Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/threonine-protein kinase TNNI3K

Gene

Tnni3k

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in cardiac physiology.By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.By similarity

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei490 – 4901ATPPROSITE-ProRule annotation
Active sitei588 – 5881Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi469 – 4779ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein kinase TNNI3K (EC:2.7.11.1)
Alternative name(s):
Cardiac ankyrin repeat kinase
TNNI3-interacting kinase
Gene namesi
Name:Tnni3kBy similarity
Synonyms:CarkImported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi727908. Tnni3k.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

  • Note: Expressed at lower levels in the cytoplasm.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedSequence analysis
Chaini2 – 835834Serine/threonine-protein kinase TNNI3KPRO_0000086760Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi2 – 21N-myristoyl glycineSequence analysis

Post-translational modificationi

Autophosphorylated.By similarity

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

PaxDbiQ7TQP6.
PRIDEiQ7TQP6.

PTM databases

iPTMnetiQ7TQP6.
PhosphoSiteiQ7TQP6.

Interactioni

Subunit structurei

Interacts with TNNI3, ACTC, ACTA1, MYBPC3, AIP, BABP3 and HADHB.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031479.

Structurei

3D structure databases

ProteinModelPortaliQ7TQP6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati66 – 9631ANK 1Add
BLAST
Repeati100 – 12930ANK 2Add
BLAST
Repeati133 – 16230ANK 3Add
BLAST
Repeati166 – 19530ANK 4Add
BLAST
Repeati199 – 22830ANK 5Add
BLAST
Repeati234 – 26330ANK 6Add
BLAST
Repeati269 – 29830ANK 7Add
BLAST
Repeati304 – 33532ANK 8Add
BLAST
Repeati339 – 36830ANK 9Add
BLAST
Repeati381 – 41030ANK 10Add
BLAST
Domaini463 – 723261Protein kinasePROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili21 – 5030Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 10 ANK repeats.PROSITE-ProRule annotation
Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410IT5N. Eukaryota.
COG0666. LUCA.
HOGENOMiHOG000234421.
HOVERGENiHBG079513.
InParanoidiQ7TQP6.
KOiK17535.
PhylomeDBiQ7TQP6.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF12796. Ank_2. 3 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 10 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TQP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNYKSRPTQ TCSDEWKKKV SESYAIIIER LEDNLQIKEN EFQELRHIFG
60 70 80 90 100
SDEAFSEVSL NYRTERGLSL LHLCCVCGGN KSHIRALMLK GLRPSRLTRN
110 120 130 140 150
GFPALHLAVY KDSPELITSL LHSGADVQQV GYGGLTALHI AAIAGHPEAA
160 170 180 190 200
EVLLQHGANV NVQDAVFFTP LHIAAYYGHE QVTSVLLKFG ADVNVSGEVG
210 220 230 240 250
DRPLHLASAK GFFNIVKLLV EEGSKADVNA QDNEDHVPLH FCSRFGHHNI
260 270 280 290 300
VSYLLQSDLE VQPHVINIYG DTPLHLACYN GNFEVAKEIV QVTGTESLTK
310 320 330 340 350
ENIFSETAFH SACTYGKNID LVKFLLDQNA VNINHRGRDG HTGLHSACYH
360 370 380 390 400
GHIRLVQFLL DNGADMNLVA CDPSRSSGEK DEQTCLMWAY EKGHDAIVTL
410 420 430 440 450
LKHYKRPQEE LPCNEYSQPG GDGSYVSVPS PLGKIKSMTK EKADVLLLRA
460 470 480 490 500
ELPSRFHLQL SEIEFHEIIG SGSFGKVYKG RCRNKIVAIK RYRANTYCSK
510 520 530 540 550
SDVDMFCREV SILCQLNHPC VVQFVGACLD DPSQFAIVTQ YISGGSLFSL
560 570 580 590 600
LHEQKRILDL QSKLIIAVDV AKGMEYLHSL TQPIIHRDLN SHNILLYEDG
610 620 630 640 650
HAVVADFGES RFLQSLDEDN MTKQPGNLRW MAPEVFTQCT RYTIKADVFS
660 670 680 690 700
YSLCLWELLT GEIPFAHLKP AAAAADMAYH HIRPPIGYSI PKPISSLLIR
710 720 730 740 750
GWNACPEGRP EFSEVVSKLE ECLCNVELMS PASSNSSGSL SPSSSSDCLL
760 770 780 790 800
SRGGPGRSHV AALRSRFELE YALNARSYAG WSQSVGTHSN PGLSLEEMNR
810 820 830
STQYSTVDKY GYVSDPMSLT HLHSRQDDSN FEDSN
Length:835
Mass (Da):92,732
Last modified:January 23, 2007 - v3
Checksum:i35A022D1011615D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY303692 mRNA. Translation: AAP72031.1.
RefSeqiNP_861434.1. NM_181769.1.
UniGeneiRn.3434.

Genome annotation databases

GeneIDi295531.
KEGGirno:295531.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY303692 mRNA. Translation: AAP72031.1.
RefSeqiNP_861434.1. NM_181769.1.
UniGeneiRn.3434.

3D structure databases

ProteinModelPortaliQ7TQP6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000031479.

PTM databases

iPTMnetiQ7TQP6.
PhosphoSiteiQ7TQP6.

Proteomic databases

PaxDbiQ7TQP6.
PRIDEiQ7TQP6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi295531.
KEGGirno:295531.

Organism-specific databases

CTDi51086.
RGDi727908. Tnni3k.

Phylogenomic databases

eggNOGiENOG410IT5N. Eukaryota.
COG0666. LUCA.
HOGENOMiHOG000234421.
HOVERGENiHBG079513.
InParanoidiQ7TQP6.
KOiK17535.
PhylomeDBiQ7TQP6.

Miscellaneous databases

PROiQ7TQP6.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
[Graphical view]
PfamiPF12796. Ank_2. 3 hits.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 10 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 6 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTNI3K_RAT
AccessioniPrimary (citable) accession number: Q7TQP6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 101 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.