwayi UPA00143 .

    Miscellaneous databases

    NextBioi 649071.
    PROi Q7TSL3.

    Gene expression databases

    Genevestigatori Q7TSL3.

    Family and domain databases

    Gene3Di 2.160.20.10. 4 hits.
    InterProi IPR006633. Carb-bd_sugar_hydrolysis-dom.
    IPR001810. F-box_dom.
    IPR007742. NosD_dom.
    IPR022441. Para_beta_helix_rpt-2.
    IPR006626. PbH1.
    IPR012334. Pectin_lyas_fold.
    IPR011050. Pectin_lyase_fold/virulence.
    IPR003126. Znf_N-recognin.
    [Graphical view ]
    Pfami PF12937. F-box-like. 1 hit.
    PF05048. NosD. 1 hit.
    PF02207. zf-UBR. 1 hit.
    [Graphical view ]
    SMARTi SM00722. CASH. 3 hits.
    SM00256. FBOX. 1 hit.
    SM00710. PbH1. 19 hits.
    [Graphical view ]
    SUPFAMi SSF51126. SSF51126. 3 hits.
    SSF81383. SSF81383. 1 hit.
    TIGRFAMsi TIGR03804. para_beta_helix. 4 hits.
    PROSITEi PS50181. FBOX. 1 hit.
    PS51157. ZF_UBR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Shan Y.X., Ye G.M., Guo Z.K., Huang C.Q., Pan J., Yu L.
      Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiFBX11_RAT
    AccessioniPrimary (citable) accession number: Q7TSL3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 7, 2003
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3