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Protein

Protein TBATA

Gene

Tbata

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Isoform 1 and isoform 2 may play a role in spermatid differentiation. Isoform 1 and isoform 2 regulate thymus function by modulating stromal cell proliferation via interference with the NEDD8 pathway.2 Publications

GO - Biological processi

  • multicellular organism development Source: UniProtKB-KW
  • spermatid differentiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Differentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Protein TBATA
Alternative name(s):
Protein SPATIAL
Stromal protein associated with thymii and lymph node1 Publication
Thymus, brain and testes-associated protein
Gene namesi
Name:Tbata
Synonyms:Spatial
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1923820. Tbata.

Subcellular locationi

Isoform 1 :
  • Cytoplasmcytosol 1 Publication

  • Note: Located throughout the cytosol of early round spermatids. By the end stages of round spermatid development, concentrated at the side of the cell near the nascent flagellum and in the manchette. In mature sperm, located in the principle piece of the tail.1 Publication
Isoform 2 :
  • Cytoplasmcytosol 1 Publication

  • Note: Located throughout the cytosol of early round spermatids. By the end stages of round spermatid development, concentrated at the side of the cell near the nascent flagellum and in the manchette. In mature sperm, located in the principle piece of the tail.1 Publication
Isoform 6 :
  • Nucleus 1 Publication
Isoform 7 :
  • Nucleus 1 Publication

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 393393Protein TBATAPRO_0000351147Add
BLAST

Proteomic databases

MaxQBiQ7TSD4.
PaxDbiQ7TSD4.
PRIDEiQ7TSD4.

PTM databases

iPTMnetiQ7TSD4.
PhosphoSiteiQ7TSD4.

Expressioni

Tissue specificityi

Expressed in the subcapsular region of the thymus and lymph node (at protein level). Highly expressed in thymic cortical stromal cells and testis. Lower levels found in brain cortex, hippocampus, kidney, cerebellum, skeletal muscle, epididymis and ovary. No expression detected in other lymphoid organs including bone marrow and spleen. Isoform 1 and isoform 2 are expressed predominantly in testis. Isoform 3, isoform 4 and isoform 5 are expressed predominantly in thymus although isoform 3 is also expressed in testis. In the CNS, highly expressed in restricted areas, the cerebellum and hippocampus.1 Publication

Developmental stagei

In testis, isoform 1 and isoform 2 are expressed only in the adult from postnatal week 7. Expression is detected in pachytene spermatocytes, increases greatly in round spermatids and is very strong in round/elongating and elongating spermatids. Expression is reduced in condensed spermatids and persists in spermatozoa. Isoform 3 is specifically expressed in round spermatids and is greatly reduced in spermatids under maturation (at protein level). Isoform 7 is detected in the embryo from day 10 while isoform 7 is not detected until day 12. In brain, predominantly expressed by granule cells during cerebellar development. Isoform 1 and isoform 3 are differentially expressed during cerebellar development.4 Publications

Inductioni

Up-regulated in aged mice (4 months of age or older).

Gene expression databases

BgeeiENSMUSG00000020096.
ExpressionAtlasiQ7TSD4. baseline and differential.
GenevisibleiQ7TSD4. MM.

Interactioni

Subunit structurei

Interacts with KIF17. Interacts with UBA3.3 Publications

Protein-protein interaction databases

BioGridi211165. 1 interaction.
STRINGi10090.ENSMUSP00000036422.

Structurei

3D structure databases

ProteinModelPortaliQ7TSD4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TBATA family.Curated

Phylogenomic databases

eggNOGiENOG410IXP6. Eukaryota.
ENOG4111YVM. LUCA.
GeneTreeiENSGT00510000048896.
HOVERGENiHBG106634.
InParanoidiQ7TSD4.
OMAiYPLMSPK.
OrthoDBiEOG091G0BB5.
PhylomeDBiQ7TSD4.
TreeFamiTF333401.

Sequences (8)i

Sequence statusi: Complete.

This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q7TSD4-1) [UniParc]FASTAAdd to basket
Also known as: Epsilon1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTTEVNQLSE HPLVSPKAEP QPETKPENLP RSHGDVGLQK ETVVPGIVDF
60 70 80 90 100
ELIHEELKTT KPQTSQPTPS AYRFGRLSHH SFFSRHHPQP QRVTHIQVTG
110 120 130 140 150
REDLEHSLPL TTSFQLLQAP GVQPMDLTPS ADIAGKPVCV VRDEFSLSAL
160 170 180 190 200
TQPTFLSRCL MGMPTISVPI GDPQSNRNPQ LSTSDTWRKK LKDLASRVTV
210 220 230 240 250
FTKEIQPKPD EQKEEPPLRE PPPREQGAKY SAETGRLIPA SSQALTRRNR
260 270 280 290 300
QGQRVHPSSK DGGVQASILQ DQELLILELL CQILQTDSLR AIQFWLLYAP
310 320 330 340 350
SKEKDLALGL LQTAVAQLIP QPLSSIPAEK LWNHLQELQE PQETQEAAYS
360 370 380 390
PSLKKTRSPP LPKTDKPEYI GKAQVLLVHP SEDPEEKTTK AES
Length:393
Mass (Da):43,842
Last modified:September 23, 2008 - v2
Checksum:iED5BB0126B6A6947
GO
Isoform 21 Publication (identifier: Q7TSD4-2) [UniParc]FASTAAdd to basket
Also known as: Delta1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     98-131: Missing.

Show »
Length:359
Mass (Da):40,210
Checksum:i418A5272069D84A2
GO
Isoform 31 Publication (identifier: Q7TSD4-3) [UniParc]FASTAAdd to basket
Also known as: Beta1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MTTEVNQLSEHPLV → MFLGNVYKGSLAPRRDEVT
     98-131: Missing.
     185-185: D → DLKTQGGQNNTYRPPPPSFLSSQT
     212-226: QKEEPPLREPPPREQ → VGVAQRMEPRKKRPS
     227-393: Missing.

Show »
Length:220
Mass (Da):24,681
Checksum:i45862E8F97E595EC
GO
Isoform 41 Publication (identifier: Q7TSD4-4) [UniParc]FASTAAdd to basket
Also known as: Alpha1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MTTEVNQLSEHPLV → MFLGNVYKGSLAPRRDEVT
     184-184: S → SAEDTGRTKQHLPPPTPILPVLS
     212-226: QKEEPPLREPPPREQ → VGVAQRMEPRKKRPS
     227-393: Missing.

Show »
Length:253
Mass (Da):28,162
Checksum:iA68B01E6E0629743
GO
Isoform 51 Publication (identifier: Q7TSD4-5) [UniParc]FASTAAdd to basket
Also known as: Gamma1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     98-131: Missing.
     212-226: QKEEPPLREPPPREQ → VGVAQRMEPRKKRPS
     227-393: Missing.

Show »
Length:192
Mass (Da):21,625
Checksum:i5F4394DADF12A0BF
GO
Isoform 61 Publication (identifier: Q7TSD4-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MTTEVNQLSEHPLV → MFLGNVYKGSLAPRRDEVT
     212-226: QKEEPPLREPPPREQ → VGVAQRMEPRKKRPS
     227-393: Missing.

Show »
Length:231
Mass (Da):25,812
Checksum:iB99BDB8A19BAD71B
GO
Isoform 71 Publication (identifier: Q7TSD4-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MTTEVNQLSEHPLV → MFLGNVYKGSLAPRRDEVT
     98-131: Missing.
     212-226: QKEEPPLREPPPREQ → VGVAQRMEPRKKRPS
     227-393: Missing.

Show »
Length:197
Mass (Da):22,180
Checksum:i3287375B23E0656F
GO
Isoform 8 (identifier: Q7TSD4-8) [UniParc]FASTAAdd to basket
Also known as: Zeta

The sequence of this isoform differs from the canonical sequence as follows:
     1-14: MTTEVNQLSEHPLV → MFLGNVYKGSLAPRRDEVT
     98-166: VTGREDLEHS...SRCLMGMPTI → APSSSWGPAH...VQSEPPAFYF
     167-393: Missing.

Show »
Length:171
Mass (Da):19,081
Checksum:i79EC56ADC5B52935
GO

Sequence cautioni

The sequence AAP41211 differs from that shown. Reason: Frameshift at positions 22, 24, 45, 180 and 212. Curated
The sequence AAP50907 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAP50908 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1414MTTEV…EHPLV → MFLGNVYKGSLAPRRDEVT in isoform 3, isoform 4, isoform 6, isoform 7 and isoform 8. 3 PublicationsVSP_052935Add
BLAST
Alternative sequencei98 – 16669VTGRE…GMPTI → APSSSWGPAHGSHSLCRYRW EACLRGQGRVLSVGLDSAHI LIPLSDGDAHHLCPHWGSTV QSEPPAFYF in isoform 8. 1 PublicationVSP_052936Add
BLAST
Alternative sequencei98 – 13134Missing in isoform 2, isoform 3, isoform 5 and isoform 7. 3 PublicationsVSP_052937Add
BLAST
Alternative sequencei167 – 393227Missing in isoform 8. 1 PublicationVSP_052938Add
BLAST
Alternative sequencei184 – 1841S → SAEDTGRTKQHLPPPTPILP VLS in isoform 4. 1 PublicationVSP_052939
Alternative sequencei185 – 1851D → DLKTQGGQNNTYRPPPPSFL SSQT in isoform 3. 1 PublicationVSP_052940
Alternative sequencei212 – 22615QKEEP…PPREQ → VGVAQRMEPRKKRPS in isoform 3, isoform 4, isoform 5, isoform 6 and isoform 7. 2 PublicationsVSP_052941Add
BLAST
Alternative sequencei227 – 393167Missing in isoform 3, isoform 4, isoform 5, isoform 6 and isoform 7. 2 PublicationsVSP_052942Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257502 mRNA. Translation: AAG37103.1.
AF257503 mRNA. Translation: AAG37104.1.
AF521591 mRNA. Translation: AAP50907.1. Different initiation.
AF521592 mRNA. Translation: AAP50908.1. Different initiation.
AY243457 mRNA. Translation: AAP41210.2.
AY243458 mRNA. Translation: AAP41211.1. Frameshift.
AY243459 mRNA. Translation: AAP41212.1.
EU622858 mRNA. Translation: ACD01420.1.
AK038284 mRNA. Translation: BAC29958.1.
CCDSiCCDS23873.1. [Q7TSD4-1]
CCDS23874.2. [Q7TSD4-5]
CCDS48572.1. [Q7TSD4-2]
CCDS48573.1. [Q7TSD4-6]
RefSeqiNP_001017407.1. NM_001017407.1. [Q7TSD4-7]
NP_001017409.1. NM_001017409.1.
NP_001017419.1. NM_001017419.2. [Q7TSD4-2]
NP_001017433.1. NM_001017433.2. [Q7TSD4-1]
NP_075551.3. NM_023064.3. [Q7TSD4-6]
UniGeneiMm.30227.

Genome annotation databases

EnsembliENSMUST00000035894; ENSMUSP00000036422; ENSMUSG00000020096. [Q7TSD4-1]
ENSMUST00000121297; ENSMUSP00000113253; ENSMUSG00000020096. [Q7TSD4-5]
ENSMUST00000122261; ENSMUSP00000113902; ENSMUSG00000020096. [Q7TSD4-2]
GeneIDi65971.
KEGGimmu:65971.
UCSCiuc007ffm.2. mouse. [Q7TSD4-5]
uc007ffn.2. mouse. [Q7TSD4-1]
uc007ffo.2. mouse. [Q7TSD4-2]
uc007ffq.1. mouse. [Q7TSD4-7]
uc007ffr.2. mouse. [Q7TSD4-6]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF257502 mRNA. Translation: AAG37103.1.
AF257503 mRNA. Translation: AAG37104.1.
AF521591 mRNA. Translation: AAP50907.1. Different initiation.
AF521592 mRNA. Translation: AAP50908.1. Different initiation.
AY243457 mRNA. Translation: AAP41210.2.
AY243458 mRNA. Translation: AAP41211.1. Frameshift.
AY243459 mRNA. Translation: AAP41212.1.
EU622858 mRNA. Translation: ACD01420.1.
AK038284 mRNA. Translation: BAC29958.1.
CCDSiCCDS23873.1. [Q7TSD4-1]
CCDS23874.2. [Q7TSD4-5]
CCDS48572.1. [Q7TSD4-2]
CCDS48573.1. [Q7TSD4-6]
RefSeqiNP_001017407.1. NM_001017407.1. [Q7TSD4-7]
NP_001017409.1. NM_001017409.1.
NP_001017419.1. NM_001017419.2. [Q7TSD4-2]
NP_001017433.1. NM_001017433.2. [Q7TSD4-1]
NP_075551.3. NM_023064.3. [Q7TSD4-6]
UniGeneiMm.30227.

3D structure databases

ProteinModelPortaliQ7TSD4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211165. 1 interaction.
STRINGi10090.ENSMUSP00000036422.

PTM databases

iPTMnetiQ7TSD4.
PhosphoSiteiQ7TSD4.

Proteomic databases

MaxQBiQ7TSD4.
PaxDbiQ7TSD4.
PRIDEiQ7TSD4.

Protocols and materials databases

DNASUi65971.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035894; ENSMUSP00000036422; ENSMUSG00000020096. [Q7TSD4-1]
ENSMUST00000121297; ENSMUSP00000113253; ENSMUSG00000020096. [Q7TSD4-5]
ENSMUST00000122261; ENSMUSP00000113902; ENSMUSG00000020096. [Q7TSD4-2]
GeneIDi65971.
KEGGimmu:65971.
UCSCiuc007ffm.2. mouse. [Q7TSD4-5]
uc007ffn.2. mouse. [Q7TSD4-1]
uc007ffo.2. mouse. [Q7TSD4-2]
uc007ffq.1. mouse. [Q7TSD4-7]
uc007ffr.2. mouse. [Q7TSD4-6]

Organism-specific databases

CTDi219793.
MGIiMGI:1923820. Tbata.

Phylogenomic databases

eggNOGiENOG410IXP6. Eukaryota.
ENOG4111YVM. LUCA.
GeneTreeiENSGT00510000048896.
HOVERGENiHBG106634.
InParanoidiQ7TSD4.
OMAiYPLMSPK.
OrthoDBiEOG091G0BB5.
PhylomeDBiQ7TSD4.
TreeFamiTF333401.

Miscellaneous databases

ChiTaRSiTbata. mouse.
PROiQ7TSD4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020096.
ExpressionAtlasiQ7TSD4. baseline and differential.
GenevisibleiQ7TSD4. MM.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiTBATA_MOUSE
AccessioniPrimary (citable) accession number: Q7TSD4
Secondary accession number(s): B2ZA64
, Q6XBG6, Q6XBG7, Q6XBG8, Q7TSD5, Q8BYU0, Q9EQE4, Q9EQE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 23, 2008
Last sequence update: September 23, 2008
Last modified: September 7, 2016
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.