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Q7TSJ7 (Q7TSJ7_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names

Mitogen-activated protein kinase 8 Ensembl ENSMUSP00000107575
Gene names
Name:Mapk8 MGI 1346861 EMBL AAH53027.1 Ensembl ENSMUSP00000107575
OrganismMus musculus (Mouse) [Reference proteome] EMBL AAH53027.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length427 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein. SAAS SAAS003527

Sequence similarities

Contains protein kinase domain. SAAS SAAS003527

Ontologies

Keywords
   LigandATP-binding SAAS SAAS003527
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase SAAS SAAS003527
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processJNK cascade

Inferred from sequence orthology PubMed 17681137. Source: MGI

JUN phosphorylation

Inferred from mutant phenotype PubMed 14967141. Source: MGI

cellular response to hydrogen peroxide

Inferred from direct assay PubMed 20808772. Source: MGI

cellular response to nitric oxide

Inferred from mutant phenotype PubMed 18007661. Source: MGI

determination of dorsal identity

Inferred from sequence orthology PubMed 17681137. Source: MGI

ossification

Inferred from mutant phenotype PubMed 15820682. Source: MGI

peptidyl-threonine phosphorylation

Inferred from mutant phenotype PubMed 14967141. Source: MGI

positive regulation of apoptotic signaling pathway

Inferred from genetic interaction PubMed 16458303. Source: MGI

positive regulation of determination of dorsal identity

Inferred from direct assay PubMed 18316368. Source: MGI

programmed necrotic cell death

Inferred from mutant phenotype PubMed 18007661. Source: MGI

protein phosphorylation

Inferred from direct assay PubMed 15767678. Source: MGI

regulation of gene expression

Inferred from mutant phenotype PubMed 19289495. Source: MGI

response to cadmium ion

Inferred from genetic interaction PubMed 16458303. Source: MGI

   Cellular_componentcytoplasm

Inferred from direct assay PubMed 15030387. Source: MGI

cytosol

Inferred from direct assay PubMed 11884367. Source: MGI

mitochondrion

Inferred from direct assay PubMed 11884367. Source: MGI

nucleus

Inferred from direct assay PubMed 15030387PubMed 15483136. Source: MGI

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

JUN kinase activity

Inferred from direct assay PubMed 15579909PubMed 19289495. Source: MGI

kinase activity

Inferred from direct assay PubMed 12808090PubMed 15483136PubMed 15767678. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q7TSJ7 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 822396CFE35786A7

FASTA42748,386
        10         20         30         40         50         60 
MSRSKRDNNF YSVEIGDSTF TVLKRYQNLK PIGSGAQGIV CAAYDAILER NVAIKKLSRP 

        70         80         90        100        110        120 
FQNQTHAKRA YRELVLMKCV NHKNIIGLLN VFTPQKSLEE FQDVYIVMEL MDANLCQVIQ 

       130        140        150        160        170        180 
MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF 

       190        200        210        220        230        240 
MMTPYVVTRY YRAPEVILGM GYKENVDLWS VGCIMGEMVC HKILFPGRDY IDQWNKVIEQ 

       250        260        270        280        290        300 
LGTPCPEFMK KLQPTVRTYV ENRPKYAGYS FEKLFPDVLF PADSEHNKLK ASQARDLLSK 

       310        320        330        340        350        360 
MLVIDASKRI SVDEALQHPY INVWYDPSEA EAPPPKIPDK QLDEREHTIE EWKELIYKEV 

       370        380        390        400        410        420 
MDLEERTKNG VIRGQPSPLG AAMINGSQHP SSSPSVNDMS SMSTDPTLAS DTDSSLEASA 


GPLGCCR 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6 EMBL AAH53027.1.
Tissue: Brain EMBL AAH53027.1.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J Ensembl ENSMUSP00000107575.
[3]Ensembl
Submitted (JUL-2011) to UniProtKB
Cited for: IDENTIFICATION.
Strain: C57BL/6J Ensembl ENSMUSP00000107575.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC154649 Genomic DNA. No translation available.
BC053027 mRNA. Translation: AAH53027.1.
RefSeqXP_006519093.1. XM_006519030.1.
UniGeneMm.21495.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000111944; ENSMUSP00000107575; ENSMUSG00000021936.
GeneID26419.
UCSCuc007szq.2. mouse.

Organism-specific databases

MGIMGI:1346861. Mapk8.

Phylogenomic databases

GeneTreeENSGT00550000074271.
HOGENOMHOG000233024.
HOVERGENHBG014652.
InParanoidQ7TSJ7.

Gene expression databases

GenevestigatorQ7TSJ7.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008351. MAPK_JNK.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSPR01772. JNKMAPKINASE.
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS01351. MAPK. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameQ7TSJ7_MOUSE
AccessionPrimary (citable) accession number: Q7TSJ7
Entry history
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: April 16, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)