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Protein

Zinc finger protein 184

Gene

Zfp184

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri201 – 223C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri565 – 587C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri593 – 615C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri621 – 643C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri649 – 671C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri677 – 698C2H2-type 18; degeneratePROSITE-ProRule annotationAdd BLAST22
Zinc fingeri704 – 726C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 184
Gene namesi
Name:Zfp184
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1922244. Zfp184.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003484691 – 737Zinc finger protein 184Add BLAST737

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei117PhosphoserineBy similarity1
Cross-linki185Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ7TSH9.
PaxDbiQ7TSH9.
PRIDEiQ7TSH9.

PTM databases

iPTMnetiQ7TSH9.
PhosphoSitePlusiQ7TSH9.

Expressioni

Gene expression databases

BgeeiENSMUSG00000006720.
ExpressionAtlasiQ7TSH9. baseline and differential.
GenevisibleiQ7TSH9. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006903.

Structurei

3D structure databases

ProteinModelPortaliQ7TSH9.
SMRiQ7TSH9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 99KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri201 – 223C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri257 – 279C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri285 – 307C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri313 – 335C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri341 – 363C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri369 – 391C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri397 – 419C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri425 – 447C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri453 – 475C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri481 – 503C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri509 – 531C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri537 – 559C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri565 – 587C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri593 – 615C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri621 – 643C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri649 – 671C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri677 – 698C2H2-type 18; degeneratePROSITE-ProRule annotationAdd BLAST22
Zinc fingeri704 – 726C2H2-type 19PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00850000132243.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ7TSH9.
KOiK09228.
OMAiMEPSIPV.
OrthoDBiEOG091G02KC.
PhylomeDBiQ7TSH9.
TreeFamiTF350822.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
InterProiView protein in InterPro
IPR001909. KRAB.
IPR013087. Znf_C2H2_type.
PfamiView protein in Pfam
PF01352. KRAB. 1 hit.
SMARTiView protein in SMART
SM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 19 hits.
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF57667. SSF57667. 10 hits.
PROSITEiView protein in PROSITE
PS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 18 hits.
PS50157. ZINC_FINGER_C2H2_2. 19 hits.

Sequencei

Sequence statusi: Complete.

Q7TSH9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLSFADSA SLHEGRPLLL PSSFRESVTF KDVVVNFTQE EWKHLDPIQR
60 70 80 90 100
DLFRDVTLEN YTHLVSIGLQ VSKPDMISQL EQGTEPWTED SCIPVGPLED
110 120 130 140 150
WKKRAGNSVS SLELDISEEH LFSETVVTNS KRDDGSLEKL QANQQMLPRE
160 170 180 190 200
VQITEKTAPT CESNLSVSSS FITQTEVALD QPSTKTRAKQ NSHPVKKEKL
210 220 230 240 250
CKCNECGKAF TYCSALIRHQ RTHTGEKPYK CNECNKAFSR SENLINHQRI
260 270 280 290 300
HTGDKPYKCD QCGKGFIEGP SLTQHQRIHT GEKPYKCDEC GKAFSQRTHL
310 320 330 340 350
VQHQRIHTGE KPYTCTECGK SFSQRGHFME HQKIHTGEKP FKCEECEKTF
360 370 380 390 400
TRSTHLTQHQ KIHTGEKTYK CNECGKAFNG PSTFIRHHMI HTGEKPYECN
410 420 430 440 450
ECGKAFSQHS NLTQHQKTHT GEKPYDCAEC GKAFSYWSSL AQHLKIHTGE
460 470 480 490 500
KPYKCSDCGK AFSYCSSLTQ HRRIHTREKP FECSECGKAF SYLSNLNQHQ
510 520 530 540 550
KTHTQEKAYE CKECGKAFIR SSSLAKHERI HTGEKPYQCH ECGKTFSYGS
560 570 580 590 600
SLIQHKKIHT GERPYKCNEC GRAFNQKIHL TQHKRIHTGA KPYACPKCGK
610 620 630 640 650
TFRHCSSLAQ HQKTHTEEKP YQCNKCEKTF SQNSRLTQHQ RIHTGEKPYK
660 670 680 690 700
CSECDKCFTG SVHLTEHRST HTGEKPYNSE CPQTFSQSTY LTQHQKIHSG
710 720 730
EKLLGCEDCE KAFQCHSALT KHQRLHPAVA AVGTSLT
Length:737
Mass (Da):84,027
Last modified:October 1, 2003 - v1
Checksum:i8846AE11B55D040A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC053084 mRNA. Translation: AAH53084.1.
CCDSiCCDS26302.1.
RefSeqiNP_898835.1. NM_183014.1.
XP_006516659.1. XM_006516596.3.
XP_006516660.1. XM_006516597.3.
UniGeneiMm.187446.

Genome annotation databases

EnsembliENSMUST00000006903; ENSMUSP00000006903; ENSMUSG00000006720.
ENSMUST00000102978; ENSMUSP00000100043; ENSMUSG00000006720.
ENSMUST00000176511; ENSMUSP00000135173; ENSMUSG00000006720.
GeneIDi193452.
KEGGimmu:193452.
UCSCiuc007pry.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiZN184_MOUSE
AccessioniPrimary (citable) accession number: Q7TSH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 1, 2003
Last modified: September 27, 2017
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families