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Reviewed, UniProtKB/Swiss-Prot Q7TS72 (IP3KC_MOUSE)

Last modified November 3, 2009. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Inositol-trisphosphate 3-kinase C
    EC=2.7.1.127
Alternative name(s):
    Inositol 1,4,5-trisphosphate 3-kinase C
      Short name=IP3K-C
Gene names
Name: Itpkc
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length678 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate By similarity.

Catalytic activity

ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.

Enzyme regulation

Activated by calcium/calmodulin. Inhibited by high concentrations of the substrate Ins(1,2,4)P3, and allosterically activated by the product Ins(1,3,4,5)P4 By similarity.

Subcellular location

Nucleus By similarity. Cytoplasm By similarity. Note: Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity By similarity.

Sequence similarities

Belongs to the inositol phosphokinase (IPK) family.

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Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   LigandATP-binding
Calmodulin-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

calmodulin binding

Inferred from electronic annotation. Source: UniProtKB-KW

inositol trisphosphate 3-kinase activity

Inferred from direct assay. Source: MGI

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 678678Inositol-trisphosphate 3-kinase C
PRO_0000234071

Regions

Nucleotide binding466 – 4683ATP By similarity
Region318 – 3269Nuclear export signal By similarity
Region502 – 5087Substrate binding By similarity
Region504 – 5129Calmodulin-binding By similarity
Region529 – 5368Substrate binding By similarity

Sites

Binding site4261ATP By similarity
Binding site4791ATP By similarity
Binding site4811Substrate By similarity
Binding site5531ATP By similarity
Binding site6331ATP By similarity
Binding site6361Substrate By similarity

Experimental info

Sequence conflict4581D → N in BAE32904. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
Q7TS72-1 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 0D3705B3D682B6ED

FASTA67874,493
        10         20         30         40         50         60 
MRRCPCRGSL SEAEAGALPA EARMGLEALR GGRRRQPGLQ RPGPGAGGPT GRPEGGGPRA 

        70         80         90        100        110        120 
WIEESSLHSE AERTDLEPAP CPNGPQAESC GDGHAECEAA GLVVASEKPR QNKELDGSNL 

       130        140        150        160        170        180 
QTHPRRNSPL VEMEMAGSWT DGFRTDLHRS DLQSRPKRAS LCTQPGFDES WTELDRSDMW 

       190        200        210        220        230        240 
QTLPERDNKP RVDNLRTHHG VSKLQTHPVC LSPESSADNS GKELSADASR TPHDTDGFWI 

       250        260        270        280        290        300 
ESQTDDSLKG PSTQTACRQP GSDGFSSKDT ESALTQPGTD GLRDDSVLGE SNGNDPLDLS 

       310        320        330        340        350        360 
EPGELVTNLC SHLECSSLCP VPRLIITPET PEPEAQPVGP QSRIEGGTGG FSSASSFDES 

       370        380        390        400        410        420 
EDDLVAGGGG TSDPEDRAGS KPWKKLKTVL KYSPFVVSFH KHYYPWVQLS GHAGNFQAGE 

       430        440        450        460        470        480 
DGRILKRFCQ CEQRSLELLM GDPLRPFVPA YYGMVQRDGQ AFNQMEDLLA DFEGPSIMDC 

       490        500        510        520        530        540 
KMGSRTYLEE ELVKARERPK PRKDMYEKMV AVDPGAPTPE EHAQGAITKP RYMQWRETLS 

       550        560        570        580        590        600 
STSTLGFRIE GIKKADGTCN TNFKKTQALE QVTKVLEDFV NGDLGILRKY VARLEDLRET 

       610        620        630        640        650        660 
LENSPFFKTH EVVGSSLLFV HDHTGLAKVW MIDFGKTVAL PDHQMLSHRL PWTEGNREDG 

       670 
YLWGLDNLIC LLQGLAQS

« Hide

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References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: NOD.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Limb.
+Additional computationally mapped references.

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Cross-references

Sequence databases

AK154888 mRNA. Translation: BAE32904.1.
BC053450 mRNA. Translation: AAH53450.1.
IPIIPI00113805.
RefSeqNP_853624.1.
UniGeneMm.30963
Mm.474636

3D structure databases

SMRQ7TS72. Positions 420-678.
ModBaseSearch...

Protein-protein interaction databases

IntActQ7TS72. 1 interaction.
STRINGQ7TS72.

Proteomic databases

PRIDEQ7TS72.

Genome annotation databases

EnsemblENSMUST00000003850; ENSMUSP00000003850; ENSMUSG00000003752; Mus musculus. [Genome view]
GeneID233011.
KEGGmmu:233011.
UCSCuc009fvk.1. mouse.

Organism-specific databases

CTD233011.
MGIMGI:2442554. Itpkc.

Phylogenomic databases

HOGENOMQ7TS72.
HOVERGENQ7TS72.
OMAMRRCPCR.

Enzyme and pathway databases

BRENDA2.7.1.127. 244.

Gene expression databases

ArrayExpressQ7TS72.
BgeeQ7TS72.
CleanExMM_ITPKC.
GenevestigatorQ7TS72.
GermOnlineENSMUSG00000003752. Mus musculus.

Family and domain databases

InterProIPR005522. IPK.
[Graphical view]
PANTHERPTHR12400. IPK. 1 hit.
PfamPF03770. IPK. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio381458.
SOURCESearch...

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Entry information

Entry nameIP3KC_MOUSE
AccessionPrimary (citable) accession number: Q7TS72
Secondary accession number(s): Q3U384
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: October 1, 2003
Last modified: November 3, 2009
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents