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Q7TSH4

- CP110_MOUSE

UniProt

Q7TSH4 - CP110_MOUSE

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Protein

Centriolar coiled-coil protein of 110 kDa

Gene

Ccp110

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Necessary for centrosome duplication at different stages of procentriole formation. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (By similarity). Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation.By similarity1 Publication

GO - Biological processi

  1. cell projection organization Source: UniProtKB-KW
  2. centriole replication Source: Ensembl
  3. centrosome duplication Source: UniProtKB
  4. regulation of cytokinesis Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cilium biogenesis/degradation

Enzyme and pathway databases

ReactomeiREACT_196635. Regulation of PLK1 Activity at G2/M Transition.

Names & Taxonomyi

Protein namesi
Recommended name:
Centriolar coiled-coil protein of 110 kDa
Alternative name(s):
Centrosomal protein of 110 kDa
Short name:
Cep110
Short name:
Cp110
Gene namesi
Name:Ccp110
Synonyms:Cep110, Cp110, Kiaa0419
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:2141942. Ccp110.

Subcellular locationi

Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole By similarity
Note: Recruited early and then associates with the growing distal tips. Recruited to the mother centriole by KIF24 (By similarity). Removed from centrioles by TTBK2, leading to initiation of ciliogenesis.By similarity1 Publication

GO - Cellular componenti

  1. centriole Source: UniProtKB
  2. centrosome Source: MGI
  3. protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10041004Centriolar coiled-coil protein of 110 kDaPRO_0000089461Add
BLAST

Post-translational modificationi

Phosphorylated by CDKs.By similarity
Ubiquitinated by the SCF(CCNF) during G2 phase, leading to its degradation by the proteasome and preventing centrosome reduplication. Deubiquitinated by USP33 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ7TSH4.
PaxDbiQ7TSH4.
PRIDEiQ7TSH4.

PTM databases

PhosphoSiteiQ7TSH4.

Expressioni

Gene expression databases

BgeeiQ7TSH4.
CleanExiMM_6330503K22RIK.
MM_CEP110.
ExpressionAtlasiQ7TSH4. baseline and differential.
GenevestigatoriQ7TSH4.

Interactioni

Subunit structurei

Interacts with CALM1, CETN2, CEP76 and CEP97. Interacts with NEURL4 and CCNF; these interactions are not mutually exclusive and both lead to CCP110 ubiquitination and proteasome-dependent degradation. Via its interaction with NEURL4, may indirectly interact with HERC2. Interacts with KIF24, leading to its recruitment to centrioles. Interacts with USP20 and USP33 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Calm3P622044EBI-646843,EBI-397460

Protein-protein interaction databases

BioGridi221690. 1 interaction.
IntActiQ7TSH4. 5 interactions.
STRINGi10090.ENSMUSP00000102167.

Structurei

3D structure databases

ProteinModelPortaliQ7TSH4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 221221CEP97 bindingBy similarityAdd
BLAST
Regioni64 – 8219Calmodulin-bindingBy similarityAdd
BLAST
Regioni349 – 564216Interaction with CEP76By similarityAdd
BLAST
Regioni773 – 81341Calmodulin-bindingBy similarityAdd
BLAST
Regioni901 – 91616Calmodulin-bindingBy similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili51 – 9040Sequence AnalysisAdd
BLAST
Coiled coili641 – 69959Sequence AnalysisAdd
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG82086.
GeneTreeiENSGT00390000004090.
HOVERGENiHBG050873.
InParanoidiQ7TSH4.
KOiK16453.
OMAiFYLWGSS.
OrthoDBiEOG7SV0XP.
PhylomeDBiQ7TSH4.
TreeFamiTF332788.

Sequencei

Sequence statusi: Complete.

Q7TSH4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEEYEEFCEK ALGRAQEASL STGSFLPAQA ESVSLIRFHG VAVLSPLLTI
60 70 80 90 100
EKRKKIQEEK QKALDVQSRK QANRKKALLT RVQEILENVQ VRKAPNASDF
110 120 130 140 150
DQWATETIYS NPEVTDLNVP VRVPNSLPSP TEHCTSVKLE KITGLLPVNN
160 170 180 190 200
EDQQTPKRVG LPGDSEVSGS LRQCESPESR QAEDGAALRL SSASPQETII
210 220 230 240 250
SDVLGKEEQD PSCLAEVTPD PYIMSLQNLM KRSKEYVERE LSSRSLRNSL
260 270 280 290 300
KRSVNETHSD RENDAAKASD CVKEKAPPMP IGRHCGSAIP DKPSLNKSNV
310 320 330 340 350
LLQGASQASS MGTAGLASFS KIDLPAGAAP PAAPDAGSDF TVIPTFVTEN
360 370 380 390 400
KVKSLKGPYA KLPSPEPSMS PTMHRRHSRS ASACQILINN PVNACELSPK
410 420 430 440 450
GKEEAVDRTA PAAAETTNES ETVPKSPTDL TGVCSSNVSA TKITSESTRE
460 470 480 490 500
MVVGKPSQRQ QALGAHLGNN VTVERSAMEG PFIADDRGAQ KVDGTCMAVP
510 520 530 540 550
KLHELQPSSQ CVSSQTLEDV CELKSASLLA KNSCNLQMEL NKSYDVKHPS
560 570 580 590 600
PLLTQTQTSR QQMDTPPVFR GNEQFVDNSF EKVKRRLDLD VDSLQKENCP
610 620 630 640 650
YIITAGVAEQ ERDRLLERRY PKGFVHINKN KMLETSPKEG QELLKSKMLA
660 670 680 690 700
FEEMRKRLEE QHAQQLSLLI AEQEREQEQL QKEIEEQEKM LKEKAVTTDV
710 720 730 740 750
SDLNSALEWR QRTDSALLET MLSQVDSLQT SNNSGFITSA LQYSFGSAGE
760 770 780 790 800
APFYLWGSLT SGVTRVSGTR PCGRAQAKWS QVFNPEIHAK FNKITAVAKG
810 820 830 840 850
FLTRKLMQTD KLKQLRQTVK DTMEFIRSFQ SEAPLKRGVV SAQDASLQER
860 870 880 890 900
VLAQLRAALY GIHDIFFVMD AAERMSILHH DREARKEKLL RQMDKMKSPR
910 920 930 940 950
VALSVATQKS LDRKKFMKVA EMGMPNKKFL LKQNPSETRV LQPNQGQNAP
960 970 980 990 1000
VHRLLSRQGT PKTSVKGVVQ NRQKPSQSRV PNRAPVSGAY AGKTQRKRPN

VATI
Length:1,004
Mass (Da):111,139
Last modified:October 1, 2003 - v1
Checksum:iC8D81F5F2FE213A8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC053103 mRNA. Translation: AAH53103.1.
AK172946 mRNA. Translation: BAD32224.1.
CCDSiCCDS21775.1.
RefSeqiNP_892040.1. NM_182995.1.
UniGeneiMm.23279.

Genome annotation databases

EnsembliENSMUST00000038650; ENSMUSP00000038881; ENSMUSG00000033904.
ENSMUST00000106557; ENSMUSP00000102167; ENSMUSG00000033904.
GeneIDi101565.
KEGGimmu:101565.
UCSCiuc009jkj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC053103 mRNA. Translation: AAH53103.1 .
AK172946 mRNA. Translation: BAD32224.1 .
CCDSi CCDS21775.1.
RefSeqi NP_892040.1. NM_182995.1.
UniGenei Mm.23279.

3D structure databases

ProteinModelPortali Q7TSH4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 221690. 1 interaction.
IntActi Q7TSH4. 5 interactions.
STRINGi 10090.ENSMUSP00000102167.

PTM databases

PhosphoSitei Q7TSH4.

Proteomic databases

MaxQBi Q7TSH4.
PaxDbi Q7TSH4.
PRIDEi Q7TSH4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000038650 ; ENSMUSP00000038881 ; ENSMUSG00000033904 .
ENSMUST00000106557 ; ENSMUSP00000102167 ; ENSMUSG00000033904 .
GeneIDi 101565.
KEGGi mmu:101565.
UCSCi uc009jkj.1. mouse.

Organism-specific databases

CTDi 9738.
MGIi MGI:2141942. Ccp110.
Rougei Search...

Phylogenomic databases

eggNOGi NOG82086.
GeneTreei ENSGT00390000004090.
HOVERGENi HBG050873.
InParanoidi Q7TSH4.
KOi K16453.
OMAi FYLWGSS.
OrthoDBi EOG7SV0XP.
PhylomeDBi Q7TSH4.
TreeFami TF332788.

Enzyme and pathway databases

Reactomei REACT_196635. Regulation of PLK1 Activity at G2/M Transition.

Miscellaneous databases

NextBioi 355018.
PROi Q7TSH4.
SOURCEi Search...

Gene expression databases

Bgeei Q7TSH4.
CleanExi MM_6330503K22RIK.
MM_CEP110.
ExpressionAtlasi Q7TSH4. baseline and differential.
Genevestigatori Q7TSH4.

Family and domain databases

ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
    DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 165-959.
    Tissue: Embryonic intestine.
  3. "The spinocerebellar ataxia-associated gene tau tubulin kinase 2 controls the initiation of ciliogenesis."
    Goetz S.C., Liem K.F. Jr., Anderson K.V.
    Cell 151:847-858(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiCP110_MOUSE
AccessioniPrimary (citable) accession number: Q7TSH4
Secondary accession number(s): Q6A072
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3