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Protein

Hairy and enhancer of split-related protein HELT

Gene

Helt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGCG-3'. Required for the development of GABAergic neurons.4 Publications

GO - Molecular functioni

  • DNA binding Source: MGI
  • DNA binding transcription factor activity Source: MGI
  • protein homodimerization activity Source: MGI
  • RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB
  • transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: NTNU_SB

GO - Biological processi

  • central nervous system development Source: MGI
  • GABAergic neuron differentiation in basal ganglia Source: MGI
  • gene expression Source: MGI
  • multicellular organism aging Source: MGI
  • multicellular organism growth Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • neuron differentiation Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • post-embryonic development Source: MGI
  • suckling behavior Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Hairy and enhancer of split-related protein HELT
Alternative name(s):
HES/HEY-like transcription factor
Protein Hes-like
Protein megane
Gene namesi
Name:Helt
Synonyms:Hesl, Mgn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:3040955 Helt

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Death between 2 and 5 weeks of age. The mesencephalic GABAergic progenitors in these animals fail to develop into neurons.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003493791 – 240Hairy and enhancer of split-related protein HELTAdd BLAST240

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei48N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ7TS99
PRIDEiQ7TS99

PTM databases

iPTMnetiQ7TS99
PhosphoSitePlusiQ7TS99

Expressioni

Tissue specificityi

Expressed in heart and testis.

Developmental stagei

Expressed in the progenitor domains for mesencephalic GABAergic neurons.4 Publications

Gene expression databases

BgeeiENSMUSG00000047171
ExpressionAtlasiQ7TS99 baseline and differential

Interactioni

Subunit structurei

Self-associates. Interacts with HES5 and HEY2.1 Publication

GO - Molecular functioni

  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

BioGridi231505, 3 interactors
STRINGi10090.ENSMUSP00000054823

Structurei

3D structure databases

ProteinModelPortaliQ7TS99
SMRiQ7TS99
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 65bHLHPROSITE-ProRule annotationAdd BLAST56
Domaini86 – 121OrangePROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the HEY family.Curated

Phylogenomic databases

eggNOGiKOG4304 Eukaryota
ENOG4111F0X LUCA
GeneTreeiENSGT00700000104130
HOGENOMiHOG000082510
HOVERGENiHBG054492
InParanoidiQ7TS99
OMAiMKNLVHY
OrthoDBiEOG091G115T
PhylomeDBiQ7TS99
TreeFamiTF323617

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
IPR003650 Orange_dom
PfamiView protein in Pfam
PF07527 Hairy_orange, 1 hit
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
PS51054 ORANGE, 1 hit

Sequencei

Sequence statusi: Complete.

Q7TS99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDRLKERKR TPVSHKVIEK RRRDRINRCL NELGKTVPMA LAKQSSGKLE
60 70 80 90 100
KAEILEMTVQ YLRALHSADF PRGREKELLA EFANYFHYGY HECMKNLVHY
110 120 130 140 150
LTTVERMETK DTKYARILAF LQSKARLGAE PTFPPLSLPE PDFSYQLHAA
160 170 180 190 200
SPEFPGHSPG EATMFPQGAT PGSFPWPPGA ARSPALPYLS SATVPLPSPA
210 220 230 240
QQHSPFLAPM QGLDRHYLNL IGHGHPNGLN LHTPQHPPVL
Length:240
Mass (Da):26,973
Last modified:October 1, 2003 - v1
Checksum:i50B3821703D5294F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB120968 mRNA Translation: BAD11127.1
AB098077 mRNA Translation: BAC77659.1
DQ294234 mRNA Translation: ABB96784.1
BC103599 mRNA Translation: AAI03600.1
BC103600 mRNA Translation: AAI03601.1
BC103601 mRNA Translation: AAI03602.1
CCDSiCCDS22290.1
RefSeqiNP_776150.2, NM_173789.4
UniGeneiMm.145631

Genome annotation databases

EnsembliENSMUST00000058636; ENSMUSP00000054823; ENSMUSG00000047171
GeneIDi234219
KEGGimmu:234219
UCSCiuc009lqb.1 mouse

Similar proteinsi

Entry informationi

Entry nameiHELT_MOUSE
AccessioniPrimary (citable) accession number: Q7TS99
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 1, 2003
Last modified: March 28, 2018
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health