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Q7TSC1 (PRC2A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein PRRC2A
Alternative name(s):
HLA-B-associated transcript 2
Proline-rich and coiled-coil-containing protein 2A
Gene names
Name:Prrc2a
Synonyms:Bat2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length2158 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in the regulation of pre-mRNA splicing By similarity.

Subcellular location

Cytoplasm By similarity. Nucleus By similarity.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   DomainRepeat
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 21582158Protein PRRC2A
PRO_0000064831

Regions

Repeat41 – 95551-1
Repeat98 – 154571-2
Repeat281 – 337571-3
Repeat337 – 428922-1
Repeat486 – 559742-2
Repeat1756 – 1811561-4
Repeat1917 – 1966503-1
Repeat1983 – 2032503-2
Repeat2058 – 2107503-3
Region41 – 181117714 X 57 AA type A repeats
Region337 – 5592232 X type B repeats
Region1917 – 21071913 X 50 AA type C repeats
Compositional bias401 – 41313Poly-Pro
Compositional bias464 – 4696Poly-Arg
Compositional bias470 – 4734Poly-Glu
Compositional bias657 – 66913Poly-Gln
Compositional bias696 – 7005Poly-Pro
Compositional bias826 – 8338Poly-Pro
Compositional bias912 – 9154Poly-Pro
Compositional bias954 – 9574Poly-Pro
Compositional bias1234 – 12396Poly-Arg
Compositional bias1292 – 12954Poly-Pro
Compositional bias1409 – 14179Poly-Gly
Compositional bias1447 – 14537Poly-Pro

Amino acid modifications

Modified residue271N6-acetyllysine By similarity
Modified residue1661Phosphoserine Ref.8
Modified residue3421Phosphoserine Ref.7
Modified residue3501Phosphoserine Ref.7
Modified residue3781Phosphoserine By similarity
Modified residue3811Phosphoserine By similarity
Modified residue4541Phosphoserine By similarity
Modified residue6091Phosphothreonine Ref.5
Modified residue7591Phosphoserine Ref.6
Modified residue7611Phosphoserine Ref.6
Modified residue7641Phosphoserine By similarity
Modified residue7821Phosphothreonine Ref.4
Modified residue8081Phosphoserine Ref.9
Modified residue10021Phosphoserine Ref.5
Modified residue10121Phosphoserine By similarity
Modified residue10831Phosphoserine By similarity
Modified residue10871Phosphoserine Ref.6 Ref.7
Modified residue10901Phosphoserine Ref.6 Ref.7
Modified residue10921Phosphotyrosine By similarity
Modified residue11081Phosphoserine By similarity
Modified residue11451Phosphoserine By similarity
Modified residue11941N6-acetyllysine By similarity
Modified residue12171Phosphoserine Ref.5 Ref.6 Ref.9
Modified residue13021Phosphoserine By similarity
Modified residue13491Phosphothreonine By similarity
Modified residue21141Phosphoserine By similarity

Experimental info

Sequence conflict18461Missing in AAC82480. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q7TSC1 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 85A5CBDCDA84A256

FASTA2,158229,203
        10         20         30         40         50         60 
MSDRSGPTAK GKDGKKYSSL NLFDTYKGKS LEIQKPAVAP RHGLQSLGKV AIARRMPPPA 

        70         80         90        100        110        120 
NLPSLKAENK GNDPNVSLVP KDGTGWASKQ EQSDPKSSDA STAQPPESQP LPASQTPASN 

       130        140        150        160        170        180 
QPKRPPTAPE NTPSVPSGVK SWAQASVTHG AHGDGGRASN LLSRFSREEF PTLQAAGDQD 

       190        200        210        220        230        240 
KAAKERESAE QSSGPGPSLR PQNSTTWRDG GGRGPDDLEG PDSKLHHGHD PRGGLQPSGP 

       250        260        270        280        290        300 
PQFPPYRGMM PPFMYPPYLP FPPPYGPQGP YRYPTPDGPS RFPRVAGPRG SGPPMRLVEP 

       310        320        330        340        350        360 
VGRPSILKED NLKEFDQLDQ ENDDGWAGAH EEVDYTEKLK FSDEEDGRDS DEEGAEGHKD 

       370        380        390        400        410        420 
SQSAAAEEPE TDGKKGTSPG SELPPPKTAW TENARPSETE PAPPTPKPPP PPPHRGPVGN 

       430        440        450        460        470        480 
WGPPGDYPDR GGPPCKPPAP EDEDEAWRQR RKQSSSEISL AVERARRRRE EEERRMQEER 

       490        500        510        520        530        540 
RAACAEKLKR LDEKFGAPDK RLKAEPAAPP VTPAAPALPP VVPKEIPAAP ALPPTPTPTP 

       550        560        570        580        590        600 
EKEPEEPAQA PPVQAAPSPG VAPVPTLVSG GGCTANSNSS GSFEASPVEP QLPSKEGPEP 

       610        620        630        640        650        660 
PEEVPPPTTP PAPKMEPKGD GVGSTRQPPS QGLGYPKYQK SLPPRFQRQQ QEQLLKQQQQ 

       670        680        690        700        710        720 
QQQWQQQQQG TAPPAPVPPS PPQPVTLGAV PAPQAPPPPP KALYPGALGR PPPMPPMNFD 

       730        740        750        760        770        780 
PRWMMIPPYV DPRLLQGRPP LDFYPPGVHP SGLVPRERSD SGGSSSEPFE RHAPPLLRER 

       790        800        810        820        830        840 
GTPPVDPKLA WVGDVFTTTP TDPRPLTSPL RQAADEEEKS MRSETPPVPP PPPYLANYPG 

       850        860        870        880        890        900 
FPENGTPGPP ISRFPLEESA PPGPRPLPWP PGNDEAAKMQ APPPKKEPSK EEPPQLSGPE 

       910        920        930        940        950        960 
AGRKPARGGQ GPPPPRRENR TETRWGPRPG SCRRGIPPEE PGVPPRRAGP IKKPPPPVKV 

       970        980        990       1000       1010       1020 
EELPPKSLEQ GDETPKVPKP DALKTAKGKV GPKETPPGGN LSPAPRLRRD YSYERVGPTS 

      1030       1040       1050       1060       1070       1080 
CRGRGRGEYF ARGRGFRGTY GGRGRGARSR EFRSYREFRG DDGRGGGSGG TNHPSAPRGR 

      1090       1100       1110       1120       1130       1140 
TASETRSEGS EYEEIPKRRR QRGSETGSET HESDLAPSDK EAPPPKEGVL GQVPLAPPQP 

      1150       1160       1170       1180       1190       1200 
GAPPSPAPAR FSTARGGRVF TPRGVPSRRG RGGGRPPPVC SGWSPPAKSL VPKKPPTGPL 

      1210       1220       1230       1240       1250       1260 
PPSKEPLKEK LISGPLSPMS RAGNMGVGME DGERPRRRRH GRAQQQDKPP RFRRLKQERE 

      1270       1280       1290       1300       1310       1320 
NAARGADGKP PSLTLAASTP GPEETLTAAT VPPPPRRTAA KSPDLSNQNS DQANEEWETA 

      1330       1340       1350       1360       1370       1380 
SESSDFASER RGDKETPPAA LMTSKAVGTP GANAGGAGPG ISAMSRGDLS QRAKDLSKRS 

      1390       1400       1410       1420       1430       1440 
FSSQRPGMDR QNRRPGTGGK TGSGGGSSGG GGAGPGGRTG PGRGDKRSWP SPKNRSRPPE 

      1450       1460       1470       1480       1490       1500 
ERPPGLPLPP PPPSSSAVFR LDQVIHSNPA GIQQALAQLS SRQGNVTAPG GHPRPKPGPP 

      1510       1520       1530       1540       1550       1560 
QAPQGSSPRP PTRYDPPRAS SAISSDPHFE EPGPMVRGVG GTPRDSAGVN PFPPKRRERP 

      1570       1580       1590       1600       1610       1620 
PRKPELLQEE TVPASHSSGF LGSKPEVPGP QEESRDSGTE ALTPHIWNRL HTATSRKSYQ 

      1630       1640       1650       1660       1670       1680 
PGSIEPWMEP LSPFEDVAGT EMSQSDSGVD LSGDSQVSSG PCSQRSSPDG GLKGSAEGPP 

      1690       1700       1710       1720       1730       1740 
KRPGGPSPLN AVPGESASGS EPSEPPRRRP PASHEGERKE LPREQPLPPG PIGTERSQRT 

      1750       1760       1770       1780       1790       1800 
DRGPEPGPLR PAHRPGSQVE FGTTNKDSDL CLVVGDTLKG EKELVASATE AVPISRDWEL 

      1810       1820       1830       1840       1850       1860 
LPSASTSAEP QPKSLGSGQC VPEPSPSGQR PYPEVFYGSP GPPNSQQVSG GAPIDSQLHP 

      1870       1880       1890       1900       1910       1920 
NSGGFRPGTP SLHQYRSQPL YLPPGPAPPS ALLSGVALKG QFLDFSALQA TELGKLPAGG 

      1930       1940       1950       1960       1970       1980 
VLYPPPSFLY SAAFCPSPLP DPPLLQVRQD LPSPSDFYST PLQPGGQSGF LPSGAPAQQM 

      1990       2000       2010       2020       2030       2040 
LLPVVDSQLP VVNFGSLPPA PPPAPPPLSL LPVGPALQPP NLAVRPPPAP AARVLPSPAR 

      2050       2060       2070       2080       2090       2100 
PFAPSLGRAE LHPVELKPFQ DYRKLSSNLG GPGSSRTPPS GRPFSGLNSR LKAPPSTYSG 

      2110       2120       2130       2140       2150 
VFRTQRIDLY QQASPPDALR WMPKPWERAG PPSREGPPRR AEEPGSRGEK EPGLPPPR

« Hide

References

« Hide 'large scale' references
[1]"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
Genome Res. 13:2621-2636(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 129.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Eye and Mammary gland.
[3]Lubec G., Sunyer B., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 82-89, MASS SPECTROMETRY.
Strain: OF1.
Tissue: Hippocampus.
[4]"Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-782, MASS SPECTROMETRY.
Tissue: Brain.
[5]"Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-609; SER-1002 AND SER-1217, MASS SPECTROMETRY.
Tissue: Brain cortex.
[6]"Large-scale phosphorylation analysis of mouse liver."
Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-759; SER-761; SER-1087; SER-1090 AND SER-1217, MASS SPECTROMETRY.
Tissue: Liver.
[7]"Solid tumor proteome and phosphoproteome analysis by high resolution mass spectrometry."
Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J., Faessler R., Mann M.
J. Proteome Res. 7:5314-5326(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-342; SER-350; SER-1087 AND SER-1090, MASS SPECTROMETRY.
Tissue: Melanoma.
[8]"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M., English L., Lemieux S., Courcelles M., Desjardins M., Thibault P.
Immunity 30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-166, MASS SPECTROMETRY.
Tissue: Macrophage.
[9]"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-808 AND SER-1217, MASS SPECTROMETRY.
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF109719 Genomic DNA. Translation: AAC82480.1.
BC006664 mRNA. Translation: AAH06664.1.
BC053522 mRNA. Translation: AAH53522.1.
IPIIPI00380722.
RefSeqNP_001185973.1. NM_001199044.1.
NP_064411.2. NM_020027.3.
UniGeneMm.272462.

3D structure databases

ProteinModelPortalQ7TSC1.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-49629N.
IntActQ7TSC1. 1 interaction.

PTM databases

PhosphoSiteQ7TSC1.

Proteomic databases

PaxDbQ7TSC1.
PRIDEQ7TSC1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000025253; ENSMUSP00000025253; ENSMUSG00000024393.
GeneID53761.
KEGGmmu:53761.
UCSCuc008cgj.2. mouse.

Organism-specific databases

CTD7916.
MGIMGI:1915467. Prrc2a.

Phylogenomic databases

eggNOGNOG271062.
GeneTreeENSGT00530000063496.
HOVERGENHBG004820.
InParanoidQ7TSC1.
OMAYSYERVG.
OrthoDBEOG4G7BXH.

Gene expression databases

ArrayExpressQ7TSC1.
BgeeQ7TSC1.
CleanExMM_BAT2.
GenevestigatorQ7TSC1.
GermOnlineENSMUSG00000024393. Mus musculus.

Family and domain databases

InterProIPR009738. BAT2_N.
[Graphical view]
PfamPF07001. BAT2_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPRRC2A. mouse.
NextBio310575.
SOURCESearch...

Entry information

Entry namePRC2A_MOUSE
AccessionPrimary (citable) accession number: Q7TSC1
Secondary accession number(s): Q923A9, Q9Z1R1
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: October 1, 2003
Last modified: April 3, 2013
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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