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Protein

Centriolar coiled-coil protein of 110 kDa

Gene

Ccp110

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed:23141541). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (PubMed:26965371). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (By similarity).By similarity2 Publications

GO - Biological processi

  • centriole replication Source: MGI
  • centrosome duplication Source: UniProtKB
  • ciliary basal body organization Source: UniProtKB
  • negative regulation of cilium assembly Source: UniProtKB
  • positive regulation of cilium assembly Source: UniProtKB
  • regulation of cytokinesis Source: MGI

Keywordsi

Biological processCilium biogenesis/degradation

Enzyme and pathway databases

ReactomeiR-MMU-2565942 Regulation of PLK1 Activity at G2/M Transition
R-MMU-380259 Loss of Nlp from mitotic centrosomes
R-MMU-380270 Recruitment of mitotic centrosome proteins and complexes
R-MMU-380320 Recruitment of NuMA to mitotic centrosomes
R-MMU-5620912 Anchoring of the basal body to the plasma membrane
R-MMU-5689880 Ub-specific processing proteases
R-MMU-8854518 AURKA Activation by TPX2

Names & Taxonomyi

Protein namesi
Recommended name:
Centriolar coiled-coil protein of 110 kDa
Alternative name(s):
Centrosomal protein of 110 kDa
Short name:
Cep110
Short name:
Cp110
Gene namesi
Name:Ccp110
Synonyms:Cep110, Cp110, Kiaa0419
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2141942 Ccp110

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

Pathology & Biotechi

Disruption phenotypei

Lethal within a few hours after birth with multiple defects in organogenesis. Mice show an early block in cilia formation and a phenotype reminiscent of human short rib-polydactyly syndrome.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000894611 – 1004Centriolar coiled-coil protein of 110 kDaAdd BLAST1004

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei170PhosphoserineBy similarity1
Modified residuei364PhosphoserineCombined sources1
Modified residuei370PhosphoserineBy similarity1
Modified residuei398PhosphoserineCombined sources1
Modified residuei550PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylated by CDKs.By similarity
Ubiquitinated by the SCF(CCNF) during G2 phase, leading to its degradation by the proteasome and preventing centrosome reduplication. Deubiquitinated by USP33 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ7TSH4
MaxQBiQ7TSH4
PaxDbiQ7TSH4
PRIDEiQ7TSH4

PTM databases

iPTMnetiQ7TSH4
PhosphoSitePlusiQ7TSH4

Expressioni

Gene expression databases

BgeeiENSMUSG00000033904
CleanExiMM_6330503K22RIK
MM_CEP110
ExpressionAtlasiQ7TSH4 baseline and differential
GenevisibleiQ7TSH4 MM

Interactioni

Subunit structurei

Interacts with CALM1, CETN2, CEP76, CEP97, CEP104, CEP290, TALPID3. Seems to associate with discrete CETN2, CEP97 and CEP290-containing complexes. Interacts with NEURL4 and CCNF; these interactions are not mutually exclusive and both lead to CCP110 ubiquitination and proteasome-dependent degradation. Via its interaction with NEURL4, may indirectly interact with HERC2. Interacts with KIF24, leading to its recruitment to centrioles. Interacts with USP20 and USP33 (By similarity).By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi221690, 8 interactors
CORUMiQ7TSH4
IntActiQ7TSH4, 14 interactors
STRINGi10090.ENSMUSP00000038881

Structurei

3D structure databases

ProteinModelPortaliQ7TSH4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 221CEP97 bindingBy similarityAdd BLAST221
Regioni64 – 82Calmodulin-bindingBy similarityAdd BLAST19
Regioni67 – 82Required for interaction with CEP290By similarityAdd BLAST16
Regioni349 – 564Interaction with CEP76By similarityAdd BLAST216
Regioni773 – 813Calmodulin-bindingBy similarityAdd BLAST41
Regioni901 – 916Calmodulin-bindingBy similarityAdd BLAST16

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili51 – 90Sequence analysisAdd BLAST40
Coiled coili641 – 699Sequence analysisAdd BLAST59

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IF00 Eukaryota
ENOG410XP98 LUCA
GeneTreeiENSGT00390000004090
HOVERGENiHBG050873
InParanoidiQ7TSH4
KOiK16453
OMAiPSMSPKM
OrthoDBiEOG091G0NCE
PhylomeDBiQ7TSH4
TreeFamiTF332788

Family and domain databases

InterProiView protein in InterPro
IPR033207 CCP110
PANTHERiPTHR13594 PTHR13594, 1 hit

Sequencei

Sequence statusi: Complete.

Q7TSH4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEYEEFCEK ALGRAQEASL STGSFLPAQA ESVSLIRFHG VAVLSPLLTI
60 70 80 90 100
EKRKKIQEEK QKALDVQSRK QANRKKALLT RVQEILENVQ VRKAPNASDF
110 120 130 140 150
DQWATETIYS NPEVTDLNVP VRVPNSLPSP TEHCTSVKLE KITGLLPVNN
160 170 180 190 200
EDQQTPKRVG LPGDSEVSGS LRQCESPESR QAEDGAALRL SSASPQETII
210 220 230 240 250
SDVLGKEEQD PSCLAEVTPD PYIMSLQNLM KRSKEYVERE LSSRSLRNSL
260 270 280 290 300
KRSVNETHSD RENDAAKASD CVKEKAPPMP IGRHCGSAIP DKPSLNKSNV
310 320 330 340 350
LLQGASQASS MGTAGLASFS KIDLPAGAAP PAAPDAGSDF TVIPTFVTEN
360 370 380 390 400
KVKSLKGPYA KLPSPEPSMS PTMHRRHSRS ASACQILINN PVNACELSPK
410 420 430 440 450
GKEEAVDRTA PAAAETTNES ETVPKSPTDL TGVCSSNVSA TKITSESTRE
460 470 480 490 500
MVVGKPSQRQ QALGAHLGNN VTVERSAMEG PFIADDRGAQ KVDGTCMAVP
510 520 530 540 550
KLHELQPSSQ CVSSQTLEDV CELKSASLLA KNSCNLQMEL NKSYDVKHPS
560 570 580 590 600
PLLTQTQTSR QQMDTPPVFR GNEQFVDNSF EKVKRRLDLD VDSLQKENCP
610 620 630 640 650
YIITAGVAEQ ERDRLLERRY PKGFVHINKN KMLETSPKEG QELLKSKMLA
660 670 680 690 700
FEEMRKRLEE QHAQQLSLLI AEQEREQEQL QKEIEEQEKM LKEKAVTTDV
710 720 730 740 750
SDLNSALEWR QRTDSALLET MLSQVDSLQT SNNSGFITSA LQYSFGSAGE
760 770 780 790 800
APFYLWGSLT SGVTRVSGTR PCGRAQAKWS QVFNPEIHAK FNKITAVAKG
810 820 830 840 850
FLTRKLMQTD KLKQLRQTVK DTMEFIRSFQ SEAPLKRGVV SAQDASLQER
860 870 880 890 900
VLAQLRAALY GIHDIFFVMD AAERMSILHH DREARKEKLL RQMDKMKSPR
910 920 930 940 950
VALSVATQKS LDRKKFMKVA EMGMPNKKFL LKQNPSETRV LQPNQGQNAP
960 970 980 990 1000
VHRLLSRQGT PKTSVKGVVQ NRQKPSQSRV PNRAPVSGAY AGKTQRKRPN

VATI
Length:1,004
Mass (Da):111,139
Last modified:October 1, 2003 - v1
Checksum:iC8D81F5F2FE213A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC053103 mRNA Translation: AAH53103.1
AK172946 mRNA Translation: BAD32224.1
CCDSiCCDS21775.1
RefSeqiNP_892040.1, NM_182995.1
UniGeneiMm.23279

Genome annotation databases

EnsembliENSMUST00000038650; ENSMUSP00000038881; ENSMUSG00000033904
ENSMUST00000106557; ENSMUSP00000102167; ENSMUSG00000033904
GeneIDi101565
KEGGimmu:101565
UCSCiuc009jkj.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCP110_MOUSE
AccessioniPrimary (citable) accession number: Q7TSH4
Secondary accession number(s): Q6A072
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: October 1, 2003
Last modified: April 25, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health