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Protein

Protein PRRC2A

Gene

Prrc2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the regulation of pre-mRNA splicing.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Protein PRRC2A
Alternative name(s):
HLA-B-associated transcript 2
Proline-rich and coiled-coil-containing protein 2A
Gene namesi
Name:Prrc2a
Synonyms:Bat2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1915467. Prrc2a.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000648311 – 2158Protein PRRC2AAdd BLAST2158

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphoserineCombined sources1
Modified residuei19PhosphoserineBy similarity1
Modified residuei27N6-acetyllysineBy similarity1
Modified residuei30PhosphoserineBy similarity1
Modified residuei35N6-acetyllysineCombined sources1
Modified residuei146PhosphoserineBy similarity1
Modified residuei166PhosphoserineCombined sources1
Modified residuei204PhosphoserineBy similarity1
Modified residuei272Asymmetric dimethylarginineBy similarity1
Modified residuei296Omega-N-methylarginineBy similarity1
Modified residuei342PhosphoserineBy similarity1
Modified residuei350PhosphoserineBy similarity1
Modified residuei363PhosphoserineBy similarity1
Modified residuei378PhosphoserineCombined sources1
Modified residuei381PhosphoserineBy similarity1
Modified residuei454PhosphoserineCombined sources1
Modified residuei609PhosphothreonineCombined sources1
Modified residuei759PhosphoserineBy similarity1
Modified residuei761PhosphoserineCombined sources1
Modified residuei764PhosphoserineBy similarity1
Modified residuei807PhosphothreonineCombined sources1
Modified residuei808PhosphoserineCombined sources1
Modified residuei907Omega-N-methylarginineCombined sources1
Modified residuei931PhosphoserineBy similarity1
Modified residuei995PhosphothreonineCombined sources1
Modified residuei1002PhosphoserineBy similarity1
Modified residuei1064Omega-N-methylarginineCombined sources1
Modified residuei1081PhosphothreonineBy similarity1
Modified residuei1083PhosphoserineBy similarity1
Modified residuei1087PhosphoserineCombined sources1
Modified residuei1090PhosphoserineCombined sources1
Modified residuei1092PhosphotyrosineBy similarity1
Modified residuei1104PhosphoserineBy similarity1
Modified residuei1108PhosphoserineBy similarity1
Modified residuei1118PhosphoserineBy similarity1
Modified residuei1145PhosphoserineBy similarity1
Modified residuei1194N6-acetyllysineBy similarity1
Modified residuei1217PhosphoserineCombined sources1
Modified residuei1302PhosphoserineCombined sources1
Modified residuei1306PhosphoserineCombined sources1
Modified residuei1319PhosphothreonineCombined sources1
Modified residuei1321PhosphoserineCombined sources1
Modified residuei1324PhosphoserineBy similarity1
Modified residuei1343PhosphothreonineBy similarity1
Modified residuei1349PhosphothreonineBy similarity1
Modified residuei1380PhosphoserineBy similarity1
Modified residuei1382PhosphoserineBy similarity1
Modified residuei1401PhosphothreonineBy similarity1
Modified residuei1521PhosphoserineBy similarity1
Modified residuei1757PhosphoserineBy similarity1
Modified residuei2037PhosphoserineBy similarity1
Modified residuei2077PhosphothreonineBy similarity1
Modified residuei2114PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ7TSC1.
MaxQBiQ7TSC1.
PaxDbiQ7TSC1.
PeptideAtlasiQ7TSC1.
PRIDEiQ7TSC1.

PTM databases

iPTMnetiQ7TSC1.
PhosphoSitePlusiQ7TSC1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024393.
CleanExiMM_BAT2.
ExpressionAtlasiQ7TSC1. baseline and differential.
GenevisibleiQ7TSC1. MM.

Interactioni

Protein-protein interaction databases

BioGridi207439. 2 interactors.
DIPiDIP-49629N.
IntActiQ7TSC1. 3 interactors.
MINTiMINT-1616210.
STRINGi10090.ENSMUSP00000025253.

Structurei

3D structure databases

ProteinModelPortaliQ7TSC1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati41 – 951-1Add BLAST55
Repeati98 – 1541-2Add BLAST57
Repeati281 – 3371-3Add BLAST57
Repeati337 – 4282-1Add BLAST92
Repeati486 – 5592-2Add BLAST74
Repeati1756 – 18111-4Add BLAST56
Repeati1917 – 19663-1Add BLAST50
Repeati1983 – 20323-2Add BLAST50
Repeati2058 – 21073-3Add BLAST50

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni41 – 18114 X 57 AA type A repeatsAdd BLAST1771
Regioni337 – 5592 X type B repeatsAdd BLAST223
Regioni1917 – 21073 X 50 AA type C repeatsAdd BLAST191

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi401 – 413Poly-ProAdd BLAST13
Compositional biasi464 – 469Poly-Arg6
Compositional biasi470 – 473Poly-Glu4
Compositional biasi657 – 669Poly-GlnAdd BLAST13
Compositional biasi696 – 700Poly-Pro5
Compositional biasi826 – 833Poly-Pro8
Compositional biasi912 – 915Poly-Pro4
Compositional biasi954 – 957Poly-Pro4
Compositional biasi1234 – 1239Poly-Arg6
Compositional biasi1292 – 1295Poly-Pro4
Compositional biasi1409 – 1417Poly-Gly9
Compositional biasi1447 – 1453Poly-Pro7

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4817. Eukaryota.
ENOG410XQRI. LUCA.
GeneTreeiENSGT00530000063496.
HOVERGENiHBG004820.
InParanoidiQ7TSC1.
OMAiALRWMPK.
OrthoDBiEOG091G02WC.
PhylomeDBiQ7TSC1.
TreeFamiTF328738.

Family and domain databases

InterProiIPR009738. BAT2_N.
IPR033184. PRRC2.
[Graphical view]
PANTHERiPTHR14038. PTHR14038. 1 hit.
PfamiPF07001. BAT2_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TSC1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDRSGPTAK GKDGKKYSSL NLFDTYKGKS LEIQKPAVAP RHGLQSLGKV
60 70 80 90 100
AIARRMPPPA NLPSLKAENK GNDPNVSLVP KDGTGWASKQ EQSDPKSSDA
110 120 130 140 150
STAQPPESQP LPASQTPASN QPKRPPTAPE NTPSVPSGVK SWAQASVTHG
160 170 180 190 200
AHGDGGRASN LLSRFSREEF PTLQAAGDQD KAAKERESAE QSSGPGPSLR
210 220 230 240 250
PQNSTTWRDG GGRGPDDLEG PDSKLHHGHD PRGGLQPSGP PQFPPYRGMM
260 270 280 290 300
PPFMYPPYLP FPPPYGPQGP YRYPTPDGPS RFPRVAGPRG SGPPMRLVEP
310 320 330 340 350
VGRPSILKED NLKEFDQLDQ ENDDGWAGAH EEVDYTEKLK FSDEEDGRDS
360 370 380 390 400
DEEGAEGHKD SQSAAAEEPE TDGKKGTSPG SELPPPKTAW TENARPSETE
410 420 430 440 450
PAPPTPKPPP PPPHRGPVGN WGPPGDYPDR GGPPCKPPAP EDEDEAWRQR
460 470 480 490 500
RKQSSSEISL AVERARRRRE EEERRMQEER RAACAEKLKR LDEKFGAPDK
510 520 530 540 550
RLKAEPAAPP VTPAAPALPP VVPKEIPAAP ALPPTPTPTP EKEPEEPAQA
560 570 580 590 600
PPVQAAPSPG VAPVPTLVSG GGCTANSNSS GSFEASPVEP QLPSKEGPEP
610 620 630 640 650
PEEVPPPTTP PAPKMEPKGD GVGSTRQPPS QGLGYPKYQK SLPPRFQRQQ
660 670 680 690 700
QEQLLKQQQQ QQQWQQQQQG TAPPAPVPPS PPQPVTLGAV PAPQAPPPPP
710 720 730 740 750
KALYPGALGR PPPMPPMNFD PRWMMIPPYV DPRLLQGRPP LDFYPPGVHP
760 770 780 790 800
SGLVPRERSD SGGSSSEPFE RHAPPLLRER GTPPVDPKLA WVGDVFTTTP
810 820 830 840 850
TDPRPLTSPL RQAADEEEKS MRSETPPVPP PPPYLANYPG FPENGTPGPP
860 870 880 890 900
ISRFPLEESA PPGPRPLPWP PGNDEAAKMQ APPPKKEPSK EEPPQLSGPE
910 920 930 940 950
AGRKPARGGQ GPPPPRRENR TETRWGPRPG SCRRGIPPEE PGVPPRRAGP
960 970 980 990 1000
IKKPPPPVKV EELPPKSLEQ GDETPKVPKP DALKTAKGKV GPKETPPGGN
1010 1020 1030 1040 1050
LSPAPRLRRD YSYERVGPTS CRGRGRGEYF ARGRGFRGTY GGRGRGARSR
1060 1070 1080 1090 1100
EFRSYREFRG DDGRGGGSGG TNHPSAPRGR TASETRSEGS EYEEIPKRRR
1110 1120 1130 1140 1150
QRGSETGSET HESDLAPSDK EAPPPKEGVL GQVPLAPPQP GAPPSPAPAR
1160 1170 1180 1190 1200
FSTARGGRVF TPRGVPSRRG RGGGRPPPVC SGWSPPAKSL VPKKPPTGPL
1210 1220 1230 1240 1250
PPSKEPLKEK LISGPLSPMS RAGNMGVGME DGERPRRRRH GRAQQQDKPP
1260 1270 1280 1290 1300
RFRRLKQERE NAARGADGKP PSLTLAASTP GPEETLTAAT VPPPPRRTAA
1310 1320 1330 1340 1350
KSPDLSNQNS DQANEEWETA SESSDFASER RGDKETPPAA LMTSKAVGTP
1360 1370 1380 1390 1400
GANAGGAGPG ISAMSRGDLS QRAKDLSKRS FSSQRPGMDR QNRRPGTGGK
1410 1420 1430 1440 1450
TGSGGGSSGG GGAGPGGRTG PGRGDKRSWP SPKNRSRPPE ERPPGLPLPP
1460 1470 1480 1490 1500
PPPSSSAVFR LDQVIHSNPA GIQQALAQLS SRQGNVTAPG GHPRPKPGPP
1510 1520 1530 1540 1550
QAPQGSSPRP PTRYDPPRAS SAISSDPHFE EPGPMVRGVG GTPRDSAGVN
1560 1570 1580 1590 1600
PFPPKRRERP PRKPELLQEE TVPASHSSGF LGSKPEVPGP QEESRDSGTE
1610 1620 1630 1640 1650
ALTPHIWNRL HTATSRKSYQ PGSIEPWMEP LSPFEDVAGT EMSQSDSGVD
1660 1670 1680 1690 1700
LSGDSQVSSG PCSQRSSPDG GLKGSAEGPP KRPGGPSPLN AVPGESASGS
1710 1720 1730 1740 1750
EPSEPPRRRP PASHEGERKE LPREQPLPPG PIGTERSQRT DRGPEPGPLR
1760 1770 1780 1790 1800
PAHRPGSQVE FGTTNKDSDL CLVVGDTLKG EKELVASATE AVPISRDWEL
1810 1820 1830 1840 1850
LPSASTSAEP QPKSLGSGQC VPEPSPSGQR PYPEVFYGSP GPPNSQQVSG
1860 1870 1880 1890 1900
GAPIDSQLHP NSGGFRPGTP SLHQYRSQPL YLPPGPAPPS ALLSGVALKG
1910 1920 1930 1940 1950
QFLDFSALQA TELGKLPAGG VLYPPPSFLY SAAFCPSPLP DPPLLQVRQD
1960 1970 1980 1990 2000
LPSPSDFYST PLQPGGQSGF LPSGAPAQQM LLPVVDSQLP VVNFGSLPPA
2010 2020 2030 2040 2050
PPPAPPPLSL LPVGPALQPP NLAVRPPPAP AARVLPSPAR PFAPSLGRAE
2060 2070 2080 2090 2100
LHPVELKPFQ DYRKLSSNLG GPGSSRTPPS GRPFSGLNSR LKAPPSTYSG
2110 2120 2130 2140 2150
VFRTQRIDLY QQASPPDALR WMPKPWERAG PPSREGPPRR AEEPGSRGEK

EPGLPPPR
Length:2,158
Mass (Da):229,203
Last modified:October 1, 2003 - v1
Checksum:i85A5CBDCDA84A256
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1846Missing in AAC82480 (PubMed:14656967).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109719 Genomic DNA. Translation: AAC82480.1.
BC006664 mRNA. Translation: AAH06664.1.
BC053522 mRNA. Translation: AAH53522.1.
CCDSiCCDS37596.1.
RefSeqiNP_001185973.1. NM_001199044.1.
NP_064411.2. NM_020027.3.
XP_006524683.1. XM_006524620.3.
UniGeneiMm.272462.

Genome annotation databases

EnsembliENSMUST00000025253; ENSMUSP00000025253; ENSMUSG00000024393.
GeneIDi53761.
KEGGimmu:53761.
UCSCiuc008cgj.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF109719 Genomic DNA. Translation: AAC82480.1.
BC006664 mRNA. Translation: AAH06664.1.
BC053522 mRNA. Translation: AAH53522.1.
CCDSiCCDS37596.1.
RefSeqiNP_001185973.1. NM_001199044.1.
NP_064411.2. NM_020027.3.
XP_006524683.1. XM_006524620.3.
UniGeneiMm.272462.

3D structure databases

ProteinModelPortaliQ7TSC1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207439. 2 interactors.
DIPiDIP-49629N.
IntActiQ7TSC1. 3 interactors.
MINTiMINT-1616210.
STRINGi10090.ENSMUSP00000025253.

PTM databases

iPTMnetiQ7TSC1.
PhosphoSitePlusiQ7TSC1.

Proteomic databases

EPDiQ7TSC1.
MaxQBiQ7TSC1.
PaxDbiQ7TSC1.
PeptideAtlasiQ7TSC1.
PRIDEiQ7TSC1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025253; ENSMUSP00000025253; ENSMUSG00000024393.
GeneIDi53761.
KEGGimmu:53761.
UCSCiuc008cgj.2. mouse.

Organism-specific databases

CTDi7916.
MGIiMGI:1915467. Prrc2a.

Phylogenomic databases

eggNOGiKOG4817. Eukaryota.
ENOG410XQRI. LUCA.
GeneTreeiENSGT00530000063496.
HOVERGENiHBG004820.
InParanoidiQ7TSC1.
OMAiALRWMPK.
OrthoDBiEOG091G02WC.
PhylomeDBiQ7TSC1.
TreeFamiTF328738.

Miscellaneous databases

ChiTaRSiPrrc2a. mouse.
PROiQ7TSC1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024393.
CleanExiMM_BAT2.
ExpressionAtlasiQ7TSC1. baseline and differential.
GenevisibleiQ7TSC1. MM.

Family and domain databases

InterProiIPR009738. BAT2_N.
IPR033184. PRRC2.
[Graphical view]
PANTHERiPTHR14038. PTHR14038. 1 hit.
PfamiPF07001. BAT2_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRC2A_MOUSE
AccessioniPrimary (citable) accession number: Q7TSC1
Secondary accession number(s): Q923A9, Q9Z1R1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.