Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q7TS55

- TNF18_MOUSE

UniProt

Q7TS55 - TNF18_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Tumor necrosis factor ligand superfamily member 18

Gene

Tnfsf18

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B.5 Publications

GO - Molecular functioni

  1. tumor necrosis factor receptor superfamily binding Source: UniProtKB

GO - Biological processi

  1. positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
  2. regulation of T cell proliferation Source: UniProtKB
  3. T cell proliferation involved in immune response Source: UniProtKB
  4. tumor necrosis factor-mediated signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Adaptive immunity, Immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 18
Alternative name(s):
GITR ligand
Short name:
GITRL
Glucocorticoid-induced TNF-related ligand
Gene namesi
Name:Tnfsf18
Synonyms:Gitrl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:2673064. Tnfsf18.

Subcellular locationi

Cell membrane 2 Publications; Single-pass type II membrane protein 2 Publications

GO - Cellular componenti

  1. cell surface Source: UniProtKB
  2. extracellular space Source: UniProtKB-KW
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 173173Tumor necrosis factor ligand superfamily member 18PRO_0000415333Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi52 ↔ 723 Publications
Glycosylationi74 – 741N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ7TS55.

Expressioni

Tissue specificityi

Detected in immature and mature dendritic cells and in macrophages (at protein level). Detected in spleen, lung, heart, thymus, monocytes, macrophages, B-cells and dendritic cells.3 Publications

Inductioni

Up-regulated by exposure to bacterial lipopolysaccharide (LPS).1 Publication

Gene expression databases

GenevestigatoriQ7TS55.

Interactioni

Subunit structurei

Homotrimer. Homodimer.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Tnfrsf18O357143EBI-523345,EBI-523358

Protein-protein interaction databases

DIPiDIP-29663N.
IntActiQ7TS55. 1 interaction.

Structurei

Secondary structure

1
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi53 – 575
Turni58 – 614
Beta strandi62 – 698
Beta strandi71 – 755
Beta strandi81 – 833
Beta strandi87 – 959
Helixi100 – 1023
Beta strandi109 – 1157
Beta strandi118 – 12710
Beta strandi130 – 1389
Beta strandi143 – 1497
Helixi151 – 1533
Beta strandi160 – 1656
Beta strandi171 – 1733

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2Q8OX-ray1.75A/B43-173[»]
2QDNX-ray2.09A/B46-173[»]
3B9IX-ray2.49A/B46-173[»]
3FC0X-ray1.76A/B46-173[»]
ProteinModelPortaliQ7TS55.
SMRiQ7TS55. Positions 51-173.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7TS55.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini42 – 173132ExtracellularSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei21 – 4121Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG39473.
GeneTreeiENSGT00390000002560.
HOGENOMiHOG000026597.
HOVERGENiHBG061857.
InParanoidiQ7TS55.
KOiK05479.
OMAiTYKEPAP.
OrthoDBiEOG7S7SG4.
PhylomeDBiQ7TS55.
TreeFamiTF338614.

Family and domain databases

Gene3Di2.60.120.40. 1 hit.
InterProiIPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view]
PfamiPF00229. TNF. 1 hit.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7TS55-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEEMPLRESS PQRAERCKKS WLLCIVALLL MLLCSLGTLI YTSLKPTAIE
60 70 80 90 100
SCMVKFELSS SKWHMTSPKP HCVNTTSDGK LKILQSGTYL IYGQVIPVDK
110 120 130 140 150
KYIKDNAPFV VQIYKKNDVL QTLMNDFQIL PIGGVYELHA GDNIYLKFNS
160 170
KDHIQKTNTY WGIILMPDLP FIS
Length:173
Mass (Da):19,732
Last modified:October 1, 2003 - v1
Checksum:i0F08494CACF424D2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti48 – 481A → V in AAP96745. (PubMed:14647196)Curated
Sequence conflicti157 – 1571T → N in AAP96745. (PubMed:14647196)Curated
Sequence conflicti157 – 1571T → N in CAE12166. (PubMed:14608036)Curated
Sequence conflicti157 – 1571T → N in CAE12167. (PubMed:14608036)Curated
Sequence conflicti157 – 1571T → N in AAO89011. 1 PublicationCurated
Sequence conflicti157 – 1571T → N in AAI37815. (PubMed:15489334)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY359852 mRNA. Translation: AAQ55265.1.
AY267900 mRNA. Translation: AAP96745.1.
AJ577579 mRNA. Translation: CAE12166.1.
AJ577580 mRNA. Translation: CAE12167.1.
AY320040 mRNA. Translation: AAP70494.1.
AY234223 mRNA. Translation: AAO89011.1.
AC163268 Genomic DNA. No translation available.
BC137814 mRNA. Translation: AAI37815.1.
BC137815 mRNA. Translation: AAI37816.1.
CCDSiCCDS15417.1.
RefSeqiNP_899247.3. NM_183391.3.
UniGeneiMm.276823.

Genome annotation databases

EnsembliENSMUST00000086084; ENSMUSP00000083251; ENSMUSG00000066755.
GeneIDi240873.
KEGGimmu:240873.
UCSCiuc007dfo.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY359852 mRNA. Translation: AAQ55265.1 .
AY267900 mRNA. Translation: AAP96745.1 .
AJ577579 mRNA. Translation: CAE12166.1 .
AJ577580 mRNA. Translation: CAE12167.1 .
AY320040 mRNA. Translation: AAP70494.1 .
AY234223 mRNA. Translation: AAO89011.1 .
AC163268 Genomic DNA. No translation available.
BC137814 mRNA. Translation: AAI37815.1 .
BC137815 mRNA. Translation: AAI37816.1 .
CCDSi CCDS15417.1.
RefSeqi NP_899247.3. NM_183391.3.
UniGenei Mm.276823.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2Q8O X-ray 1.75 A/B 43-173 [» ]
2QDN X-ray 2.09 A/B 46-173 [» ]
3B9I X-ray 2.49 A/B 46-173 [» ]
3FC0 X-ray 1.76 A/B 46-173 [» ]
ProteinModelPortali Q7TS55.
SMRi Q7TS55. Positions 51-173.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-29663N.
IntActi Q7TS55. 1 interaction.

Proteomic databases

PRIDEi Q7TS55.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000086084 ; ENSMUSP00000083251 ; ENSMUSG00000066755 .
GeneIDi 240873.
KEGGi mmu:240873.
UCSCi uc007dfo.2. mouse.

Organism-specific databases

CTDi 8995.
MGIi MGI:2673064. Tnfsf18.

Phylogenomic databases

eggNOGi NOG39473.
GeneTreei ENSGT00390000002560.
HOGENOMi HOG000026597.
HOVERGENi HBG061857.
InParanoidi Q7TS55.
KOi K05479.
OMAi TYKEPAP.
OrthoDBi EOG7S7SG4.
PhylomeDBi Q7TS55.
TreeFami TF338614.

Miscellaneous databases

EvolutionaryTracei Q7TS55.
NextBioi 384771.
PROi Q7TS55.
SOURCEi Search...

Gene expression databases

Genevestigatori Q7TS55.

Family and domain databases

Gene3Di 2.60.120.40. 1 hit.
InterProi IPR006052. TNF_dom.
IPR008983. Tumour_necrosis_fac-like_dom.
[Graphical view ]
Pfami PF00229. TNF. 1 hit.
[Graphical view ]
SUPFAMi SSF49842. SSF49842. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a ligand for glucocorticoid-induced tumor necrosis factor receptor constitutively expressed in dendritic cells."
    Yu K.Y., Kim H.S., Song S.Y., Min S.S., Jeong J.J., Youn B.S.
    Biochem. Biophys. Res. Commun. 310:433-438(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Strain: 129/J.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: BALB/c.
  3. "Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells."
    Tone M., Tone Y., Adams E., Yates S.F., Frewin M.R., Cobbold S.P., Waldmann H.
    Proc. Natl. Acad. Sci. U.S.A. 100:15059-15064(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, INDUCTION, TISSUE SPECIFICITY.
    Strain: CBA/Ca.
  4. "The natural ligand for glucocorticoid-induced TNF receptor-related protein abrogates regulatory T cell suppression."
    Ji H.B., Liao G., Faubion W.A., Abadia-Molina A.C., Cozzo C., Laroux F.S., Caton A., Terhorst C.
    J. Immunol. 172:5823-5827(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBUNIT.
    Strain: C57BL/6.
    Tissue: Spleen.
  5. "Cloning and characterization of the mouse ortholog of human GITR ligand (TNFSF18)."
    Bianchini R., Nocentini G., Ronchetti S., Ayroldi E., Riccardi C.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: DBA/2J.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  8. "Evolution of GITRL immune function: murine GITRL exhibits unique structural and biochemical properties within the TNF superfamily."
    Chattopadhyay K., Ramagopal U.A., Brenowitz M., Nathenson S.G., Almo S.C.
    Proc. Natl. Acad. Sci. U.S.A. 105:635-640(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.09 ANGSTROMS) OF 46-173, SUBUNIT, DISULFIDE BOND.
  9. Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 43-173, FUNCTION, SUBUNIT, DISULFIDE BOND.
  10. "1.8 A structure of murine GITR ligand dimer expressed in Drosophila melanogaster S2 cells."
    Chattopadhyay K., Ramagopal U.A., Nathenson S.G., Almo S.C.
    Acta Crystallogr. D 65:434-439(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.76 ANGSTROMS) OF 46-173, GLYCOSYLATION, SUBUNIT, DISULFIDE BOND.

Entry informationi

Entry nameiTNF18_MOUSE
AccessioniPrimary (citable) accession number: Q7TS55
Secondary accession number(s): Q7TNY2, Q80YG2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 25, 2012
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3