Vav2

Functionⁱ

GO - Molecular functionⁱ

epidermal growth factor receptor binding Source: Ensembl
metal ion binding Source: UniProtKB-KW
Rho guanyl-nucleotide exchange factor activity Source: InterPro

GO - Biological processⁱ

cell migration Source: Ensembl
lamellipodium assembly Source: Ensembl
positive regulation of phosphatidylinositol 3-kinase activity Source: Ensembl
regulation of Rho protein signal transduction Source: InterPro
small GTPase mediated signal transduction Source: Ensembl

Keywordsⁱ

Molecular function	Guanine-nucleotide releasing factorSAAS annotation
Ligand	Metal-bindingSAAS annotation, ZincSAAS annotation

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Guanine nucleotide exchange factor VAV2Imported Submitted name: Vav2 proteinImported
Gene namesⁱ	Name:Vav2Imported
Organismⁱ	Mus musculus (Mouse)Imported
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:102718. Vav2.

Subcellular locationⁱ

GO - Cellular componentⁱ

cytoplasm Source: Ensembl
plasma membrane Source: Ensembl

Complete GO annotation...

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000009621.

Bgeeⁱ

ENSMUSG00000009621.

Interactionⁱ

GO - Molecular functionⁱ

epidermal growth factor receptor binding Source: Ensembl

Complete GO annotation...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	1 – 106	Actin-bindingInterPro annotationAdd BLAST	106
Domainⁱ	159 – 337	DH (DBL-homology)InterPro annotationAdd BLAST	179
Domainⁱ	366 – 473	PHInterPro annotationAdd BLAST	108
Domainⁱ	484 – 533	Phorbol-ester/DAG-typeInterPro annotationAdd BLAST	50
Domainⁱ	547 – 613	SH3InterPro annotationAdd BLAST	67
Domainⁱ	634 – 705	SH2InterPro annotationAdd BLAST	72

Keywords - Domainⁱ

SH2 domainPROSITE-ProRule annotationSAAS annotation, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00880000137925.
HOVERGENⁱ	HBG018066.
KEGG Orthology (KO) More...KOⁱ	K05730.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00029. C1. 1 hit.
Gene3Dⁱ	1.10.418.10. 2 hits. 2.30.29.30. 1 hit. 3.30.505.10. 1 hit.
InterProⁱ	View protein in InterPro IPR022613. CAMSAP_CH. IPR001715. CH-domain. IPR000219. DH-domain. IPR001331. GDS_CDC24_CS. IPR002219. PE/DAG-bd. IPR011993. PH_dom-like. IPR001849. PH_domain. IPR000980. SH2. IPR011511. SH3_2. IPR001452. SH3_domain.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00130. C1_1. 1 hit. PF11971. CAMSAP_CH. 1 hit. PF00169. PH. 1 hit. PF00621. RhoGEF. 1 hit. PF00017. SH2. 1 hit. PF07653. SH3_2. 1 hit.
SMARTⁱ	View protein in SMART SM00109. C1. 1 hit. SM00233. PH. 1 hit. SM00325. RhoGEF. 1 hit. SM00252. SH2. 1 hit. SM00326. SH3. 1 hit.
SUPFAMⁱ	SSF47576. SSF47576. 1 hit. SSF48065. SSF48065. 1 hit. SSF50044. SSF50044. 1 hit. SSF50729. SSF50729. 1 hit. SSF55550. SSF55550. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50021. CH. 1 hit. PS00741. DH_1. 1 hit. PS50010. DH_2. 1 hit. PS50003. PH_DOMAIN. 1 hit. PS50001. SH2. 1 hit. PS50002. SH3. 1 hit. PS00479. ZF_DAG_PE_1. 1 hit. PS50081. ZF_DAG_PE_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q7TSI6-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEQWRQCGRW LIDCKVLPPN HRVVWPSAVV FDLAQALRDG VLLCQLLHNL 
        60         70         80         90        100
SPGSIDLKDI NFRPQMSQVI SAVSRLSLHS IAQSKGIRPF PSEETAENDD 
       110        120        130        140        150
DVYRSLEELA DEHDLGEDIY DCVPCEDEGD DIYEDIIKVE VQQPMIRYMQ 
       160        170        180        190        200
KMGMTEDDKR SCCLLEIQET EAKYYRTLED IEKNYMGPLR LVLSPADMAA 
       210        220        230        240        250
VFINLEDLIK VHHSFLRAID VSMMAGGSTL AKVFLEFKER LLIYGEYCSH 
       260        270        280        290        300
MEHAQSTLNQ LLASREDFRQ KVEECTLRVQ DGKFKLQDLL VVPMQRVLKY 
       310        320        330        340        350
HLLLKELLSH SADRPERQQL KEALEAMQDL AMYINEVKRD KETLKKISEF 
       360        370        380        390        400
QCSIENLQVK LEEFGRPKID GELKVRSIVN HTKQDRYLFL FDKVVIVCKR 
       410        420        430        440        450
KGYSYELKEV IELLFHKMTD DPMHNKDIKK SHGKMWSYGF YLIHLQGKQG 
       460        470        480        490        500
FQFFCKTEDM KRKWMEQFEM AMSNIKPDKA NANHHSFQMY TFDKTTNCKA 
       510        520        530        540        550
CKMFLRGTFY QGYLCTRCGV GAHKECLEVI PPCKMSSPAD VDAPGAGPGP 
       560        570        580        590        600
KMVAVQNYHG NPAPPGKPVL TFQTGDVIEL LRGDPDSPWW EGRLVQTRKS 
       610        620        630        640        650
GYFPSSSVKP CPVDGRPPTG RPPSREIDYT AYPWFAGNME RQQTDNLLKS 
       660        670        680        690        700
HASGTYLIRE RPAEAERFAI SIKFNDEVKH IKVVEKDSWI HITEAKKFES 
       710        720        730        740        750
LLSILSAIFG SPAPEGEVFE ALAILAGLGW RAGGVLPVSL TQGKLQAVGH 
       760        770        780        790        800
YTQVPLQVSG ANHQQGLKPV SSFLRFLQLF FSQSSGPQLC PPGPFCSLLV 
       810        820 
SVHTAGHRHS RGQVQLCCSR HAGAVTARR

Length:829

Mass (Da):94,258

Last modified:October 1, 2003 - v1

Checksum:ⁱB27FD65E5FEFE112

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL731552 Genomic DNA. No translation available. AL772282 Genomic DNA. No translation available. BC053060 mRNA. Translation: AAH53060.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_033526.1. NM_009500.2.
UniGeneⁱ	Mm.179011.

Genome annotation databases

Ensemblⁱ	ENSMUST00000185188; ENSMUSP00000138964; ENSMUSG00000009621.
GeneIDⁱ	22325.
KEGGⁱ	mmu:22325.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AL731552 Genomic DNA. No translation available. AL772282 Genomic DNA. No translation available. BC053060 mRNA. Translation: AAH53060.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_033526.1. NM_009500.2.
UniGeneⁱ	Mm.179011.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000185188; ENSMUSP00000138964; ENSMUSG00000009621.
GeneIDⁱ	22325.
KEGGⁱ	mmu:22325.

Organism-specific databases

CTDⁱ	7410.
MGIⁱ	MGI:102718. Vav2.

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00880000137925.
HOVERGENⁱ	HBG018066.
KEGG Orthology (KO) More...KOⁱ	K05730.

Miscellaneous databases

ChiTaRSⁱ	Vav2. mouse.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000009621.

Bgeeⁱ

ENSMUSG00000009621.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00029. C1. 1 hit.
Gene3Dⁱ	1.10.418.10. 2 hits. 2.30.29.30. 1 hit. 3.30.505.10. 1 hit.
InterProⁱ	View protein in InterPro IPR022613. CAMSAP_CH. IPR001715. CH-domain. IPR000219. DH-domain. IPR001331. GDS_CDC24_CS. IPR002219. PE/DAG-bd. IPR011993. PH_dom-like. IPR001849. PH_domain. IPR000980. SH2. IPR011511. SH3_2. IPR001452. SH3_domain.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00130. C1_1. 1 hit. PF11971. CAMSAP_CH. 1 hit. PF00169. PH. 1 hit. PF00621. RhoGEF. 1 hit. PF00017. SH2. 1 hit. PF07653. SH3_2. 1 hit.
SMARTⁱ	View protein in SMART SM00109. C1. 1 hit. SM00233. PH. 1 hit. SM00325. RhoGEF. 1 hit. SM00252. SH2. 1 hit. SM00326. SH3. 1 hit.
SUPFAMⁱ	SSF47576. SSF47576. 1 hit. SSF48065. SSF48065. 1 hit. SSF50044. SSF50044. 1 hit. SSF50729. SSF50729. 1 hit. SSF55550. SSF55550. 1 hit.
PROSITEⁱ	View protein in PROSITE PS50021. CH. 1 hit. PS00741. DH_1. 1 hit. PS50010. DH_2. 1 hit. PS50003. PH_DOMAIN. 1 hit. PS50001. SH2. 1 hit. PS50002. SH3. 1 hit. PS00479. ZF_DAG_PE_1. 1 hit. PS50081. ZF_DAG_PE_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	Q7TSI6_MOUSE
Accessionⁱ	Q7TSI6Primary (citable) accession number: Q7TSI6
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	October 1, 2003
	Last sequence update:	October 1, 2003
	Last modified:	June 7, 2017
	This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

UniProtKB - Q7TSI6 (Q7TSI6_MOUSE)

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Guanine nucleotide exchange factor VAV2

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Organism-specific databases

Subcellular locationⁱ

GO - Cellular componentⁱ

Expressionⁱ

Gene expression databases

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Domains and Repeats

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q7TSI6 (Q7TSI6_MOUSE)

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Guanine nucleotide exchange factor VAV2

Vav2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ