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Q7TQP4 (RL3R2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Relaxin-3 receptor 2
Short name=RLN3 receptor 2
Alternative name(s):
G-protein coupled receptor 100
Insulin-like peptide INSL5 receptor
Relaxin family peptide receptor 4
Gene names
Name:Rxfp4
Synonyms:Gpr100, Rln3r2
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length414 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Detected only in bone marrow.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionangiotensin type II receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 414414Relaxin-3 receptor 2
PRO_0000070107

Regions

Topological domain1 – 4343Extracellular Potential
Transmembrane44 – 6421Helical; Name=1; Potential
Topological domain65 – 7713Cytoplasmic Potential
Transmembrane78 – 9821Helical; Name=2; Potential
Topological domain99 – 11618Extracellular Potential
Transmembrane117 – 13721Helical; Name=3; Potential
Topological domain138 – 15518Cytoplasmic Potential
Transmembrane156 – 17621Helical; Name=4; Potential
Topological domain177 – 20933Extracellular Potential
Transmembrane210 – 23021Helical; Name=5; Potential
Topological domain231 – 25525Cytoplasmic Potential
Transmembrane256 – 27621Helical; Name=6; Potential
Topological domain277 – 29317Extracellular Potential
Transmembrane294 – 31623Helical; Name=7; Potential
Topological domain317 – 41498Cytoplasmic Potential
Compositional bias225 – 2284Poly-Leu

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Glycosylation171N-linked (GlcNAc...) Potential
Disulfide bond114 ↔ 191 By similarity

Experimental info

Sequence conflict411M → L in AAO85051. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q7TQP4 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: EBB47A1C62E6DB0B

FASTA41445,460
        10         20         30         40         50         60 
MATSNSSASL PTLFWVNGSG DSVLSTDGAA MPVQFLVLRI MVALAYGLVG IIGLLGNLAV 

        70         80         90        100        110        120 
LWVLGNCGQR VPGLSSDTFV FSLALADLGL ALTLPFWATE SAMDFHWPFG SALCKVVLTT 

       130        140        150        160        170        180 
TVLSIYASTF LITALSIARY WVVAMAVGPG SHLSVFWARV VTLAVWVAAA LVTVPTAIFG 

       190        200        210        220        230        240 
AEVELWGVCL CLLRFPSRYW LGAYQLQRVV LAFIVPLGVI TTSYLLLLAF LERQQRCRPR 

       250        260        270        280        290        300 
QWQDSRVVAR SVRVLVASFA LCWVPNHVVT LWEILVRFDL VPWDSTFYTF HTYILPITTC 

       310        320        330        340        350        360 
LAHSNSCLNP VIYCLLRREP QQVLVSSFRA LWSRLWPQRK ACMEQMALKE VGGRTVASTQ 

       370        380        390        400        410 
ESGSSRTHTN TMEHLDEGCS LNTLLSETYQ GQSPQILGRS SCSLSQAAVS PGEV

« Hide

References

« Hide 'large scale' references
[1]"Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives."
Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C., Schioeth H.B.
FEBS Lett. 554:381-388(2003) [PubMed: 14623098] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The G protein-coupled receptor repertoires of human and mouse."
Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E., Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C., Bergmann J.E., Gaitanaris G.A.
Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003) [PubMed: 12679517] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 41-159.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY288422 mRNA. Translation: AAP72131.1.
AY255539 mRNA. Translation: AAO85051.1.
IPIIPI00266049.
RefSeqNP_861538.1. NM_181817.1.
UniGeneMm.269130.

3D structure databases

ProteinModelPortalQ7TQP4.
SMRQ7TQP4. Positions 35-334.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ7TQP4.

Protein family/group databases

GPCRDBSearch...

Proteomic databases

PRIDEQ7TQP4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000063119; ENSMUSP00000058732; ENSMUSG00000049741.
GeneID242093.
KEGGmmu:242093.

Organism-specific databases

CTD339403.
MGIMGI:2182926. Rxfp4.

Phylogenomic databases

GeneTreeENSGT00560000076900.
HOGENOMHBG445265.
HOVERGENHBG101327.
InParanoidQ7TQP4.
OMACLLRFPS.
OrthoDBEOG4FN4J1.
PhylomeDBQ7TQP4.

Gene expression databases

BgeeQ7TQP4.
CleanExMM_RXFP4.
GenevestigatorQ7TQP4.

Family and domain databases

InterProIPR000276. 7TM_GPCR_Rhodpsn.
IPR000248. ATII_rcpt.
IPR017452. GPCR_Rhodpsn_supfam.
[Graphical view]
KOK08398.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00241. ANGIOTENSINR.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. False negative.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio385227.
SOURCESearch...

Entry information

Entry nameRL3R2_MOUSE
AccessionPrimary (citable) accession number: Q7TQP4
Secondary accession number(s): Q80UD6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: October 1, 2003
Last modified: November 16, 2011
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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