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Q7TSE6

- ST38L_MOUSE

UniProt

Q7TSE6 - ST38L_MOUSE

Protein

Serine/threonine-protein kinase 38-like

Gene

Stk38l

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Involved in the regulation of structural processes in differentiating and mature neuronal cells.2 Publications

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Cofactori

    Magnesium.By similarity

    Enzyme regulationi

    Activated by binding of S100B which releases autoinhibitory N-lobe interactions, enabling ATP to bind and the autophosphorylation of Ser-282. Thr-442 then undergoes calcium-dependent phosphorylation by STK24/MST3. Interactions between phosphorylated Thr-442 and the N-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of MOB1/MOBKL1A and MOB2 to the N-terminal of STK38L By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei119 – 1191ATPBy similarityPROSITE-ProRule annotation
    Active sitei213 – 2131Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi96 – 1049ATPBy similarityPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB
    2. magnesium ion binding Source: UniProtKB
    3. protein serine/threonine kinase activity Source: UniProtKB

    GO - Biological processi

    1. intracellular signal transduction Source: UniProtKB
    2. protein phosphorylation Source: UniProtKB
    3. regulation of cellular component organization Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    Actin-binding, ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serine/threonine-protein kinase 38-like (EC:2.7.11.1)
    Alternative name(s):
    NDR2 protein kinase
    Nuclear Dbf2-related kinase 2
    Gene namesi
    Name:Stk38lImported
    Synonyms:Ndr21 Publication
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:1922250. Stk38l.

    Subcellular locationi

    Cytoplasm 1 Publication. Cytoplasmcytoskeleton 1 Publication. Membrane 1 Publication
    Note: Associated with the actin cytoskeleton. Co-localizes with STK24/MST3 in the membrane.

    GO - Cellular componenti

    1. actin cytoskeleton Source: UniProtKB
    2. cytoplasm Source: UniProtKB
    3. nucleus Source: Ensembl
    4. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 464463Serine/threonine-protein kinase 38-likePRO_0000086721Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei75 – 751PhosphothreonineBy similarity
    Modified residuei282 – 2821Phosphoserine; by autocatalysisBy similarity
    Modified residuei442 – 4421Phosphothreonine; by STK24/MST3By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ7TSE6.
    PaxDbiQ7TSE6.
    PRIDEiQ7TSE6.

    PTM databases

    PhosphoSiteiQ7TSE6.

    Expressioni

    Tissue specificityi

    Highly expressed in the large and small intestine, stomach and testis. High levels also present in the brain, in particular the neurocortex, basal forebrain, hippocampus, the amygdala, cerebellum and brainstem.2 Publications

    Gene expression databases

    BgeeiQ7TSE6.
    CleanExiMM_STK38L.
    GenevestigatoriQ7TSE6.

    Interactioni

    Subunit structurei

    Homodimeric S100B binds two molecules of STK38L. Interacts with MOB1 and MOB2 By similarity. Interacts with MICAL1; leading to inhibit the protein kinase activity by antagonizing activation by MST1/STK4.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi231267. 1 interaction.
    IntActiQ7TSE6. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7TSE6.
    SMRiQ7TSE6. Positions 79-443.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini90 – 383294Protein kinasePROSITE-ProRule annotationAdd
    BLAST
    Domaini384 – 45370AGC-kinase C-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni64 – 8926S100B bindingBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 1 AGC-kinase C-terminal domain.Curated
    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00750000117396.
    HOGENOMiHOG000233033.
    HOVERGENiHBG104247.
    KOiK08790.
    OMAiYMKAGKA.
    OrthoDBiEOG7BZVS1.
    TreeFamiTF105337.

    Family and domain databases

    InterProiIPR000961. AGC-kinase_C.
    IPR011009. Kinase-like_dom.
    IPR017892. Pkinase_C.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    PF00433. Pkinase_C. 1 hit.
    [Graphical view]
    SMARTiSM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 2 hits.
    PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q7TSE6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAMTAGATTT FPMSNHTRER VTVAKLTLEN FYSNLILQHE ERETRQKKLE    50
    VAMEEEGLAD EEKKLRRSQH ARKETEFLRL KRTRLGLDDF ESLKVIGRGA 100
    FGEVRLVQKK DTGHIYAMKI LRKADMLEKE QVAHIRAERD ILVEADGAWV 150
    VKMFYSFQDK RNLYLIMEFL PGGDMMTLLM KKDTLTEEET QFYISETVLA 200
    IDAIHQLGFI HRDVKPDNLL LDAKGHVKLS DFGLCTGLKK AHRTEFYRNL 250
    THNPPSDFSF QNMNSKRKAE TWKKNRRQLA YSTVGTPDYI APEVFMQTGY 300
    NKLCDWWSLG VIMYEMLIGF PPFCSETPQE TYRKVMSWKE TLAFPPEVPV 350
    SEKAKDLILR FCTDSENRIG NGGVEEIKGH PFFEGVDWGH IRERPAAIPI 400
    EIRSIDDTSN FDDFPESDIL QPVPNTTEPD YKSKDWVFLN YTYKRFEGLT 450
    QRGSIPTYMK AGKL 464
    Length:464
    Mass (Da):53,772
    Last modified:July 27, 2011 - v2
    Checksum:iBE7E0CECDB63A8FD
    GO
    Isoform 2 (identifier: Q7TSE6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         423-423: V → VAFFLFLV

    Note: No experimental confirmation available.

    Show »
    Length:471
    Mass (Da):54,610
    Checksum:iAE9B2D42B1351E75
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti97 – 971G → A in AAP44998. (PubMed:15037617)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei423 – 4231V → VAFFLFLV in isoform 2. 1 PublicationVSP_012334

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY292400 mRNA. Translation: AAP44998.1.
    AY223819 mRNA. Translation: AAO66474.1.
    AK052288 mRNA. Translation: BAC34918.1.
    CU207394 Genomic DNA. Translation: CAQ51943.1.
    CH466572 Genomic DNA. Translation: EDL10715.1.
    BC062170 mRNA. Translation: AAH62170.1.
    CCDSiCCDS39712.1. [Q7TSE6-1]
    RefSeqiNP_766322.1. NM_172734.3. [Q7TSE6-1]
    XP_006536130.1. XM_006536067.1. [Q7TSE6-2]
    UniGeneiMm.322121.

    Genome annotation databases

    EnsembliENSMUST00000001675; ENSMUSP00000001675; ENSMUSG00000001630. [Q7TSE6-1]
    ENSMUST00000111644; ENSMUSP00000107271; ENSMUSG00000001630. [Q7TSE6-2]
    GeneIDi232533.
    KEGGimmu:232533.
    UCSCiuc009esh.2. mouse. [Q7TSE6-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY292400 mRNA. Translation: AAP44998.1 .
    AY223819 mRNA. Translation: AAO66474.1 .
    AK052288 mRNA. Translation: BAC34918.1 .
    CU207394 Genomic DNA. Translation: CAQ51943.1 .
    CH466572 Genomic DNA. Translation: EDL10715.1 .
    BC062170 mRNA. Translation: AAH62170.1 .
    CCDSi CCDS39712.1. [Q7TSE6-1 ]
    RefSeqi NP_766322.1. NM_172734.3. [Q7TSE6-1 ]
    XP_006536130.1. XM_006536067.1. [Q7TSE6-2 ]
    UniGenei Mm.322121.

    3D structure databases

    ProteinModelPortali Q7TSE6.
    SMRi Q7TSE6. Positions 79-443.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 231267. 1 interaction.
    IntActi Q7TSE6. 1 interaction.

    PTM databases

    PhosphoSitei Q7TSE6.

    Proteomic databases

    MaxQBi Q7TSE6.
    PaxDbi Q7TSE6.
    PRIDEi Q7TSE6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000001675 ; ENSMUSP00000001675 ; ENSMUSG00000001630 . [Q7TSE6-1 ]
    ENSMUST00000111644 ; ENSMUSP00000107271 ; ENSMUSG00000001630 . [Q7TSE6-2 ]
    GeneIDi 232533.
    KEGGi mmu:232533.
    UCSCi uc009esh.2. mouse. [Q7TSE6-1 ]

    Organism-specific databases

    CTDi 23012.
    MGIi MGI:1922250. Stk38l.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00750000117396.
    HOGENOMi HOG000233033.
    HOVERGENi HBG104247.
    KOi K08790.
    OMAi YMKAGKA.
    OrthoDBi EOG7BZVS1.
    TreeFami TF105337.

    Miscellaneous databases

    ChiTaRSi STK38L. mouse.
    NextBioi 381139.
    PROi Q7TSE6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q7TSE6.
    CleanExi MM_STK38L.
    Genevestigatori Q7TSE6.

    Family and domain databases

    InterProi IPR000961. AGC-kinase_C.
    IPR011009. Kinase-like_dom.
    IPR017892. Pkinase_C.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    PF00433. Pkinase_C. 1 hit.
    [Graphical view ]
    SMARTi SM00133. S_TK_X. 1 hit.
    SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 2 hits.
    PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Regulation of NDR2 protein kinase by multi-site phosphorylation and the S100B calcium-binding protein."
      Stegert M.R., Tamaskovic R., Bichsel S.J., Hergovich A., Hemmings B.A.
      J. Biol. Chem. 279:23806-23812(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
      Strain: C57BL/6Imported.
      Tissue: BrainImported.
    2. "Neuronal functions of the novel serine/threonine kinase Ndr2."
      Stork O., Zhdanov A., Kudersky A., Yoshikawa T., Obata K., Pape H.-C.
      J. Biol. Chem. 279:45773-45781(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
      Strain: C57BL/6Imported.
      Tissue: BasophilImported.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Fetal heart.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
      Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Fetal jawImported and Fetal limbImported.
    7. Cited for: FUNCTION, INTERACTION WITH MICAL1.

    Entry informationi

    Entry nameiST38L_MOUSE
    AccessioniPrimary (citable) accession number: Q7TSE6
    Secondary accession number(s): B2KFR4, Q6P6K6, Q8BWK4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 21, 2004
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 109 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3