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Q7TSH2

- KPBB_MOUSE

UniProt

Q7TSH2 - KPBB_MOUSE

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Protein

Phosphorylase b kinase regulatory subunit beta

Gene
Phkb
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The beta chain acts as a regulatory unit and modulates the activity of the holoenzyme in response to phosphorylation By similarity.

Enzyme regulationi

By phosphorylation of various serine residues By similarity.

Pathwayi

GO - Molecular functioni

  1. hydrolase activity, hydrolyzing O-glycosyl compounds Source: InterPro
  2. phosphorylase kinase activity Source: Ensembl

GO - Biological processi

  1. glycogen metabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Biological processi

Carbohydrate metabolism, Glycogen metabolism

Keywords - Ligandi

Calmodulin-binding

Enzyme and pathway databases

UniPathwayiUPA00163.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphorylase b kinase regulatory subunit beta
Short name:
Phosphorylase kinase subunit beta
Gene namesi
Name:Phkb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 8

Organism-specific databases

MGIiMGI:97578. Phkb.

Subcellular locationi

GO - Cellular componenti

  1. phosphorylase kinase complex Source: Ensembl
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10851085Phosphorylase b kinase regulatory subunit betaPRO_0000057737Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei10 – 101Phosphoserine By similarity
Modified residuei19 – 191Phosphoserine By similarity
Modified residuei693 – 6931Phosphoserine By similarity
Lipidationi1082 – 10821S-farnesyl cysteine By similarity

Post-translational modificationi

Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated By similarity.

Keywords - PTMi

Lipoprotein, Phosphoprotein, Prenylation

Proteomic databases

MaxQBiQ7TSH2.
PaxDbiQ7TSH2.
PRIDEiQ7TSH2.

PTM databases

PhosphoSiteiQ7TSH2.

Expressioni

Gene expression databases

ArrayExpressiQ7TSH2.
BgeeiQ7TSH2.
CleanExiMM_PHKB.
GenevestigatoriQ7TSH2.

Interactioni

Subunit structurei

Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin By similarity.

Protein-protein interaction databases

BioGridi221792. 1 interaction.
IntActiQ7TSH2. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ7TSH2.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni760 – 78728Calmodulin-binding Reviewed predictionAdd
BLAST
Regioni912 – 94332Calmodulin-binding Reviewed predictionAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG82518.
GeneTreeiENSGT00520000055553.
HOGENOMiHOG000231477.
HOVERGENiHBG097309.
InParanoidiQ7TSH2.
KOiK07190.
OMAiLKGKYGF.
OrthoDBiEOG73Z2SM.
PhylomeDBiQ7TSH2.
TreeFamiTF313970.

Family and domain databases

InterProiIPR008928. 6-hairpin_glycosidase-like.
IPR011613. Glyco_hydro_15.
IPR008734. PHK_A/B_su.
[Graphical view]
PANTHERiPTHR10749. PTHR10749. 1 hit.
PfamiPF00723. Glyco_hydro_15. 1 hit.
[Graphical view]
SUPFAMiSSF48208. SSF48208. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7TSH2-1 [UniParc]FASTAAdd to Basket

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MANSPDAAFS SPALLRSGSV YEPLKSINLP RPDNETLWDK LDHYYRIVKS     50
TMLMYQSPTT GLFPTKTCGG EEKSKVHESL YCAAGAWALA LAYRRIDDDK 100
GRTHELEHSA IKCMRGILYC YMRQADKVQQ FKQDPRPTTC LHSVFSVHTG 150
DELLSYEEYG HLQINAVSLF LLYLVEMISS GLQIIYNTDE VSFIQNLVFC 200
VERVYRVPDF GVWERGSKYN NGSTELHSSS VGLAKAALEA INGFNLFGNQ 250
GCSWSVIFVD LDAHNRNRQT LCSLLPRESR SHNTDAALLP CISYPAFALD 300
DEALFSQTLD KVIRKLKGKY GFKRFLRDGY RTPLEDPNRR YYKPAEIKLF 350
DGIECEFPIF FLYMMIDGVF RGNLEQVKEY QDLLTPLLHQ TTEGYPVVPK 400
YYYVPADFVE CEKRNPGSQK RFPSNCGRDG KLFLWGQALY IIAKLLADEL 450
ISPKDIDPVQ RFVPLQNQRN VSMRYSNQGP LENDLVVHVA LVAESQRLQV 500
FLNTYGIQTQ TPQQVEPIQI WPQQELVKAY FHLGINEKLG LSGRPDRPIG 550
CLGTSKIYRI LGKTVVCYPI IFDLSDFYMS QDVLLLIDDI KNALQFIKQY 600
WKMHGRPLFL VLIREDNIRG SRFNPILDML AAFKKGIIGG VKVHVDRLQT 650
LISGAVVEQL DFLRISDTEK LPEFKSFEEL EFPKHSKVKR QSSTADAPEA 700
QHEPGITITE WKNKSTHEIL QKLNDCGCLA GQTILLGILL KREGPNFITM 750
EGTVSDHIER VYRRAGSKKL WSVVRRAASL LNKVVDSLAP SITNVLVQGK 800
QVTLGAFGHE EEVISNPLSP RVIKNIIYYK CNTHDEREAV IQQELVIHIG 850
WIISNSPELF SGMLKIRIGW IIHAMEYELQ VRGGDKPAVD LYQLSPSEVK 900
QLLLDILQPQ QSGRCWLNRR QIDGSLNRTP PEFYDRVWQI LERTPNGIVV 950
AGKHLPQQPT LSDMTMYEMN FSLLVEDMLG NIDQPKYRQI IVELLMVVSI 1000
VLERNPELEF QDKVDLDRLV KEAFHEFQKD ESRLKEIEKQ DDMTSFYNTP 1050
PLGKRGTCSY LTKVVMNSLL EGEVKPSNED SCLVS 1085
Length:1,085
Mass (Da):123,889
Last modified:October 1, 2003 - v1
Checksum:i8EC52645AD89FDF5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC053105 mRNA. Translation: AAH53105.1.
CCDSiCCDS22501.1.
RefSeqiNP_955517.1. NM_199446.1.
XP_006530595.1. XM_006530532.1.
XP_006530596.1. XM_006530533.1.
XP_006530597.1. XM_006530534.1.
UniGeneiMm.237296.

Genome annotation databases

EnsembliENSMUST00000053771; ENSMUSP00000050788; ENSMUSG00000036879.
GeneIDi102093.
KEGGimmu:102093.
UCSCiuc009mqj.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BC053105 mRNA. Translation: AAH53105.1 .
CCDSi CCDS22501.1.
RefSeqi NP_955517.1. NM_199446.1.
XP_006530595.1. XM_006530532.1.
XP_006530596.1. XM_006530533.1.
XP_006530597.1. XM_006530534.1.
UniGenei Mm.237296.

3D structure databases

ProteinModelPortali Q7TSH2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 221792. 1 interaction.
IntActi Q7TSH2. 1 interaction.

PTM databases

PhosphoSitei Q7TSH2.

Proteomic databases

MaxQBi Q7TSH2.
PaxDbi Q7TSH2.
PRIDEi Q7TSH2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000053771 ; ENSMUSP00000050788 ; ENSMUSG00000036879 .
GeneIDi 102093.
KEGGi mmu:102093.
UCSCi uc009mqj.1. mouse.

Organism-specific databases

CTDi 5257.
MGIi MGI:97578. Phkb.

Phylogenomic databases

eggNOGi NOG82518.
GeneTreei ENSGT00520000055553.
HOGENOMi HOG000231477.
HOVERGENi HBG097309.
InParanoidi Q7TSH2.
KOi K07190.
OMAi LKGKYGF.
OrthoDBi EOG73Z2SM.
PhylomeDBi Q7TSH2.
TreeFami TF313970.

Enzyme and pathway databases

UniPathwayi UPA00163 .

Miscellaneous databases

NextBioi 355270.
PROi Q7TSH2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q7TSH2.
Bgeei Q7TSH2.
CleanExi MM_PHKB.
Genevestigatori Q7TSH2.

Family and domain databases

InterProi IPR008928. 6-hairpin_glycosidase-like.
IPR011613. Glyco_hydro_15.
IPR008734. PHK_A/B_su.
[Graphical view ]
PANTHERi PTHR10749. PTHR10749. 1 hit.
Pfami PF00723. Glyco_hydro_15. 1 hit.
[Graphical view ]
SUPFAMi SSF48208. SSF48208. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6.
    Tissue: Brain.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiKPBB_MOUSE
AccessioniPrimary (citable) accession number: Q7TSH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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