Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q7TSC1

- PRC2A_MOUSE

UniProt

Q7TSC1 - PRC2A_MOUSE

Protein

Protein PRRC2A

Gene

Prrc2a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May play a role in the regulation of pre-mRNA splicing.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein PRRC2A
    Alternative name(s):
    HLA-B-associated transcript 2
    Proline-rich and coiled-coil-containing protein 2A
    Gene namesi
    Name:Prrc2a
    Synonyms:Bat2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 17

    Organism-specific databases

    MGIiMGI:1915467. Prrc2a.

    Subcellular locationi

    Cytoplasm By similarity. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 21582158Protein PRRC2APRO_0000064831Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei27 – 271N6-acetyllysineBy similarity
    Modified residuei35 – 351N6-acetyllysine1 Publication
    Modified residuei166 – 1661Phosphoserine1 Publication
    Modified residuei342 – 3421PhosphoserineBy similarity
    Modified residuei350 – 3501PhosphoserineBy similarity
    Modified residuei378 – 3781PhosphoserineBy similarity
    Modified residuei381 – 3811PhosphoserineBy similarity
    Modified residuei454 – 4541PhosphoserineBy similarity
    Modified residuei609 – 6091Phosphothreonine1 Publication
    Modified residuei759 – 7591PhosphoserineBy similarity
    Modified residuei761 – 7611PhosphoserineBy similarity
    Modified residuei764 – 7641PhosphoserineBy similarity
    Modified residuei808 – 8081Phosphoserine1 Publication
    Modified residuei995 – 9951Phosphothreonine1 Publication
    Modified residuei1002 – 10021Phosphoserine1 Publication
    Modified residuei1083 – 10831PhosphoserineBy similarity
    Modified residuei1087 – 10871Phosphoserine1 Publication
    Modified residuei1090 – 10901Phosphoserine1 Publication
    Modified residuei1092 – 10921PhosphotyrosineBy similarity
    Modified residuei1108 – 11081PhosphoserineBy similarity
    Modified residuei1145 – 11451PhosphoserineBy similarity
    Modified residuei1194 – 11941N6-acetyllysineBy similarity
    Modified residuei1217 – 12171Phosphoserine1 Publication
    Modified residuei1302 – 13021PhosphoserineBy similarity
    Modified residuei1349 – 13491PhosphothreonineBy similarity
    Modified residuei1401 – 14011PhosphothreonineBy similarity
    Modified residuei2114 – 21141PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ7TSC1.
    PaxDbiQ7TSC1.
    PRIDEiQ7TSC1.

    PTM databases

    PhosphoSiteiQ7TSC1.

    Expressioni

    Gene expression databases

    ArrayExpressiQ7TSC1.
    BgeeiQ7TSC1.
    CleanExiMM_BAT2.
    GenevestigatoriQ7TSC1.

    Interactioni

    Protein-protein interaction databases

    BioGridi207439. 2 interactions.
    DIPiDIP-49629N.
    IntActiQ7TSC1. 3 interactions.
    MINTiMINT-1616210.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7TSC1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati41 – 95551-1Add
    BLAST
    Repeati98 – 154571-2Add
    BLAST
    Repeati281 – 337571-3Add
    BLAST
    Repeati337 – 428922-1Add
    BLAST
    Repeati486 – 559742-2Add
    BLAST
    Repeati1756 – 1811561-4Add
    BLAST
    Repeati1917 – 1966503-1Add
    BLAST
    Repeati1983 – 2032503-2Add
    BLAST
    Repeati2058 – 2107503-3Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni41 – 181117714 X 57 AA type A repeatsAdd
    BLAST
    Regioni337 – 5592232 X type B repeatsAdd
    BLAST
    Regioni1917 – 21071913 X 50 AA type C repeatsAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi401 – 41313Poly-ProAdd
    BLAST
    Compositional biasi464 – 4696Poly-Arg
    Compositional biasi470 – 4734Poly-Glu
    Compositional biasi657 – 66913Poly-GlnAdd
    BLAST
    Compositional biasi696 – 7005Poly-Pro
    Compositional biasi826 – 8338Poly-Pro
    Compositional biasi912 – 9154Poly-Pro
    Compositional biasi954 – 9574Poly-Pro
    Compositional biasi1234 – 12396Poly-Arg
    Compositional biasi1292 – 12954Poly-Pro
    Compositional biasi1409 – 14179Poly-Gly
    Compositional biasi1447 – 14537Poly-Pro

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG271062.
    GeneTreeiENSGT00530000063496.
    HOVERGENiHBG004820.
    InParanoidiQ7TSC1.
    OMAiDALRWMP.
    OrthoDBiEOG7DZ8J2.
    PhylomeDBiQ7TSC1.
    TreeFamiTF328738.

    Family and domain databases

    InterProiIPR009738. BAT2_N.
    [Graphical view]
    PfamiPF07001. BAT2_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7TSC1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDRSGPTAK GKDGKKYSSL NLFDTYKGKS LEIQKPAVAP RHGLQSLGKV     50
    AIARRMPPPA NLPSLKAENK GNDPNVSLVP KDGTGWASKQ EQSDPKSSDA 100
    STAQPPESQP LPASQTPASN QPKRPPTAPE NTPSVPSGVK SWAQASVTHG 150
    AHGDGGRASN LLSRFSREEF PTLQAAGDQD KAAKERESAE QSSGPGPSLR 200
    PQNSTTWRDG GGRGPDDLEG PDSKLHHGHD PRGGLQPSGP PQFPPYRGMM 250
    PPFMYPPYLP FPPPYGPQGP YRYPTPDGPS RFPRVAGPRG SGPPMRLVEP 300
    VGRPSILKED NLKEFDQLDQ ENDDGWAGAH EEVDYTEKLK FSDEEDGRDS 350
    DEEGAEGHKD SQSAAAEEPE TDGKKGTSPG SELPPPKTAW TENARPSETE 400
    PAPPTPKPPP PPPHRGPVGN WGPPGDYPDR GGPPCKPPAP EDEDEAWRQR 450
    RKQSSSEISL AVERARRRRE EEERRMQEER RAACAEKLKR LDEKFGAPDK 500
    RLKAEPAAPP VTPAAPALPP VVPKEIPAAP ALPPTPTPTP EKEPEEPAQA 550
    PPVQAAPSPG VAPVPTLVSG GGCTANSNSS GSFEASPVEP QLPSKEGPEP 600
    PEEVPPPTTP PAPKMEPKGD GVGSTRQPPS QGLGYPKYQK SLPPRFQRQQ 650
    QEQLLKQQQQ QQQWQQQQQG TAPPAPVPPS PPQPVTLGAV PAPQAPPPPP 700
    KALYPGALGR PPPMPPMNFD PRWMMIPPYV DPRLLQGRPP LDFYPPGVHP 750
    SGLVPRERSD SGGSSSEPFE RHAPPLLRER GTPPVDPKLA WVGDVFTTTP 800
    TDPRPLTSPL RQAADEEEKS MRSETPPVPP PPPYLANYPG FPENGTPGPP 850
    ISRFPLEESA PPGPRPLPWP PGNDEAAKMQ APPPKKEPSK EEPPQLSGPE 900
    AGRKPARGGQ GPPPPRRENR TETRWGPRPG SCRRGIPPEE PGVPPRRAGP 950
    IKKPPPPVKV EELPPKSLEQ GDETPKVPKP DALKTAKGKV GPKETPPGGN 1000
    LSPAPRLRRD YSYERVGPTS CRGRGRGEYF ARGRGFRGTY GGRGRGARSR 1050
    EFRSYREFRG DDGRGGGSGG TNHPSAPRGR TASETRSEGS EYEEIPKRRR 1100
    QRGSETGSET HESDLAPSDK EAPPPKEGVL GQVPLAPPQP GAPPSPAPAR 1150
    FSTARGGRVF TPRGVPSRRG RGGGRPPPVC SGWSPPAKSL VPKKPPTGPL 1200
    PPSKEPLKEK LISGPLSPMS RAGNMGVGME DGERPRRRRH GRAQQQDKPP 1250
    RFRRLKQERE NAARGADGKP PSLTLAASTP GPEETLTAAT VPPPPRRTAA 1300
    KSPDLSNQNS DQANEEWETA SESSDFASER RGDKETPPAA LMTSKAVGTP 1350
    GANAGGAGPG ISAMSRGDLS QRAKDLSKRS FSSQRPGMDR QNRRPGTGGK 1400
    TGSGGGSSGG GGAGPGGRTG PGRGDKRSWP SPKNRSRPPE ERPPGLPLPP 1450
    PPPSSSAVFR LDQVIHSNPA GIQQALAQLS SRQGNVTAPG GHPRPKPGPP 1500
    QAPQGSSPRP PTRYDPPRAS SAISSDPHFE EPGPMVRGVG GTPRDSAGVN 1550
    PFPPKRRERP PRKPELLQEE TVPASHSSGF LGSKPEVPGP QEESRDSGTE 1600
    ALTPHIWNRL HTATSRKSYQ PGSIEPWMEP LSPFEDVAGT EMSQSDSGVD 1650
    LSGDSQVSSG PCSQRSSPDG GLKGSAEGPP KRPGGPSPLN AVPGESASGS 1700
    EPSEPPRRRP PASHEGERKE LPREQPLPPG PIGTERSQRT DRGPEPGPLR 1750
    PAHRPGSQVE FGTTNKDSDL CLVVGDTLKG EKELVASATE AVPISRDWEL 1800
    LPSASTSAEP QPKSLGSGQC VPEPSPSGQR PYPEVFYGSP GPPNSQQVSG 1850
    GAPIDSQLHP NSGGFRPGTP SLHQYRSQPL YLPPGPAPPS ALLSGVALKG 1900
    QFLDFSALQA TELGKLPAGG VLYPPPSFLY SAAFCPSPLP DPPLLQVRQD 1950
    LPSPSDFYST PLQPGGQSGF LPSGAPAQQM LLPVVDSQLP VVNFGSLPPA 2000
    PPPAPPPLSL LPVGPALQPP NLAVRPPPAP AARVLPSPAR PFAPSLGRAE 2050
    LHPVELKPFQ DYRKLSSNLG GPGSSRTPPS GRPFSGLNSR LKAPPSTYSG 2100
    VFRTQRIDLY QQASPPDALR WMPKPWERAG PPSREGPPRR AEEPGSRGEK 2150
    EPGLPPPR 2158
    Length:2,158
    Mass (Da):229,203
    Last modified:October 1, 2003 - v1
    Checksum:i85A5CBDCDA84A256
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1846 – 18461Missing in AAC82480. (PubMed:14656967)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF109719 Genomic DNA. Translation: AAC82480.1.
    BC006664 mRNA. Translation: AAH06664.1.
    BC053522 mRNA. Translation: AAH53522.1.
    CCDSiCCDS37596.1.
    RefSeqiNP_001185973.1. NM_001199044.1.
    NP_064411.2. NM_020027.3.
    XP_006524683.1. XM_006524620.1.
    XP_006525476.1. XM_006525413.1.
    XP_006536721.1. XM_006536658.1.
    XP_006537452.1. XM_006537389.1.
    UniGeneiMm.272462.

    Genome annotation databases

    EnsembliENSMUST00000025253; ENSMUSP00000025253; ENSMUSG00000024393.
    GeneIDi53761.
    KEGGimmu:53761.
    UCSCiuc008cgj.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF109719 Genomic DNA. Translation: AAC82480.1 .
    BC006664 mRNA. Translation: AAH06664.1 .
    BC053522 mRNA. Translation: AAH53522.1 .
    CCDSi CCDS37596.1.
    RefSeqi NP_001185973.1. NM_001199044.1.
    NP_064411.2. NM_020027.3.
    XP_006524683.1. XM_006524620.1.
    XP_006525476.1. XM_006525413.1.
    XP_006536721.1. XM_006536658.1.
    XP_006537452.1. XM_006537389.1.
    UniGenei Mm.272462.

    3D structure databases

    ProteinModelPortali Q7TSC1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 207439. 2 interactions.
    DIPi DIP-49629N.
    IntActi Q7TSC1. 3 interactions.
    MINTi MINT-1616210.

    PTM databases

    PhosphoSitei Q7TSC1.

    Proteomic databases

    MaxQBi Q7TSC1.
    PaxDbi Q7TSC1.
    PRIDEi Q7TSC1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025253 ; ENSMUSP00000025253 ; ENSMUSG00000024393 .
    GeneIDi 53761.
    KEGGi mmu:53761.
    UCSCi uc008cgj.2. mouse.

    Organism-specific databases

    CTDi 7916.
    MGIi MGI:1915467. Prrc2a.

    Phylogenomic databases

    eggNOGi NOG271062.
    GeneTreei ENSGT00530000063496.
    HOVERGENi HBG004820.
    InParanoidi Q7TSC1.
    OMAi DALRWMP.
    OrthoDBi EOG7DZ8J2.
    PhylomeDBi Q7TSC1.
    TreeFami TF328738.

    Miscellaneous databases

    ChiTaRSi PRRC2A. mouse.
    NextBioi 310575.
    PROi Q7TSC1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7TSC1.
    Bgeei Q7TSC1.
    CleanExi MM_BAT2.
    Genevestigatori Q7TSC1.

    Family and domain databases

    InterProi IPR009738. BAT2_N.
    [Graphical view ]
    Pfami PF07001. BAT2_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
      Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
      Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 129.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye and Mammary gland.
    3. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 82-89, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.
    4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-995; SER-1002; SER-1087 AND SER-1090, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Liver.
    5. "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
      Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-166 AND THR-609, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
      Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-808 AND SER-1217, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.
    7. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-35, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiPRC2A_MOUSE
    AccessioniPrimary (citable) accession number: Q7TSC1
    Secondary accession number(s): Q923A9, Q9Z1R1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2005
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3