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UniProtKB - Q7TSI8 (Q7TSI8_MOUSE)

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Protein

Fibroblast growth factor receptor

Gene

Fgfr3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei611Proton acceptorUniRule annotation1

GO - Molecular functioni

Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionKinase, ReceptorUniRule annotationSAAS annotationImported, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation
LigandATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-109704. PI3K Cascade.
R-MMU-1257604. PIP3 activates AKT signaling.
R-MMU-190371. FGFR3b ligand binding and activation.
R-MMU-190372. FGFR3c ligand binding and activation.
R-MMU-5654227. Phospholipase C-mediated cascade, FGFR3.
R-MMU-5654693. FRS-mediated FGFR1 signaling.
R-MMU-5654700. FRS-mediated FGFR2 signaling.
R-MMU-5654704. SHC-mediated cascade:FGFR3.
R-MMU-5654706. FRS-mediated FGFR3 signaling.
R-MMU-5654710. PI-3K cascade:FGFR3.
R-MMU-5654712. FRS-mediated FGFR4 signaling.
R-MMU-5654732. Negative regulation of FGFR3 signaling.
R-MMU-5673001. RAF/MAP kinase cascade.
R-MMU-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Fibroblast growth factor receptorUniRule annotation (EC:2.7.10.1UniRule annotation)
Gene namesi
Name:Fgfr3Imported
ORF Names:mCG_16331Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:95524. Fgfr3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei366 – 390HelicalSequence analysisAdd BLAST25

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_501068365321 – 800Fibroblast growth factor receptorSequence analysisAdd BLAST780

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000054252.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 108Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST70
Domaini145 – 238Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST94
Domaini247 – 349Ig-like (immunoglobulin-like)InterPro annotationAdd BLAST103
Domaini466 – 755Protein kinaseInterPro annotationAdd BLAST290

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.UniRule annotation

Keywords - Domaini

Immunoglobulin domainSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG0200. Eukaryota.
COG0515. LUCA.
GeneTreeiENSGT00760000118923.
HOVERGENiHBG000345.
KOiK05094.

Family and domain databases

Gene3Di2.60.40.10. 4 hits.
InterProiView protein in InterPro
IPR028176. FGF_rcpt_3.
IPR016248. FGF_rcpt_fam.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
PANTHERiPTHR24416:SF401. PTHR24416:SF401. 1 hit.
PfamiView protein in Pfam
PF07679. I-set. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PIRSFiPIRSF000628. FGFR. 1 hit.
PRINTSiPR00109. TYRKINASE.
SMARTiView protein in SMART
SM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
SM00219. TyrKc. 1 hit.
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7TSI8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVPACVLVF CVAVVAGATS EPPGPEQRVV RRAAEVPGPE PSQQEQVAFG 
        60         70         80         90        100
SGDTVELSCH PPGGAPTGPT VWAKDGTGLV ASHRILVGPQ RLQVLNASHE 
       110        120        130        140        150
DAGVYSCQHR LTRRVLCHFS VRVTDAPSSG DDEDGEDVAE DTGAPYWTRP 
       160        170        180        190        200
ERMDKKLLAV PAANTVRFRC PAAGNPTPSI SWLKNGKEFR GEHRIGGIKL 
       210        220        230        240        250
RHQQWSLVME SVVPSDRGNY TCVVENKFGS IRQTYTLDVL ERSPHRPILQ 
       260        270        280        290        300
AGLPANQTAI LGSDVEFHCK VYSDAQPHIQ WLKHVEVNGS KVGPDGTPYV 
       310        320        330        340        350
TVLKTAGANT TDKELEVLSL HNVTFEDAGE YTCLAGNSIG FSHHSAWLVV 
       360        370        380        390        400
LPAEEELMET DEAGSVYAGV LSYGVVFFLF ILVVAAVILC RLRSPPKKGL 
       410        420        430        440        450
GSPTVHKVSR FPLKRQVSLE SNSSMNSNTP LVRIARLSSG EGPVLANVSE 
       460        470        480        490        500
LELPADPKWE LSRTRLTLGK PLGEGCFGQV VMAEAIGIDK DRTAKPVTVA 
       510        520        530        540        550
VKMLKDDATD KDLSDLVSEM EMMKMIGKHK NIINLLGACT QGGPLYVLVE 
       560        570        580        590        600
YAAKGNLREF LRARRPPGMD YSFDACRLPE EQLTCKDLVS CAYQVARGME 
       610        620        630        640        650
YLASQKCIHR DLAARNVLVT EDNVMKIADF GLARDVHNLD YYKKTTNGRL 
       660        670        680        690        700
PVKWMAPEAL FDRVYTHQSD VWSFGVLLWE IFTLGGSPYP GIPVEELFKL 
       710        720        730        740        750
LKEGHRMDKP ASCTHDLYMI MRECWHAVPS QRPTFKQLVE DLDRILTVTS 
       760        770        780        790        800
TDEYLDLSVP FEQYSPGGQD TPSSSSSGDD SVFTHDLLPP GPPSNGGPRT
Length:800
Mass (Da):87,677
Last modified:October 1, 2003 - v1
Checksum:i2A7215F13F67E5E9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC162898 Genomic DNA. No translation available.
BC053056 mRNA. Translation: AAH53056.1.
CH466524 Genomic DNA. Translation: EDL37432.1.
RefSeqiNP_001156687.1. NM_001163215.2.
NP_032036.2. NM_008010.5.
UniGeneiMm.6904.

Genome annotation databases

EnsembliENSMUST00000067150; ENSMUSP00000070998; ENSMUSG00000054252.
ENSMUST00000169212; ENSMUSP00000130856; ENSMUSG00000054252.
GeneIDi14184.
KEGGimmu:14184.
UCSCiuc008xbe.3. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ7TSI8_MOUSE
AccessioniPrimary (citable) accession number: Q7TSI8
Secondary accession number(s): E9QLT8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: July 5, 2017
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported