Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

APC membrane recruitment protein 1

Gene

Amer1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • adipose tissue development Source: MGI
  • bone development Source: MGI
  • kidney development Source: MGI
  • mesenchymal cell differentiation involved in kidney development Source: MGI
  • negative regulation of canonical Wnt signaling pathway Source: UniProtKB
  • positive regulation of canonical Wnt signaling pathway Source: UniProtKB
  • positive regulation of cellular protein catabolic process Source: MGI
  • positive regulation of protein ubiquitination Source: MGI
  • regulation of canonical Wnt signaling pathway Source: UniProtKB
  • Wnt signaling pathway Source: UniProtKB-KW

Keywordsi

Biological processWnt signaling pathway
LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-195253 Degradation of beta-catenin by the destruction complex
R-MMU-196299 Beta-catenin phosphorylation cascade
R-MMU-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane

Names & Taxonomyi

Protein namesi
Recommended name:
APC membrane recruitment protein 1
Short name:
Amer1
Alternative name(s):
Protein FAM123B
Gene namesi
Name:Amer1
Synonyms:Fam123b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1919595 Amer1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002818881 – 1132APC membrane recruitment protein 1Add BLAST1132

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ7TS75
PaxDbiQ7TS75
PeptideAtlasiQ7TS75
PRIDEiQ7TS75

PTM databases

iPTMnetiQ7TS75
PhosphoSitePlusiQ7TS75

Expressioni

Tissue specificityi

Expressed in kidney.1 Publication

Developmental stagei

In embryos, it is highly expressed in the neonatal brain and kidney and then declines substantially in the mature organs. Also expressed in lung and spleen. Expressed in the condensing metanephric mesenchyme and in early epithelial structures that are precursors to glomeruli.1 Publication

Gene expression databases

BgeeiENSMUSG00000050332
GenevisibleiQ7TS75 MM

Interactioni

Subunit structurei

Interacts with CTNNB1, AXIN1, LRP6, KEAP1, APC and BTRC. Interacts with SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes containing BTRC and/or FBXW11. Identified in the beta-catenin destruction complex containing CTNNB1, APC, AXIN1 and AXIN2. Interacts with WT1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109502

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi375 – 381Poly-Asp7
Compositional biasi382 – 427Glu-richAdd BLAST46
Compositional biasi756 – 766Poly-GluAdd BLAST11
Compositional biasi934 – 942Poly-Glu9

Sequence similaritiesi

Belongs to the Amer family.Curated

Phylogenomic databases

eggNOGiENOG410IJHD Eukaryota
ENOG410XU7Y LUCA
GeneTreeiENSGT00530000063529
HOGENOMiHOG000049188
HOVERGENiHBG107863
InParanoidiQ7TS75
KOiK19407
OMAiRDGEGKC
OrthoDBiEOG091G08AF
PhylomeDBiQ7TS75
TreeFamiTF333006

Family and domain databases

InterProiView protein in InterPro
IPR019003 AMER
PANTHERiPTHR22237 PTHR22237, 1 hit
PfamiView protein in Pfam
PF09422 WTX, 1 hit

Sequencei

Sequence statusi: Complete.

Q7TS75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESQQDEAVQ TKGASTSSDA QDQGAEKGAK NKTTEATEGP TSEPPLSGPG
60 70 80 90 100
RLKKTAMKLF GGKKGICTLP SFFGGGRSKG SGKVSSKKSL NKSKTHDGLS
110 120 130 140 150
EASQGPEDVV IEETDLSTPL SKSSAQFPSS QSANGALEIG SKHKTSGTEA
160 170 180 190 200
IEKAGVEKVP SVHKPKKSLK SFFSSIRRHR KGKTSGADQS VPGAKELEGA
210 220 230 240 250
RTRSHEHVSS ISLPSSEEIF RDTRKENAKP QDAPGPKMSP AQVHFSPTTE
260 270 280 290 300
KAACKNPEKL TRTCASEFMQ PKPVLEGGSL EEPHTSETEG KVVAGEVNPP
310 320 330 340 350
NGPVGDQLSL LFGDVTSLKS FDSLTGCGDI IAEQDMDSMT DSMASGGQRA
360 370 380 390 400
NRDGTKRSSC LVTYQGGGEE MALPDDDDND DEEEEEEEEE EEEEEEEEEE
410 420 430 440 450
EEEEEEEEEL LEDEEEVKDG EENDDLEYLW ASAQIYPRFN MNLGYHTAIS
460 470 480 490 500
PSHQGYMLLD PVQSYPNLGL GELLTPQSDQ QESAPNSDEG YYDSTTPGFE
510 520 530 540 550
DDSGEALGLA HRDCLPRDSY SGDALYEFYE PDDSLEHSPP GDDCLYDLRG
560 570 580 590 600
RNSEMLDPFL NLEPFSSRPP GAMETEEERL VTIQKQLLYW ELRREQREAQ
610 620 630 640 650
EACAREAHAR EAYARDTHTR ESYGRNVRAR ETQALEAHSQ EGRVQETKVR
660 670 680 690 700
QEKPALEYQM RPLGPSVMGL VAGTSGGSQT SHRGTTSAFP ATSSSEPDWR
710 720 730 740 750
DFRPLEKRFE GTCSKKDQST CLMQLFQSDA MFEPDMQEAN FGGSPRKAYP
760 770 780 790 800
SYSPPEEPEE EEEEKEGNAT VSFSQALVEF TSNGNLFTSM SYSSDSDSSF
810 820 830 840 850
TQNLPELPPM VTFDIADVER DGEGKCEENP EFNNDEDLTA SLEAFELGYY
860 870 880 890 900
HKHAFNSYHS RFYQGLPWGV SSLPRYLGLP GVHPRPPPAA MALNRRSRSL
910 920 930 940 950
DNAESLELEL SSSHLAQGYM ESDELQAHQE DSDEEGEEEE GEWGRDSPLS
960 970 980 990 1000
LYTEPPGVYD WPPWAHCPLP VGPGLAWMSP NQLYEPFNQS SYVQATCCVP
1010 1020 1030 1040 1050
PVAMPVSVPG RTPGDSVSQL ARPSHLPLPM GPCYNLQSQA SQSGRAKPRD
1060 1070 1080 1090 1100
VLLPVDEPSC SSISGANSQS QAKPVGITHG IPQLPRVRPE PFQLQPNHYR
1110 1120 1130
ASNLDLSKER GEQGASLSTS YSSTAMNGNL AK
Length:1,132
Mass (Da):124,164
Last modified:March 21, 2012 - v3
Checksum:i7039226488581FCC
GO

Sequence cautioni

The sequence AAH53442 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAC25373 differs from that shown. Reason: Frameshift at positions 235 and 284.Curated
The sequence BAC33914 differs from that shown. Reason: Erroneous termination at position 4. Translated as Gln.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL671765 Genomic DNA No translation available.
AK049774 mRNA Translation: BAC33914.1 Sequence problems.
AK012651 mRNA Translation: BAC25373.1 Frameshift.
BC053442 mRNA Translation: AAH53442.1 Sequence problems.
CCDSiCCDS41067.1
RefSeqiNP_780388.2, NM_175179.4
UniGeneiMm.182867

Genome annotation databases

EnsembliENSMUST00000084535; ENSMUSP00000109502; ENSMUSG00000050332
GeneIDi72345
KEGGimmu:72345
UCSCiuc009ttx.2 mouse

Similar proteinsi

Entry informationi

Entry nameiAMER1_MOUSE
AccessioniPrimary (citable) accession number: Q7TS75
Secondary accession number(s): B1AUM2, Q8BT92, Q8C7P7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 21, 2012
Last modified: May 23, 2018
This is version 91 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health