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Q7TSJ2

- MAP6_MOUSE

UniProt

Q7TSJ2 - MAP6_MOUSE

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Protein
Microtubule-associated protein 6
Gene
Map6, Mtap6
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in microtubule stabilization in many cell types, including neuronal cells. Specifically has microtubule cold stabilizing activity. Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B.1 Publication

GO - Molecular functioni

  1. microtubule binding Source: MGI

GO - Biological processi

  1. dendrite morphogenesis Source: UniProtKB
  2. lysosome localization Source: UniProtKB
  3. microtubule cytoskeleton organization Source: InterPro
  4. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated protein 6
Short name:
MAP-6
Alternative name(s):
Stable tubule-only polypeptide
Short name:
STOP
Gene namesi
Name:Map6
Synonyms:Mtap6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1201690. Map6.

Subcellular locationi

Cytoplasmcytoskeleton. Golgi apparatus
Note: Isoform 1 and isoform 2 associate with axonal microtubules in neurons. Isoform 3 associates with microtubules in fibroblasts.2 Publications

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-SubCell
  2. microtubule Source: UniProtKB-KW
  3. perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus, Microtubule

Pathology & Biotechi

Disruption phenotypei

Mice are devoid of cold-stable microtubules and show no detectable defects in brain anatomy but show synaptic defects, with depleted synaptic vesicle pools and impaired synaptic plasticity, associated with severe behavioral disorders, including a disorganized activity with disruption of normal behavioral sequences and episodes of hyperlocomotion or apparent prostration, anxiety, severe social withdrawal and complete nurturing defects. The behavioral defects are alleviated by long-term treatment with neuroleptics.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 906906Microtubule-associated protein 6
PRO_0000344045Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi5 – 51S-palmitoyl cysteine By similarity
Lipidationi10 – 101S-palmitoyl cysteine By similarity
Lipidationi11 – 111S-palmitoyl cysteine By similarity
Modified residuei141 – 1411Phosphotyrosine1 Publication

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiQ7TSJ2.
PaxDbiQ7TSJ2.
PRIDEiQ7TSJ2.

Expressioni

Tissue specificityi

Isoform 1 is specifically expressed in adult brain. Isoform 2 is predominantly expressed in embryonic brain; expression persists at low levels in the adult brain. Isoform 3 is expressed at high levels in lung and at lower levels in testis, heart, muscle and kidney (at protein level). Oligodendrocytes express a major isoform of 89 kDa (O-STOP). Astrocytes also express an isoform of 60 kDa (A-STOP).2 Publications

Developmental stagei

Isoform 2 is expressed in embryonic brain.1 Publication

Gene expression databases

ArrayExpressiQ7TSJ2.
BgeeiQ7TSJ2.
GenevestigatoriQ7TSJ2.

Interactioni

Subunit structurei

Interacts with calmodulin (via C-terminus); the interaction is dependent on Ca2+. Interacts with TMEM106B By similarity.1 Publication

Protein-protein interaction databases

BioGridi201587. 4 interactions.
IntActiQ7TSJ2. 5 interactions.
MINTiMINT-4105179.

Structurei

3D structure databases

ProteinModelPortaliQ7TSJ2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati222 – 26746Mc-1
Add
BLAST
Repeati268 – 31346Mc-2
Add
BLAST
Repeati314 – 35946Mc-3
Add
BLAST
Repeati360 – 40546Mc-4
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 1515Calmodulin-binding By similarity
Add
BLAST
Regioni116 – 13924Mn 1 By similarity
Add
BLAST
Regioni124 – 13815Calmodulin-binding By similarity
Add
BLAST
Regioni151 – 17424Mn 2 By similarity
Add
BLAST
Regioni160 – 17415Calmodulin-binding By similarity
Add
BLAST
Regioni187 – 20115Calmodulin-binding By similarity
Add
BLAST
Regioni222 – 4051844 X approximate tandem repeat Mc
Add
BLAST
Regioni235 – 24915Calmodulin-binding By similarity
Add
BLAST
Regioni280 – 29415Calmodulin-binding By similarity
Add
BLAST
Regioni325 – 33915Calmodulin-binding By similarity
Add
BLAST
Regioni375 – 38915Calmodulin-binding By similarity
Add
BLAST
Regioni427 – 45024Mn 3 By similarity
Add
BLAST
Regioni435 – 44915Calmodulin-binding By similarity
Add
BLAST
Regioni486 – 50015Calmodulin-binding By similarity
Add
BLAST
Regioni513 – 52715Calmodulin-binding By similarity
Add
BLAST

Sequence similaritiesi

Belongs to the STOP family.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG87903.
GeneTreeiENSGT00530000063947.
HOGENOMiHOG000113479.
HOVERGENiHBG053112.
InParanoidiQ7TSJ2.
KOiK10432.
OMAiRKAGPAW.
OrthoDBiEOG7ZWD1D.
PhylomeDBiQ7TSJ2.
TreeFamiTF338320.

Family and domain databases

InterProiIPR007882. MAP6.
IPR024963. MAP6/FAM154.
[Graphical view]
PANTHERiPTHR14759. PTHR14759. 1 hit.
PfamiPF05217. STOP. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative promoter usage and alternative splicing. Align

Note: Comment: Additional isoforms seem to exist.

Isoform 1 (identifier: Q7TSJ2-1) [UniParc]FASTAAdd to Basket

Also known as: N-STOP, Neuronal STOP

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAWPCITRAC CIARFWNQLD KADIAVPLVF TKYSEATEHP GAPPQPPAPL    50
QPALAPPSRA VAIETQPAQG ESDAVARATG PAPGPSVDRE TVAAPGRSGL 100
GLGAASASTS GSGPADSVMR QDYRAWKVQR PEPSCRPRSE YQPSDAPFER 150
ETQYQKDFRA WPLPRRGDHP WIPKPVQIPA TSQPSQPVLG VPKRRPQSQE 200
RGPMQLSADA RDPEGAGGAG VLAAGKASGV DQRDTRRKAG PAWMVTRNEG 250
HEEKPLPPAQ SQTQEGGPAA GKASGADQRD TRRKAGPAWM VTRSEGHEEK 300
PLPPAQSQTQ EGGPAAGKAS GADQRDTRRK AGPAWMVTRT EGHEETPLPP 350
AQSQTQEGGP AAGKASGADE RDTRRKAGPA WMVRRSEGHE QTPAAHAQGT 400
GPEGGKGRAV ADALNRQIRE EVASTVSSSY RNEFRAWTDI KPVKPIKAKP 450
QYKPPDDKMV HETSYSAQFK GEANKPSAAD NKAMDRRRIR SLYSEPFKEC 500
PKVEKPSVQS SKPKKTSTSH KPPRKAKDKQ VVSGQAAKKK TTEGPSATKP 550
DDKEQSKEMN NKLAEAKESR VKPTSDASKN RGPVTKEPHK DQGSVAPGLP 600
KGQEPLKDQG PVVPGLPKDQ VPVVPGSLKG QSPTAPGPTK DQGAVLLGPV 650
KDLGPVAPAP IKVQDHIASE LLKNKDSVPL APAKAQSPLL PEPLKNQSPV 700
VPASTKDQSF PTPAPRKDPG PVIPEPEKDR APTVPERRKD QHVSIMASLK 750
NEAPMVPESV KNQGLAGPEL VKDTGTDTTA PRYLKGHDSV FVAPVKNQGP 800
VIPEPVKSQD PIIPALAKDQ GPMLPEPPKN QSPVVLGPIK NQDPIIPVPL 850
KGQDPLVPAP TKDQGPTAPD PLKTQGPKGT QLPTVSPSPP VMIPTVPHTE 900
YIEGSP 906

Note: Produced by alternative promoter usage.

Length:906
Mass (Da):96,450
Last modified:July 22, 2008 - v2
Checksum:iF3CED1FCF1E2CD83
GO
Isoform 2 (identifier: Q7TSJ2-2) [UniParc]FASTAAdd to Basket

Also known as: E-STOP, Early STOP

The sequence of this isoform differs from the canonical sequence as follows:
     569-906: Missing.

Note: Produced by alternative splicing of isoform 1.

Show »
Length:568
Mass (Da):61,105
Checksum:i81B1DFF1B51D2658
GO
Isoform 3 (identifier: Q7TSJ2-3) [UniParc]FASTAAdd to Basket

Also known as: F-STOP, Fibroblastic STOP

The sequence of this isoform differs from the canonical sequence as follows:
     1-203: Missing.
     503-509: VEKPSVQ → EPGQTHQ
     510-906: Missing.

Note: Produced by alternative promoter usage.

Show »
Length:306
Mass (Da):32,803
Checksum:iE19396DFF272B496
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 203203Missing in isoform 3.
VSP_034724Add
BLAST
Alternative sequencei503 – 5097VEKPSVQ → EPGQTHQ in isoform 3.
VSP_034725
Alternative sequencei510 – 906397Missing in isoform 3.
VSP_034726Add
BLAST
Alternative sequencei569 – 906338Missing in isoform 2.
VSP_034727Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti81 – 811P → L in CAA75049. 1 Publication
Sequence conflicti87 – 871V → G in CAA75930. 1 Publication
Sequence conflicti344 – 3441E → K in CAA75930. 1 Publication
Sequence conflicti344 – 3441E → K in CAA75989. 1 Publication
Sequence conflicti405 – 4051G → S in CAA75049. 1 Publication
Sequence conflicti755 – 7573MVP → VVH in CAA75930. 1 Publication
Sequence conflicti755 – 7551M → V in CAA75049. 1 Publication
Sequence conflicti825 – 8251P → S in CAA75930. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y14754, Y14755, Y14756 Genomic DNA. Translation: CAA75049.1.
Y16008 Genomic DNA. Translation: CAA75930.1.
Y16032 mRNA. Translation: CAA75989.1.
BC053039 mRNA. Translation: AAH53039.1.
CCDSiCCDS21479.1. [Q7TSJ2-1]
CCDS40029.1. [Q7TSJ2-3]
PIRiJC5963.
RefSeqiNP_001036820.2. NM_001043355.2. [Q7TSJ2-3]
NP_001041632.1. NM_001048167.1. [Q7TSJ2-2]
NP_034967.2. NM_010837.3. [Q7TSJ2-1]
UniGeneiMm.154087.

Genome annotation databases

EnsembliENSMUST00000068973; ENSMUSP00000064787; ENSMUSG00000055407. [Q7TSJ2-1]
ENSMUST00000107100; ENSMUSP00000102717; ENSMUSG00000055407. [Q7TSJ2-3]
GeneIDi17760.
KEGGimmu:17760.
UCSCiuc009ilg.1. mouse. [Q7TSJ2-1]
uc009ili.1. mouse. [Q7TSJ2-3]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y14754 , Y14755 , Y14756 Genomic DNA. Translation: CAA75049.1 .
Y16008 Genomic DNA. Translation: CAA75930.1 .
Y16032 mRNA. Translation: CAA75989.1 .
BC053039 mRNA. Translation: AAH53039.1 .
CCDSi CCDS21479.1. [Q7TSJ2-1 ]
CCDS40029.1. [Q7TSJ2-3 ]
PIRi JC5963.
RefSeqi NP_001036820.2. NM_001043355.2. [Q7TSJ2-3 ]
NP_001041632.1. NM_001048167.1. [Q7TSJ2-2 ]
NP_034967.2. NM_010837.3. [Q7TSJ2-1 ]
UniGenei Mm.154087.

3D structure databases

ProteinModelPortali Q7TSJ2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201587. 4 interactions.
IntActi Q7TSJ2. 5 interactions.
MINTi MINT-4105179.

Proteomic databases

MaxQBi Q7TSJ2.
PaxDbi Q7TSJ2.
PRIDEi Q7TSJ2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000068973 ; ENSMUSP00000064787 ; ENSMUSG00000055407 . [Q7TSJ2-1 ]
ENSMUST00000107100 ; ENSMUSP00000102717 ; ENSMUSG00000055407 . [Q7TSJ2-3 ]
GeneIDi 17760.
KEGGi mmu:17760.
UCSCi uc009ilg.1. mouse. [Q7TSJ2-1 ]
uc009ili.1. mouse. [Q7TSJ2-3 ]

Organism-specific databases

CTDi 4135.
MGIi MGI:1201690. Map6.

Phylogenomic databases

eggNOGi NOG87903.
GeneTreei ENSGT00530000063947.
HOGENOMi HOG000113479.
HOVERGENi HBG053112.
InParanoidi Q7TSJ2.
KOi K10432.
OMAi RKAGPAW.
OrthoDBi EOG7ZWD1D.
PhylomeDBi Q7TSJ2.
TreeFami TF338320.

Miscellaneous databases

NextBioi 292441.
PROi Q7TSJ2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q7TSJ2.
Bgeei Q7TSJ2.
Genevestigatori Q7TSJ2.

Family and domain databases

InterProi IPR007882. MAP6.
IPR024963. MAP6/FAM154.
[Graphical view ]
PANTHERi PTHR14759. PTHR14759. 1 hit.
Pfami PF05217. STOP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic structure and chromosomal mapping of the mouse STOP gene (Mtap6)."
    Denarier E., Aguezzoul M., Jolly C., Vourc'h C., Roure A., Andrieux A., Bosc C., Job D.
    Biochem. Biophys. Res. Commun. 243:791-796(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS 1 AND 2).
    Strain: 129/SvJ.
    Tissue: Liver.
  2. "Nonneuronal isoforms of STOP protein are responsible for microtubule cold stability in mammalian fibroblasts."
    Denarier E., Fourest-Lieuvin A., Bosc C., Pirollet F., Chapel A., Margolis R.L., Job D.
    Proc. Natl. Acad. Sci. U.S.A. 95:6055-6060(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), FUNCTION, SUBCELLULAR LOCATION.
    Strain: Swiss Webster / NIH.
    Tissue: Fibroblast.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: C57BL/6.
    Tissue: Brain.
  4. "The suppression of brain cold-stable microtubules in mice induces synaptic defects associated with neuroleptic-sensitive behavioral disorders."
    Andrieux A., Salin P.A., Vernet M., Kujala P., Baratier J., Gory-Faure S., Bosc C., Pointu H., Proietto D., Schweitzer A., Denarier E., Klumperman J., Job D.
    Genes Dev. 16:2350-2364(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISRUPTION PHENOTYPE.
  5. "Unusual Ca(2+)-calmodulin binding interactions of the microtubule-associated protein F-STOP."
    Bouvier D., Vanhaverbeke C., Simorre J.P., Arlaud G.J., Bally I., Forge V., Margolis R.L., Gans P., Kleman J.P.
    Biochemistry 42:11484-11493(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CALMODULIN.
  6. "Overlap of promoter and coding sequences in the mouse STOP gene (Mtap6)."
    Aguezzoul M., Andrieux A., Denarier E.
    Genomics 81:623-627(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE PROMOTER USAGE, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY.
  7. "Astrocytes and oligodendrocytes express different STOP protein isoforms."
    Galiano M.R., Bosc C., Schweitzer A., Andrieux A., Job D., Hallak M.E.
    J. Neurosci. Res. 78:329-337(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
  8. "STOP-like protein 21 is a novel member of the STOP family, revealing a Golgi localization of STOP proteins."
    Gory-Faure S., Windscheid V., Bosc C., Peris L., Proietto D., Franck R., Denarier E., Job D., Andrieux A.
    J. Biol. Chem. 281:28387-28396(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  9. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.
  10. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-141, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  11. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiMAP6_MOUSE
AccessioniPrimary (citable) accession number: Q7TSJ2
Secondary accession number(s): O55129
, O70586, O70587, Q78DV4, Q78DV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: July 9, 2014
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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