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Q7TQP3

- GP119_MOUSE

UniProt

Q7TQP3 - GP119_MOUSE

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Protein

Glucose-dependent insulinotropic receptor

Gene

Gpr119

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.1 Publication

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: UniProtKB-KW
  2. phosphatidylcholine binding Source: MGI

GO - Biological processi

  1. insulin secretion Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiREACT_253751. Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).
REACT_259776. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-dependent insulinotropic receptor
Alternative name(s):
G-protein coupled receptor 119
Gene namesi
Name:Gpr119
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:2668412. Gpr119.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 66ExtracellularSequence Analysis
Transmembranei7 – 2721Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini28 – 3710CytoplasmicSequence Analysis
Transmembranei38 – 5821Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini59 – 8123ExtracellularSequence AnalysisAdd
BLAST
Transmembranei82 – 10221Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini103 – 12523CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei126 – 14621Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini147 – 16418ExtracellularSequence AnalysisAdd
BLAST
Transmembranei165 – 18521Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini186 – 22641CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei227 – 24721Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini248 – 26215ExtracellularSequence AnalysisAdd
BLAST
Transmembranei263 – 28321Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini284 – 33552CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
  3. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 335335Glucose-dependent insulinotropic receptorPRO_0000069608Add
BLAST

Proteomic databases

PRIDEiQ7TQP3.

PTM databases

PhosphoSiteiQ7TQP3.

Expressioni

Tissue specificityi

Expression restricted to the beta-cells of pancreatic islets.2 Publications

Inductioni

Up-regulated in islets of obese hyperglycemic db/db mice.

Gene expression databases

CleanExiMM_GPR119.
GenevestigatoriQ7TQP3.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliQ7TQP3.
SMRiQ7TQP3. Positions 1-288.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi305 – 3084Poly-Leu

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG246868.
GeneTreeiENSGT00550000074524.
HOGENOMiHOG000112765.
HOVERGENiHBG051773.
InParanoidiQ7TQP3.
KOiK08424.
OMAiSFFAVFH.
OrthoDBiEOG75B85V.
PhylomeDBiQ7TQP3.
TreeFamiTF325411.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR028336. GPR119.
[Graphical view]
PANTHERiPTHR22750:SF7. PTHR22750:SF7. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TQP3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESSFSFGVI LAVLTILIIA VNALVVVAML LSIYKNDGVG LCFTLNLAVA
60 70 80 90 100
DTLIGVAISG LVTDQLSSSA QHTQKTLCSL RMAFVTSSAA ASVLTVMLIA
110 120 130 140 150
FDRYLAIKQP LRYFQIMNGL VAGACIAGLW LVSYLIGFLP LGVSIFQQTT
160 170 180 190 200
YHGPCSFFAV FHPRFVLTLS CAGFFPAVLL FVFFYCDMLK IASVHSQQIR
210 220 230 240 250
KMEHAGAMAG AYRPPRSVND FKAVRTIAVL IGSFTLSWSP FLITSIVQVA
260 270 280 290 300
CHKCCLYQVL EKYLWLLGVG NSLLNPLIYA YWQREVRQQL YHMALGVKKF
310 320 330
FTSILLLLPA RNRGPERTRE SAYHIVTISH PELDG
Length:335
Mass (Da):36,995
Last modified:October 1, 2003 - v1
Checksum:i16AAF4D518A06ECD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288423 mRNA. Translation: AAP72132.1.
AB233291 mRNA. Translation: BAE80212.1.
AL672042 Genomic DNA. Translation: CAM27332.1.
BC115557 mRNA. Translation: AAI15558.1.
BC115558 mRNA. Translation: AAI15559.1.
CCDSiCCDS30113.1.
RefSeqiNP_861416.1. NM_181751.2.
XP_006541551.1. XM_006541488.1.
UniGeneiMm.269129.

Genome annotation databases

EnsembliENSMUST00000053970; ENSMUSP00000060591; ENSMUSG00000051209.
GeneIDi236781.
KEGGimmu:236781.
UCSCiuc009tcs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288423 mRNA. Translation: AAP72132.1 .
AB233291 mRNA. Translation: BAE80212.1 .
AL672042 Genomic DNA. Translation: CAM27332.1 .
BC115557 mRNA. Translation: AAI15558.1 .
BC115558 mRNA. Translation: AAI15559.1 .
CCDSi CCDS30113.1.
RefSeqi NP_861416.1. NM_181751.2.
XP_006541551.1. XM_006541488.1.
UniGenei Mm.269129.

3D structure databases

ProteinModelPortali Q7TQP3.
SMRi Q7TQP3. Positions 1-288.
ModBasei Search...
MobiDBi Search...

Chemistry

BindingDBi Q7TQP3.
ChEMBLi CHEMBL5263.
GuidetoPHARMACOLOGYi 126.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q7TQP3.

Proteomic databases

PRIDEi Q7TQP3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000053970 ; ENSMUSP00000060591 ; ENSMUSG00000051209 .
GeneIDi 236781.
KEGGi mmu:236781.
UCSCi uc009tcs.1. mouse.

Organism-specific databases

CTDi 139760.
MGIi MGI:2668412. Gpr119.

Phylogenomic databases

eggNOGi NOG246868.
GeneTreei ENSGT00550000074524.
HOGENOMi HOG000112765.
HOVERGENi HBG051773.
InParanoidi Q7TQP3.
KOi K08424.
OMAi SFFAVFH.
OrthoDBi EOG75B85V.
PhylomeDBi Q7TQP3.
TreeFami TF325411.

Enzyme and pathway databases

Reactomei REACT_253751. Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).
REACT_259776. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).

Miscellaneous databases

NextBioi 383066.
PROi Q7TQP3.
SOURCEi Search...

Gene expression databases

CleanExi MM_GPR119.
Genevestigatori Q7TQP3.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR028336. GPR119.
[Graphical view ]
PANTHERi PTHR22750:SF7. PTHR22750:SF7. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives."
    Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C., Schioeth H.B.
    FEBS Lett. 554:381-388(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Expression and distribution of Gpr119 in the pancreatic islets of mice and rats: predominant localization in pancreatic polypeptide-secreting PP-cells."
    Sakamoto Y., Inoue H., Kawakami S., Miyawaki K., Miyamoto T., Mizuta K., Itakura M.
    Biochem. Biophys. Res. Commun. 351:474-480(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor."
    Soga T., Ohishi T., Matsui T., Saito T., Matsumoto M., Takasaki J., Matsumoto S., Kamohara M., Hiyama H., Yoshida S., Momose K., Ueda Y., Matsushime H., Kobori M., Furuichi K.
    Biochem. Biophys. Res. Commun. 326:744-751(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  6. "A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release."
    Chu Z.L., Jones R.M., He H., Carroll C., Gutierrez V., Lucman A., Moloney M., Gao H., Mondala H., Bagnol D., Unett D., Liang Y., Demarest K., Semple G., Behan D.P., Leonard J.
    Endocrinology 148:2601-2609(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiGP119_MOUSE
AccessioniPrimary (citable) accession number: Q7TQP3
Secondary accession number(s): Q2ABS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: October 1, 2003
Last modified: November 26, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3