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Protein
Submitted name:

BCL-WEL

Gene

Bcl2l2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • BH domain binding Source: RGD
  • protein heterodimerization activity Source: RGD

GO - Biological processi

  • apoptotic process Source: RGD
  • regulation of apoptotic process Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
BCL-WELImported
Gene namesi
Name:Bcl2l2Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi620717. Bcl2l2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei196 – 21722HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • cytoplasm Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • mitochondrion Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Proteomic databases

PaxDbiQ7TS60.

Interactioni

GO - Molecular functioni

  • BH domain binding Source: RGD
  • protein heterodimerization activity Source: RGD

Protein-protein interaction databases

IntActiQ7TS60. 1 interaction.
STRINGi10116.ENSRNOP00000020409.

Structurei

3D structure databases

ProteinModelPortaliQ7TS60.
SMRiQ7TS60. Positions 27-209.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini36 – 5318BH4_2InterPro annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG4209. Eukaryota.
ENOG4111PFV. LUCA.
HOGENOMiHOG000056452.
HOVERGENiHBG004472.

Family and domain databases

InterProiIPR013280. Apop_reg_BclW.
IPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR003093. Bcl2_BH4.
IPR020731. Bcl2_BH4_motif_CS.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF13. PTHR11256:SF13. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
PF02180. BH4. 1 hit.
[Graphical view]
PRINTSiPR01865. APOPREGBCLW.
PR01862. BCL2FAMILY.
SMARTiSM00265. BH4. 1 hit.
[Graphical view]
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
PS01260. BH4_1. 1 hit.
PS50063. BH4_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TS60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLFGLCQYF SYIYVSLSSL PLSAARMATP ASTPDTRALV ADFVGYKLRQ
60 70 80 90 100
KGYVCGAGPG EGPAADPLHQ AMRAAGDEFE TRFRRTFSDL AAQLHVTPGS
110 120 130 140 150
AQQRFTQVSD ELFQGGPNWG RLVAFFVFGA ALCAESVNKE MEPLVGQVQD
160 170 180 190 200
WMVTYLETRL ADWIHSSGGW AEFTALYGDG ALEEARRLRE GNWASVRTVL
210
TGAVALGALV TVGAFFASK
Length:219
Mass (Da):23,720
Last modified:October 1, 2003 - v1
Checksum:i30E36041BC1DC66F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY185100 mRNA. Translation: AAO64470.1.
RefSeqiXP_008768914.1. XM_008770692.1.
XP_008768915.1. XM_008770693.1.
XP_008768916.1. XM_008770694.1.
UniGeneiRn.44267.

Genome annotation databases

GeneIDi60434.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY185100 mRNA. Translation: AAO64470.1.
RefSeqiXP_008768914.1. XM_008770692.1.
XP_008768915.1. XM_008770693.1.
XP_008768916.1. XM_008770694.1.
UniGeneiRn.44267.

3D structure databases

ProteinModelPortaliQ7TS60.
SMRiQ7TS60. Positions 27-209.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ7TS60. 1 interaction.
STRINGi10116.ENSRNOP00000020409.

Proteomic databases

PaxDbiQ7TS60.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi60434.

Organism-specific databases

CTDi599.
RGDi620717. Bcl2l2.

Phylogenomic databases

eggNOGiKOG4209. Eukaryota.
ENOG4111PFV. LUCA.
HOGENOMiHOG000056452.
HOVERGENiHBG004472.

Family and domain databases

InterProiIPR013280. Apop_reg_BclW.
IPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR003093. Bcl2_BH4.
IPR020731. Bcl2_BH4_motif_CS.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF13. PTHR11256:SF13. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
PF02180. BH4. 1 hit.
[Graphical view]
PRINTSiPR01865. APOPREGBCLW.
PR01862. BCL2FAMILY.
SMARTiSM00265. BH4. 1 hit.
[Graphical view]
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
PS01260. BH4_1. 1 hit.
PS50063. BH4_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Bcl-2-related protein family gene expression during oligodendroglial differentiation."
    Itoh T., Itoh A., Pleasure D.
    J. Neurochem. 85:1500-1512(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.

Entry informationi

Entry nameiQ7TS60_RAT
AccessioniPrimary (citable) accession number: Q7TS60
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: May 11, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.