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Q7TSL3 (FBX11_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
F-box only protein 11
Gene names
Name:Fbxo11
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length843 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2 and BCL6. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53 By similarity.

Pathway

Protein modification; protein ubiquitination.

Subunit structure

Component of the SCF(FBXO11) complex consisting of CUL1, RBX1, SKP1 and FBXO11. Interacts with p53/TP53, BCL6 and DTL (when not phosphorylated) By similarity.

Subcellular location

Nucleus By similarity. Chromosome By similarity.

Sequence similarities

Contains 1 F-box domain.

Contains 19 PbH1 repeats.

Contains 1 UBR-type zinc finger.

Ontologies

Keywords
   Biological processUbl conjugation pathway
   Cellular componentChromosome
Nucleus
   DomainRepeat
Zinc-finger
   LigandMetal-binding
Zinc
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentchromosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionubiquitin-protein ligase activity

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 843843F-box only protein 11
PRO_0000119892

Regions

Domain69 – 11547F-box
Repeat311 – 33323PbH1 1
Repeat334 – 35623PbH1 2
Repeat357 – 37923PbH1 3
Repeat380 – 40223PbH1 4
Repeat403 – 42523PbH1 5
Repeat426 – 44823PbH1 6
Repeat449 – 47123PbH1 7
Repeat472 – 49423PbH1 8
Repeat495 – 51723PbH1 9
Repeat518 – 54023PbH1 10
Repeat541 – 56323PbH1 11
Repeat564 – 58623PbH1 12
Repeat587 – 60923PbH1 13
Repeat610 – 63223PbH1 14
Repeat633 – 65523PbH1 15
Repeat656 – 67823PbH1 16
Repeat679 – 70123PbH1 17
Repeat702 – 72423PbH1 18
Repeat725 – 74622PbH1 19
Zinc finger749 – 82072UBR-type

Sequences

Sequence LengthMass (Da)Tools
Q7TSL3 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 0C2498C81F96EB42

FASTA84394,042
        10         20         30         40         50         60 
MVAEESGPGA QNSPYQLRRK TLLPKRTACP TKNSMEGAST STTENFGHRA KRARVSGKSQ 

        70         80         90        100        110        120 
DLSAAPAEQY LQEKLPDEVV LKIFSYLLEQ DLCRAACVCK RFSELANDPI LWKRLYMEVF 

       130        140        150        160        170        180 
EYTRPMMHPE PGKFYQINPE EYEHPNPWKE SFQQLYKGAH VKPGFAEHFY SNPARYKGRE 

       190        200        210        220        230        240 
NMLYYDTIED ALGGVQEAHF DGLIFVHSGI YTDEWIYIES PITMIGAAPG KVADKVIIEN 

       250        260        270        280        290        300 
TRDSTFVFME GSEDAYVGYM TIRFNPDDKS AQHHNAHHCL EITVNCSPII DHCIIRSTCT 

       310        320        330        340        350        360 
VGSAVCVSGQ GACPTIKHCN ISDCENVGLY ITDHAQGIYE DNEISNNALA GIWVKNHGNP 

       370        380        390        400        410        420 
IIRRNHIHHG RDVGVFTFDH GMGYFESCNI HRNRIAGFEV KAYANPTVVR CEIHHGQTGG 

       430        440        450        460        470        480 
IYVHEKGRGQ FIENKIYANN FAGVWITSNS DPTIRGNSIF NGNQGGVYIF GDGRGLIEGN 

       490        500        510        520        530        540 
DIYGNALAGI QIRTNSCPIV RHNKIHDGQH GGIYVHEKGQ GVIEENEVYS NTLAGVWVTT 

       550        560        570        580        590        600 
GSTPVLRRNR IHSGKQVGVY FYDNGHGVLE DNDIYNHMYS GVQIRTGSNP KIRRNKIWGG 

       610        620        630        640        650        660 
QNGGILVYNS GLGCIEDNEI FDNAMAGVWI KTDSNPTLRR NKIHDGRDGG ICIFNGGRGL 

       670        680        690        700        710        720 
LEENDIFRNA QAGVLISTNS HPVLRKNRIF DGFAAGIEIT NHATATLEGN QIFNNRFGGL 

       730        740        750        760        770        780 
FLASGVNVTM KDNKIMNNQD AIEKAVSRGQ CLYKISSYTS YPMHDFYRCH TCNTTDRNAI 

       790        800        810        820        830        840 
CVNCIKKCHQ GHDVEFIRHD RFFCDCGAGT LSNPCTLAGE PTHDTDTLYD SAPPIESNTL 


QHN 

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References

[1]Shan Y.X., Ye G.M., Guo Z.K., Huang C.Q., Pan J., Yu L.
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY274810 mRNA. Translation: AAP42075.1.
RefSeqNP_853662.1. NM_181631.2.
XP_006239792.1. XM_006239730.1.
UniGeneRn.36585.

3D structure databases

ProteinModelPortalQ7TSL3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000021998.

PTM databases

PhosphoSiteQ7TSL3.

Proteomic databases

PaxDbQ7TSL3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000021998; ENSRNOP00000021998; ENSRNOG00000016396.
GeneID301674.
KEGGrno:301674.

Organism-specific databases

CTD80204.
RGD727935. Fbxo11.

Phylogenomic databases

eggNOGNOG12793.
GeneTreeENSGT00530000063425.
HOGENOMHOG000020584.
HOVERGENHBG051565.
InParanoidQ7TSL3.
KOK10297.
OMAGLYVTDY.
OrthoDBEOG73803Z.
PhylomeDBQ7TSL3.

Enzyme and pathway databases

UniPathwayUPA00143.

Gene expression databases

GenevestigatorQ7TSL3.

Family and domain databases

Gene3D2.160.20.10. 4 hits.
InterProIPR006633. Carb-bd_sugar_hydrolysis-dom.
IPR001810. F-box_dom.
IPR007742. NosD_dom.
IPR022441. Para_beta_helix_rpt-2.
IPR006626. PbH1.
IPR012334. Pectin_lyas_fold.
IPR011050. Pectin_lyase_fold/virulence.
IPR003126. Znf_N-recognin.
[Graphical view]
PfamPF05048. NosD. 1 hit.
PF02207. zf-UBR. 1 hit.
[Graphical view]
SMARTSM00722. CASH. 3 hits.
SM00256. FBOX. 1 hit.
SM00710. PbH1. 19 hits.
[Graphical view]
SUPFAMSSF51126. SSF51126. 3 hits.
SSF81383. SSF81383. 1 hit.
TIGRFAMsTIGR03804. para_beta_helix. 4 hits.
PROSITEPS50181. FBOX. 1 hit.
PS51157. ZF_UBR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio649071.
PROQ7TSL3.

Entry information

Entry nameFBX11_RAT
AccessionPrimary (citable) accession number: Q7TSL3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: October 1, 2003
Last modified: April 16, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways