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Protein
Submitted name:

Guanine nucleotide exchange factor VAV2

Gene

Vav2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-bindingSAAS annotation, ZincSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Guanine nucleotide exchange factor VAV2Imported
Submitted name:
Vav2 proteinImported
Gene namesi
Name:Vav2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:102718. Vav2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

PeptideAtlasiQ7TSI6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 106106Actin-bindingInterPro annotationAdd
BLAST
Domaini159 – 337179DH (DBL-homology)InterPro annotationAdd
BLAST
Domaini366 – 473108PHInterPro annotationAdd
BLAST
Domaini484 – 53350Phorbol-ester/DAG-typeInterPro annotationAdd
BLAST
Domaini547 – 61367SH3InterPro annotationAdd
BLAST
Domaini634 – 70572SH2InterPro annotationAdd
BLAST

Sequence similaritiesi

Contains 1 PH domain.UniRule annotation
Contains DH (DBL-homology) domain.SAAS annotation
Contains SH2 domain.SAAS annotation

Keywords - Domaini

SH2 domainSAAS annotation, SH3 domainSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00800000124085.
HOVERGENiHBG018066.
KOiK05730.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR022613. CAMSAP_CH.
IPR001715. CH-domain.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR002219. PE/DAG-bd.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000980. SH2.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR028530. Vav.
[Graphical view]
PANTHERiPTHR22826:SF95. PTHR22826:SF95. 1 hit.
PfamiPF00130. C1_1. 1 hit.
PF11971. CAMSAP_CH. 1 hit.
PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00017. SH2. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50021. CH. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TSI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQWRQCGRW LIDCKVLPPN HRVVWPSAVV FDLAQALRDG VLLCQLLHNL
60 70 80 90 100
SPGSIDLKDI NFRPQMSQVI SAVSRLSLHS IAQSKGIRPF PSEETAENDD
110 120 130 140 150
DVYRSLEELA DEHDLGEDIY DCVPCEDEGD DIYEDIIKVE VQQPMIRYMQ
160 170 180 190 200
KMGMTEDDKR SCCLLEIQET EAKYYRTLED IEKNYMGPLR LVLSPADMAA
210 220 230 240 250
VFINLEDLIK VHHSFLRAID VSMMAGGSTL AKVFLEFKER LLIYGEYCSH
260 270 280 290 300
MEHAQSTLNQ LLASREDFRQ KVEECTLRVQ DGKFKLQDLL VVPMQRVLKY
310 320 330 340 350
HLLLKELLSH SADRPERQQL KEALEAMQDL AMYINEVKRD KETLKKISEF
360 370 380 390 400
QCSIENLQVK LEEFGRPKID GELKVRSIVN HTKQDRYLFL FDKVVIVCKR
410 420 430 440 450
KGYSYELKEV IELLFHKMTD DPMHNKDIKK SHGKMWSYGF YLIHLQGKQG
460 470 480 490 500
FQFFCKTEDM KRKWMEQFEM AMSNIKPDKA NANHHSFQMY TFDKTTNCKA
510 520 530 540 550
CKMFLRGTFY QGYLCTRCGV GAHKECLEVI PPCKMSSPAD VDAPGAGPGP
560 570 580 590 600
KMVAVQNYHG NPAPPGKPVL TFQTGDVIEL LRGDPDSPWW EGRLVQTRKS
610 620 630 640 650
GYFPSSSVKP CPVDGRPPTG RPPSREIDYT AYPWFAGNME RQQTDNLLKS
660 670 680 690 700
HASGTYLIRE RPAEAERFAI SIKFNDEVKH IKVVEKDSWI HITEAKKFES
710 720 730 740 750
LLSILSAIFG SPAPEGEVFE ALAILAGLGW RAGGVLPVSL TQGKLQAVGH
760 770 780 790 800
YTQVPLQVSG ANHQQGLKPV SSFLRFLQLF FSQSSGPQLC PPGPFCSLLV
810 820
SVHTAGHRHS RGQVQLCCSR HAGAVTARR
Length:829
Mass (Da):94,258
Last modified:October 1, 2003 - v1
Checksum:iB27FD65E5FEFE112
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731552 Genomic DNA. No translation available.
AL772282 Genomic DNA. No translation available.
BC053060 mRNA. Translation: AAH53060.1.
RefSeqiNP_033526.1. NM_009500.2.
UniGeneiMm.179011.

Genome annotation databases

EnsembliENSMUST00000185188; ENSMUSP00000138964; ENSMUSG00000009621.
GeneIDi22325.
KEGGimmu:22325.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731552 Genomic DNA. No translation available.
AL772282 Genomic DNA. No translation available.
BC053060 mRNA. Translation: AAH53060.1.
RefSeqiNP_033526.1. NM_009500.2.
UniGeneiMm.179011.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiQ7TSI6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000185188; ENSMUSP00000138964; ENSMUSG00000009621.
GeneIDi22325.
KEGGimmu:22325.

Organism-specific databases

CTDi7410.
MGIiMGI:102718. Vav2.

Phylogenomic databases

GeneTreeiENSGT00800000124085.
HOVERGENiHBG018066.
KOiK05730.

Miscellaneous databases

ChiTaRSiVav2. mouse.
SOURCEiSearch...

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
1.20.900.10. 1 hit.
2.30.29.30. 1 hit.
3.30.505.10. 1 hit.
InterProiIPR022613. CAMSAP_CH.
IPR001715. CH-domain.
IPR000219. DH-domain.
IPR001331. GDS_CDC24_CS.
IPR002219. PE/DAG-bd.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000980. SH2.
IPR011511. SH3_2.
IPR001452. SH3_domain.
IPR028530. Vav.
[Graphical view]
PANTHERiPTHR22826:SF95. PTHR22826:SF95. 1 hit.
PfamiPF00130. C1_1. 1 hit.
PF11971. CAMSAP_CH. 1 hit.
PF00169. PH. 1 hit.
PF00621. RhoGEF. 1 hit.
PF00017. SH2. 1 hit.
PF07653. SH3_2. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 1 hit.
SM00233. PH. 1 hit.
SM00325. RhoGEF. 1 hit.
SM00252. SH2. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
SSF48065. SSF48065. 1 hit.
SSF50044. SSF50044. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF55550. SSF55550. 1 hit.
PROSITEiPS50021. CH. 1 hit.
PS00741. DH_1. 1 hit.
PS50010. DH_2. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS50001. SH2. 1 hit.
PS50002. SH3. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6Imported.
    Tissue: BrainImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. Ensembl
    Submitted (DEC-2013) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ7TSI6_MOUSE
AccessioniPrimary (citable) accession number: Q7TSI6
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: July 6, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.