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Protein

Carbonyl reductase family member 4

Gene

Cbr4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

The heterotetramer with HSD17B8 has NADH-dependent 3-ketoacyl-acyl carrier protein reductase activity. May play a role in biosynthesis of fatty acids in mitochondria. The homotetramer may act as NADPH-dependent quinone reductase. Has broad substrate specificity and reduces 9,10-phenanthrenequinone, 1,4-benzoquinone and various other o-quinones and p-quinones (in vitro) (By similarity).By similarity

Pathwayi: fatty acid biosynthesis

This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei134 – 1341SubstrateBy similarity
Active sitei147 – 1471Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 3125NAD or NADPBy similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NAD, NADP

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Carbonyl reductase family member 4 (EC:1.-.-.-)
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] reductase (EC:1.1.1.-)
Quinone reductase CBR4
Gene namesi
Name:Cbr4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 16

Organism-specific databases

RGDi727826. Cbr4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 236236Carbonyl reductase family member 4PRO_0000319880Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei40 – 401N6-acetyllysineBy similarity
Modified residuei96 – 961N6-acetyllysineBy similarity
Modified residuei194 – 1941N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ7TS56.

PTM databases

iPTMnetiQ7TS56.
PhosphoSiteiQ7TS56.

Expressioni

Gene expression databases

ExpressionAtlasiQ7TS56. baseline and differential.
GenevisibleiQ7TS56. RN.

Interactioni

Subunit structurei

Homotetramer. Heterotetramer with HSD17B8; contains two molecules of HSD17B8 and CBR4 (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ7TS56.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00760000118868.
HOVERGENiHBG002145.
InParanoidiQ7TS56.
KOiK11539.
OMAiRTPMHGD.
OrthoDBiEOG091G0N2V.
PhylomeDBiQ7TS56.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TS56-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKVCAVFGG SRGIGKAVAQ LMAQKGYRLA IVARNLEVAK ATASELGGIH
60 70 80 90 100
LAFRCNIAKE GDVHSTFEEM EKHLGPVNFL VNAAGINRDS LLVRTKTEDM
110 120 130 140 150
LSQLHTNLLG TMLTCRAAMR TMIQQGGSIV NVGSIIGLKG NVGQAAYSAT
160 170 180 190 200
KGGLIGFSRS LAKEVARKKI RVNVVAPGFI HTDMTKHLKE EHFKKNIPLG
210 220 230
RFGEALEVAH AVVFLLESPY ITGHVLIVDG GLQLTA
Length:236
Mass (Da):25,287
Last modified:October 1, 2003 - v1
Checksum:i3223506C39975316
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY305858 mRNA. Translation: AAP70488.1.
BC086378 mRNA. Translation: AAH86378.1.
RefSeqiNP_872613.1. NM_182672.2.
UniGeneiRn.3599.

Genome annotation databases

EnsembliENSRNOT00000032199; ENSRNOP00000038351; ENSRNOG00000024411.
GeneIDi359725.
KEGGirno:359725.
UCSCiRGD:727826. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY305858 mRNA. Translation: AAP70488.1.
BC086378 mRNA. Translation: AAH86378.1.
RefSeqiNP_872613.1. NM_182672.2.
UniGeneiRn.3599.

3D structure databases

ProteinModelPortaliQ7TS56.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ7TS56.
PhosphoSiteiQ7TS56.

Proteomic databases

PRIDEiQ7TS56.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000032199; ENSRNOP00000038351; ENSRNOG00000024411.
GeneIDi359725.
KEGGirno:359725.
UCSCiRGD:727826. rat.

Organism-specific databases

CTDi84869.
RGDi727826. Cbr4.

Phylogenomic databases

GeneTreeiENSGT00760000118868.
HOVERGENiHBG002145.
InParanoidiQ7TS56.
KOiK11539.
OMAiRTPMHGD.
OrthoDBiEOG091G0N2V.
PhylomeDBiQ7TS56.

Enzyme and pathway databases

UniPathwayiUPA00094.

Miscellaneous databases

PROiQ7TS56.

Gene expression databases

ExpressionAtlasiQ7TS56. baseline and differential.
GenevisibleiQ7TS56. RN.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCBR4_RAT
AccessioniPrimary (citable) accession number: Q7TS56
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2003
Last modified: September 7, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.