Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q7TSG2

- CTDP1_MOUSE

UniProt

Q7TSG2 - CTDP1_MOUSE

Protein

RNA polymerase II subunit A C-terminal domain phosphatase

Gene

Ctdp1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation By similarity.By similarity

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    GO - Molecular functioni

    1. CTD phosphatase activity Source: Ensembl
    2. protein binding Source: MGI

    GO - Biological processi

    1. exit from mitosis Source: UniProtKB
    2. protein dephosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Enzyme and pathway databases

    ReactomeiREACT_203462. Formation of the Early Elongation Complex.
    REACT_226490. RNA Polymerase II Transcription Elongation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    RNA polymerase II subunit A C-terminal domain phosphatase (EC:3.1.3.16)
    Alternative name(s):
    TFIIF-associating CTD phosphatase
    Gene namesi
    Name:Ctdp1
    Synonyms:Fcp1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:1926953. Ctdp1.

    Subcellular locationi

    Nucleus By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosome By similarity. Cytoplasmcytoskeletonspindle By similarity. Cytoplasmcytoskeletonspindle pole By similarity. Midbody By similarity
    Note: Found at centrosomes in prometaphase, at spindle and spindle poles in metaphase and at spindle midzone and midbody in anaphase and telophase-G1 respectively.By similarity

    GO - Cellular componenti

    1. actin cytoskeleton Source: Ensembl
    2. centrosome Source: UniProtKB
    3. cytoplasm Source: UniProtKB-KW
    4. midbody Source: UniProtKB
    5. nucleus Source: UniProtKB-SubCell
    6. spindle Source: UniProtKB
    7. spindle midzone Source: UniProtKB
    8. spindle pole Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 960960RNA polymerase II subunit A C-terminal domain phosphatasePRO_0000212565Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity
    Modified residuei664 – 6641PhosphoserineBy similarity
    Modified residuei730 – 7301Phosphoserine1 Publication
    Modified residuei770 – 7701N6-acetyllysine1 Publication
    Modified residuei860 – 8601PhosphoserineBy similarity
    Modified residuei863 – 8631PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylated. In the presence of TFIIF, the phosphorylated form has an increased CTD phosphatase activity. The phosphorylation is required for the physical interaction with GTF2F1 By similarity.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ7TSG2.
    PaxDbiQ7TSG2.
    PRIDEiQ7TSG2.

    PTM databases

    PhosphoSiteiQ7TSG2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ7TSG2.
    BgeeiQ7TSG2.
    GenevestigatoriQ7TSG2.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with GTF2F1 By similarity. Interacts with WDR77, SNRPB and SNRNP70 By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ7TSG2.
    SMRiQ7TSG2. Positions 168-370, 547-718.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini178 – 341164FCP1 homologyPROSITE-ProRule annotationAdd
    BLAST
    Domaini619 – 718100BRCTPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi414 – 4174Poly-Ser
    Compositional biasi568 – 5725Poly-Glu
    Compositional biasi573 – 5786Poly-Asp

    Sequence similaritiesi

    Contains 1 BRCT domain.PROSITE-ProRule annotation
    Contains 1 FCP1 homology domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG5190.
    GeneTreeiENSGT00390000015641.
    HOGENOMiHOG000112039.
    HOVERGENiHBG051213.
    InParanoidiQ7TSG2.
    KOiK15732.
    OMAiEAPDIRK.
    OrthoDBiEOG7WMCJ8.
    PhylomeDBiQ7TSG2.
    TreeFamiTF315104.

    Family and domain databases

    Gene3Di3.40.50.1000. 2 hits.
    3.40.50.10190. 1 hit.
    InterProiIPR001357. BRCT_dom.
    IPR015388. FCP1_C.
    IPR011947. FCP1_euk.
    IPR023214. HAD-like_dom.
    IPR004274. NIF.
    IPR011053. Single_hybrid_motif.
    [Graphical view]
    PfamiPF09309. FCP1_C. 1 hit.
    PF03031. NIF. 1 hit.
    PF12738. PTCB-BRCT. 1 hit.
    [Graphical view]
    SMARTiSM00292. BRCT. 1 hit.
    SM00577. CPDc. 1 hit.
    [Graphical view]
    SUPFAMiSSF51230. SSF51230. 1 hit.
    SSF52113. SSF52113. 1 hit.
    SSF56784. SSF56784. 1 hit.
    TIGRFAMsiTIGR02250. FCP1_euk. 1 hit.
    PROSITEiPS50172. BRCT. 1 hit.
    PS50969. FCP1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7TSG2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEAPPAAGVP TECTPAVAGA EVRCPGPTPL RLLEWKVAAG ATVRIGSVLA    50
    VCETAASAQP AGPAPARAAS GGCVRAARTE RRLRSERAGV VRELCAQPGQ 100
    VVAPGALLVR LEGCSHPVVM KGLCAECGQD LTQLQSKNGR QQVPLSTATV 150
    SMVHSVPELM VSSEQAEKLG REDQQRLHRN RKLVLMVDLD QTLIHTTEQH 200
    CPQMSNKGIF HFQLGRGEPM LHTRLRPHCK DFLEKIAKLY ELHVFTFGSR 250
    LYAHTIAGFL DPEKKLFSHR ILSRDECIDP FSKTGNLRNL FPCGDSMVCI 300
    IDDREDVWKF APNLITVKKY VYFPGTGDVN APPAARETQA RRKVNHSSKG 350
    GDALEQALSV RDPEDGRPAP GVEHSNGLGK ASRELNGGEA VPGVFPSKAD 400
    EKEAWPLTRA SPASSSSGHE PTEAPELPVS CEWDGRTTPG VQPTQGDAAT 450
    QDLDFDLSSD SESSESSSRS EGQRAPAPQE RTKAAPEHSG PQDTSGGRAA 500
    ASPLGESGPS IHPHDKGSDL DTQEEGERDS LCGLGNGSVD RKEAETESQN 550
    SEQSGVTAGE SLDQSVGEEE EEDTDDDDHL IHLEEILVRV HTDYYTKYDR 600
    YLNKELEEAP DIRKIVPELK SKVLADVAVI FSGLHPTNFP VEKTREHYHA 650
    TALGAKVLTQ LVLSPDAPDR ATHLIAARAG TEKVRQAQEC KHLHVVSPDW 700
    LWSCLERWDK VEEQLFPLID DDTRTHRDNS PAVFPDRHSV LPTALFHPTP 750
    IHSKAHPGPE VRIYDSNTGK LIRMGPQGSA PAPSSAPLNH GEPSSFRAVQ 800
    PHQQQMFGEE LPESQDGEQP GPARRKRQPS MSEAMPLYTL CKEDLESMDK 850
    EVDDILGEGS DDSDIEKKKP EDQDNEQERA PKPRKPRAPG IRREQPVGLP 900
    SSGERSTPGM RGPRGHKRKL NEEDAASESS GESSNDDEEG SSSEADEMAA 950
    ALEAELNDLM 960
    Length:960
    Mass (Da):104,554
    Last modified:October 1, 2003 - v1
    Checksum:i7D1EB42C6D15C95C
    GO
    Isoform 2 (identifier: Q7TSG2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-788: Missing.
         789-796: NHGEPSSF → MSRIILVV

    Note: No experimental confirmation available.

    Show »
    Length:172
    Mass (Da):19,043
    Checksum:iE3243D9122FC5811
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti759 – 7613PEV → GTR in AAH52934. (PubMed:15489334)Curated
    Sequence conflicti897 – 8971V → I in AAH52934. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 788788Missing in isoform 2. 1 PublicationVSP_009866Add
    BLAST
    Alternative sequencei789 – 7968NHGEPSSF → MSRIILVV in isoform 2. 1 PublicationVSP_009867

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK016213 mRNA. Translation: BAB30150.1.
    BC052934 mRNA. Translation: AAH52934.1.
    BC053435 mRNA. Translation: AAH53435.1.
    CCDSiCCDS29368.1. [Q7TSG2-1]
    RefSeqiNP_080571.2. NM_026295.2. [Q7TSG2-1]
    UniGeneiMm.312893.

    Genome annotation databases

    EnsembliENSMUST00000036229; ENSMUSP00000038938; ENSMUSG00000033323. [Q7TSG2-1]
    GeneIDi67655.
    KEGGimmu:67655.
    UCSCiuc008ftb.1. mouse. [Q7TSG2-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK016213 mRNA. Translation: BAB30150.1 .
    BC052934 mRNA. Translation: AAH52934.1 .
    BC053435 mRNA. Translation: AAH53435.1 .
    CCDSi CCDS29368.1. [Q7TSG2-1 ]
    RefSeqi NP_080571.2. NM_026295.2. [Q7TSG2-1 ]
    UniGenei Mm.312893.

    3D structure databases

    ProteinModelPortali Q7TSG2.
    SMRi Q7TSG2. Positions 168-370, 547-718.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q7TSG2.

    Proteomic databases

    MaxQBi Q7TSG2.
    PaxDbi Q7TSG2.
    PRIDEi Q7TSG2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000036229 ; ENSMUSP00000038938 ; ENSMUSG00000033323 . [Q7TSG2-1 ]
    GeneIDi 67655.
    KEGGi mmu:67655.
    UCSCi uc008ftb.1. mouse. [Q7TSG2-1 ]

    Organism-specific databases

    CTDi 9150.
    MGIi MGI:1926953. Ctdp1.

    Phylogenomic databases

    eggNOGi COG5190.
    GeneTreei ENSGT00390000015641.
    HOGENOMi HOG000112039.
    HOVERGENi HBG051213.
    InParanoidi Q7TSG2.
    KOi K15732.
    OMAi EAPDIRK.
    OrthoDBi EOG7WMCJ8.
    PhylomeDBi Q7TSG2.
    TreeFami TF315104.

    Enzyme and pathway databases

    Reactomei REACT_203462. Formation of the Early Elongation Complex.
    REACT_226490. RNA Polymerase II Transcription Elongation.

    Miscellaneous databases

    NextBioi 325156.
    PROi Q7TSG2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7TSG2.
    Bgeei Q7TSG2.
    Genevestigatori Q7TSG2.

    Family and domain databases

    Gene3Di 3.40.50.1000. 2 hits.
    3.40.50.10190. 1 hit.
    InterProi IPR001357. BRCT_dom.
    IPR015388. FCP1_C.
    IPR011947. FCP1_euk.
    IPR023214. HAD-like_dom.
    IPR004274. NIF.
    IPR011053. Single_hybrid_motif.
    [Graphical view ]
    Pfami PF09309. FCP1_C. 1 hit.
    PF03031. NIF. 1 hit.
    PF12738. PTCB-BRCT. 1 hit.
    [Graphical view ]
    SMARTi SM00292. BRCT. 1 hit.
    SM00577. CPDc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51230. SSF51230. 1 hit.
    SSF52113. SSF52113. 1 hit.
    SSF56784. SSF56784. 1 hit.
    TIGRFAMsi TIGR02250. FCP1_euk. 1 hit.
    PROSITEi PS50172. BRCT. 1 hit.
    PS50969. FCP1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Embryo and Lung.
    3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-730, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    4. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-770, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiCTDP1_MOUSE
    AccessioniPrimary (citable) accession number: Q7TSG2
    Secondary accession number(s): Q7TSS7, Q9D4S8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3