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Protein

Inositol-trisphosphate 3-kinase C

Gene

Itpkc

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate.By similarity

Catalytic activityi

ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.

Enzyme regulationi

Activated by calcium/calmodulin. Inhibited by high concentrations of the substrate Ins(1,2,4)P3, and allosterically activated by the product Ins(1,3,4,5)P4 (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei426 – 4261ATPBy similarity
Binding sitei479 – 4791ATPBy similarity
Binding sitei481 – 4811SubstrateBy similarity
Binding sitei553 – 5531ATPBy similarity
Binding sitei633 – 6331ATPBy similarity
Binding sitei636 – 6361SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi466 – 4683ATPBy similarity

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • inositol-1,4,5-trisphosphate 3-kinase activity Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Calmodulin-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-1855204. Synthesis of IP3 and IP4 in the cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol-trisphosphate 3-kinase C (EC:2.7.1.127)
Alternative name(s):
Inositol 1,4,5-trisphosphate 3-kinase C
Short name:
IP3 3-kinase C
Short name:
IP3K C
Short name:
InsP 3-kinase C
Gene namesi
Name:Itpkc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2442554. Itpkc.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

  • Note: Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 678678Inositol-trisphosphate 3-kinase CPRO_0000234071Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei160 – 1601PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ7TS72.
MaxQBiQ7TS72.
PaxDbiQ7TS72.
PRIDEiQ7TS72.

PTM databases

iPTMnetiQ7TS72.
PhosphoSiteiQ7TS72.

Expressioni

Gene expression databases

BgeeiQ7TS72.
CleanExiMM_ITPKC.
GenevisibleiQ7TS72. MM.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Il16O548243EBI-648015,EBI-641708

Protein-protein interaction databases

IntActiQ7TS72. 1 interaction.
STRINGi10090.ENSMUSP00000003850.

Structurei

3D structure databases

ProteinModelPortaliQ7TS72.
SMRiQ7TS72. Positions 389-678.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni502 – 5087Substrate bindingBy similarity
Regioni504 – 5129Calmodulin-bindingBy similarity
Regioni529 – 5368Substrate bindingBy similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi318 – 3269Nuclear export signalBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1621. Eukaryota.
ENOG410Y8AC. LUCA.
GeneTreeiENSGT00390000017438.
HOGENOMiHOG000113089.
HOVERGENiHBG081804.
InParanoidiQ7TS72.
KOiK00911.
OMAiSWKELYT.
OrthoDBiEOG7DVDB7.
PhylomeDBiQ7TS72.
TreeFamiTF318394.

Family and domain databases

InterProiIPR005522. IPK.
[Graphical view]
PANTHERiPTHR12400. PTHR12400. 2 hits.
PfamiPF03770. IPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TS72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRCPCRGSL SEAEAGALPA EARMGLEALR GGRRRQPGLQ RPGPGAGGPT
60 70 80 90 100
GRPEGGGPRA WIEESSLHSE AERTDLEPAP CPNGPQAESC GDGHAECEAA
110 120 130 140 150
GLVVASEKPR QNKELDGSNL QTHPRRNSPL VEMEMAGSWT DGFRTDLHRS
160 170 180 190 200
DLQSRPKRAS LCTQPGFDES WTELDRSDMW QTLPERDNKP RVDNLRTHHG
210 220 230 240 250
VSKLQTHPVC LSPESSADNS GKELSADASR TPHDTDGFWI ESQTDDSLKG
260 270 280 290 300
PSTQTACRQP GSDGFSSKDT ESALTQPGTD GLRDDSVLGE SNGNDPLDLS
310 320 330 340 350
EPGELVTNLC SHLECSSLCP VPRLIITPET PEPEAQPVGP QSRIEGGTGG
360 370 380 390 400
FSSASSFDES EDDLVAGGGG TSDPEDRAGS KPWKKLKTVL KYSPFVVSFH
410 420 430 440 450
KHYYPWVQLS GHAGNFQAGE DGRILKRFCQ CEQRSLELLM GDPLRPFVPA
460 470 480 490 500
YYGMVQRDGQ AFNQMEDLLA DFEGPSIMDC KMGSRTYLEE ELVKARERPK
510 520 530 540 550
PRKDMYEKMV AVDPGAPTPE EHAQGAITKP RYMQWRETLS STSTLGFRIE
560 570 580 590 600
GIKKADGTCN TNFKKTQALE QVTKVLEDFV NGDLGILRKY VARLEDLRET
610 620 630 640 650
LENSPFFKTH EVVGSSLLFV HDHTGLAKVW MIDFGKTVAL PDHQMLSHRL
660 670
PWTEGNREDG YLWGLDNLIC LLQGLAQS
Length:678
Mass (Da):74,493
Last modified:October 1, 2003 - v1
Checksum:i0D3705B3D682B6ED
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti458 – 4581D → N in BAE32904 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK154888 mRNA. Translation: BAE32904.1.
BC053450 mRNA. Translation: AAH53450.1.
CCDSiCCDS21015.1.
RefSeqiNP_853624.1. NM_181593.2.
UniGeneiMm.30963.
Mm.474636.

Genome annotation databases

EnsembliENSMUST00000003850; ENSMUSP00000003850; ENSMUSG00000003752.
GeneIDi233011.
KEGGimmu:233011.
UCSCiuc009fvk.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK154888 mRNA. Translation: BAE32904.1.
BC053450 mRNA. Translation: AAH53450.1.
CCDSiCCDS21015.1.
RefSeqiNP_853624.1. NM_181593.2.
UniGeneiMm.30963.
Mm.474636.

3D structure databases

ProteinModelPortaliQ7TS72.
SMRiQ7TS72. Positions 389-678.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ7TS72. 1 interaction.
STRINGi10090.ENSMUSP00000003850.

PTM databases

iPTMnetiQ7TS72.
PhosphoSiteiQ7TS72.

Proteomic databases

EPDiQ7TS72.
MaxQBiQ7TS72.
PaxDbiQ7TS72.
PRIDEiQ7TS72.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003850; ENSMUSP00000003850; ENSMUSG00000003752.
GeneIDi233011.
KEGGimmu:233011.
UCSCiuc009fvk.1. mouse.

Organism-specific databases

CTDi80271.
MGIiMGI:2442554. Itpkc.

Phylogenomic databases

eggNOGiKOG1621. Eukaryota.
ENOG410Y8AC. LUCA.
GeneTreeiENSGT00390000017438.
HOGENOMiHOG000113089.
HOVERGENiHBG081804.
InParanoidiQ7TS72.
KOiK00911.
OMAiSWKELYT.
OrthoDBiEOG7DVDB7.
PhylomeDBiQ7TS72.
TreeFamiTF318394.

Enzyme and pathway databases

ReactomeiR-MMU-1855204. Synthesis of IP3 and IP4 in the cytosol.

Miscellaneous databases

PROiQ7TS72.
SOURCEiSearch...

Gene expression databases

BgeeiQ7TS72.
CleanExiMM_ITPKC.
GenevisibleiQ7TS72. MM.

Family and domain databases

InterProiIPR005522. IPK.
[Graphical view]
PANTHERiPTHR12400. PTHR12400. 2 hits.
PfamiPF03770. IPK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: NOD.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Limb.
  3. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-160, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Kidney, Lung and Spleen.

Entry informationi

Entry nameiIP3KC_MOUSE
AccessioniPrimary (citable) accession number: Q7TS72
Secondary accession number(s): Q3U384
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 1, 2003
Last modified: June 8, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.