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Q7TSH4

- CP110_MOUSE

UniProt

Q7TSH4 - CP110_MOUSE

Protein

Centriolar coiled-coil protein of 110 kDa

Gene

Ccp110

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Necessary for centrosome duplication at different stages of procentriole formation. Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 By similarity. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation.By similarity1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. cell projection organization Source: UniProtKB-KW
    2. centriole replication Source: Ensembl
    3. centrosome duplication Source: UniProtKB
    4. regulation of cytokinesis Source: Ensembl

    Keywords - Biological processi

    Cilium biogenesis/degradation

    Enzyme and pathway databases

    ReactomeiREACT_196635. Regulation of PLK1 Activity at G2/M Transition.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Centriolar coiled-coil protein of 110 kDa
    Alternative name(s):
    Centrosomal protein of 110 kDa
    Short name:
    Cep110
    Short name:
    Cp110
    Gene namesi
    Name:Ccp110
    Synonyms:Cep110, Cp110, Kiaa0419
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:2141942. Ccp110.

    Subcellular locationi

    Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole By similarity
    Note: Recruited early and then associates with the growing distal tips. Recruited to the mother centriole by KIF24 By similarity. Removed from centrioles by TTBK2, leading to initiation of ciliogenesis.By similarity1 Publication

    GO - Cellular componenti

    1. centriole Source: UniProtKB
    2. protein complex Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10041004Centriolar coiled-coil protein of 110 kDaPRO_0000089461Add
    BLAST

    Post-translational modificationi

    Phosphorylated by CDKs.By similarity
    Ubiquitinated by the SCF(CCNF) during G2 phase, leading to its degradation by the proteasome and preventing centrosome reduplication. Deubiquitinated by USP33 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ7TSH4.
    PRIDEiQ7TSH4.

    PTM databases

    PhosphoSiteiQ7TSH4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ7TSH4.
    BgeeiQ7TSH4.
    CleanExiMM_6330503K22RIK.
    MM_CEP110.
    GenevestigatoriQ7TSH4.

    Interactioni

    Subunit structurei

    Interacts with CALM1, CETN2, CEP76 and CEP97. Interacts with NEURL4 and CCNF; these interactions are not mutually exclusive and both lead to CCP110 ubiquitination and proteasome-dependent degradation. Via its interaction with NEURL4, may indirectly interact with HERC2. Interacts with KIF24, leading to its recruitment to centrioles. Interacts with USP20 and USP33 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Calm3P622044EBI-646843,EBI-397460

    Protein-protein interaction databases

    BioGridi221690. 1 interaction.
    IntActiQ7TSH4. 5 interactions.
    STRINGi10090.ENSMUSP00000102167.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7TSH4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 221221CEP97 bindingBy similarityAdd
    BLAST
    Regioni64 – 8219Calmodulin-bindingBy similarityAdd
    BLAST
    Regioni349 – 564216Interaction with CEP76By similarityAdd
    BLAST
    Regioni773 – 81341Calmodulin-bindingBy similarityAdd
    BLAST
    Regioni901 – 91616Calmodulin-bindingBy similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili51 – 9040Sequence AnalysisAdd
    BLAST
    Coiled coili641 – 69959Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG82086.
    GeneTreeiENSGT00390000004090.
    HOVERGENiHBG050873.
    InParanoidiQ7TSH4.
    KOiK16453.
    OMAiFYLWGSS.
    OrthoDBiEOG7SV0XP.
    PhylomeDBiQ7TSH4.
    TreeFamiTF332788.

    Sequencei

    Sequence statusi: Complete.

    Q7TSH4-1 [UniParc]FASTAAdd to Basket

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    MEEYEEFCEK ALGRAQEASL STGSFLPAQA ESVSLIRFHG VAVLSPLLTI     50
    EKRKKIQEEK QKALDVQSRK QANRKKALLT RVQEILENVQ VRKAPNASDF 100
    DQWATETIYS NPEVTDLNVP VRVPNSLPSP TEHCTSVKLE KITGLLPVNN 150
    EDQQTPKRVG LPGDSEVSGS LRQCESPESR QAEDGAALRL SSASPQETII 200
    SDVLGKEEQD PSCLAEVTPD PYIMSLQNLM KRSKEYVERE LSSRSLRNSL 250
    KRSVNETHSD RENDAAKASD CVKEKAPPMP IGRHCGSAIP DKPSLNKSNV 300
    LLQGASQASS MGTAGLASFS KIDLPAGAAP PAAPDAGSDF TVIPTFVTEN 350
    KVKSLKGPYA KLPSPEPSMS PTMHRRHSRS ASACQILINN PVNACELSPK 400
    GKEEAVDRTA PAAAETTNES ETVPKSPTDL TGVCSSNVSA TKITSESTRE 450
    MVVGKPSQRQ QALGAHLGNN VTVERSAMEG PFIADDRGAQ KVDGTCMAVP 500
    KLHELQPSSQ CVSSQTLEDV CELKSASLLA KNSCNLQMEL NKSYDVKHPS 550
    PLLTQTQTSR QQMDTPPVFR GNEQFVDNSF EKVKRRLDLD VDSLQKENCP 600
    YIITAGVAEQ ERDRLLERRY PKGFVHINKN KMLETSPKEG QELLKSKMLA 650
    FEEMRKRLEE QHAQQLSLLI AEQEREQEQL QKEIEEQEKM LKEKAVTTDV 700
    SDLNSALEWR QRTDSALLET MLSQVDSLQT SNNSGFITSA LQYSFGSAGE 750
    APFYLWGSLT SGVTRVSGTR PCGRAQAKWS QVFNPEIHAK FNKITAVAKG 800
    FLTRKLMQTD KLKQLRQTVK DTMEFIRSFQ SEAPLKRGVV SAQDASLQER 850
    VLAQLRAALY GIHDIFFVMD AAERMSILHH DREARKEKLL RQMDKMKSPR 900
    VALSVATQKS LDRKKFMKVA EMGMPNKKFL LKQNPSETRV LQPNQGQNAP 950
    VHRLLSRQGT PKTSVKGVVQ NRQKPSQSRV PNRAPVSGAY AGKTQRKRPN 1000
    VATI 1004
    Length:1,004
    Mass (Da):111,139
    Last modified:October 1, 2003 - v1
    Checksum:iC8D81F5F2FE213A8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC053103 mRNA. Translation: AAH53103.1.
    AK172946 mRNA. Translation: BAD32224.1.
    CCDSiCCDS21775.1.
    RefSeqiNP_892040.1. NM_182995.1.
    UniGeneiMm.23279.

    Genome annotation databases

    EnsembliENSMUST00000038650; ENSMUSP00000038881; ENSMUSG00000033904.
    ENSMUST00000106557; ENSMUSP00000102167; ENSMUSG00000033904.
    GeneIDi101565.
    KEGGimmu:101565.
    UCSCiuc009jkj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC053103 mRNA. Translation: AAH53103.1 .
    AK172946 mRNA. Translation: BAD32224.1 .
    CCDSi CCDS21775.1.
    RefSeqi NP_892040.1. NM_182995.1.
    UniGenei Mm.23279.

    3D structure databases

    ProteinModelPortali Q7TSH4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 221690. 1 interaction.
    IntActi Q7TSH4. 5 interactions.
    STRINGi 10090.ENSMUSP00000102167.

    PTM databases

    PhosphoSitei Q7TSH4.

    Proteomic databases

    PaxDbi Q7TSH4.
    PRIDEi Q7TSH4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000038650 ; ENSMUSP00000038881 ; ENSMUSG00000033904 .
    ENSMUST00000106557 ; ENSMUSP00000102167 ; ENSMUSG00000033904 .
    GeneIDi 101565.
    KEGGi mmu:101565.
    UCSCi uc009jkj.1. mouse.

    Organism-specific databases

    CTDi 9738.
    MGIi MGI:2141942. Ccp110.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG82086.
    GeneTreei ENSGT00390000004090.
    HOVERGENi HBG050873.
    InParanoidi Q7TSH4.
    KOi K16453.
    OMAi FYLWGSS.
    OrthoDBi EOG7SV0XP.
    PhylomeDBi Q7TSH4.
    TreeFami TF332788.

    Enzyme and pathway databases

    Reactomei REACT_196635. Regulation of PLK1 Activity at G2/M Transition.

    Miscellaneous databases

    NextBioi 355018.
    PROi Q7TSH4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7TSH4.
    Bgeei Q7TSH4.
    CleanExi MM_6330503K22RIK.
    MM_CEP110.
    Genevestigatori Q7TSH4.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    2. "Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S., Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H., Nagase T., Ohara O., Koga H.
      DNA Res. 11:205-218(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 165-959.
      Tissue: Embryonic intestine.
    3. "The spinocerebellar ataxia-associated gene tau tubulin kinase 2 controls the initiation of ciliogenesis."
      Goetz S.C., Liem K.F. Jr., Anderson K.V.
      Cell 151:847-858(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiCP110_MOUSE
    AccessioniPrimary (citable) accession number: Q7TSH4
    Secondary accession number(s): Q6A072
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 23, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3