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Q7TQP3

- GP119_MOUSE

UniProt

Q7TQP3 - GP119_MOUSE

Protein

Glucose-dependent insulinotropic receptor

Gene

Gpr119

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 79 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.1 Publication

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: UniProtKB-KW
    2. phosphatidylcholine binding Source: MGI

    GO - Biological processi

    1. insulin secretion Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-dependent insulinotropic receptor
    Alternative name(s):
    G-protein coupled receptor 119
    Gene namesi
    Name:Gpr119
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:2668412. Gpr119.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. receptor complex Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 335335Glucose-dependent insulinotropic receptorPRO_0000069608Add
    BLAST

    Proteomic databases

    PRIDEiQ7TQP3.

    PTM databases

    PhosphoSiteiQ7TQP3.

    Expressioni

    Tissue specificityi

    Expression restricted to the beta-cells of pancreatic islets.2 Publications

    Inductioni

    Up-regulated in islets of obese hyperglycemic db/db mice.

    Gene expression databases

    CleanExiMM_GPR119.
    GenevestigatoriQ7TQP3.

    Interactioni

    Structurei

    3D structure databases

    ProteinModelPortaliQ7TQP3.
    SMRiQ7TQP3. Positions 1-288.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 66ExtracellularSequence Analysis
    Topological domaini28 – 3710CytoplasmicSequence Analysis
    Topological domaini59 – 8123ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini103 – 12523CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini147 – 16418ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini186 – 22641CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini248 – 26215ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini284 – 33552CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei38 – 5821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei82 – 10221Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei126 – 14621Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei165 – 18521Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei227 – 24721Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei263 – 28321Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi305 – 3084Poly-Leu

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG246868.
    GeneTreeiENSGT00550000074524.
    HOGENOMiHOG000112765.
    HOVERGENiHBG051773.
    InParanoidiQ7TQP3.
    KOiK08424.
    OMAiSFFAVFH.
    OrthoDBiEOG75B85V.
    PhylomeDBiQ7TQP3.
    TreeFamiTF325411.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR028336. GPR119.
    [Graphical view]
    PANTHERiPTHR22750:SF7. PTHR22750:SF7. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7TQP3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESSFSFGVI LAVLTILIIA VNALVVVAML LSIYKNDGVG LCFTLNLAVA    50
    DTLIGVAISG LVTDQLSSSA QHTQKTLCSL RMAFVTSSAA ASVLTVMLIA 100
    FDRYLAIKQP LRYFQIMNGL VAGACIAGLW LVSYLIGFLP LGVSIFQQTT 150
    YHGPCSFFAV FHPRFVLTLS CAGFFPAVLL FVFFYCDMLK IASVHSQQIR 200
    KMEHAGAMAG AYRPPRSVND FKAVRTIAVL IGSFTLSWSP FLITSIVQVA 250
    CHKCCLYQVL EKYLWLLGVG NSLLNPLIYA YWQREVRQQL YHMALGVKKF 300
    FTSILLLLPA RNRGPERTRE SAYHIVTISH PELDG 335
    Length:335
    Mass (Da):36,995
    Last modified:October 1, 2003 - v1
    Checksum:i16AAF4D518A06ECD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY288423 mRNA. Translation: AAP72132.1.
    AB233291 mRNA. Translation: BAE80212.1.
    AL672042 Genomic DNA. Translation: CAM27332.1.
    BC115557 mRNA. Translation: AAI15558.1.
    BC115558 mRNA. Translation: AAI15559.1.
    CCDSiCCDS30113.1.
    RefSeqiNP_861416.1. NM_181751.2.
    XP_006541551.1. XM_006541488.1.
    UniGeneiMm.269129.

    Genome annotation databases

    EnsembliENSMUST00000053970; ENSMUSP00000060591; ENSMUSG00000051209.
    GeneIDi236781.
    KEGGimmu:236781.
    UCSCiuc009tcs.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY288423 mRNA. Translation: AAP72132.1 .
    AB233291 mRNA. Translation: BAE80212.1 .
    AL672042 Genomic DNA. Translation: CAM27332.1 .
    BC115557 mRNA. Translation: AAI15558.1 .
    BC115558 mRNA. Translation: AAI15559.1 .
    CCDSi CCDS30113.1.
    RefSeqi NP_861416.1. NM_181751.2.
    XP_006541551.1. XM_006541488.1.
    UniGenei Mm.269129.

    3D structure databases

    ProteinModelPortali Q7TQP3.
    SMRi Q7TQP3. Positions 1-288.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q7TQP3.
    ChEMBLi CHEMBL5263.
    GuidetoPHARMACOLOGYi 126.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q7TQP3.

    Proteomic databases

    PRIDEi Q7TQP3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000053970 ; ENSMUSP00000060591 ; ENSMUSG00000051209 .
    GeneIDi 236781.
    KEGGi mmu:236781.
    UCSCi uc009tcs.1. mouse.

    Organism-specific databases

    CTDi 139760.
    MGIi MGI:2668412. Gpr119.

    Phylogenomic databases

    eggNOGi NOG246868.
    GeneTreei ENSGT00550000074524.
    HOGENOMi HOG000112765.
    HOVERGENi HBG051773.
    InParanoidi Q7TQP3.
    KOi K08424.
    OMAi SFFAVFH.
    OrthoDBi EOG75B85V.
    PhylomeDBi Q7TQP3.
    TreeFami TF325411.

    Miscellaneous databases

    NextBioi 383066.
    PROi Q7TQP3.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_GPR119.
    Genevestigatori Q7TQP3.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR028336. GPR119.
    [Graphical view ]
    PANTHERi PTHR22750:SF7. PTHR22750:SF7. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives."
      Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C., Schioeth H.B.
      FEBS Lett. 554:381-388(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Expression and distribution of Gpr119 in the pancreatic islets of mice and rats: predominant localization in pancreatic polypeptide-secreting PP-cells."
      Sakamoto Y., Inoue H., Kawakami S., Miyawaki K., Miyamoto T., Mizuta K., Itakura M.
      Biochem. Biophys. Res. Commun. 351:474-480(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    5. "Lysophosphatidylcholine enhances glucose-dependent insulin secretion via an orphan G-protein-coupled receptor."
      Soga T., Ohishi T., Matsui T., Saito T., Matsumoto M., Takasaki J., Matsumoto S., Kamohara M., Hiyama H., Yoshida S., Momose K., Ueda Y., Matsushime H., Kobori M., Furuichi K.
      Biochem. Biophys. Res. Commun. 326:744-751(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION.
    6. "A role for beta-cell-expressed G protein-coupled receptor 119 in glycemic control by enhancing glucose-dependent insulin release."
      Chu Z.L., Jones R.M., He H., Carroll C., Gutierrez V., Lucman A., Moloney M., Gao H., Mondala H., Bagnol D., Unett D., Liang Y., Demarest K., Semple G., Behan D.P., Leonard J.
      Endocrinology 148:2601-2609(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiGP119_MOUSE
    AccessioniPrimary (citable) accession number: Q7TQP3
    Secondary accession number(s): Q2ABS2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 12, 2005
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 79 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3