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Q7TSH4 (CP110_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Centriolar coiled-coil protein of 110 kDa
Alternative name(s):
Centrosomal protein of 110 kDa
Short name=Cep110
Short name=Cp110
Gene names
Name:Ccp110
Synonyms:Cep110, Cp110, Kiaa0419
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1004 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Necessary for centrosome duplication at different stages of procentriole formation. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 By similarity. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation. Ref.3

Subunit structure

Interacts with CALM1, CETN2, CEP76 and CEP97. Interacts with NEURL4 and CCNF; these interactions are not mutually exclusive and both lead to CCP110 ubiquitination and proteasome-dependent degradation. Via its interaction with NEURL4, may indirectly interact with HERC2. Interacts with KIF24, leading to its recruitment to centrioles. Interacts with USP20 and USP33 By similarity.

Subcellular location

Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole By similarity. Note: Recruited early and then associates with the growing distal tips. Recruited to the mother centriole by KIF24 By similarity. Removed from centrioles by TTBK2, leading to initiation of ciliogenesis. Ref.3

Post-translational modification

Phosphorylated by CDKs By similarity.

Ubiquitinated by the SCF(CCNF) during G2 phase, leading to its degradation by the proteasome and preventing centrosome reduplication. Deubiquitinated by USP33 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate By similarity.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Calm3P622044EBI-646843,EBI-397460

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10041004Centriolar coiled-coil protein of 110 kDa
PRO_0000089461

Regions

Region1 – 221221CEP97 binding By similarity
Region64 – 8219Calmodulin-binding By similarity
Region349 – 564216Interaction with CEP76 By similarity
Region773 – 81341Calmodulin-binding By similarity
Region901 – 91616Calmodulin-binding By similarity
Coiled coil51 – 9040 Potential
Coiled coil641 – 69959 Potential

Sequences

Sequence LengthMass (Da)Tools
Q7TSH4 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: C8D81F5F2FE213A8

FASTA1,004111,139
        10         20         30         40         50         60 
MEEYEEFCEK ALGRAQEASL STGSFLPAQA ESVSLIRFHG VAVLSPLLTI EKRKKIQEEK 

        70         80         90        100        110        120 
QKALDVQSRK QANRKKALLT RVQEILENVQ VRKAPNASDF DQWATETIYS NPEVTDLNVP 

       130        140        150        160        170        180 
VRVPNSLPSP TEHCTSVKLE KITGLLPVNN EDQQTPKRVG LPGDSEVSGS LRQCESPESR 

       190        200        210        220        230        240 
QAEDGAALRL SSASPQETII SDVLGKEEQD PSCLAEVTPD PYIMSLQNLM KRSKEYVERE 

       250        260        270        280        290        300 
LSSRSLRNSL KRSVNETHSD RENDAAKASD CVKEKAPPMP IGRHCGSAIP DKPSLNKSNV 

       310        320        330        340        350        360 
LLQGASQASS MGTAGLASFS KIDLPAGAAP PAAPDAGSDF TVIPTFVTEN KVKSLKGPYA 

       370        380        390        400        410        420 
KLPSPEPSMS PTMHRRHSRS ASACQILINN PVNACELSPK GKEEAVDRTA PAAAETTNES 

       430        440        450        460        470        480 
ETVPKSPTDL TGVCSSNVSA TKITSESTRE MVVGKPSQRQ QALGAHLGNN VTVERSAMEG 

       490        500        510        520        530        540 
PFIADDRGAQ KVDGTCMAVP KLHELQPSSQ CVSSQTLEDV CELKSASLLA KNSCNLQMEL 

       550        560        570        580        590        600 
NKSYDVKHPS PLLTQTQTSR QQMDTPPVFR GNEQFVDNSF EKVKRRLDLD VDSLQKENCP 

       610        620        630        640        650        660 
YIITAGVAEQ ERDRLLERRY PKGFVHINKN KMLETSPKEG QELLKSKMLA FEEMRKRLEE 

       670        680        690        700        710        720 
QHAQQLSLLI AEQEREQEQL QKEIEEQEKM LKEKAVTTDV SDLNSALEWR QRTDSALLET 

       730        740        750        760        770        780 
MLSQVDSLQT SNNSGFITSA LQYSFGSAGE APFYLWGSLT SGVTRVSGTR PCGRAQAKWS 

       790        800        810        820        830        840 
QVFNPEIHAK FNKITAVAKG FLTRKLMQTD KLKQLRQTVK DTMEFIRSFQ SEAPLKRGVV 

       850        860        870        880        890        900 
SAQDASLQER VLAQLRAALY GIHDIFFVMD AAERMSILHH DREARKEKLL RQMDKMKSPR 

       910        920        930        940        950        960 
VALSVATQKS LDRKKFMKVA EMGMPNKKFL LKQNPSETRV LQPNQGQNAP VHRLLSRQGT 

       970        980        990       1000 
PKTSVKGVVQ NRQKPSQSRV PNRAPVSGAY AGKTQRKRPN VATI 

« Hide

References

« Hide 'large scale' references
[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6.
Tissue: Brain.
[2]"Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 165-959.
Tissue: Embryonic intestine.
[3]"The spinocerebellar ataxia-associated gene tau tubulin kinase 2 controls the initiation of ciliogenesis."
Goetz S.C., Liem K.F. Jr., Anderson K.V.
Cell 151:847-858(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC053103 mRNA. Translation: AAH53103.1.
AK172946 mRNA. Translation: BAD32224.1.
CCDSCCDS21775.1.
RefSeqNP_892040.1. NM_182995.1.
UniGeneMm.23279.

3D structure databases

ProteinModelPortalQ7TSH4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid221690. 1 interaction.
IntActQ7TSH4. 5 interactions.
STRING10090.ENSMUSP00000102167.

PTM databases

PhosphoSiteQ7TSH4.

Proteomic databases

PaxDbQ7TSH4.
PRIDEQ7TSH4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000038650; ENSMUSP00000038881; ENSMUSG00000033904.
ENSMUST00000106557; ENSMUSP00000102167; ENSMUSG00000033904.
GeneID101565.
KEGGmmu:101565.
UCSCuc009jkj.1. mouse.

Organism-specific databases

CTD9738.
MGIMGI:2141942. Ccp110.
RougeSearch...

Phylogenomic databases

eggNOGNOG82086.
GeneTreeENSGT00390000004090.
HOVERGENHBG050873.
InParanoidQ7TSH4.
KOK16453.
OMAFYLWGSS.
OrthoDBEOG7SV0XP.
PhylomeDBQ7TSH4.
TreeFamTF332788.

Gene expression databases

ArrayExpressQ7TSH4.
BgeeQ7TSH4.
CleanExMM_6330503K22RIK.
MM_CEP110.
GenevestigatorQ7TSH4.

Family and domain databases

ProtoNetSearch...

Other

NextBio355018.
PROQ7TSH4.
SOURCESearch...

Entry information

Entry nameCP110_MOUSE
AccessionPrimary (citable) accession number: Q7TSH4
Secondary accession number(s): Q6A072
Entry history
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot