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Protein

ADAMTS-like protein 2

Gene

Adamtsl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • metalloendopeptidase activity Source: InterPro
  • microfibril binding Source: MGI
  • zinc ion binding Source: InterPro

GO - Biological processi

  • extracellular matrix organization Source: MGI
  • lobar bronchus epithelium development Source: MGI
  • negative regulation of transforming growth factor beta receptor signaling pathway Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
ADAMTS-like protein 2
Short name:
ADAMTSL-2
Alternative name(s):
TSP1-repeat-containing protein 1
Short name:
TCP-1
Gene namesi
Name:Adamtsl2
Synonyms:Kiaa0605, Tcp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1925044. Adamtsl2.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: MGI
  • proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence analysisAdd
BLAST
Chaini30 – 957928ADAMTS-like protein 2PRO_0000249683Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi59 ↔ 100PROSITE-ProRule annotation
Disulfide bondi63 ↔ 105PROSITE-ProRule annotation
Disulfide bondi74 ↔ 90PROSITE-ProRule annotation
Glycosylationi87 – 871N-linked (GlcNAc...)Sequence analysis
Glycosylationi374 – 3741N-linked (GlcNAc...)Sequence analysis
Glycosylationi435 – 4351N-linked (GlcNAc...)Sequence analysis
Glycosylationi482 – 4821N-linked (GlcNAc...)Sequence analysis
Glycosylationi518 – 5181N-linked (GlcNAc...)Sequence analysis
Glycosylationi530 – 5301N-linked (GlcNAc...)Sequence analysis
Glycosylationi539 – 5391N-linked (GlcNAc...)Sequence analysis
Glycosylationi550 – 5501N-linked (GlcNAc...)Sequence analysis
Glycosylationi737 – 7371N-linked (GlcNAc...)Sequence analysis
Glycosylationi813 – 8131N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Glycosylated (By similarity). Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Also can be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion (By similarity).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ7TSK7.
PaxDbiQ7TSK7.
PRIDEiQ7TSK7.

PTM databases

iPTMnetiQ7TSK7.
SwissPalmiQ7TSK7.

Expressioni

Gene expression databases

BgeeiQ7TSK7.
CleanExiMM_ADAMTSL2.
MM_TCP1.
ExpressionAtlasiQ7TSK7. baseline and differential.
GenevisibleiQ7TSK7. MM.

Interactioni

Subunit structurei

Interacts with LTBP1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000088774.

Structurei

3D structure databases

ProteinModelPortaliQ7TSK7.
SMRiQ7TSK7. Positions 50-236.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 10660TSP type-1 1PROSITE-ProRule annotationAdd
BLAST
Domaini570 – 62455TSP type-1 2PROSITE-ProRule annotationAdd
BLAST
Domaini628 – 69265TSP type-1 3PROSITE-ProRule annotationAdd
BLAST
Domaini694 – 74249TSP type-1 4PROSITE-ProRule annotationAdd
BLAST
Domaini743 – 80159TSP type-1 5PROSITE-ProRule annotationAdd
BLAST
Domaini803 – 85755TSP type-1 6PROSITE-ProRule annotationAdd
BLAST
Domaini859 – 91456TSP type-1 7PROSITE-ProRule annotationAdd
BLAST
Domaini918 – 95639PLACPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PLAC domain.PROSITE-ProRule annotation
Contains 7 TSP type-1 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IND9. Eukaryota.
ENOG410Y9HP. LUCA.
GeneTreeiENSGT00760000118885.
HOGENOMiHOG000116076.
HOVERGENiHBG079685.
InParanoidiQ7TSK7.
OMAiNRTCTGT.
OrthoDBiEOG74N5FZ.
PhylomeDBiQ7TSK7.
TreeFamiTF316874.

Family and domain databases

InterProiIPR010294. ADAM_spacer1.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR010909. PLAC.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF05986. ADAM_spacer1. 1 hit.
PF08686. PLAC. 1 hit.
PF00090. TSP_1. 5 hits.
[Graphical view]
PRINTSiPR01857. ADAMTSFAMILY.
SMARTiSM00209. TSP1. 7 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 7 hits.
PROSITEiPS50900. PLAC. 1 hit.
PS50092. TSP1. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TSK7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGRRQHPHW AWSLLAVAVV AGGAAPTEAS DNSPTSNSLE GGADTTAYWW
60 70 80 90 100
GEWTKWTACS RSCGGGVTSQ ERHCLQQRRK SVPGTGNRTC VGTSKRYQLC
110 120 130 140 150
RVQECPPDGR SFREEQCVSF NSRVYDGRAY QWKPLYPDDY VHISSKPCDL
160 170 180 190 200
HCSTVDGQRQ LTVPARDGTS CKLTDLRGVC VSGKCEPIGC DGVLFSTHTL
210 220 230 240 250
DKCGVCQGDG SSCTHVTGNY RKGNNHLGYS LVTHIPAGAR DIQIVERKKS
260 270 280 290 300
ADVLALADEA GFYFFNGNYK VDSPKNFNIA GTVVKYRRPM DVYETGIEYI
310 320 330 340 350
VAQGPTNQGL NVMVWNQNGK SPSITFEYTL LQSPHMHHLP PVYYSFSEAA
360 370 380 390 400
SQSTESTERQ ELDSARLLGF MQHNGSLYRQ TSSERLGLNS QLFQPPAPEV
410 420 430 440 450
ELGPSRGQES NEVCKQASGG VCEGPPRGKG FQDHNATGRA FSADKDDREI
460 470 480 490 500
SAHFTSHELL SANTISDQLL GTGSESEEFS LNETMNSIFA QGAPRSSPAE
510 520 530 540 550
SLYVDYEENE GPAAYLINGS YLELSSDRIN TSSEAPFPNT SASPPNLAGN
560 570 580 590 600
RTHKARTRPK ARKQGVSPAD MYRWKLSSHE PCSATCTTGV MSTYAMCVRY
610 620 630 640 650
DGVEVDDSYC DALTRPEPVH EFCAGRECQP RWETSSWSEC SRTCGEGHQF
660 670 680 690 700
RIVRCWKMLS PGFDSSVYSD LCEATEAVRP EERKTCRNPA CGPQWEMSEW
710 720 730 740 750
SECTAKCGER SVVTRDIRCS EDEKLCDPST KPVGEKNCTG PPCDRQWTVS
760 770 780 790 800
DWGPCSGSCG QGRTIRHVYC KTSDGRVVPE SQCQTETKPL AIHPCGDKNC
810 820 830 840 850
PAHWLAQDWE RCNTTCGRGV KKRLVLCMEL ANGKPQIRSG PECGLARKPP
860 870 880 890 900
EESTCFERPC FKWYTSPWSE CTKTCGVGVR MRDVKCYQGT DIVRGCDPLV
910 920 930 940 950
KPVGRQACDL QPCPTEPPDD SCQDQPGTNC ALAIKVNLCG HWYYSKACCR

SCRPPHS
Length:957
Mass (Da):105,647
Last modified:October 1, 2003 - v1
Checksum:iD92FB05E0CF7FEC0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti441 – 4411F → L in BAE33926 (PubMed:16141072).Curated
Sequence conflicti749 – 7491V → A in BAE33926 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096928 mRNA. Translation: BAC76875.1.
AK156991 mRNA. Translation: BAE33926.1.
CCDSiCCDS15824.1.
RefSeqiNP_084257.1. NM_029981.1.
UniGeneiMm.330088.

Genome annotation databases

EnsembliENSMUST00000091233; ENSMUSP00000088774; ENSMUSG00000036040.
GeneIDi77794.
KEGGimmu:77794.
UCSCiuc008ixa.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB096928 mRNA. Translation: BAC76875.1.
AK156991 mRNA. Translation: BAE33926.1.
CCDSiCCDS15824.1.
RefSeqiNP_084257.1. NM_029981.1.
UniGeneiMm.330088.

3D structure databases

ProteinModelPortaliQ7TSK7.
SMRiQ7TSK7. Positions 50-236.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000088774.

PTM databases

iPTMnetiQ7TSK7.
SwissPalmiQ7TSK7.

Proteomic databases

MaxQBiQ7TSK7.
PaxDbiQ7TSK7.
PRIDEiQ7TSK7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000091233; ENSMUSP00000088774; ENSMUSG00000036040.
GeneIDi77794.
KEGGimmu:77794.
UCSCiuc008ixa.1. mouse.

Organism-specific databases

CTDi9719.
MGIiMGI:1925044. Adamtsl2.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IND9. Eukaryota.
ENOG410Y9HP. LUCA.
GeneTreeiENSGT00760000118885.
HOGENOMiHOG000116076.
HOVERGENiHBG079685.
InParanoidiQ7TSK7.
OMAiNRTCTGT.
OrthoDBiEOG74N5FZ.
PhylomeDBiQ7TSK7.
TreeFamiTF316874.

Miscellaneous databases

PROiQ7TSK7.
SOURCEiSearch...

Gene expression databases

BgeeiQ7TSK7.
CleanExiMM_ADAMTSL2.
MM_TCP1.
ExpressionAtlasiQ7TSK7. baseline and differential.
GenevisibleiQ7TSK7. MM.

Family and domain databases

InterProiIPR010294. ADAM_spacer1.
IPR013273. Peptidase_M12B_ADAM-TS.
IPR010909. PLAC.
IPR000884. TSP1_rpt.
[Graphical view]
PfamiPF05986. ADAM_spacer1. 1 hit.
PF08686. PLAC. 1 hit.
PF00090. TSP_1. 5 hits.
[Graphical view]
PRINTSiPR01857. ADAMTSFAMILY.
SMARTiSM00209. TSP1. 7 hits.
[Graphical view]
SUPFAMiSSF82895. SSF82895. 7 hits.
PROSITEiPS50900. PLAC. 1 hit.
PS50092. TSP1. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of TSP1-repeats-containing protein expressed in splenic CD11c+ cells."
    Kishi Y., Toji S., Tanaka M., Miyajima A., Yahara I.
    Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
    Tissue: Spleen.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
    Tissue: Spleen.

Entry informationi

Entry nameiATL2_MOUSE
AccessioniPrimary (citable) accession number: Q7TSK7
Secondary accession number(s): Q3U0C8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: October 1, 2003
Last modified: June 8, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Although strongly similar to members of the ADAMTS family it lacks the metalloprotease and disintegrin-like domains which are typical of that family.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.