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Q7TSC1

- PRC2A_MOUSE

UniProt

Q7TSC1 - PRC2A_MOUSE

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Protein
Protein PRRC2A
Gene
Prrc2a, Bat2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

May play a role in the regulation of pre-mRNA splicing By similarity.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein PRRC2A
Alternative name(s):
HLA-B-associated transcript 2
Proline-rich and coiled-coil-containing protein 2A
Gene namesi
Name:Prrc2a
Synonyms:Bat2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 17

Organism-specific databases

MGIiMGI:1915467. Prrc2a.

Subcellular locationi

Cytoplasm By similarity. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 21582158Protein PRRC2A
PRO_0000064831Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei27 – 271N6-acetyllysine By similarity
Modified residuei35 – 351N6-acetyllysine1 Publication
Modified residuei166 – 1661Phosphoserine1 Publication
Modified residuei342 – 3421Phosphoserine By similarity
Modified residuei350 – 3501Phosphoserine By similarity
Modified residuei378 – 3781Phosphoserine By similarity
Modified residuei381 – 3811Phosphoserine By similarity
Modified residuei454 – 4541Phosphoserine By similarity
Modified residuei609 – 6091Phosphothreonine1 Publication
Modified residuei759 – 7591Phosphoserine By similarity
Modified residuei761 – 7611Phosphoserine By similarity
Modified residuei764 – 7641Phosphoserine By similarity
Modified residuei808 – 8081Phosphoserine1 Publication
Modified residuei995 – 9951Phosphothreonine1 Publication
Modified residuei1002 – 10021Phosphoserine1 Publication
Modified residuei1083 – 10831Phosphoserine By similarity
Modified residuei1087 – 10871Phosphoserine1 Publication
Modified residuei1090 – 10901Phosphoserine1 Publication
Modified residuei1092 – 10921Phosphotyrosine By similarity
Modified residuei1108 – 11081Phosphoserine By similarity
Modified residuei1145 – 11451Phosphoserine By similarity
Modified residuei1194 – 11941N6-acetyllysine By similarity
Modified residuei1217 – 12171Phosphoserine1 Publication
Modified residuei1302 – 13021Phosphoserine By similarity
Modified residuei1349 – 13491Phosphothreonine By similarity
Modified residuei1401 – 14011Phosphothreonine By similarity
Modified residuei2114 – 21141Phosphoserine By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ7TSC1.
PaxDbiQ7TSC1.
PRIDEiQ7TSC1.

PTM databases

PhosphoSiteiQ7TSC1.

Expressioni

Gene expression databases

ArrayExpressiQ7TSC1.
BgeeiQ7TSC1.
CleanExiMM_BAT2.
GenevestigatoriQ7TSC1.

Interactioni

Protein-protein interaction databases

BioGridi207439. 2 interactions.
DIPiDIP-49629N.
IntActiQ7TSC1. 3 interactions.
MINTiMINT-1616210.

Structurei

3D structure databases

ProteinModelPortaliQ7TSC1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati41 – 95551-1
Add
BLAST
Repeati98 – 154571-2
Add
BLAST
Repeati281 – 337571-3
Add
BLAST
Repeati337 – 428922-1
Add
BLAST
Repeati486 – 559742-2
Add
BLAST
Repeati1756 – 1811561-4
Add
BLAST
Repeati1917 – 1966503-1
Add
BLAST
Repeati1983 – 2032503-2
Add
BLAST
Repeati2058 – 2107503-3
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni41 – 181117714 X 57 AA type A repeats
Add
BLAST
Regioni337 – 5592232 X type B repeats
Add
BLAST
Regioni1917 – 21071913 X 50 AA type C repeats
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi401 – 41313Poly-Pro
Add
BLAST
Compositional biasi464 – 4696Poly-Arg
Compositional biasi470 – 4734Poly-Glu
Compositional biasi657 – 66913Poly-Gln
Add
BLAST
Compositional biasi696 – 7005Poly-Pro
Compositional biasi826 – 8338Poly-Pro
Compositional biasi912 – 9154Poly-Pro
Compositional biasi954 – 9574Poly-Pro
Compositional biasi1234 – 12396Poly-Arg
Compositional biasi1292 – 12954Poly-Pro
Compositional biasi1409 – 14179Poly-Gly
Compositional biasi1447 – 14537Poly-Pro

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG271062.
GeneTreeiENSGT00530000063496.
HOVERGENiHBG004820.
InParanoidiQ7TSC1.
OMAiDALRWMP.
OrthoDBiEOG7DZ8J2.
PhylomeDBiQ7TSC1.
TreeFamiTF328738.

Family and domain databases

InterProiIPR009738. BAT2_N.
[Graphical view]
PfamiPF07001. BAT2_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TSC1-1 [UniParc]FASTAAdd to Basket

« Hide

MSDRSGPTAK GKDGKKYSSL NLFDTYKGKS LEIQKPAVAP RHGLQSLGKV     50
AIARRMPPPA NLPSLKAENK GNDPNVSLVP KDGTGWASKQ EQSDPKSSDA 100
STAQPPESQP LPASQTPASN QPKRPPTAPE NTPSVPSGVK SWAQASVTHG 150
AHGDGGRASN LLSRFSREEF PTLQAAGDQD KAAKERESAE QSSGPGPSLR 200
PQNSTTWRDG GGRGPDDLEG PDSKLHHGHD PRGGLQPSGP PQFPPYRGMM 250
PPFMYPPYLP FPPPYGPQGP YRYPTPDGPS RFPRVAGPRG SGPPMRLVEP 300
VGRPSILKED NLKEFDQLDQ ENDDGWAGAH EEVDYTEKLK FSDEEDGRDS 350
DEEGAEGHKD SQSAAAEEPE TDGKKGTSPG SELPPPKTAW TENARPSETE 400
PAPPTPKPPP PPPHRGPVGN WGPPGDYPDR GGPPCKPPAP EDEDEAWRQR 450
RKQSSSEISL AVERARRRRE EEERRMQEER RAACAEKLKR LDEKFGAPDK 500
RLKAEPAAPP VTPAAPALPP VVPKEIPAAP ALPPTPTPTP EKEPEEPAQA 550
PPVQAAPSPG VAPVPTLVSG GGCTANSNSS GSFEASPVEP QLPSKEGPEP 600
PEEVPPPTTP PAPKMEPKGD GVGSTRQPPS QGLGYPKYQK SLPPRFQRQQ 650
QEQLLKQQQQ QQQWQQQQQG TAPPAPVPPS PPQPVTLGAV PAPQAPPPPP 700
KALYPGALGR PPPMPPMNFD PRWMMIPPYV DPRLLQGRPP LDFYPPGVHP 750
SGLVPRERSD SGGSSSEPFE RHAPPLLRER GTPPVDPKLA WVGDVFTTTP 800
TDPRPLTSPL RQAADEEEKS MRSETPPVPP PPPYLANYPG FPENGTPGPP 850
ISRFPLEESA PPGPRPLPWP PGNDEAAKMQ APPPKKEPSK EEPPQLSGPE 900
AGRKPARGGQ GPPPPRRENR TETRWGPRPG SCRRGIPPEE PGVPPRRAGP 950
IKKPPPPVKV EELPPKSLEQ GDETPKVPKP DALKTAKGKV GPKETPPGGN 1000
LSPAPRLRRD YSYERVGPTS CRGRGRGEYF ARGRGFRGTY GGRGRGARSR 1050
EFRSYREFRG DDGRGGGSGG TNHPSAPRGR TASETRSEGS EYEEIPKRRR 1100
QRGSETGSET HESDLAPSDK EAPPPKEGVL GQVPLAPPQP GAPPSPAPAR 1150
FSTARGGRVF TPRGVPSRRG RGGGRPPPVC SGWSPPAKSL VPKKPPTGPL 1200
PPSKEPLKEK LISGPLSPMS RAGNMGVGME DGERPRRRRH GRAQQQDKPP 1250
RFRRLKQERE NAARGADGKP PSLTLAASTP GPEETLTAAT VPPPPRRTAA 1300
KSPDLSNQNS DQANEEWETA SESSDFASER RGDKETPPAA LMTSKAVGTP 1350
GANAGGAGPG ISAMSRGDLS QRAKDLSKRS FSSQRPGMDR QNRRPGTGGK 1400
TGSGGGSSGG GGAGPGGRTG PGRGDKRSWP SPKNRSRPPE ERPPGLPLPP 1450
PPPSSSAVFR LDQVIHSNPA GIQQALAQLS SRQGNVTAPG GHPRPKPGPP 1500
QAPQGSSPRP PTRYDPPRAS SAISSDPHFE EPGPMVRGVG GTPRDSAGVN 1550
PFPPKRRERP PRKPELLQEE TVPASHSSGF LGSKPEVPGP QEESRDSGTE 1600
ALTPHIWNRL HTATSRKSYQ PGSIEPWMEP LSPFEDVAGT EMSQSDSGVD 1650
LSGDSQVSSG PCSQRSSPDG GLKGSAEGPP KRPGGPSPLN AVPGESASGS 1700
EPSEPPRRRP PASHEGERKE LPREQPLPPG PIGTERSQRT DRGPEPGPLR 1750
PAHRPGSQVE FGTTNKDSDL CLVVGDTLKG EKELVASATE AVPISRDWEL 1800
LPSASTSAEP QPKSLGSGQC VPEPSPSGQR PYPEVFYGSP GPPNSQQVSG 1850
GAPIDSQLHP NSGGFRPGTP SLHQYRSQPL YLPPGPAPPS ALLSGVALKG 1900
QFLDFSALQA TELGKLPAGG VLYPPPSFLY SAAFCPSPLP DPPLLQVRQD 1950
LPSPSDFYST PLQPGGQSGF LPSGAPAQQM LLPVVDSQLP VVNFGSLPPA 2000
PPPAPPPLSL LPVGPALQPP NLAVRPPPAP AARVLPSPAR PFAPSLGRAE 2050
LHPVELKPFQ DYRKLSSNLG GPGSSRTPPS GRPFSGLNSR LKAPPSTYSG 2100
VFRTQRIDLY QQASPPDALR WMPKPWERAG PPSREGPPRR AEEPGSRGEK 2150
EPGLPPPR 2158
Length:2,158
Mass (Da):229,203
Last modified:October 1, 2003 - v1
Checksum:i85A5CBDCDA84A256
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1846 – 18461Missing in AAC82480. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF109719 Genomic DNA. Translation: AAC82480.1.
BC006664 mRNA. Translation: AAH06664.1.
BC053522 mRNA. Translation: AAH53522.1.
CCDSiCCDS37596.1.
RefSeqiNP_001185973.1. NM_001199044.1.
NP_064411.2. NM_020027.3.
XP_006524683.1. XM_006524620.1.
XP_006525476.1. XM_006525413.1.
XP_006536721.1. XM_006536658.1.
XP_006537452.1. XM_006537389.1.
UniGeneiMm.272462.

Genome annotation databases

EnsembliENSMUST00000025253; ENSMUSP00000025253; ENSMUSG00000024393.
GeneIDi53761.
KEGGimmu:53761.
UCSCiuc008cgj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF109719 Genomic DNA. Translation: AAC82480.1 .
BC006664 mRNA. Translation: AAH06664.1 .
BC053522 mRNA. Translation: AAH53522.1 .
CCDSi CCDS37596.1.
RefSeqi NP_001185973.1. NM_001199044.1.
NP_064411.2. NM_020027.3.
XP_006524683.1. XM_006524620.1.
XP_006525476.1. XM_006525413.1.
XP_006536721.1. XM_006536658.1.
XP_006537452.1. XM_006537389.1.
UniGenei Mm.272462.

3D structure databases

ProteinModelPortali Q7TSC1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 207439. 2 interactions.
DIPi DIP-49629N.
IntActi Q7TSC1. 3 interactions.
MINTi MINT-1616210.

PTM databases

PhosphoSitei Q7TSC1.

Proteomic databases

MaxQBi Q7TSC1.
PaxDbi Q7TSC1.
PRIDEi Q7TSC1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025253 ; ENSMUSP00000025253 ; ENSMUSG00000024393 .
GeneIDi 53761.
KEGGi mmu:53761.
UCSCi uc008cgj.2. mouse.

Organism-specific databases

CTDi 7916.
MGIi MGI:1915467. Prrc2a.

Phylogenomic databases

eggNOGi NOG271062.
GeneTreei ENSGT00530000063496.
HOVERGENi HBG004820.
InParanoidi Q7TSC1.
OMAi DALRWMP.
OrthoDBi EOG7DZ8J2.
PhylomeDBi Q7TSC1.
TreeFami TF328738.

Miscellaneous databases

ChiTaRSi PRRC2A. mouse.
NextBioi 310575.
PROi Q7TSC1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q7TSC1.
Bgeei Q7TSC1.
CleanExi MM_BAT2.
Genevestigatori Q7TSC1.

Family and domain databases

InterProi IPR009738. BAT2_N.
[Graphical view ]
Pfami PF07001. BAT2_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
    Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
    Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 129.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye and Mammary gland.
  3. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 82-89, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.
  4. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-995; SER-1002; SER-1087 AND SER-1090, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  5. "The phagosomal proteome in interferon-gamma-activated macrophages."
    Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
    Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-166 AND THR-609, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-808 AND SER-1217, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  7. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-35, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiPRC2A_MOUSE
AccessioniPrimary (citable) accession number: Q7TSC1
Secondary accession number(s): Q923A9, Q9Z1R1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi