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Q7TSH2

- KPBB_MOUSE

UniProt

Q7TSH2 - KPBB_MOUSE

Protein

Phosphorylase b kinase regulatory subunit beta

Gene

Phkb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The beta chain acts as a regulatory unit and modulates the activity of the holoenzyme in response to phosphorylation By similarity.By similarity

    Enzyme regulationi

    By phosphorylation of various serine residues.By similarity

    Pathwayi

    GO - Molecular functioni

    1. hydrolase activity, hydrolyzing O-glycosyl compounds Source: InterPro
    2. phosphorylase kinase activity Source: Ensembl

    GO - Biological processi

    1. glycogen metabolic process Source: UniProtKB-UniPathway

    Keywords - Biological processi

    Carbohydrate metabolism, Glycogen metabolism

    Keywords - Ligandi

    Calmodulin-binding

    Enzyme and pathway databases

    UniPathwayiUPA00163.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphorylase b kinase regulatory subunit beta
    Short name:
    Phosphorylase kinase subunit beta
    Gene namesi
    Name:Phkb
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 8

    Organism-specific databases

    MGIiMGI:97578. Phkb.

    Subcellular locationi

    Cell membrane Curated; Lipid-anchor Curated; Cytoplasmic side Curated

    GO - Cellular componenti

    1. phosphorylase kinase complex Source: Ensembl
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10851085Phosphorylase b kinase regulatory subunit betaPRO_0000057737Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei10 – 101PhosphoserineBy similarity
    Modified residuei19 – 191PhosphoserineBy similarity
    Modified residuei693 – 6931PhosphoserineBy similarity
    Lipidationi1082 – 10821S-farnesyl cysteineBy similarity

    Post-translational modificationi

    Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.By similarity

    Keywords - PTMi

    Lipoprotein, Phosphoprotein, Prenylation

    Proteomic databases

    MaxQBiQ7TSH2.
    PaxDbiQ7TSH2.
    PRIDEiQ7TSH2.

    PTM databases

    PhosphoSiteiQ7TSH2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ7TSH2.
    BgeeiQ7TSH2.
    CleanExiMM_PHKB.
    GenevestigatoriQ7TSH2.

    Interactioni

    Subunit structurei

    Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin By similarity.By similarity

    Protein-protein interaction databases

    BioGridi221792. 1 interaction.
    IntActiQ7TSH2. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7TSH2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni760 – 78728Calmodulin-bindingSequence AnalysisAdd
    BLAST
    Regioni912 – 94332Calmodulin-bindingSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG82518.
    GeneTreeiENSGT00520000055553.
    HOGENOMiHOG000231477.
    HOVERGENiHBG097309.
    InParanoidiQ7TSH2.
    KOiK07190.
    OMAiLKGKYGF.
    OrthoDBiEOG73Z2SM.
    PhylomeDBiQ7TSH2.
    TreeFamiTF313970.

    Family and domain databases

    InterProiIPR008928. 6-hairpin_glycosidase-like.
    IPR011613. Glyco_hydro_15.
    IPR008734. PHK_A/B_su.
    [Graphical view]
    PANTHERiPTHR10749. PTHR10749. 1 hit.
    PfamiPF00723. Glyco_hydro_15. 1 hit.
    [Graphical view]
    SUPFAMiSSF48208. SSF48208. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q7TSH2-1 [UniParc]FASTAAdd to Basket

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    MANSPDAAFS SPALLRSGSV YEPLKSINLP RPDNETLWDK LDHYYRIVKS     50
    TMLMYQSPTT GLFPTKTCGG EEKSKVHESL YCAAGAWALA LAYRRIDDDK 100
    GRTHELEHSA IKCMRGILYC YMRQADKVQQ FKQDPRPTTC LHSVFSVHTG 150
    DELLSYEEYG HLQINAVSLF LLYLVEMISS GLQIIYNTDE VSFIQNLVFC 200
    VERVYRVPDF GVWERGSKYN NGSTELHSSS VGLAKAALEA INGFNLFGNQ 250
    GCSWSVIFVD LDAHNRNRQT LCSLLPRESR SHNTDAALLP CISYPAFALD 300
    DEALFSQTLD KVIRKLKGKY GFKRFLRDGY RTPLEDPNRR YYKPAEIKLF 350
    DGIECEFPIF FLYMMIDGVF RGNLEQVKEY QDLLTPLLHQ TTEGYPVVPK 400
    YYYVPADFVE CEKRNPGSQK RFPSNCGRDG KLFLWGQALY IIAKLLADEL 450
    ISPKDIDPVQ RFVPLQNQRN VSMRYSNQGP LENDLVVHVA LVAESQRLQV 500
    FLNTYGIQTQ TPQQVEPIQI WPQQELVKAY FHLGINEKLG LSGRPDRPIG 550
    CLGTSKIYRI LGKTVVCYPI IFDLSDFYMS QDVLLLIDDI KNALQFIKQY 600
    WKMHGRPLFL VLIREDNIRG SRFNPILDML AAFKKGIIGG VKVHVDRLQT 650
    LISGAVVEQL DFLRISDTEK LPEFKSFEEL EFPKHSKVKR QSSTADAPEA 700
    QHEPGITITE WKNKSTHEIL QKLNDCGCLA GQTILLGILL KREGPNFITM 750
    EGTVSDHIER VYRRAGSKKL WSVVRRAASL LNKVVDSLAP SITNVLVQGK 800
    QVTLGAFGHE EEVISNPLSP RVIKNIIYYK CNTHDEREAV IQQELVIHIG 850
    WIISNSPELF SGMLKIRIGW IIHAMEYELQ VRGGDKPAVD LYQLSPSEVK 900
    QLLLDILQPQ QSGRCWLNRR QIDGSLNRTP PEFYDRVWQI LERTPNGIVV 950
    AGKHLPQQPT LSDMTMYEMN FSLLVEDMLG NIDQPKYRQI IVELLMVVSI 1000
    VLERNPELEF QDKVDLDRLV KEAFHEFQKD ESRLKEIEKQ DDMTSFYNTP 1050
    PLGKRGTCSY LTKVVMNSLL EGEVKPSNED SCLVS 1085
    Length:1,085
    Mass (Da):123,889
    Last modified:October 1, 2003 - v1
    Checksum:i8EC52645AD89FDF5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC053105 mRNA. Translation: AAH53105.1.
    CCDSiCCDS22501.1.
    RefSeqiNP_955517.1. NM_199446.1.
    XP_006530595.1. XM_006530532.1.
    XP_006530596.1. XM_006530533.1.
    XP_006530597.1. XM_006530534.1.
    UniGeneiMm.237296.

    Genome annotation databases

    EnsembliENSMUST00000053771; ENSMUSP00000050788; ENSMUSG00000036879.
    GeneIDi102093.
    KEGGimmu:102093.
    UCSCiuc009mqj.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC053105 mRNA. Translation: AAH53105.1 .
    CCDSi CCDS22501.1.
    RefSeqi NP_955517.1. NM_199446.1.
    XP_006530595.1. XM_006530532.1.
    XP_006530596.1. XM_006530533.1.
    XP_006530597.1. XM_006530534.1.
    UniGenei Mm.237296.

    3D structure databases

    ProteinModelPortali Q7TSH2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 221792. 1 interaction.
    IntActi Q7TSH2. 1 interaction.

    PTM databases

    PhosphoSitei Q7TSH2.

    Proteomic databases

    MaxQBi Q7TSH2.
    PaxDbi Q7TSH2.
    PRIDEi Q7TSH2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000053771 ; ENSMUSP00000050788 ; ENSMUSG00000036879 .
    GeneIDi 102093.
    KEGGi mmu:102093.
    UCSCi uc009mqj.1. mouse.

    Organism-specific databases

    CTDi 5257.
    MGIi MGI:97578. Phkb.

    Phylogenomic databases

    eggNOGi NOG82518.
    GeneTreei ENSGT00520000055553.
    HOGENOMi HOG000231477.
    HOVERGENi HBG097309.
    InParanoidi Q7TSH2.
    KOi K07190.
    OMAi LKGKYGF.
    OrthoDBi EOG73Z2SM.
    PhylomeDBi Q7TSH2.
    TreeFami TF313970.

    Enzyme and pathway databases

    UniPathwayi UPA00163 .

    Miscellaneous databases

    NextBioi 355270.
    PROi Q7TSH2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7TSH2.
    Bgeei Q7TSH2.
    CleanExi MM_PHKB.
    Genevestigatori Q7TSH2.

    Family and domain databases

    InterProi IPR008928. 6-hairpin_glycosidase-like.
    IPR011613. Glyco_hydro_15.
    IPR008734. PHK_A/B_su.
    [Graphical view ]
    PANTHERi PTHR10749. PTHR10749. 1 hit.
    Pfami PF00723. Glyco_hydro_15. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48208. SSF48208. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6.
      Tissue: Brain.
    2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.

    Entry informationi

    Entry nameiKPBB_MOUSE
    AccessioniPrimary (citable) accession number: Q7TSH2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3