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Protein
Submitted name:

Guanine nucleotide exchange factor VAV2

Gene

Vav2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-bindingSAAS annotation, ZincSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Guanine nucleotide exchange factor VAV2Imported
Submitted name:
Vav2 proteinImported
Gene namesi
Name:Vav2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:102718 Vav2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSMUSG00000009621

Interactioni

GO - Molecular functioni

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 114Calponin-homology (CH)InterPro annotationAdd BLAST114
Domaini159 – 337DHInterPro annotationAdd BLAST179
Domaini366 – 473PHInterPro annotationAdd BLAST108
Domaini484 – 533Phorbol-ester/DAG-typeInterPro annotationAdd BLAST50
Domaini547 – 613SH3InterPro annotationAdd BLAST67
Domaini634 – 705SH2InterPro annotationAdd BLAST72

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili251 – 271Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, SH2 domainPROSITE-ProRule annotation, SH3 domainPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00910000144110
HOVERGENiHBG018066
KOiK05730

Family and domain databases

CDDicd00029 C1, 1 hit
cd01223 PH_Vav, 1 hit
cd00160 RhoGEF, 1 hit
cd11980 SH3_VAV2_1, 1 hit
Gene3Di1.10.418.10, 2 hits
1.20.900.10, 1 hit
2.30.29.30, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR022613 CAMSAP_CH
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR002219 PE/DAG-bd
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR037832 PH_Vav
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR035733 VAV2_SH3_1
PfamiView protein in Pfam
PF00130 C1_1, 1 hit
PF11971 CAMSAP_CH, 1 hit
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
PF00017 SH2, 1 hit
PF07653 SH3_2, 1 hit
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00252 SH2, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
SSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50001 SH2, 1 hit
PS50002 SH3, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q7TSI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEQWRQCGRW LIDCKVLPPN HRVVWPSAVV FDLAQALRDG VLLCQLLHNL
60 70 80 90 100
SPGSIDLKDI NFRPQMSQVI SAVSRLSLHS IAQSKGIRPF PSEETAENDD
110 120 130 140 150
DVYRSLEELA DEHDLGEDIY DCVPCEDEGD DIYEDIIKVE VQQPMIRYMQ
160 170 180 190 200
KMGMTEDDKR SCCLLEIQET EAKYYRTLED IEKNYMGPLR LVLSPADMAA
210 220 230 240 250
VFINLEDLIK VHHSFLRAID VSMMAGGSTL AKVFLEFKER LLIYGEYCSH
260 270 280 290 300
MEHAQSTLNQ LLASREDFRQ KVEECTLRVQ DGKFKLQDLL VVPMQRVLKY
310 320 330 340 350
HLLLKELLSH SADRPERQQL KEALEAMQDL AMYINEVKRD KETLKKISEF
360 370 380 390 400
QCSIENLQVK LEEFGRPKID GELKVRSIVN HTKQDRYLFL FDKVVIVCKR
410 420 430 440 450
KGYSYELKEV IELLFHKMTD DPMHNKDIKK SHGKMWSYGF YLIHLQGKQG
460 470 480 490 500
FQFFCKTEDM KRKWMEQFEM AMSNIKPDKA NANHHSFQMY TFDKTTNCKA
510 520 530 540 550
CKMFLRGTFY QGYLCTRCGV GAHKECLEVI PPCKMSSPAD VDAPGAGPGP
560 570 580 590 600
KMVAVQNYHG NPAPPGKPVL TFQTGDVIEL LRGDPDSPWW EGRLVQTRKS
610 620 630 640 650
GYFPSSSVKP CPVDGRPPTG RPPSREIDYT AYPWFAGNME RQQTDNLLKS
660 670 680 690 700
HASGTYLIRE RPAEAERFAI SIKFNDEVKH IKVVEKDSWI HITEAKKFES
710 720 730 740 750
LLSILSAIFG SPAPEGEVFE ALAILAGLGW RAGGVLPVSL TQGKLQAVGH
760 770 780 790 800
YTQVPLQVSG ANHQQGLKPV SSFLRFLQLF FSQSSGPQLC PPGPFCSLLV
810 820
SVHTAGHRHS RGQVQLCCSR HAGAVTARR
Length:829
Mass (Da):94,258
Last modified:October 1, 2003 - v1
Checksum:iB27FD65E5FEFE112
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731552 Genomic DNA No translation available.
AL772282 Genomic DNA No translation available.
BC053060 mRNA Translation: AAH53060.1
RefSeqiNP_033526.1, NM_009500.2
UniGeneiMm.179011

Genome annotation databases

EnsembliENSMUST00000185188; ENSMUSP00000138964; ENSMUSG00000009621
GeneIDi22325
KEGGimmu:22325

Similar proteinsi

Entry informationi

Entry nameiQ7TSI6_MOUSE
AccessioniPrimary (citable) accession number: Q7TSI6
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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