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Protein

Vesicular glutamate transporter 3

Gene

Slc17a8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.2 Publications

GO - Molecular functioni

GO - Biological processi

  • brain development Source: RGD
  • cochlea development Source: RGD
  • neural retina development Source: RGD
  • neurotransmitter transport Source: UniProtKB-KW
  • sensory perception of sound Source: UniProtKB-KW
  • sodium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Hearing, Ion transport, Neurotransmitter transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-RNO-428643. Organic anion transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicular glutamate transporter 3
Short name:
VGluT3
Alternative name(s):
Solute carrier family 17 member 8
Gene namesi
Name:Slc17a8
Synonyms:Vglut3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi628870. Slc17a8.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 76CytoplasmicSequence analysisAdd BLAST76
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Topological domaini98 – 130VesicularSequence analysisAdd BLAST33
Transmembranei131 – 151HelicalSequence analysisAdd BLAST21
Topological domaini152 – 153CytoplasmicSequence analysis2
Transmembranei154 – 174HelicalSequence analysisAdd BLAST21
Topological domaini175 – 182VesicularSequence analysis8
Transmembranei183 – 203HelicalSequence analysisAdd BLAST21
Topological domaini204 – 221CytoplasmicSequence analysisAdd BLAST18
Transmembranei222 – 242HelicalSequence analysisAdd BLAST21
Topological domaini243 – 249VesicularSequence analysis7
Transmembranei250 – 270HelicalSequence analysisAdd BLAST21
Topological domaini271 – 314CytoplasmicSequence analysisAdd BLAST44
Transmembranei315 – 335HelicalSequence analysisAdd BLAST21
Topological domaini336 – 353VesicularSequence analysisAdd BLAST18
Transmembranei354 – 374HelicalSequence analysisAdd BLAST21
Topological domaini375 – 390CytoplasmicSequence analysisAdd BLAST16
Transmembranei391 – 411HelicalSequence analysisAdd BLAST21
Topological domaini412 – 413VesicularSequence analysis2
Transmembranei414 – 434HelicalSequence analysisAdd BLAST21
Topological domaini435 – 447CytoplasmicSequence analysisAdd BLAST13
Transmembranei448 – 468HelicalSequence analysisAdd BLAST21
Topological domaini469 – 481VesicularSequence analysisAdd BLAST13
Transmembranei482 – 502HelicalSequence analysisAdd BLAST21
Topological domaini503 – 585CytoplasmicSequence analysisAdd BLAST83

GO - Cellular componenti

  • apical dendrite Source: RGD
  • axon terminus Source: RGD
  • basilar dendrite Source: RGD
  • cell junction Source: UniProtKB-KW
  • cytoplasm Source: RGD
  • cytoplasmic, membrane-bounded vesicle Source: RGD
  • dendrite Source: RGD
  • excitatory synapse Source: RGD
  • glial limiting end-foot Source: RGD
  • integral component of membrane Source: GO_Central
  • multivesicular body Source: RGD
  • neuronal cell body Source: RGD
  • pericellular basket Source: RGD
  • perikaryon Source: RGD
  • synapse Source: RGD
  • synaptic vesicle membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse, Synaptosome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3472.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003316161 – 588Vesicular glutamate transporter 3Add BLAST588

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi106N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ7TSF2.
PRIDEiQ7TSF2.

Expressioni

Tissue specificityi

Expressed in brain, kidney and liver. Expressed within the amygdala, brainstem, cerberal cortex, dorsal root ganglia, dorsal spinal cord, hippocampus, hypothalamus, retina, striatum and ventral spinal cord. Expressed within neurons of the caudate-putamen, olfactory tubercle, nucleus accumbens, hippocampus, interpeduncular nucleus and dorsal and medial raphe nuclei. Expressed in inner hair cells of the ear. Expressed at synaptic terminals within the lateral superior olive (LSO), a nucleus of the mammalian sound localization system, and in the medial nucleus of the trapezoid body (MNTB), which provides inhibitory input to the LSO.6 Publications

Gene expression databases

BgeeiENSRNOG00000007581.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010207.

Chemistry databases

BindingDBiQ7TSF2.

Structurei

3D structure databases

ProteinModelPortaliQ7TSF2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2532. Eukaryota.
ENOG410XPWC. LUCA.
GeneTreeiENSGT00760000119079.
HOGENOMiHOG000230812.
HOVERGENiHBG008834.
InParanoidiQ7TSF2.
KOiK12302.
OMAiGATIQNC.
OrthoDBiEOG091G06DG.
PhylomeDBiQ7TSF2.
TreeFamiTF313535.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TSF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFNAFDTFK EKILKPGKEG VKNAVGDSLG ILQRKLDGTN EEGDAIELSE
60 70 80 90 100
EGRPVQTSRA RAPVCDCSCC GIPKRYIIAV MSGLGFCISF GIRCNLGVAI
110 120 130 140 150
VEMVNNSTVY VDGKPEIQTA QFNWDPETVG LIHGSFFWGY IVTQIPGGFI
160 170 180 190 200
SNKFAANRVF GAAIFLTSTL NMFIPSAARV HYGCVMCVRI LQGLVEGVTY
210 220 230 240 250
PACHGMWSKW APPLERSRLA TTSFCGSYAG AVVAMPLAGV LVQYIGWASV
260 270 280 290 300
FYIYGMFGII WYMFWLLQAY ECPAVHPTIS NEERTYIETS IGEGANLASL
310 320 330 340 350
SKFNTPWRRF FTSLPVYAII VANFCRSWTF YLLLISQPAY FEEVFGFAIS
360 370 380 390 400
KVGLLSAVPH MVMTIVVPIG GQLADYLRSR KILTTTAVRK IMNCGGFGME
410 420 430 440 450
ATLLLVVGFS HTKGVAISFL VLAVGFSGFA ISGFNVNHLD IAPRYASILM
460 470 480 490 500
GISNGVGTLS GMVCPLIVGA MTKHKTREEW QNVFLIAALV HYSGVIFYGV
510 520 530 540 550
FASGEKQDWA DPENLSEEKC GIIDQDELAE ETELNHEAFV SPRKKMSYGA
560 570 580
TTQNCEVQKT DRRQQRESAF EGEEPLSYQN EEDFSETS
Length:588
Mass (Da):64,755
Last modified:April 29, 2008 - v2
Checksum:i9644C021D94286B5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4N → K in AAM50094 (PubMed:12388773).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ491795 mRNA. Translation: CAD37138.1.
AY117026 mRNA. Translation: AAM50094.1.
RefSeqiNP_714947.1. NM_153725.1.
UniGeneiRn.84876.

Genome annotation databases

EnsembliENSRNOT00000010207; ENSRNOP00000010207; ENSRNOG00000007581.
ENSRNOT00000092527; ENSRNOP00000075876; ENSRNOG00000007581.
GeneIDi266767.
KEGGirno:266767.
UCSCiRGD:628870. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ491795 mRNA. Translation: CAD37138.1.
AY117026 mRNA. Translation: AAM50094.1.
RefSeqiNP_714947.1. NM_153725.1.
UniGeneiRn.84876.

3D structure databases

ProteinModelPortaliQ7TSF2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010207.

Chemistry databases

BindingDBiQ7TSF2.
ChEMBLiCHEMBL3472.

Proteomic databases

PaxDbiQ7TSF2.
PRIDEiQ7TSF2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010207; ENSRNOP00000010207; ENSRNOG00000007581.
ENSRNOT00000092527; ENSRNOP00000075876; ENSRNOG00000007581.
GeneIDi266767.
KEGGirno:266767.
UCSCiRGD:628870. rat.

Organism-specific databases

CTDi246213.
RGDi628870. Slc17a8.

Phylogenomic databases

eggNOGiKOG2532. Eukaryota.
ENOG410XPWC. LUCA.
GeneTreeiENSGT00760000119079.
HOGENOMiHOG000230812.
HOVERGENiHBG008834.
InParanoidiQ7TSF2.
KOiK12302.
OMAiGATIQNC.
OrthoDBiEOG091G06DG.
PhylomeDBiQ7TSF2.
TreeFamiTF313535.

Enzyme and pathway databases

ReactomeiR-RNO-428643. Organic anion transporters.

Miscellaneous databases

PROiQ7TSF2.

Gene expression databases

BgeeiENSRNOG00000007581.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVGLU3_RAT
AccessioniPrimary (citable) accession number: Q7TSF2
Secondary accession number(s): Q8K1Q1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: September 7, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.