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Q7TSC1

- PRC2A_MOUSE

UniProt

Q7TSC1 - PRC2A_MOUSE

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Protein

Protein PRRC2A

Gene

Prrc2a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in the regulation of pre-mRNA splicing.By similarity

GO - Molecular functioni

  1. poly(A) RNA binding Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein PRRC2A
Alternative name(s):
HLA-B-associated transcript 2
Proline-rich and coiled-coil-containing protein 2A
Gene namesi
Name:Prrc2a
Synonyms:Bat2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1915467. Prrc2a.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: Ensembl
  3. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21582158Protein PRRC2APRO_0000064831Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei27 – 271N6-acetyllysineBy similarity
Modified residuei35 – 351N6-acetyllysine1 Publication
Modified residuei166 – 1661Phosphoserine1 Publication
Modified residuei342 – 3421PhosphoserineBy similarity
Modified residuei350 – 3501PhosphoserineBy similarity
Modified residuei378 – 3781PhosphoserineBy similarity
Modified residuei381 – 3811PhosphoserineBy similarity
Modified residuei454 – 4541PhosphoserineBy similarity
Modified residuei609 – 6091Phosphothreonine1 Publication
Modified residuei759 – 7591PhosphoserineBy similarity
Modified residuei761 – 7611PhosphoserineBy similarity
Modified residuei764 – 7641PhosphoserineBy similarity
Modified residuei808 – 8081Phosphoserine1 Publication
Modified residuei995 – 9951Phosphothreonine1 Publication
Modified residuei1002 – 10021Phosphoserine1 Publication
Modified residuei1083 – 10831PhosphoserineBy similarity
Modified residuei1087 – 10871Phosphoserine1 Publication
Modified residuei1090 – 10901Phosphoserine1 Publication
Modified residuei1092 – 10921PhosphotyrosineBy similarity
Modified residuei1108 – 11081PhosphoserineBy similarity
Modified residuei1145 – 11451PhosphoserineBy similarity
Modified residuei1194 – 11941N6-acetyllysineBy similarity
Modified residuei1217 – 12171Phosphoserine1 Publication
Modified residuei1302 – 13021PhosphoserineBy similarity
Modified residuei1349 – 13491PhosphothreonineBy similarity
Modified residuei1401 – 14011PhosphothreonineBy similarity
Modified residuei2114 – 21141PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ7TSC1.
PaxDbiQ7TSC1.
PRIDEiQ7TSC1.

PTM databases

PhosphoSiteiQ7TSC1.

Expressioni

Gene expression databases

BgeeiQ7TSC1.
CleanExiMM_BAT2.
ExpressionAtlasiQ7TSC1. baseline and differential.
GenevestigatoriQ7TSC1.

Interactioni

Protein-protein interaction databases

BioGridi207439. 2 interactions.
DIPiDIP-49629N.
IntActiQ7TSC1. 3 interactions.
MINTiMINT-1616210.

Structurei

3D structure databases

ProteinModelPortaliQ7TSC1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati41 – 95551-1Add
BLAST
Repeati98 – 154571-2Add
BLAST
Repeati281 – 337571-3Add
BLAST
Repeati337 – 428922-1Add
BLAST
Repeati486 – 559742-2Add
BLAST
Repeati1756 – 1811561-4Add
BLAST
Repeati1917 – 1966503-1Add
BLAST
Repeati1983 – 2032503-2Add
BLAST
Repeati2058 – 2107503-3Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni41 – 181117714 X 57 AA type A repeatsAdd
BLAST
Regioni337 – 5592232 X type B repeatsAdd
BLAST
Regioni1917 – 21071913 X 50 AA type C repeatsAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi401 – 41313Poly-ProAdd
BLAST
Compositional biasi464 – 4696Poly-Arg
Compositional biasi470 – 4734Poly-Glu
Compositional biasi657 – 66913Poly-GlnAdd
BLAST
Compositional biasi696 – 7005Poly-Pro
Compositional biasi826 – 8338Poly-Pro
Compositional biasi912 – 9154Poly-Pro
Compositional biasi954 – 9574Poly-Pro
Compositional biasi1234 – 12396Poly-Arg
Compositional biasi1292 – 12954Poly-Pro
Compositional biasi1409 – 14179Poly-Gly
Compositional biasi1447 – 14537Poly-Pro

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG271062.
GeneTreeiENSGT00530000063496.
HOVERGENiHBG004820.
InParanoidiQ7TSC1.
OMAiDALRWMP.
OrthoDBiEOG7DZ8J2.
PhylomeDBiQ7TSC1.
TreeFamiTF328738.

Family and domain databases

InterProiIPR009738. BAT2_N.
[Graphical view]
PfamiPF07001. BAT2_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TSC1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDRSGPTAK GKDGKKYSSL NLFDTYKGKS LEIQKPAVAP RHGLQSLGKV
60 70 80 90 100
AIARRMPPPA NLPSLKAENK GNDPNVSLVP KDGTGWASKQ EQSDPKSSDA
110 120 130 140 150
STAQPPESQP LPASQTPASN QPKRPPTAPE NTPSVPSGVK SWAQASVTHG
160 170 180 190 200
AHGDGGRASN LLSRFSREEF PTLQAAGDQD KAAKERESAE QSSGPGPSLR
210 220 230 240 250
PQNSTTWRDG GGRGPDDLEG PDSKLHHGHD PRGGLQPSGP PQFPPYRGMM
260 270 280 290 300
PPFMYPPYLP FPPPYGPQGP YRYPTPDGPS RFPRVAGPRG SGPPMRLVEP
310 320 330 340 350
VGRPSILKED NLKEFDQLDQ ENDDGWAGAH EEVDYTEKLK FSDEEDGRDS
360 370 380 390 400
DEEGAEGHKD SQSAAAEEPE TDGKKGTSPG SELPPPKTAW TENARPSETE
410 420 430 440 450
PAPPTPKPPP PPPHRGPVGN WGPPGDYPDR GGPPCKPPAP EDEDEAWRQR
460 470 480 490 500
RKQSSSEISL AVERARRRRE EEERRMQEER RAACAEKLKR LDEKFGAPDK
510 520 530 540 550
RLKAEPAAPP VTPAAPALPP VVPKEIPAAP ALPPTPTPTP EKEPEEPAQA
560 570 580 590 600
PPVQAAPSPG VAPVPTLVSG GGCTANSNSS GSFEASPVEP QLPSKEGPEP
610 620 630 640 650
PEEVPPPTTP PAPKMEPKGD GVGSTRQPPS QGLGYPKYQK SLPPRFQRQQ
660 670 680 690 700
QEQLLKQQQQ QQQWQQQQQG TAPPAPVPPS PPQPVTLGAV PAPQAPPPPP
710 720 730 740 750
KALYPGALGR PPPMPPMNFD PRWMMIPPYV DPRLLQGRPP LDFYPPGVHP
760 770 780 790 800
SGLVPRERSD SGGSSSEPFE RHAPPLLRER GTPPVDPKLA WVGDVFTTTP
810 820 830 840 850
TDPRPLTSPL RQAADEEEKS MRSETPPVPP PPPYLANYPG FPENGTPGPP
860 870 880 890 900
ISRFPLEESA PPGPRPLPWP PGNDEAAKMQ APPPKKEPSK EEPPQLSGPE
910 920 930 940 950
AGRKPARGGQ GPPPPRRENR TETRWGPRPG SCRRGIPPEE PGVPPRRAGP
960 970 980 990 1000
IKKPPPPVKV EELPPKSLEQ GDETPKVPKP DALKTAKGKV GPKETPPGGN
1010 1020 1030 1040 1050
LSPAPRLRRD YSYERVGPTS CRGRGRGEYF ARGRGFRGTY GGRGRGARSR
1060 1070 1080 1090 1100
EFRSYREFRG DDGRGGGSGG TNHPSAPRGR TASETRSEGS EYEEIPKRRR
1110 1120 1130 1140 1150
QRGSETGSET HESDLAPSDK EAPPPKEGVL GQVPLAPPQP GAPPSPAPAR
1160 1170 1180 1190 1200
FSTARGGRVF TPRGVPSRRG RGGGRPPPVC SGWSPPAKSL VPKKPPTGPL
1210 1220 1230 1240 1250
PPSKEPLKEK LISGPLSPMS RAGNMGVGME DGERPRRRRH GRAQQQDKPP
1260 1270 1280 1290 1300
RFRRLKQERE NAARGADGKP PSLTLAASTP GPEETLTAAT VPPPPRRTAA
1310 1320 1330 1340 1350
KSPDLSNQNS DQANEEWETA SESSDFASER RGDKETPPAA LMTSKAVGTP
1360 1370 1380 1390 1400
GANAGGAGPG ISAMSRGDLS QRAKDLSKRS FSSQRPGMDR QNRRPGTGGK
1410 1420 1430 1440 1450
TGSGGGSSGG GGAGPGGRTG PGRGDKRSWP SPKNRSRPPE ERPPGLPLPP
1460 1470 1480 1490 1500
PPPSSSAVFR LDQVIHSNPA GIQQALAQLS SRQGNVTAPG GHPRPKPGPP
1510 1520 1530 1540 1550
QAPQGSSPRP PTRYDPPRAS SAISSDPHFE EPGPMVRGVG GTPRDSAGVN
1560 1570 1580 1590 1600
PFPPKRRERP PRKPELLQEE TVPASHSSGF LGSKPEVPGP QEESRDSGTE
1610 1620 1630 1640 1650
ALTPHIWNRL HTATSRKSYQ PGSIEPWMEP LSPFEDVAGT EMSQSDSGVD
1660 1670 1680 1690 1700
LSGDSQVSSG PCSQRSSPDG GLKGSAEGPP KRPGGPSPLN AVPGESASGS
1710 1720 1730 1740 1750
EPSEPPRRRP PASHEGERKE LPREQPLPPG PIGTERSQRT DRGPEPGPLR
1760 1770 1780 1790 1800
PAHRPGSQVE FGTTNKDSDL CLVVGDTLKG EKELVASATE AVPISRDWEL
1810 1820 1830 1840 1850
LPSASTSAEP QPKSLGSGQC VPEPSPSGQR PYPEVFYGSP GPPNSQQVSG
1860 1870 1880 1890 1900
GAPIDSQLHP NSGGFRPGTP SLHQYRSQPL YLPPGPAPPS ALLSGVALKG
1910 1920 1930 1940 1950
QFLDFSALQA TELGKLPAGG VLYPPPSFLY SAAFCPSPLP DPPLLQVRQD
1960 1970 1980 1990 2000
LPSPSDFYST PLQPGGQSGF LPSGAPAQQM LLPVVDSQLP VVNFGSLPPA
2010 2020 2030 2040 2050
PPPAPPPLSL LPVGPALQPP NLAVRPPPAP AARVLPSPAR PFAPSLGRAE
2060 2070 2080 2090 2100
LHPVELKPFQ DYRKLSSNLG GPGSSRTPPS GRPFSGLNSR LKAPPSTYSG
2110 2120 2130 2140 2150
VFRTQRIDLY QQASPPDALR WMPKPWERAG PPSREGPPRR AEEPGSRGEK

EPGLPPPR
Length:2,158
Mass (Da):229,203
Last modified:October 1, 2003 - v1
Checksum:i85A5CBDCDA84A256
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1846 – 18461Missing in AAC82480. (PubMed:14656967)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109719 Genomic DNA. Translation: AAC82480.1.
BC006664 mRNA. Translation: AAH06664.1.
BC053522 mRNA. Translation: AAH53522.1.
CCDSiCCDS37596.1.
RefSeqiNP_001185973.1. NM_001199044.1.
NP_064411.2. NM_020027.3.
XP_006524683.1. XM_006524620.1.
XP_006525476.1. XM_006525413.1.
XP_006536721.1. XM_006536658.1.
XP_006537452.1. XM_006537389.1.
UniGeneiMm.272462.

Genome annotation databases

EnsembliENSMUST00000025253; ENSMUSP00000025253; ENSMUSG00000024393.
GeneIDi53761.
KEGGimmu:53761.
UCSCiuc008cgj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109719 Genomic DNA. Translation: AAC82480.1 .
BC006664 mRNA. Translation: AAH06664.1 .
BC053522 mRNA. Translation: AAH53522.1 .
CCDSi CCDS37596.1.
RefSeqi NP_001185973.1. NM_001199044.1.
NP_064411.2. NM_020027.3.
XP_006524683.1. XM_006524620.1.
XP_006525476.1. XM_006525413.1.
XP_006536721.1. XM_006536658.1.
XP_006537452.1. XM_006537389.1.
UniGenei Mm.272462.

3D structure databases

ProteinModelPortali Q7TSC1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 207439. 2 interactions.
DIPi DIP-49629N.
IntActi Q7TSC1. 3 interactions.
MINTi MINT-1616210.

PTM databases

PhosphoSitei Q7TSC1.

Proteomic databases

MaxQBi Q7TSC1.
PaxDbi Q7TSC1.
PRIDEi Q7TSC1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025253 ; ENSMUSP00000025253 ; ENSMUSG00000024393 .
GeneIDi 53761.
KEGGi mmu:53761.
UCSCi uc008cgj.2. mouse.

Organism-specific databases

CTDi 7916.
MGIi MGI:1915467. Prrc2a.

Phylogenomic databases

eggNOGi NOG271062.
GeneTreei ENSGT00530000063496.
HOVERGENi HBG004820.
InParanoidi Q7TSC1.
OMAi DALRWMP.
OrthoDBi EOG7DZ8J2.
PhylomeDBi Q7TSC1.
TreeFami TF328738.

Miscellaneous databases

ChiTaRSi Prrc2a. mouse.
NextBioi 310575.
PROi Q7TSC1.
SOURCEi Search...

Gene expression databases

Bgeei Q7TSC1.
CleanExi MM_BAT2.
ExpressionAtlasi Q7TSC1. baseline and differential.
Genevestigatori Q7TSC1.

Family and domain databases

InterProi IPR009738. BAT2_N.
[Graphical view ]
Pfami PF07001. BAT2_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
    Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
    Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 129.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye and Mammary gland.
  3. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 82-89, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-995; SER-1002; SER-1087 AND SER-1090, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-166 AND THR-609, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-808 AND SER-1217, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  7. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-35, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiPRC2A_MOUSE
AccessioniPrimary (citable) accession number: Q7TSC1
Secondary accession number(s): Q923A9, Q9Z1R1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: October 1, 2003
Last modified: November 26, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3