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Protein

Serine/threonine-protein kinase Nek5

Gene

Nek5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotation1
Active sitei124Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • positive regulation of cysteine-type endopeptidase activity Source: MGI
  • positive regulation of striated muscle cell differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase Nek5 (EC:2.7.11.1)
Alternative name(s):
Never in mitosis A-related kinase 5
Short name:
NimA-related protein kinase 5
Gene namesi
Name:Nek5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2142824. Nek5.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002597661 – 627Serine/threonine-protein kinase Nek5Add BLAST627

Proteomic databases

PaxDbiQ7TSC3.
PRIDEiQ7TSC3.

PTM databases

PhosphoSitePlusiQ7TSC3.

Expressioni

Gene expression databases

BgeeiENSMUSG00000037738.
GenevisibleiQ7TSC3. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000126705.

Structurei

3D structure databases

ProteinModelPortaliQ7TSC3.
SMRiQ7TSC3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 255Protein kinasePROSITE-ProRule annotationAdd BLAST252

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0589. Eukaryota.
ENOG410Y7JF. LUCA.
GeneTreeiENSGT00760000118997.
HOGENOMiHOG000113763.
InParanoidiQ7TSC3.
KOiK08857.
OMAiAVCGHYD.
OrthoDBiEOG091G0GU4.
PhylomeDBiQ7TSC3.
TreeFamiTF106472.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7TSC3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDNFHLIKII GEGTFGKVYL AKDKSESSHC VIKEISLTKE KEASKNEVIL
60 70 80 90 100
LARMEHPNIV TFFSSFQENG RLFIVMEYCD GGDLMQRIQR QRGVMFSEDQ
110 120 130 140 150
ILCWFVQISL GLKHIHDRKI LHRDIKSQNI FLSKNGMVAK LGDFGTARTL
160 170 180 190 200
NDSMELAQTC AGTPYYLSPE ICQNRPYNNK TDIWSLGCVL YELCTLKHPF
210 220 230 240 250
ESNNFHHLVL KICQGRVAPI SPHFSRDLQS LIPQLFRVSP QDRPSVTSLL
260 270 280 290 300
KRPFLETLIA RSLYPEVCSR RIQSHAHMEN MAIGPTACWR VSPWSAAYLQ
310 320 330 340 350
RKFEAQQYKL KVERQLGLRP SSVEPHPNEG EKLQSHWEET KFQELQYRKN
360 370 380 390 400
KMKDQEYWKQ LEEIRQQYHN DMKEIKKKMG RELKRVVKFE ISLDKCISEE
410 420 430 440 450
DTVQENEAVD KLNATLSFED GTKFQEHRCK EEHEDYTDRA FEELCGPEAE
460 470 480 490 500
GFFQDVIAAE NRRQWDAGAP HTLLRIMAMA DVTSTCPTMP DDGQVIVMEG
510 520 530 540 550
SVENGKQWWL DVPGTPCALA AECACSGSLS ASKGETVMIK PQLPKEDQEK
560 570 580 590 600
VEIATGIMVD DEQLEPGSDE DDIKFEESED ELRSEIIESL EKLAASTEEA
610 620
EQAPSSSKNA EEPGEKEKTN LPVKKLQ
Note: No experimental confirmation available.
Length:627
Mass (Da):71,790
Last modified:October 1, 2003 - v1
Checksum:iAD5789B6621ACA2F
GO
Isoform 2 (identifier: Q7TSC3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     295-336: SAAYLQRKFE...PNEGEKLQSH → WDHVTMSLKS...HPQCHKNEKF
     337-627: Missing.

Note: No experimental confirmation available.
Show »
Length:336
Mass (Da):38,757
Checksum:i6BDD377D72E0143B
GO
Isoform 3 (identifier: Q7TSC3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     573-627: IKFEESEDEL...KTNLPVKKLQ → MQEGRGIKNS...VTPPPLQRKI

Note: No experimental confirmation available.
Show »
Length:614
Mass (Da):70,032
Checksum:iDA95120EA45D71BC
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021531295 – 336SAAYL…KLQSH → WDHVTMSLKSMRGWLGVVAY RLPSLHKILPEFHPQCHKNE KF in isoform 2. 1 PublicationAdd BLAST42
Alternative sequenceiVSP_021532337 – 627Missing in isoform 2. 1 PublicationAdd BLAST291
Alternative sequenceiVSP_021533573 – 627IKFEE…VKKLQ → MQEGRGIKNSMPSSATSKIK ASPGCMASCPNSVTPPPLQR KI in isoform 3. 1 PublicationAdd BLAST55

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032672 mRNA. Translation: BAC27980.1.
AK054168 mRNA. Translation: BAC35677.1.
BC053516 mRNA. Translation: AAH53516.1.
CCDSiCCDS52518.1. [Q7TSC3-3]
RefSeqiNP_808566.2. NM_177898.4. [Q7TSC3-3]
XP_006509223.1. XM_006509160.3. [Q7TSC3-1]
UniGeneiMm.113940.

Genome annotation databases

EnsembliENSMUST00000169834; ENSMUSP00000126705; ENSMUSG00000037738. [Q7TSC3-3]
ENSMUST00000209656; ENSMUSP00000148211; ENSMUSG00000037738. [Q7TSC3-1]
GeneIDi330721.
KEGGimmu:330721.
UCSCiuc009lco.1. mouse. [Q7TSC3-3]
uc009lcp.1. mouse. [Q7TSC3-1]
uc009lcq.1. mouse. [Q7TSC3-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032672 mRNA. Translation: BAC27980.1.
AK054168 mRNA. Translation: BAC35677.1.
BC053516 mRNA. Translation: AAH53516.1.
CCDSiCCDS52518.1. [Q7TSC3-3]
RefSeqiNP_808566.2. NM_177898.4. [Q7TSC3-3]
XP_006509223.1. XM_006509160.3. [Q7TSC3-1]
UniGeneiMm.113940.

3D structure databases

ProteinModelPortaliQ7TSC3.
SMRiQ7TSC3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000126705.

PTM databases

PhosphoSitePlusiQ7TSC3.

Proteomic databases

PaxDbiQ7TSC3.
PRIDEiQ7TSC3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000169834; ENSMUSP00000126705; ENSMUSG00000037738. [Q7TSC3-3]
ENSMUST00000209656; ENSMUSP00000148211; ENSMUSG00000037738. [Q7TSC3-1]
GeneIDi330721.
KEGGimmu:330721.
UCSCiuc009lco.1. mouse. [Q7TSC3-3]
uc009lcp.1. mouse. [Q7TSC3-1]
uc009lcq.1. mouse. [Q7TSC3-2]

Organism-specific databases

CTDi341676.
MGIiMGI:2142824. Nek5.

Phylogenomic databases

eggNOGiKOG0589. Eukaryota.
ENOG410Y7JF. LUCA.
GeneTreeiENSGT00760000118997.
HOGENOMiHOG000113763.
InParanoidiQ7TSC3.
KOiK08857.
OMAiAVCGHYD.
OrthoDBiEOG091G0GU4.
PhylomeDBiQ7TSC3.
TreeFamiTF106472.

Miscellaneous databases

PROiQ7TSC3.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037738.
GenevisibleiQ7TSC3. MM.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNEK5_MOUSE
AccessioniPrimary (citable) accession number: Q7TSC3
Secondary accession number(s): Q8C6N6, Q8CCJ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.