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Protein

Microtubule-associated protein 6

Gene

Map6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in microtubule stabilization in many cell types, including neuronal cells. Specifically has microtubule cold stabilizing activity. Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B.1 Publication

GO - Molecular functioni

  • microtubule binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Microtubule-associated protein 6
Short name:
MAP-6
Alternative name(s):
Stable tubule-only polypeptide
Short name:
STOP
Gene namesi
Name:Map6
Synonyms:Mtap6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1201690. Map6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus, Microtubule

Pathology & Biotechi

Disruption phenotypei

Mice are devoid of cold-stable microtubules and show no detectable defects in brain anatomy but show synaptic defects, with depleted synaptic vesicle pools and impaired synaptic plasticity, associated with severe behavioral disorders, including a disorganized activity with disruption of normal behavioral sequences and episodes of hyperlocomotion or apparent prostration, anxiety, severe social withdrawal and complete nurturing defects. The behavioral defects are alleviated by long-term treatment with neuroleptics.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003440451 – 906Microtubule-associated protein 6Add BLAST906

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi5S-palmitoyl cysteineBy similarity1
Lipidationi10S-palmitoyl cysteineBy similarity1
Lipidationi11S-palmitoyl cysteineBy similarity1
Modified residuei98PhosphoserineCombined sources1
Modified residuei141PhosphotyrosineCombined sources1
Modified residuei185PhosphoserineBy similarity1
Modified residuei207PhosphoserineCombined sources1
Modified residuei632PhosphoserineCombined sources1
Modified residuei687PhosphoserineCombined sources1
Modified residuei905PhosphoserineCombined sources1

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiQ7TSJ2.
PeptideAtlasiQ7TSJ2.
PRIDEiQ7TSJ2.

PTM databases

iPTMnetiQ7TSJ2.
PhosphoSitePlusiQ7TSJ2.

Expressioni

Tissue specificityi

Isoform 1 is specifically expressed in adult brain. Isoform 2 is predominantly expressed in embryonic brain; expression persists at low levels in the adult brain. Isoform 3 is expressed at high levels in lung and at lower levels in testis, heart, muscle and kidney (at protein level). Oligodendrocytes express a major isoform of 89 kDa (O-STOP). Astrocytes also express an isoform of 60 kDa (A-STOP).2 Publications

Developmental stagei

Isoform 2 is expressed in embryonic brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000055407.
ExpressionAtlasiQ7TSJ2. baseline and differential.
GenevisibleiQ7TSJ2. MM.

Interactioni

Subunit structurei

Interacts with calmodulin (via C-terminus); the interaction is dependent on Ca2+ (PubMed:14516200). Interacts with TMEM106B (By similarity). Interacts with ZDHHC13 (via ANK repeats) (PubMed:26198635). Interacts with ZDHHC17 (via ANK repeats) (PubMed:26198635).By similarity2 Publications

GO - Molecular functioni

  • microtubule binding Source: MGI

Protein-protein interaction databases

BioGridi201587. 5 interactors.
IntActiQ7TSJ2. 6 interactors.
MINTiMINT-4105179.
STRINGi10090.ENSMUSP00000064787.

Structurei

3D structure databases

ProteinModelPortaliQ7TSJ2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati222 – 267Mc-1Add BLAST46
Repeati268 – 313Mc-2Add BLAST46
Repeati314 – 359Mc-3Add BLAST46
Repeati360 – 405Mc-4Add BLAST46

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 15Calmodulin-bindingBy similarityAdd BLAST15
Regioni116 – 139Mn 1By similarityAdd BLAST24
Regioni124 – 138Calmodulin-bindingBy similarityAdd BLAST15
Regioni151 – 174Mn 2By similarityAdd BLAST24
Regioni160 – 174Calmodulin-bindingBy similarityAdd BLAST15
Regioni187 – 201Calmodulin-bindingBy similarityAdd BLAST15
Regioni222 – 4054 X approximate tandem repeat McAdd BLAST184
Regioni235 – 249Calmodulin-bindingBy similarityAdd BLAST15
Regioni280 – 294Calmodulin-bindingBy similarityAdd BLAST15
Regioni325 – 339Calmodulin-bindingBy similarityAdd BLAST15
Regioni375 – 389Calmodulin-bindingBy similarityAdd BLAST15
Regioni427 – 450Mn 3By similarityAdd BLAST24
Regioni435 – 449Calmodulin-bindingBy similarityAdd BLAST15
Regioni486 – 500Calmodulin-bindingBy similarityAdd BLAST15
Regioni513 – 527Calmodulin-bindingBy similarityAdd BLAST15

Sequence similaritiesi

Belongs to the STOP family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IIA0. Eukaryota.
ENOG4110KV2. LUCA.
GeneTreeiENSGT00530000063947.
HOGENOMiHOG000113479.
HOVERGENiHBG053112.
InParanoidiQ7TSJ2.
KOiK10432.
OMAiRKAGPAW.
OrthoDBiEOG091G0A3G.
PhylomeDBiQ7TSJ2.
TreeFamiTF338320.

Family and domain databases

InterProiIPR007882. MAP6.
[Graphical view]
PANTHERiPTHR14759. PTHR14759. 2 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative promoter usage and alternative splicing. AlignAdd to basket

Note: Comment: Additional isoforms seem to exist.
Isoform 1 (identifier: Q7TSJ2-1) [UniParc]FASTAAdd to basket
Also known as: N-STOP, Neuronal STOP

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAWPCITRAC CIARFWNQLD KADIAVPLVF TKYSEATEHP GAPPQPPAPL
60 70 80 90 100
QPALAPPSRA VAIETQPAQG ESDAVARATG PAPGPSVDRE TVAAPGRSGL
110 120 130 140 150
GLGAASASTS GSGPADSVMR QDYRAWKVQR PEPSCRPRSE YQPSDAPFER
160 170 180 190 200
ETQYQKDFRA WPLPRRGDHP WIPKPVQIPA TSQPSQPVLG VPKRRPQSQE
210 220 230 240 250
RGPMQLSADA RDPEGAGGAG VLAAGKASGV DQRDTRRKAG PAWMVTRNEG
260 270 280 290 300
HEEKPLPPAQ SQTQEGGPAA GKASGADQRD TRRKAGPAWM VTRSEGHEEK
310 320 330 340 350
PLPPAQSQTQ EGGPAAGKAS GADQRDTRRK AGPAWMVTRT EGHEETPLPP
360 370 380 390 400
AQSQTQEGGP AAGKASGADE RDTRRKAGPA WMVRRSEGHE QTPAAHAQGT
410 420 430 440 450
GPEGGKGRAV ADALNRQIRE EVASTVSSSY RNEFRAWTDI KPVKPIKAKP
460 470 480 490 500
QYKPPDDKMV HETSYSAQFK GEANKPSAAD NKAMDRRRIR SLYSEPFKEC
510 520 530 540 550
PKVEKPSVQS SKPKKTSTSH KPPRKAKDKQ VVSGQAAKKK TTEGPSATKP
560 570 580 590 600
DDKEQSKEMN NKLAEAKESR VKPTSDASKN RGPVTKEPHK DQGSVAPGLP
610 620 630 640 650
KGQEPLKDQG PVVPGLPKDQ VPVVPGSLKG QSPTAPGPTK DQGAVLLGPV
660 670 680 690 700
KDLGPVAPAP IKVQDHIASE LLKNKDSVPL APAKAQSPLL PEPLKNQSPV
710 720 730 740 750
VPASTKDQSF PTPAPRKDPG PVIPEPEKDR APTVPERRKD QHVSIMASLK
760 770 780 790 800
NEAPMVPESV KNQGLAGPEL VKDTGTDTTA PRYLKGHDSV FVAPVKNQGP
810 820 830 840 850
VIPEPVKSQD PIIPALAKDQ GPMLPEPPKN QSPVVLGPIK NQDPIIPVPL
860 870 880 890 900
KGQDPLVPAP TKDQGPTAPD PLKTQGPKGT QLPTVSPSPP VMIPTVPHTE

YIEGSP
Note: Produced by alternative promoter usage.
Length:906
Mass (Da):96,450
Last modified:July 22, 2008 - v2
Checksum:iF3CED1FCF1E2CD83
GO
Isoform 2 (identifier: Q7TSJ2-2) [UniParc]FASTAAdd to basket
Also known as: E-STOP, Early STOP

The sequence of this isoform differs from the canonical sequence as follows:
     569-906: Missing.

Note: Produced by alternative splicing of isoform 1.
Show »
Length:568
Mass (Da):61,105
Checksum:i81B1DFF1B51D2658
GO
Isoform 3 (identifier: Q7TSJ2-3) [UniParc]FASTAAdd to basket
Also known as: F-STOP, Fibroblastic STOP

The sequence of this isoform differs from the canonical sequence as follows:
     1-203: Missing.
     503-509: VEKPSVQ → EPGQTHQ
     510-906: Missing.

Note: Produced by alternative promoter usage.
Show »
Length:306
Mass (Da):32,803
Checksum:iE19396DFF272B496
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81P → L in CAA75049 (PubMed:9501006).Curated1
Sequence conflicti87V → G in CAA75930 (PubMed:9501006).Curated1
Sequence conflicti344E → K in CAA75930 (PubMed:9501006).Curated1
Sequence conflicti344E → K in CAA75989 (PubMed:9600916).Curated1
Sequence conflicti405G → S in CAA75049 (PubMed:9501006).Curated1
Sequence conflicti755 – 757MVP → VVH in CAA75930 (PubMed:9501006).Curated3
Sequence conflicti755M → V in CAA75049 (PubMed:9501006).Curated1
Sequence conflicti825P → S in CAA75930 (PubMed:9501006).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0347241 – 203Missing in isoform 3. 1 PublicationAdd BLAST203
Alternative sequenceiVSP_034725503 – 509VEKPSVQ → EPGQTHQ in isoform 3. 1 Publication7
Alternative sequenceiVSP_034726510 – 906Missing in isoform 3. 1 PublicationAdd BLAST397
Alternative sequenceiVSP_034727569 – 906Missing in isoform 2. 1 PublicationAdd BLAST338

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14754, Y14755, Y14756 Genomic DNA. Translation: CAA75049.1.
Y16008 Genomic DNA. Translation: CAA75930.1.
Y16032 mRNA. Translation: CAA75989.1.
BC053039 mRNA. Translation: AAH53039.1.
CCDSiCCDS21479.1. [Q7TSJ2-1]
CCDS40029.1. [Q7TSJ2-3]
PIRiJC5963.
RefSeqiNP_001036820.2. NM_001043355.2. [Q7TSJ2-3]
NP_001041632.1. NM_001048167.1. [Q7TSJ2-2]
NP_034967.2. NM_010837.3. [Q7TSJ2-1]
UniGeneiMm.154087.

Genome annotation databases

EnsembliENSMUST00000068973; ENSMUSP00000064787; ENSMUSG00000055407. [Q7TSJ2-1]
ENSMUST00000107100; ENSMUSP00000102717; ENSMUSG00000055407. [Q7TSJ2-3]
ENSMUST00000127492; ENSMUSP00000146340; ENSMUSG00000055407. [Q7TSJ2-2]
ENSMUST00000207883; ENSMUSP00000146585; ENSMUSG00000055407. [Q7TSJ2-1]
ENSMUST00000208605; ENSMUSP00000146897; ENSMUSG00000055407. [Q7TSJ2-3]
GeneIDi17760.
KEGGimmu:17760.
UCSCiuc009ilg.1. mouse. [Q7TSJ2-1]
uc009ili.1. mouse. [Q7TSJ2-3]

Keywords - Coding sequence diversityi

Alternative promoter usage, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y14754, Y14755, Y14756 Genomic DNA. Translation: CAA75049.1.
Y16008 Genomic DNA. Translation: CAA75930.1.
Y16032 mRNA. Translation: CAA75989.1.
BC053039 mRNA. Translation: AAH53039.1.
CCDSiCCDS21479.1. [Q7TSJ2-1]
CCDS40029.1. [Q7TSJ2-3]
PIRiJC5963.
RefSeqiNP_001036820.2. NM_001043355.2. [Q7TSJ2-3]
NP_001041632.1. NM_001048167.1. [Q7TSJ2-2]
NP_034967.2. NM_010837.3. [Q7TSJ2-1]
UniGeneiMm.154087.

3D structure databases

ProteinModelPortaliQ7TSJ2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201587. 5 interactors.
IntActiQ7TSJ2. 6 interactors.
MINTiMINT-4105179.
STRINGi10090.ENSMUSP00000064787.

PTM databases

iPTMnetiQ7TSJ2.
PhosphoSitePlusiQ7TSJ2.

Proteomic databases

PaxDbiQ7TSJ2.
PeptideAtlasiQ7TSJ2.
PRIDEiQ7TSJ2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068973; ENSMUSP00000064787; ENSMUSG00000055407. [Q7TSJ2-1]
ENSMUST00000107100; ENSMUSP00000102717; ENSMUSG00000055407. [Q7TSJ2-3]
ENSMUST00000127492; ENSMUSP00000146340; ENSMUSG00000055407. [Q7TSJ2-2]
ENSMUST00000207883; ENSMUSP00000146585; ENSMUSG00000055407. [Q7TSJ2-1]
ENSMUST00000208605; ENSMUSP00000146897; ENSMUSG00000055407. [Q7TSJ2-3]
GeneIDi17760.
KEGGimmu:17760.
UCSCiuc009ilg.1. mouse. [Q7TSJ2-1]
uc009ili.1. mouse. [Q7TSJ2-3]

Organism-specific databases

CTDi4135.
MGIiMGI:1201690. Map6.

Phylogenomic databases

eggNOGiENOG410IIA0. Eukaryota.
ENOG4110KV2. LUCA.
GeneTreeiENSGT00530000063947.
HOGENOMiHOG000113479.
HOVERGENiHBG053112.
InParanoidiQ7TSJ2.
KOiK10432.
OMAiRKAGPAW.
OrthoDBiEOG091G0A3G.
PhylomeDBiQ7TSJ2.
TreeFamiTF338320.

Miscellaneous databases

PROiQ7TSJ2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055407.
ExpressionAtlasiQ7TSJ2. baseline and differential.
GenevisibleiQ7TSJ2. MM.

Family and domain databases

InterProiIPR007882. MAP6.
[Graphical view]
PANTHERiPTHR14759. PTHR14759. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiMAP6_MOUSE
AccessioniPrimary (citable) accession number: Q7TSJ2
Secondary accession number(s): O55129
, O70586, O70587, Q78DV4, Q78DV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 22, 2008
Last modified: November 2, 2016
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.