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Protein

Glucose-dependent insulinotropic receptor

Gene

Gpr119

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the endogenous fatty-acid ethanolamide oleoylethanolamide (OEA) and lysophosphatidylcholine (LPC). Functions as a glucose-dependent insulinotropic receptor. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Seems to act through a G(s) mediated pathway.1 Publication

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB-KW
  • phosphatidylcholine binding Source: MGI

GO - Biological processi

  • insulin secretion Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-381771. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).
R-MMU-400511. Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-dependent insulinotropic receptor
Alternative name(s):
G-protein coupled receptor 119
Gene namesi
Name:Gpr119
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:2668412. Gpr119.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6ExtracellularSequence analysis6
Transmembranei7 – 27Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini28 – 37CytoplasmicSequence analysis10
Transmembranei38 – 58Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini59 – 81ExtracellularSequence analysisAdd BLAST23
Transmembranei82 – 102Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini103 – 125CytoplasmicSequence analysisAdd BLAST23
Transmembranei126 – 146Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini147 – 164ExtracellularSequence analysisAdd BLAST18
Transmembranei165 – 185Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini186 – 226CytoplasmicSequence analysisAdd BLAST41
Transmembranei227 – 247Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini248 – 262ExtracellularSequence analysisAdd BLAST15
Transmembranei263 – 283Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini284 – 335CytoplasmicSequence analysisAdd BLAST52

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5263.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696081 – 335Glucose-dependent insulinotropic receptorAdd BLAST335

Proteomic databases

PaxDbiQ7TQP3.
PRIDEiQ7TQP3.

PTM databases

iPTMnetiQ7TQP3.
PhosphoSitePlusiQ7TQP3.

Expressioni

Tissue specificityi

Expression restricted to the beta-cells of pancreatic islets.2 Publications

Inductioni

Up-regulated in islets of obese hyperglycemic db/db mice.

Gene expression databases

CleanExiMM_GPR119.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060591.

Chemistry databases

BindingDBiQ7TQP3.

Structurei

3D structure databases

ProteinModelPortaliQ7TQP3.
SMRiQ7TQP3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi305 – 308Poly-Leu4

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00550000074524.
HOGENOMiHOG000112765.
HOVERGENiHBG051773.
InParanoidiQ7TQP3.
KOiK08424.
OMAiQSWCFVL.
OrthoDBiEOG091G0I71.
PhylomeDBiQ7TQP3.
TreeFamiTF325411.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR028336. GPR119.
[Graphical view]
PANTHERiPTHR22750:SF7. PTHR22750:SF7. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TQP3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESSFSFGVI LAVLTILIIA VNALVVVAML LSIYKNDGVG LCFTLNLAVA
60 70 80 90 100
DTLIGVAISG LVTDQLSSSA QHTQKTLCSL RMAFVTSSAA ASVLTVMLIA
110 120 130 140 150
FDRYLAIKQP LRYFQIMNGL VAGACIAGLW LVSYLIGFLP LGVSIFQQTT
160 170 180 190 200
YHGPCSFFAV FHPRFVLTLS CAGFFPAVLL FVFFYCDMLK IASVHSQQIR
210 220 230 240 250
KMEHAGAMAG AYRPPRSVND FKAVRTIAVL IGSFTLSWSP FLITSIVQVA
260 270 280 290 300
CHKCCLYQVL EKYLWLLGVG NSLLNPLIYA YWQREVRQQL YHMALGVKKF
310 320 330
FTSILLLLPA RNRGPERTRE SAYHIVTISH PELDG
Length:335
Mass (Da):36,995
Last modified:October 1, 2003 - v1
Checksum:i16AAF4D518A06ECD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288423 mRNA. Translation: AAP72132.1.
AB233291 mRNA. Translation: BAE80212.1.
AL672042 Genomic DNA. Translation: CAM27332.1.
BC115557 mRNA. Translation: AAI15558.1.
BC115558 mRNA. Translation: AAI15559.1.
CCDSiCCDS30113.1.
RefSeqiNP_861416.1. NM_181751.2.
UniGeneiMm.269129.

Genome annotation databases

EnsembliENSMUST00000053970; ENSMUSP00000060591; ENSMUSG00000051209.
GeneIDi236781.
KEGGimmu:236781.
UCSCiuc009tcs.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288423 mRNA. Translation: AAP72132.1.
AB233291 mRNA. Translation: BAE80212.1.
AL672042 Genomic DNA. Translation: CAM27332.1.
BC115557 mRNA. Translation: AAI15558.1.
BC115558 mRNA. Translation: AAI15559.1.
CCDSiCCDS30113.1.
RefSeqiNP_861416.1. NM_181751.2.
UniGeneiMm.269129.

3D structure databases

ProteinModelPortaliQ7TQP3.
SMRiQ7TQP3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060591.

Chemistry databases

BindingDBiQ7TQP3.
ChEMBLiCHEMBL5263.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ7TQP3.
PhosphoSitePlusiQ7TQP3.

Proteomic databases

PaxDbiQ7TQP3.
PRIDEiQ7TQP3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053970; ENSMUSP00000060591; ENSMUSG00000051209.
GeneIDi236781.
KEGGimmu:236781.
UCSCiuc009tcs.1. mouse.

Organism-specific databases

CTDi139760.
MGIiMGI:2668412. Gpr119.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00550000074524.
HOGENOMiHOG000112765.
HOVERGENiHBG051773.
InParanoidiQ7TQP3.
KOiK08424.
OMAiQSWCFVL.
OrthoDBiEOG091G0I71.
PhylomeDBiQ7TQP3.
TreeFamiTF325411.

Enzyme and pathway databases

ReactomeiR-MMU-381771. Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).
R-MMU-400511. Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP).

Miscellaneous databases

PROiQ7TQP3.
SOURCEiSearch...

Gene expression databases

CleanExiMM_GPR119.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR028336. GPR119.
[Graphical view]
PANTHERiPTHR22750:SF7. PTHR22750:SF7. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP119_MOUSE
AccessioniPrimary (citable) accession number: Q7TQP3
Secondary accession number(s): Q2ABS2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 12, 2005
Last sequence update: October 1, 2003
Last modified: November 30, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.