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Protein

Zinc finger protein ZFAT

Gene

Zfat

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation. Overexpression causes down-regulation of a number of genes involved in the immune response. Some genes are also up-regulated.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri12 – 3524C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri116 – 14126C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri271 – 29323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri299 – 32123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri326 – 34924C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri354 – 37724C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri404 – 42623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri432 – 45423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri458 – 48124C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri737 – 75923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri765 – 78824C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri793 – 81725C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri825 – 84824C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri875 – 89824C2H2-type 14; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri904 – 92623C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri932 – 95423C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri961 – 98323C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri989 – 101224C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1036 – 105924C2H2-type 19PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • hematopoietic progenitor cell differentiation Source: MGI
  • hemopoiesis Source: MGI
  • spongiotrophoblast layer development Source: MGI
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein ZFAT
Alternative name(s):
Zinc finger protein 406
Gene namesi
Name:Zfat
Synonyms:Gm922, Zfat1, Zfp406, Znf406
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:2681865. Zfat.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB-SubCell
  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12371237Zinc finger protein ZFATPRO_0000047567Add
BLAST

Proteomic databases

PaxDbiQ7TS63.
PRIDEiQ7TS63.

PTM databases

iPTMnetiQ7TS63.
PhosphoSiteiQ7TS63.

Expressioni

Tissue specificityi

Detected in spleen and thymus but not in liver, muscle, heart, kidney, brain, bone marrow or pancreas. Expressed in CD19+, CD4+ and CD8+ lymphocytes but not in CD11b+ lymphocytes or peritoneal macrophages (at protein level).1 Publication

Developmental stagei

Up-regulated during the transition from CD4-/CD8- to CD4+/CD8+ thymocytes.1 Publication

Gene expression databases

BgeeiENSMUSG00000022335.
CleanExiMM_ZFAT.
ExpressionAtlasiQ7TS63. baseline and differential.
GenevisibleiQ7TS63. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000125257.

Structurei

Secondary structure

1
1237
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi357 – 3593Combined sources
Beta strandi362 – 3654Combined sources
Helixi366 – 37611Combined sources
Beta strandi461 – 4633Combined sources
Beta strandi466 – 4694Combined sources
Helixi470 – 47910Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ELWNMR-A352-381[»]
2ELXNMR-A458-485[»]
2RV4NMR-A352-381[»]
2RV5NMR-A458-485[»]
ProteinModelPortaliQ7TS63.
SMRiQ7TS63. Positions 269-485, 739-1016.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7TS63.

Family & Domainsi

Sequence similaritiesi

Contains 19 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri12 – 3524C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri116 – 14126C2H2-type 2; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri271 – 29323C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri299 – 32123C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri326 – 34924C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri354 – 37724C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri404 – 42623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri432 – 45423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri458 – 48124C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri737 – 75923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri765 – 78824C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri793 – 81725C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri825 – 84824C2H2-type 13PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri875 – 89824C2H2-type 14; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri904 – 92623C2H2-type 15PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri932 – 95423C2H2-type 16PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri961 – 98323C2H2-type 17PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri989 – 101224C2H2-type 18PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri1036 – 105924C2H2-type 19PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129863.
HOGENOMiHOG000155776.
HOVERGENiHBG065928.
InParanoidiQ7TS63.
OMAiQHIWAHE.
OrthoDBiEOG091G00PE.
PhylomeDBiQ7TS63.
TreeFamiTF350017.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 19 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7TS63-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
METRTAENTA IFMCKCCNLF SPNQSELVTH VSEKHGEEGV NVDDVIIPLR
60 70 80 90 100
PLNTPENPNP SKGGDEFLVM KRKRGRPKGS TKKPSTEEEV VENLVSPSED
110 120 130 140 150
GPLATEEGSR LAPSSLECSK CCRKFSNTRQ LRKHICIIVL NLGEEDGDAG
160 170 180 190 200
NESDLDLEKT YKEDDREKAS KRPRAQKTEK VQKISGKEAG QLSGAKKPII
210 220 230 240 250
SVVLTAHEAI PGATKIIPVE AGPPETGAPP PETTAADLVP RRGYQEYAIQ
260 270 280 290 300
QTPYEQPMKS SRLGPTQLKI FTCEYCNKVF KFKHSLQAHL RIHTNEKPYK
310 320 330 340 350
CSQCSYASAI KANLNVHLRK HTGEKFACDY CSFTCLSKGH LKVHIERVHK
360 370 380 390 400
KIKQHCRFCK KKYSDVKNLI KHIRDMHDPQ DKKVKEALDE LRLMTREGKR
410 420 430 440 450
QLLYDCHICE RKFKNELDRD RHMLVHGDKW PFACELCGHG ATKYQALELH
460 470 480 490 500
VRKHPFVYVC ALCLKKFVSS IRLRSHIREV HGAAQETLVF TSSINQSFCL
510 520 530 540 550
LEPGGDIQQE ALGDQLQLAA EEFVCPEIDV RKEEACPGEA QPEVGLRELV
560 570 580 590 600
VPGDAHAPPP GPLATPQSES SSLSPCKLET TVVSSDLNSL GVVSDDFLLK
610 620 630 640 650
SDTSSAEPPA AAEATSDTQH RDSAQTQGEE VTLLLAKAKS AGPDPESSPG
660 670 680 690 700
GRQKVGALPA SESDSSTCLR ANPTEASDLL PTVTDGGDLG VCQPDSCTPS
710 720 730 740 750
SEHHPGSTAF MKVLDSLQKK QMNTSLCERI RKVYGDLECE YCGKLFWYQV
760 770 780 790 800
HFDMHVRTHT REHLYYCSQC HYSSITKNCL KRHVIQKHSN ILLKCPTDGC
810 820 830 840 850
DYSTPDKYKL QAHLKVHTEL DKRSYSCPVC EKSFSEDRLI KSHIKTNHPE
860 870 880 890 900
VSMNTISEVL GRRVQLKGLI GKRAMKCPYC DFYFMKNGSD LQRHIWAHEG
910 920 930 940 950
VKPFKCSLCE YATRSKSNLK AHMNRHSTEK THLCDMCGKK FKSKGTLKSH
960 970 980 990 1000
KLLHTSDGKQ FKCTVCDYTA AQKPQLLRHM EQHASFKPFR CAHCHYSCNI
1010 1020 1030 1040 1050
SGSLKRHYNR KHPNEEYTNV GSGELAAEAL IQQGGLKCPV CSFVYGTKWE
1060 1070 1080 1090 1100
FNRHLKNKHG LKVVEIDGDP KWEPAAETPE EPSTQYLYIT EAEDVQGTQA
1110 1120 1130 1140 1150
AVAALQDLRY TSESGDRLDP TAVNILQQII ELGSETHDAA AVASVVAMAP
1160 1170 1180 1190 1200
GTVTVVKQVT DEEPSSNHTV MIQETLQQAS VELAEQHHLV VSSDDVEGIE
1210 1220 1230
TVTVYTQGGE ASEFIVYVQE AVQPVEEQVG EQPAPEL
Length:1,237
Mass (Da):137,883
Last modified:July 22, 2008 - v2
Checksum:i085176A902B319E9
GO
Isoform 2 (identifier: Q7TS63-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     144-150: Missing.
     1063-1073: Missing.

Note: No experimental confirmation available.
Show »
Length:1,219
Mass (Da):135,941
Checksum:i88AC8FA17F61AA55
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei144 – 1507Missing in isoform 2. 1 PublicationVSP_034940
Alternative sequencei1063 – 107311Missing in isoform 2. 1 PublicationVSP_034941Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU221277 mRNA. Translation: ABY67968.1.
BC053930 mRNA. Translation: AAH53930.1.
CCDSiCCDS49623.1. [Q7TS63-1]
CCDS49624.1. [Q7TS63-2]
RefSeqiNP_001139360.1. NM_001145888.1. [Q7TS63-1]
NP_941046.1. NM_198644.2. [Q7TS63-2]
UniGeneiMm.309526.

Genome annotation databases

EnsembliENSMUST00000160248; ENSMUSP00000125257; ENSMUSG00000022335. [Q7TS63-1]
ENSMUST00000162054; ENSMUSP00000125732; ENSMUSG00000022335. [Q7TS63-2]
GeneIDi380993.
KEGGimmu:380993.
UCSCiuc007wbd.2. mouse. [Q7TS63-2]
uc011zto.1. mouse. [Q7TS63-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU221277 mRNA. Translation: ABY67968.1.
BC053930 mRNA. Translation: AAH53930.1.
CCDSiCCDS49623.1. [Q7TS63-1]
CCDS49624.1. [Q7TS63-2]
RefSeqiNP_001139360.1. NM_001145888.1. [Q7TS63-1]
NP_941046.1. NM_198644.2. [Q7TS63-2]
UniGeneiMm.309526.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2ELWNMR-A352-381[»]
2ELXNMR-A458-485[»]
2RV4NMR-A352-381[»]
2RV5NMR-A458-485[»]
ProteinModelPortaliQ7TS63.
SMRiQ7TS63. Positions 269-485, 739-1016.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000125257.

PTM databases

iPTMnetiQ7TS63.
PhosphoSiteiQ7TS63.

Proteomic databases

PaxDbiQ7TS63.
PRIDEiQ7TS63.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000160248; ENSMUSP00000125257; ENSMUSG00000022335. [Q7TS63-1]
ENSMUST00000162054; ENSMUSP00000125732; ENSMUSG00000022335. [Q7TS63-2]
GeneIDi380993.
KEGGimmu:380993.
UCSCiuc007wbd.2. mouse. [Q7TS63-2]
uc011zto.1. mouse. [Q7TS63-1]

Organism-specific databases

CTDi57623.
MGIiMGI:2681865. Zfat.

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129863.
HOGENOMiHOG000155776.
HOVERGENiHBG065928.
InParanoidiQ7TS63.
OMAiQHIWAHE.
OrthoDBiEOG091G00PE.
PhylomeDBiQ7TS63.
TreeFamiTF350017.

Miscellaneous databases

EvolutionaryTraceiQ7TS63.
PROiQ7TS63.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022335.
CleanExiMM_ZFAT.
ExpressionAtlasiQ7TS63. baseline and differential.
GenevisibleiQ7TS63. MM.

Family and domain databases

Gene3Di3.30.160.60. 8 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 19 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZFAT_MOUSE
AccessioniPrimary (citable) accession number: Q7TS63
Secondary accession number(s): B2C322
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: July 22, 2008
Last modified: September 7, 2016
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.