Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Vesicular glutamate transporter 3

Gene

Slc17a8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.2 Publications

GO - Molecular functioni

GO - Biological processi

  • brain development Source: RGD
  • cochlea development Source: RGD
  • neural retina development Source: RGD
  • neurotransmitter transport Source: UniProtKB-KW
  • sensory perception of sound Source: UniProtKB-KW
  • sodium ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Hearing, Ion transport, Neurotransmitter transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Enzyme and pathway databases

ReactomeiR-RNO-428643. Organic anion transporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Vesicular glutamate transporter 3
Short name:
VGluT3
Alternative name(s):
Solute carrier family 17 member 8
Gene namesi
Name:Slc17a8
Synonyms:Vglut3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi628870. Slc17a8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7676CytoplasmicSequence analysisAdd
BLAST
Transmembranei77 – 9721HelicalSequence analysisAdd
BLAST
Topological domaini98 – 13033VesicularSequence analysisAdd
BLAST
Transmembranei131 – 15121HelicalSequence analysisAdd
BLAST
Topological domaini152 – 1532CytoplasmicSequence analysis
Transmembranei154 – 17421HelicalSequence analysisAdd
BLAST
Topological domaini175 – 1828VesicularSequence analysis
Transmembranei183 – 20321HelicalSequence analysisAdd
BLAST
Topological domaini204 – 22118CytoplasmicSequence analysisAdd
BLAST
Transmembranei222 – 24221HelicalSequence analysisAdd
BLAST
Topological domaini243 – 2497VesicularSequence analysis
Transmembranei250 – 27021HelicalSequence analysisAdd
BLAST
Topological domaini271 – 31444CytoplasmicSequence analysisAdd
BLAST
Transmembranei315 – 33521HelicalSequence analysisAdd
BLAST
Topological domaini336 – 35318VesicularSequence analysisAdd
BLAST
Transmembranei354 – 37421HelicalSequence analysisAdd
BLAST
Topological domaini375 – 39016CytoplasmicSequence analysisAdd
BLAST
Transmembranei391 – 41121HelicalSequence analysisAdd
BLAST
Topological domaini412 – 4132VesicularSequence analysis
Transmembranei414 – 43421HelicalSequence analysisAdd
BLAST
Topological domaini435 – 44713CytoplasmicSequence analysisAdd
BLAST
Transmembranei448 – 46821HelicalSequence analysisAdd
BLAST
Topological domaini469 – 48113VesicularSequence analysisAdd
BLAST
Transmembranei482 – 50221HelicalSequence analysisAdd
BLAST
Topological domaini503 – 58583CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • apical dendrite Source: RGD
  • axon terminus Source: RGD
  • basilar dendrite Source: RGD
  • cell junction Source: UniProtKB-KW
  • cytoplasm Source: RGD
  • cytoplasmic, membrane-bounded vesicle Source: RGD
  • dendrite Source: RGD
  • excitatory synapse Source: RGD
  • glial limiting end-foot Source: RGD
  • integral component of membrane Source: GO_Central
  • multivesicular body Source: RGD
  • neuronal cell body Source: RGD
  • pericellular basket Source: RGD
  • perikaryon Source: RGD
  • synapse Source: RGD
  • synaptic vesicle membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Membrane, Synapse, Synaptosome

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL3472.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 588588Vesicular glutamate transporter 3PRO_0000331616Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ7TSF2.
PRIDEiQ7TSF2.

Expressioni

Tissue specificityi

Expressed in brain, kidney and liver. Expressed within the amygdala, brainstem, cerberal cortex, dorsal root ganglia, dorsal spinal cord, hippocampus, hypothalamus, retina, striatum and ventral spinal cord. Expressed within neurons of the caudate-putamen, olfactory tubercle, nucleus accumbens, hippocampus, interpeduncular nucleus and dorsal and medial raphe nuclei. Expressed in inner hair cells of the ear. Expressed at synaptic terminals within the lateral superior olive (LSO), a nucleus of the mammalian sound localization system, and in the medial nucleus of the trapezoid body (MNTB), which provides inhibitory input to the LSO.6 Publications

Gene expression databases

BgeeiENSRNOG00000007581.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010207.

Chemistry

BindingDBiQ7TSF2.

Structurei

3D structure databases

ProteinModelPortaliQ7TSF2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2532. Eukaryota.
ENOG410XPWC. LUCA.
GeneTreeiENSGT00760000119079.
HOGENOMiHOG000230812.
HOVERGENiHBG008834.
InParanoidiQ7TSF2.
KOiK12302.
OMAiGATIQNC.
OrthoDBiEOG091G06DG.
PhylomeDBiQ7TSF2.
TreeFamiTF313535.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TSF2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFNAFDTFK EKILKPGKEG VKNAVGDSLG ILQRKLDGTN EEGDAIELSE
60 70 80 90 100
EGRPVQTSRA RAPVCDCSCC GIPKRYIIAV MSGLGFCISF GIRCNLGVAI
110 120 130 140 150
VEMVNNSTVY VDGKPEIQTA QFNWDPETVG LIHGSFFWGY IVTQIPGGFI
160 170 180 190 200
SNKFAANRVF GAAIFLTSTL NMFIPSAARV HYGCVMCVRI LQGLVEGVTY
210 220 230 240 250
PACHGMWSKW APPLERSRLA TTSFCGSYAG AVVAMPLAGV LVQYIGWASV
260 270 280 290 300
FYIYGMFGII WYMFWLLQAY ECPAVHPTIS NEERTYIETS IGEGANLASL
310 320 330 340 350
SKFNTPWRRF FTSLPVYAII VANFCRSWTF YLLLISQPAY FEEVFGFAIS
360 370 380 390 400
KVGLLSAVPH MVMTIVVPIG GQLADYLRSR KILTTTAVRK IMNCGGFGME
410 420 430 440 450
ATLLLVVGFS HTKGVAISFL VLAVGFSGFA ISGFNVNHLD IAPRYASILM
460 470 480 490 500
GISNGVGTLS GMVCPLIVGA MTKHKTREEW QNVFLIAALV HYSGVIFYGV
510 520 530 540 550
FASGEKQDWA DPENLSEEKC GIIDQDELAE ETELNHEAFV SPRKKMSYGA
560 570 580
TTQNCEVQKT DRRQQRESAF EGEEPLSYQN EEDFSETS
Length:588
Mass (Da):64,755
Last modified:April 29, 2008 - v2
Checksum:i9644C021D94286B5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4 – 41N → K in AAM50094 (PubMed:12388773).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ491795 mRNA. Translation: CAD37138.1.
AY117026 mRNA. Translation: AAM50094.1.
RefSeqiNP_714947.1. NM_153725.1.
UniGeneiRn.84876.

Genome annotation databases

EnsembliENSRNOT00000010207; ENSRNOP00000010207; ENSRNOG00000007581.
ENSRNOT00000092527; ENSRNOP00000075876; ENSRNOG00000007581.
GeneIDi266767.
KEGGirno:266767.
UCSCiRGD:628870. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ491795 mRNA. Translation: CAD37138.1.
AY117026 mRNA. Translation: AAM50094.1.
RefSeqiNP_714947.1. NM_153725.1.
UniGeneiRn.84876.

3D structure databases

ProteinModelPortaliQ7TSF2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010207.

Chemistry

BindingDBiQ7TSF2.
ChEMBLiCHEMBL3472.

Proteomic databases

PaxDbiQ7TSF2.
PRIDEiQ7TSF2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010207; ENSRNOP00000010207; ENSRNOG00000007581.
ENSRNOT00000092527; ENSRNOP00000075876; ENSRNOG00000007581.
GeneIDi266767.
KEGGirno:266767.
UCSCiRGD:628870. rat.

Organism-specific databases

CTDi246213.
RGDi628870. Slc17a8.

Phylogenomic databases

eggNOGiKOG2532. Eukaryota.
ENOG410XPWC. LUCA.
GeneTreeiENSGT00760000119079.
HOGENOMiHOG000230812.
HOVERGENiHBG008834.
InParanoidiQ7TSF2.
KOiK12302.
OMAiGATIQNC.
OrthoDBiEOG091G06DG.
PhylomeDBiQ7TSF2.
TreeFamiTF313535.

Enzyme and pathway databases

ReactomeiR-RNO-428643. Organic anion transporters.

Miscellaneous databases

PROiQ7TSF2.

Gene expression databases

BgeeiENSRNOG00000007581.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVGLU3_RAT
AccessioniPrimary (citable) accession number: Q7TSF2
Secondary accession number(s): Q8K1Q1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: April 29, 2008
Last modified: September 7, 2016
This is version 90 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.