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Protein

Protein-serine/threonine kinase

Gene

Adrbk1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, ReceptorImported, Serine/threonine-protein kinaseUniRule annotationSAAS annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-serine/threonine kinaseUniRule annotation (EC:2.7.11.-UniRule annotation)
Gene namesi
Name:Adrbk1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:87940. Adrbk1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024858.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025791.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 133122RGSInterPro annotationAdd
BLAST
Domaini149 – 411263Protein kinaseInterPro annotationAdd
BLAST
Domaini412 – 47968AGC-kinase C-terminalInterPro annotationAdd
BLAST
Domaini516 – 61095PHInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili598 – 62528Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily.UniRule annotation
Contains 1 PH domain.UniRule annotation
Contains 1 RGS domain.UniRule annotation
Contains AGC-kinase C-terminal domain.SAAS annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0986. Eukaryota.
ENOG410YRQZ. LUCA.
GeneTreeiENSGT00770000120493.
HOGENOMiHOG000006742.
HOVERGENiHBG050559.
TreeFamiTF313940.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR000239. GPCR_kinase.
IPR011009. Kinase-like_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016137. RGS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR00717. GPCRKINASE.
SMARTiSM00233. PH. 1 hit.
SM00315. RGS. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TS64-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQKYLEDRGE VTFEKIFSQK LGYLLFRDFC LNHLEEAKPL VEFYEEIKKY
60 70 80 90 100
EKLETEEERV VRSREIFDSY IMKELLACSH PFSKNATEHV QGHLVKKQVP
110 120 130 140 150
PDLFQPYIEE ICQNLRGDVF QKFIESDKFT RFCQWKNVEL NIHLTMNDFS
160 170 180 190 200
VHRIIGRGGF GEVYGCRKAD TGKMYAMKCL DKKRIKMKQG ETLALNERIM
210 220 230 240 250
LSLVSTGDCP FIVCMSYAFH TPDKLSFILD LMNGGDLHYH LSQHGVFSEA
260 270 280 290 300
DMRFYAAEII LGLEHMHNRF VVYRDLKPAN ILLDEHGHVR ISDLGLACDF
310 320 330 340 350
SKKRPHASVG THGYMAPEVL QKGVAYDSSA DWFSLGCMLF KLLRGHSPFR
360 370 380 390 400
QHKTKDKHEI DRMTLTMAVE LPDSFSPELR SLLEGLLQRD VNRRLGCLGR
410 420 430 440 450
GAQEVKESPF FRSLDWQMVF LQKYPPPLIP PRGEVNAADA FDIGSFDEED
460 470 480 490 500
TKGIKLLDSD QELYRNFPLT ISERWQQEVA ETVFDTINAE TDRLEARKKA
510 520 530 540 550
KNKQLGHEED YALGKDCIVH GYMSKMGNPF LTQWQRRYFY LFPNRLEWRG
560 570 580 590 600
EGEAPQSLLT MEEIQSVEET QIKERKCLLL KIRGGKQFVL QCDSDPELVQ
610 620 630 640
WKKELRDAYR EAQQLVQRVP KMKNKPRSPV VELSKVPLIQ RGSANGL
Length:647
Mass (Da):75,153
Last modified:October 1, 2003 - v1
Checksum:iEA7A7DB50C6F4DB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC140073 Genomic DNA. No translation available.
BC053922 mRNA. Translation: AAH53922.1.
RefSeqiNP_570933.1. NM_130863.2.
UniGeneiMm.254144.

Genome annotation databases

EnsembliENSMUST00000025791; ENSMUSP00000025791; ENSMUSG00000024858.
GeneIDi110355.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC140073 Genomic DNA. No translation available.
BC053922 mRNA. Translation: AAH53922.1.
RefSeqiNP_570933.1. NM_130863.2.
UniGeneiMm.254144.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025791.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025791; ENSMUSP00000025791; ENSMUSG00000024858.
GeneIDi110355.

Organism-specific databases

CTDi110355.
MGIiMGI:87940. Adrbk1.

Phylogenomic databases

eggNOGiKOG0986. Eukaryota.
ENOG410YRQZ. LUCA.
GeneTreeiENSGT00770000120493.
HOGENOMiHOG000006742.
HOVERGENiHBG050559.
TreeFamiTF313940.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024858.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR000239. GPCR_kinase.
IPR011009. Kinase-like_dom.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016137. RGS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00169. PH. 1 hit.
PF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR00717. GPCRKINASE.
SMARTiSM00233. PH. 1 hit.
SM00315. RGS. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF50729. SSF50729. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ7TS64_MOUSE
AccessioniPrimary (citable) accession number: Q7TS64
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: September 7, 2016
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.