Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q7TSE6 (ST38L_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein kinase 38-like

EC=2.7.11.1
Alternative name(s):
NDR2 protein kinase
Nuclear Dbf2-related kinase 2
Gene names
Name:Stk38l
Synonyms:Ndr2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length464 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the regulation of structural processes in differentiating and mature neuronal cells. Ref.2 Ref.7

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Cofactor

Magnesium By similarity. UniProtKB Q9Y2H1

Enzyme regulation

Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind and the autophosphorylation of Ser-282. Thr-442 then undergoes calcium-dependent phosphorylation by STK24/MST3. Interactions between phosphorylated Thr-442 and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2 to the N-terminal of STK38L By similarity. UniProtKB Q9Y2H1

Subunit structure

Homodimeric S100B binds two molecules of STK38L. Interacts with MOB1 and MOB2 By similarity. Interacts with MICAL1; leading to inhibit the protein kinase activity by antagonizing activation by MST1/STK4. Ref.7

Subcellular location

Cytoplasm. Cytoplasmcytoskeleton. Membrane. Note: Associated with the actin cytoskeleton. Co-localizes with STK24/MST3 in the membrane. Ref.2

Tissue specificity

Highly expressed in the large and small intestine, stomach and testis. High levels also present in the brain, in particular the neurocortex, basal forebrain, hippocampus, the amygdala, cerebellum and brainstem. Ref.1 Ref.2

Sequence similarities

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.

Contains 1 AGC-kinase C-terminal domain.

Contains 1 protein kinase domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q7TSE6-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q7TSE6-2)

The sequence of this isoform differs from the canonical sequence as follows:
     423-423: V → VAFFLFLV
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 464463Serine/threonine-protein kinase 38-like
PRO_0000086721

Regions

Domain90 – 383294Protein kinase
Domain384 – 45370AGC-kinase C-terminal
Nucleotide binding96 – 1049ATP By similarity UniProtKB O95835
Region64 – 8926S100B binding By similarity UniProtKB Q15208

Sites

Active site2131Proton acceptor By similarity UniProtKB O95835
Binding site1191ATP By similarity UniProtKB Q9Y2H1

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue751Phosphothreonine By similarity UniProtKB Q9Y2H1
Modified residue2821Phosphoserine; by autocatalysis By similarity UniProtKB Q9Y2H1
Modified residue4421Phosphothreonine; by STK24/MST3 By similarity UniProtKB Q9Y2H1

Natural variations

Alternative sequence4231V → VAFFLFLV in isoform 2.
VSP_012334

Experimental info

Sequence conflict971G → A in AAP44998. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: BE7E0CECDB63A8FD

FASTA46453,772
        10         20         30         40         50         60 
MAMTAGATTT FPMSNHTRER VTVAKLTLEN FYSNLILQHE ERETRQKKLE VAMEEEGLAD 

        70         80         90        100        110        120 
EEKKLRRSQH ARKETEFLRL KRTRLGLDDF ESLKVIGRGA FGEVRLVQKK DTGHIYAMKI 

       130        140        150        160        170        180 
LRKADMLEKE QVAHIRAERD ILVEADGAWV VKMFYSFQDK RNLYLIMEFL PGGDMMTLLM 

       190        200        210        220        230        240 
KKDTLTEEET QFYISETVLA IDAIHQLGFI HRDVKPDNLL LDAKGHVKLS DFGLCTGLKK 

       250        260        270        280        290        300 
AHRTEFYRNL THNPPSDFSF QNMNSKRKAE TWKKNRRQLA YSTVGTPDYI APEVFMQTGY 

       310        320        330        340        350        360 
NKLCDWWSLG VIMYEMLIGF PPFCSETPQE TYRKVMSWKE TLAFPPEVPV SEKAKDLILR 

       370        380        390        400        410        420 
FCTDSENRIG NGGVEEIKGH PFFEGVDWGH IRERPAAIPI EIRSIDDTSN FDDFPESDIL 

       430        440        450        460 
QPVPNTTEPD YKSKDWVFLN YTYKRFEGLT QRGSIPTYMK AGKL 

« Hide

Isoform 2 [UniParc].

Checksum: AE9B2D42B1351E75
Show »

FASTA47154,610

References

« Hide 'large scale' references
[1]"Regulation of NDR2 protein kinase by multi-site phosphorylation and the S100B calcium-binding protein."
Stegert M.R., Tamaskovic R., Bichsel S.J., Hergovich A., Hemmings B.A.
J. Biol. Chem. 279:23806-23812(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
Strain: C57BL/6.
Tissue: Brain.
[2]"Neuronal functions of the novel serine/threonine kinase Ndr2."
Stork O., Zhdanov A., Kudersky A., Yoshikawa T., Obata K., Pape H.-C.
J. Biol. Chem. 279:45773-45781(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
Strain: C57BL/6.
Tissue: Basophil.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Fetal heart.
[4]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[5]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Fetal jaw and Fetal limb.
[7]"MICAL-1 is a negative regulator of MST-NDR kinase signaling and apoptosis."
Zhou Y., Adolfs Y., Pijnappel W.W., Fuller S.J., Van der Schors R.C., Li K.W., Sugden P.H., Smit A.B., Hergovich A., Pasterkamp R.J.
Mol. Cell. Biol. 31:3603-3615(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INTERACTION WITH MICAL1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY292400 mRNA. Translation: AAP44998.1.
AY223819 mRNA. Translation: AAO66474.1.
AK052288 mRNA. Translation: BAC34918.1.
CU207394 Genomic DNA. Translation: CAQ51943.1.
CH466572 Genomic DNA. Translation: EDL10715.1.
BC062170 mRNA. Translation: AAH62170.1.
RefSeqNP_766322.1. NM_172734.3.
XP_006536130.1. XM_006536067.1.
UniGeneMm.322121.

3D structure databases

ProteinModelPortalQ7TSE6.
SMRQ7TSE6. Positions 78-455.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid231267. 1 interaction.
IntActQ7TSE6. 1 interaction.

PTM databases

PhosphoSiteQ7TSE6.

Proteomic databases

PaxDbQ7TSE6.
PRIDEQ7TSE6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000001675; ENSMUSP00000001675; ENSMUSG00000001630. [Q7TSE6-1]
ENSMUST00000111644; ENSMUSP00000107271; ENSMUSG00000001630. [Q7TSE6-2]
GeneID232533.
KEGGmmu:232533.
UCSCuc009esh.2. mouse. [Q7TSE6-1]

Organism-specific databases

CTD23012.
MGIMGI:1922250. Stk38l.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00750000117396.
HOGENOMHOG000233033.
HOVERGENHBG104247.
KOK08790.
OMANGSADEH.
OrthoDBEOG7BZVS1.
TreeFamTF105337.

Gene expression databases

BgeeQ7TSE6.
CleanExMM_STK38L.
GenevestigatorQ7TSE6.

Family and domain databases

InterProIPR000961. AGC-kinase_C.
IPR011009. Kinase-like_dom.
IPR017892. Pkinase_C.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
PF00433. Pkinase_C. 1 hit.
[Graphical view]
SMARTSM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 2 hits.
PROSITEPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSTK38L. mouse.
NextBio381139.
PROQ7TSE6.
SOURCESearch...

Entry information

Entry nameST38L_MOUSE
AccessionPrimary (citable) accession number: Q7TSE6
Secondary accession number(s): B2KFR4, Q6P6K6, Q8BWK4
Entry history
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot