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Protein

Serine/threonine-protein kinase TNNI3K

Gene

Tnni3k

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May play a role in cardiac physiology.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei490ATPPROSITE-ProRule annotation1
Active sitei588Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi469 – 477ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase TNNI3K (EC:2.7.11.1)
Alternative name(s):
Cardiac ankyrin repeat kinase
TNNI3-interacting kinase
Gene namesi
Name:Tnni3kBy similarity
Synonyms:CarkImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi727908 Tnni3k

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00000867602 – 835Serine/threonine-protein kinase TNNI3KAdd BLAST834

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineSequence analysis1

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

PaxDbiQ7TQP6
PRIDEiQ7TQP6

PTM databases

iPTMnetiQ7TQP6
PhosphoSitePlusiQ7TQP6

Interactioni

Subunit structurei

Interacts with TNNI3, ACTC, ACTA1, MYBPC3, AIP, BABP3 and HADHB.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031479

Structurei

3D structure databases

ProteinModelPortaliQ7TQP6
SMRiQ7TQP6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati66 – 96ANK 1Add BLAST31
Repeati100 – 129ANK 2Add BLAST30
Repeati133 – 162ANK 3Add BLAST30
Repeati166 – 195ANK 4Add BLAST30
Repeati199 – 228ANK 5Add BLAST30
Repeati234 – 263ANK 6Add BLAST30
Repeati269 – 298ANK 7Add BLAST30
Repeati304 – 335ANK 8Add BLAST32
Repeati339 – 368ANK 9Add BLAST30
Repeati381 – 410ANK 10Add BLAST30
Domaini463 – 723Protein kinasePROSITE-ProRule annotationAdd BLAST261

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili21 – 50Sequence analysisAdd BLAST30

Sequence similaritiesi

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IT5N Eukaryota
COG0666 LUCA
HOGENOMiHOG000234421
HOVERGENiHBG079513
InParanoidiQ7TQP6
KOiK17535
PhylomeDBiQ7TQP6

Family and domain databases

CDDicd00204 ANK, 4 hits
Gene3Di1.25.40.20, 3 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF12796 Ank_2, 3 hits
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 10 hits
SUPFAMiSSF48403 SSF48403, 1 hit
SSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 6 hits
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TQP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNYKSRPTQ TCSDEWKKKV SESYAIIIER LEDNLQIKEN EFQELRHIFG
60 70 80 90 100
SDEAFSEVSL NYRTERGLSL LHLCCVCGGN KSHIRALMLK GLRPSRLTRN
110 120 130 140 150
GFPALHLAVY KDSPELITSL LHSGADVQQV GYGGLTALHI AAIAGHPEAA
160 170 180 190 200
EVLLQHGANV NVQDAVFFTP LHIAAYYGHE QVTSVLLKFG ADVNVSGEVG
210 220 230 240 250
DRPLHLASAK GFFNIVKLLV EEGSKADVNA QDNEDHVPLH FCSRFGHHNI
260 270 280 290 300
VSYLLQSDLE VQPHVINIYG DTPLHLACYN GNFEVAKEIV QVTGTESLTK
310 320 330 340 350
ENIFSETAFH SACTYGKNID LVKFLLDQNA VNINHRGRDG HTGLHSACYH
360 370 380 390 400
GHIRLVQFLL DNGADMNLVA CDPSRSSGEK DEQTCLMWAY EKGHDAIVTL
410 420 430 440 450
LKHYKRPQEE LPCNEYSQPG GDGSYVSVPS PLGKIKSMTK EKADVLLLRA
460 470 480 490 500
ELPSRFHLQL SEIEFHEIIG SGSFGKVYKG RCRNKIVAIK RYRANTYCSK
510 520 530 540 550
SDVDMFCREV SILCQLNHPC VVQFVGACLD DPSQFAIVTQ YISGGSLFSL
560 570 580 590 600
LHEQKRILDL QSKLIIAVDV AKGMEYLHSL TQPIIHRDLN SHNILLYEDG
610 620 630 640 650
HAVVADFGES RFLQSLDEDN MTKQPGNLRW MAPEVFTQCT RYTIKADVFS
660 670 680 690 700
YSLCLWELLT GEIPFAHLKP AAAAADMAYH HIRPPIGYSI PKPISSLLIR
710 720 730 740 750
GWNACPEGRP EFSEVVSKLE ECLCNVELMS PASSNSSGSL SPSSSSDCLL
760 770 780 790 800
SRGGPGRSHV AALRSRFELE YALNARSYAG WSQSVGTHSN PGLSLEEMNR
810 820 830
STQYSTVDKY GYVSDPMSLT HLHSRQDDSN FEDSN
Length:835
Mass (Da):92,732
Last modified:January 23, 2007 - v3
Checksum:i35A022D1011615D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY303692 mRNA Translation: AAP72031.1
RefSeqiNP_861434.1, NM_181769.1
UniGeneiRn.3434

Genome annotation databases

GeneIDi295531
KEGGirno:295531

Similar proteinsi

Entry informationi

Entry nameiTNI3K_RAT
AccessioniPrimary (citable) accession number: Q7TQP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 110 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health