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Protein

Relaxin-3 receptor 2

Gene

Rxfp4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-418594. G alpha (i) signalling events.
R-MMU-444821. Relaxin receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Relaxin-3 receptor 2
Short name:
RLN3 receptor 2
Alternative name(s):
G-protein coupled receptor 100
Insulin-like peptide INSL5 receptor
Relaxin family peptide receptor 4
Gene namesi
Name:Rxfp4
Synonyms:Gpr100, Rln3r2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2182926. Rxfp4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4343ExtracellularSequence analysisAdd
BLAST
Transmembranei44 – 6421Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini65 – 7713CytoplasmicSequence analysisAdd
BLAST
Transmembranei78 – 9821Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini99 – 11618ExtracellularSequence analysisAdd
BLAST
Transmembranei117 – 13721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini138 – 15518CytoplasmicSequence analysisAdd
BLAST
Transmembranei156 – 17621Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini177 – 20933ExtracellularSequence analysisAdd
BLAST
Transmembranei210 – 23021Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini231 – 25525CytoplasmicSequence analysisAdd
BLAST
Transmembranei256 – 27621Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini277 – 29317ExtracellularSequence analysisAdd
BLAST
Transmembranei294 – 31623Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini317 – 41498CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

GuidetoPHARMACOLOGYi354.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 414414Relaxin-3 receptor 2PRO_0000070107Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...)Sequence analysis
Glycosylationi17 – 171N-linked (GlcNAc...)Sequence analysis
Disulfide bondi114 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ7TQP4.
PRIDEiQ7TQP4.

PTM databases

PhosphoSiteiQ7TQP4.

Expressioni

Tissue specificityi

Detected only in bone marrow.

Gene expression databases

CleanExiMM_RXFP4.
ExpressionAtlasiQ7TQP4. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058732.

Structurei

3D structure databases

ProteinModelPortaliQ7TQP4.
SMRiQ7TQP4. Positions 3-316.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi225 – 2284Poly-Leu

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000230485.
HOVERGENiHBG101327.
InParanoidiQ7TQP4.
KOiK08398.
OMAiLWVLGNC.
OrthoDBiEOG091G0CM0.
PhylomeDBiQ7TQP4.
TreeFamiTF330024.

Family and domain databases

InterProiIPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00241. ANGIOTENSINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TQP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSNSSASL PTLFWVNGSG DSVLSTDGAA MPVQFLVLRI MVALAYGLVG
60 70 80 90 100
IIGLLGNLAV LWVLGNCGQR VPGLSSDTFV FSLALADLGL ALTLPFWATE
110 120 130 140 150
SAMDFHWPFG SALCKVVLTT TVLSIYASTF LITALSIARY WVVAMAVGPG
160 170 180 190 200
SHLSVFWARV VTLAVWVAAA LVTVPTAIFG AEVELWGVCL CLLRFPSRYW
210 220 230 240 250
LGAYQLQRVV LAFIVPLGVI TTSYLLLLAF LERQQRCRPR QWQDSRVVAR
260 270 280 290 300
SVRVLVASFA LCWVPNHVVT LWEILVRFDL VPWDSTFYTF HTYILPITTC
310 320 330 340 350
LAHSNSCLNP VIYCLLRREP QQVLVSSFRA LWSRLWPQRK ACMEQMALKE
360 370 380 390 400
VGGRTVASTQ ESGSSRTHTN TMEHLDEGCS LNTLLSETYQ GQSPQILGRS
410
SCSLSQAAVS PGEV
Length:414
Mass (Da):45,460
Last modified:October 1, 2003 - v1
Checksum:iEBB47A1C62E6DB0B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti41 – 411M → L in AAO85051 (PubMed:12679517).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288422 mRNA. Translation: AAP72131.1.
AY255539 mRNA. Translation: AAO85051.1.
CCDSiCCDS17482.1.
RefSeqiNP_861538.1. NM_181817.1.
UniGeneiMm.269130.

Genome annotation databases

EnsembliENSMUST00000063119; ENSMUSP00000058732; ENSMUSG00000049741.
GeneIDi242093.
KEGGimmu:242093.
UCSCiuc008pwc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288422 mRNA. Translation: AAP72131.1.
AY255539 mRNA. Translation: AAO85051.1.
CCDSiCCDS17482.1.
RefSeqiNP_861538.1. NM_181817.1.
UniGeneiMm.269130.

3D structure databases

ProteinModelPortaliQ7TQP4.
SMRiQ7TQP4. Positions 3-316.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058732.

Chemistry

GuidetoPHARMACOLOGYi354.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ7TQP4.

Proteomic databases

PaxDbiQ7TQP4.
PRIDEiQ7TQP4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063119; ENSMUSP00000058732; ENSMUSG00000049741.
GeneIDi242093.
KEGGimmu:242093.
UCSCiuc008pwc.1. mouse.

Organism-specific databases

CTDi339403.
MGIiMGI:2182926. Rxfp4.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119055.
HOGENOMiHOG000230485.
HOVERGENiHBG101327.
InParanoidiQ7TQP4.
KOiK08398.
OMAiLWVLGNC.
OrthoDBiEOG091G0CM0.
PhylomeDBiQ7TQP4.
TreeFamiTF330024.

Enzyme and pathway databases

ReactomeiR-MMU-418594. G alpha (i) signalling events.
R-MMU-444821. Relaxin receptors.

Miscellaneous databases

PROiQ7TQP4.
SOURCEiSearch...

Gene expression databases

CleanExiMM_RXFP4.
ExpressionAtlasiQ7TQP4. baseline and differential.

Family and domain databases

InterProiIPR000248. ATII_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00241. ANGIOTENSINR.
PR00237. GPCRRHODOPSN.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRL3R2_MOUSE
AccessioniPrimary (citable) accession number: Q7TQP4
Secondary accession number(s): Q80UD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: October 1, 2003
Last modified: September 7, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.