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Protein

Potassium voltage-gated channel subfamily F member 1

Gene

Kcnf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Putative voltage-gated potassium channel.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily F member 1
Alternative name(s):
Voltage-gated potassium channel subunit Kv5.1
Gene namesi
Name:Kcnf1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:2687399. Kcnf1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 183183CytoplasmicSequence analysisAdd
BLAST
Transmembranei184 – 20421Helical; Name=Segment S1Sequence analysisAdd
BLAST
Transmembranei224 – 24421Helical; Name=Segment S2Sequence analysisAdd
BLAST
Topological domaini245 – 2495CytoplasmicSequence analysis
Transmembranei250 – 27021Helical; Name=Segment S3Sequence analysisAdd
BLAST
Transmembranei290 – 31021Helical; Voltage-sensor; Name=Segment S4Sequence analysisAdd
BLAST
Topological domaini311 – 32414CytoplasmicSequence analysisAdd
BLAST
Transmembranei325 – 34521Helical; Name=Segment S5Sequence analysisAdd
BLAST
Intramembranei358 – 37821Pore-forming; Name=Segment H5Sequence analysisAdd
BLAST
Transmembranei386 – 40621Helical; Name=Segment S6Sequence analysisAdd
BLAST
Topological domaini407 – 49387CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 493493Potassium voltage-gated channel subfamily F member 1PRO_0000320105Add
BLAST

Proteomic databases

PaxDbiQ7TSH7.
PRIDEiQ7TSH7.

PTM databases

iPTMnetiQ7TSH7.
PhosphoSiteiQ7TSH7.

Expressioni

Gene expression databases

BgeeiQ7TSH7.

Interactioni

Subunit structurei

Heteromultimer with KCNG3, KCNG4 and KCNV2. Interacts with DLG1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000131480.

Structurei

3D structure databases

ProteinModelPortaliQ7TSH7.
SMRiQ7TSH7. Positions 25-416.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi370 – 3756Selectivity filterBy similarity

Domaini

The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3713. Eukaryota.
COG1226. LUCA.
HOGENOMiHOG000231016.
HOVERGENiHBG052230.
InParanoidiQ7TSH7.
KOiK04899.
PhylomeDBiQ7TSH7.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SUPFAMiSSF54695. SSF54695. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7TSH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDASAEQSLP EPGSQDSVAG EDIEIVVNVG GVRQVLYGDL LSQYPETRLA
60 70 80 90 100
ELINCLAGGY DTIFSLCDDY DPGKREFYFD RDPDAFKCVI EVYYFGEVHM
110 120 130 140 150
KKGICPICFK NEMDFWKVDL KFLDDCCKSH LSEKREELEE IARRVQLILD
160 170 180 190 200
DLGVDAAEGR WRRCQKCVWK FLEKPESSCP ARVVAVLSFL LILVSSVVMC
210 220 230 240 250
MGTIPELQVV DSEGNRVEHP TLENVETACI GWFTLEYLLR LFSSPNKLHF
260 270 280 290 300
ALSFMNIVDV LAILPFYVSL TLTHLGARMM ELTNVQQAVQ ALRIMRIARI
310 320 330 340 350
FKLARHSSGL QTLTYALKRS FKELGLLLMY LAVGIFVFSA LGYTMEQSHP
360 370 380 390 400
ETLFKSIPQS FWWAIITMTT VGYGDIYPKT TLGKLNAAIS FLCGVIAIAL
410 420 430 440 450
PIHPIINNFV RYYNKQRVLE TAAKHELELM ELNSSSAEGK PGGSRSDLDT
460 470 480 490
LPPEPAAREG PSWGSRLKLS HSDTFIPLLT EEKHHRTRLQ SCK
Length:493
Mass (Da):55,647
Last modified:October 1, 2003 - v1
Checksum:iF5C55969DF79FAD3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK137367 mRNA. Translation: BAE23327.1.
BC053089 mRNA. Translation: AAH53089.1.
RefSeqiNP_963289.2. NM_201531.3.
UniGeneiMm.40173.

Genome annotation databases

GeneIDi382571.
KEGGimmu:382571.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK137367 mRNA. Translation: BAE23327.1.
BC053089 mRNA. Translation: AAH53089.1.
RefSeqiNP_963289.2. NM_201531.3.
UniGeneiMm.40173.

3D structure databases

ProteinModelPortaliQ7TSH7.
SMRiQ7TSH7. Positions 25-416.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000131480.

PTM databases

iPTMnetiQ7TSH7.
PhosphoSiteiQ7TSH7.

Proteomic databases

PaxDbiQ7TSH7.
PRIDEiQ7TSH7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi382571.
KEGGimmu:382571.

Organism-specific databases

CTDi3754.
MGIiMGI:2687399. Kcnf1.

Phylogenomic databases

eggNOGiKOG3713. Eukaryota.
COG1226. LUCA.
HOGENOMiHOG000231016.
HOVERGENiHBG052230.
InParanoidiQ7TSH7.
KOiK04899.
PhylomeDBiQ7TSH7.

Miscellaneous databases

PROiQ7TSH7.
SOURCEiSearch...

Gene expression databases

BgeeiQ7TSH7.

Family and domain databases

Gene3Di1.20.120.350. 1 hit.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR003968. K_chnl_volt-dep_Kv.
IPR003971. K_chnl_volt-dep_Kv9.
IPR011333. SKP1/BTB/POZ.
IPR003131. T1-type_BTB.
IPR028325. VG_K_chnl.
[Graphical view]
PANTHERiPTHR11537. PTHR11537. 1 hit.
PfamiPF02214. BTB_2. 1 hit.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR00169. KCHANNEL.
PR01494. KV9CHANNEL.
PR01491. KVCHANNEL.
SUPFAMiSSF54695. SSF54695. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  3. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.

Entry informationi

Entry nameiKCNF1_MOUSE
AccessioniPrimary (citable) accession number: Q7TSH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2003
Last modified: July 6, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.