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Protein

DNA (cytosine-5)-methyltransferase

Gene

Dnmt1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.UniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

MethyltransferaseUniRule annotation, Transferase

Keywords - Ligandi

DNA-bindingUniRule annotation, S-adenosyl-L-methionineUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA (cytosine-5)-methyltransferaseUniRule annotation (EC:2.1.1.37UniRule annotation)
Gene namesi
Name:Dnmt1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:94912. Dnmt1.

Subcellular locationi

  • Nucleus UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

PaxDbiQ7TSJ0.
PeptideAtlasiQ7TSJ0.
PRIDEiQ7TSJ0.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000004202.

Structurei

3D structure databases

ProteinModelPortaliQ7TSJ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini656 – 70247CXXC-typeInterPro annotationAdd
BLAST
Domaini765 – 891127BAHInterPro annotationAdd
BLAST
Domaini983 – 1110128BAHInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG410IF68. Eukaryota.
COG0270. LUCA.
HOGENOMiHOG000082497.
HOVERGENiHBG051384.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR001025. BAH_dom.
IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR031303. C5_meth_CS.
IPR022702. Cytosine_MeTrfase1_RFD.
IPR010506. DMAP1-bd.
IPR017198. DNMT1_meta.
IPR029063. SAM-dependent_MTases.
IPR002857. Znf_CXXC.
[Graphical view]
PfamiPF01426. BAH. 2 hits.
PF06464. DMAP_binding. 1 hit.
PF00145. DNA_methylase. 1 hit.
PF12047. DNMT1-RFD. 1 hit.
PF02008. zf-CXXC. 1 hit.
[Graphical view]
PIRSFiPIRSF037404. DNMT1. 1 hit.
PRINTSiPR00105. C5METTRFRASE.
SMARTiSM00439. BAH. 2 hits.
SM01137. DMAP_binding. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS51038. BAH. 2 hits.
PS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
PS51058. ZF_CXXC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TSJ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPARTAPARV PALASPAGSL PDHVRRRLKD LERDGLTEKE CVREKLNLLH
60 70 80 90 100
EFLQTEIKSQ LCDLETKLHK EELSEEGYLA KVKSLLNKDL SLENGTHTLT
110 120 130 140 150
QKANGCPANG SRPTWRAEMA DSNRSPRSRP KPRGPRRSKS DSDTLCKDTR
160 170 180 190 200
HTAVETSPSS VATRRTTRQT TITAHFTKGP TKRKPKEESE EGNSAESAAE
210 220 230 240 250
ERDQDKKRRV VDTESGAAAA VEKLEEVTAG TQLGPEEPCE QEDDNRSLRR
260 270 280 290 300
HTRELSLRRK SKEDPDREAR PETHLDEDED GKKDKRSSRP RSQPRDPAAK
310 320 330 340 350
RRPKEAEPEQ VAPETPEDRD EDEREEKRRK TTRKKLESHT VPVQSRSERK
360 370 380 390 400
AAQSKSVIPK INSPKCPECG QHLDDPNLKY QQHPEDAVDE PQMLTSEKLS
410 420 430 440 450
IYDSTSTWFD TYEDSPMHRF TSFSVYCSRG HLCPVDTGLI EKNVELYFSG
460 470 480 490 500
CAKAIHDENP SMEGGINGKN LGPINQWWLS GFDGGEKVLI GFSTAFAEYI
510 520 530 540 550
LMEPSKEYEP IFGLMQEKIY ISKIVVEFLQ NNPDAVYEDL INKIETTVPP
560 570 580 590 600
STINVNRFTE DSLLRHAQFV VSQVESYDEA KDDDETPIFL SPCMRALIHL
610 620 630 640 650
AGVSLGQRRA TRRVMGATKE KDKAPTKATT TKLVYQIFDT FFSEQIEKYD
660 670 680 690 700
KEDKENAMKR RRCGVCEVCQ QPECGKCKAC KDMVKFGGTG RSKQACLKRR
710 720 730 740 750
CPNLAVKEAD DDEEADDDVS EMPSPKKLHQ GKKKKQNKDR ISWLGQPMKI
760 770 780 790 800
EENRTYYQKV SIDEEMLEVG DCVSVIPDDS SKPLYLARVT ALWEDKNGQM
810 820 830 840 850
MFHAHWFCAG TDTVLGATSD PLELFLVGEC ENMQLSYIHS KVKVIYKAPS
860 870 880 890 900
ENWAMEGGTD PETTLPGAED GKTYFFQLWY NQEYARFESP PKTQPTEDNK
910 920 930 940 950
HKFCLSCIRL AELRQKEMPK VLEQIEEVDG RVYCSSITKN GVVYRLGDSV
960 970 980 990 1000
YLPPEAFTFN IKVASPVKRP KKDPVNETLY PEHYRKYSDY IKGSNLDAPE
1010 1020 1030 1040 1050
PYRIGRIKEI HCGKKKGKVN EADIKLRLYK FYRPENTHRS YNGSYHTDIN
1060 1070 1080 1090 1100
MLYWSDEEAV VNFSDVQGRC TVEYGEDLLE SIQDYSQGGP DRFYFLEAYN
1110 1120 1130 1140 1150
SKTKNFEDPP NHARSPGNKG KGKGKGKGKG KHQVSEPKEP EAAIKLPKLR
1160 1170 1180 1190 1200
TLDVFSGCGG LSEGFHQAGI SETLWAIEMW DPAAQAFRLN NPGTTVFTED
1210 1220 1230 1240 1250
CNVLLKLVMA GEVTNSLGQR LPQKGDVEML CGGPPCQGFS GMNRFNSRTY
1260 1270 1280 1290 1300
SKFKNSLVVS FLSYCDYYRP RFFLLENVRN FVSYRRSMVL KLTLRCLVRM
1310 1320 1330 1340 1350
GYQCTFGVLQ AGQYGVAQTR RRAIILAAAP GEKLPLFPEP LHVFAPRACQ
1360 1370 1380 1390 1400
LSVVVDDKKF VSNITRLSSG PFRTITVRDT MSDLPEIQNG ASNSEIPYNG
1410 1420 1430 1440 1450
EPLSWFQRQL RGSHYQPILR DHICKDMSPL VAARMRHIPL FPGSDWRDLP
1460 1470 1480 1490 1500
NIQVRLGDGV IAHKLQYTFH DVKNGYSSTG ALRGVCSCAE GKACDPESRQ
1510 1520 1530 1540 1550
FSTLIPWCLP HTGNRHNHWA GLYGRLEWDG FFSTTVTNPE PMGKQGRVLH
1560 1570 1580 1590 1600
PEQHRVVSVR ECARSQGFPD SYRFFGNILD RHRQVGNAVP PPLAKAIGLE
1610 1620
IKLCLLSSAR ESASAAVKAK EEAATKD
Length:1,627
Mass (Da):184,015
Last modified:October 1, 2003 - v1
Checksum:iF23DC80D5FA9C5AE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC053047 mRNA. Translation: AAH53047.1.
RefSeqiNP_001300940.1. NM_001314011.1.
UniGeneiMm.128580.
Mm.485562.

Genome annotation databases

GeneIDi13433.
UCSCiuc009ojr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC053047 mRNA. Translation: AAH53047.1.
RefSeqiNP_001300940.1. NM_001314011.1.
UniGeneiMm.128580.
Mm.485562.

3D structure databases

ProteinModelPortaliQ7TSJ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000004202.

Proteomic databases

PaxDbiQ7TSJ0.
PeptideAtlasiQ7TSJ0.
PRIDEiQ7TSJ0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi13433.
UCSCiuc009ojr.2. mouse.

Organism-specific databases

CTDi1786.
MGIiMGI:94912. Dnmt1.

Phylogenomic databases

eggNOGiENOG410IF68. Eukaryota.
COG0270. LUCA.
HOGENOMiHOG000082497.
HOVERGENiHBG051384.

Miscellaneous databases

ChiTaRSiDnmt1. mouse.
SOURCEiSearch...

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR001025. BAH_dom.
IPR018117. C5_DNA_meth_AS.
IPR001525. C5_MeTfrase.
IPR031303. C5_meth_CS.
IPR022702. Cytosine_MeTrfase1_RFD.
IPR010506. DMAP1-bd.
IPR017198. DNMT1_meta.
IPR029063. SAM-dependent_MTases.
IPR002857. Znf_CXXC.
[Graphical view]
PfamiPF01426. BAH. 2 hits.
PF06464. DMAP_binding. 1 hit.
PF00145. DNA_methylase. 1 hit.
PF12047. DNMT1-RFD. 1 hit.
PF02008. zf-CXXC. 1 hit.
[Graphical view]
PIRSFiPIRSF037404. DNMT1. 1 hit.
PRINTSiPR00105. C5METTRFRASE.
SMARTiSM00439. BAH. 2 hits.
SM01137. DMAP_binding. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 2 hits.
PROSITEiPS51038. BAH. 2 hits.
PS00094. C5_MTASE_1. 1 hit.
PS00095. C5_MTASE_2. 1 hit.
PS51679. SAM_MT_C5. 1 hit.
PS51058. ZF_CXXC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ7TSJ0_MOUSE
AccessioniPrimary (citable) accession number: Q7TSJ0
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: July 6, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.