Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable G-protein coupled receptor 135

Gene

Gpr135

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 135
Gene namesi
Name:Gpr135
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2676315. Gpr135.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 64ExtracellularSequence analysisAdd BLAST64
Transmembranei65 – 85Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini86 – 109CytoplasmicSequence analysisAdd BLAST24
Transmembranei110 – 130Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini131 – 156ExtracellularSequence analysisAdd BLAST26
Transmembranei157 – 177Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini178 – 189CytoplasmicSequence analysisAdd BLAST12
Transmembranei190 – 210Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini211 – 235ExtracellularSequence analysisAdd BLAST25
Transmembranei236 – 256Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini257 – 295CytoplasmicSequence analysisAdd BLAST39
Transmembranei296 – 316Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini317 – 329ExtracellularSequence analysisAdd BLAST13
Transmembranei330 – 350Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini351 – 457CytoplasmicSequence analysisAdd BLAST107

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000696131 – 457Probable G-protein coupled receptor 135Add BLAST457

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi47N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ7TQP2.
PRIDEiQ7TQP2.

PTM databases

PhosphoSitePlusiQ7TQP2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000043398.
CleanExiMM_GPR135.
ExpressionAtlasiQ7TQP2. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058762.

Structurei

3D structure databases

ProteinModelPortaliQ7TQP2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000008078.
HOGENOMiHOG000001555.
HOVERGENiHBG051780.
InParanoidiQ7TQP2.
KOiK08427.
OMAiLGNCAVM.
OrthoDBiEOG091G0FMJ.
PhylomeDBiQ7TQP2.
TreeFamiTF333332.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TQP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEQARPPGR PAASATLQGS AHPGGAASTA TAAALSFSSV ATVTLGNQSD
60 70 80 90 100
AGRPEAAGSR GPAPLLWHGA AVAAQALVLL LIFLLSSLGN CAVMGVIVKH
110 120 130 140 150
RQLRTVTNAF ILSLSLSDLL TALLCLPAAF LDLFAPPGDS GPWRSFCAAS
160 170 180 190 200
RFFSSCFGIV STFSVALISL DRYCAIVRPP RDKLGRRRAL QLLAGAWLAA
210 220 230 240 250
LGFSLPWDLL RAPREPPAPQ SFHRCLYRTS PDPAQLGVAY SVGLVVACYL
260 270 280 290 300
LPFLLMCFCR YHICKTVRLS DVRVRPMTTY ARVLRFFSEV RTATTVLIMI
310 320 330 340 350
IFVMCCWGPY CFLVLLAATR QGQATQAPSL LNVAAVWLTW ANGAINPVIY
360 370 380 390 400
AIRNPNISML LGRNREEGYR TRNMDAFLPS QGLGFQARSR NRLRNGCANR
410 420 430 440 450
LGACSRMPSS NPASGSGGEV VMWARKNPVV LFFREGPPDS VMEVGKLHNS

ETRDSSI
Length:457
Mass (Da):49,361
Last modified:October 1, 2003 - v1
Checksum:iD8555CD6EE4BDA14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288425 mRNA. Translation: AAP72134.1.
CCDSiCCDS25965.1.
RefSeqiNP_861417.1. NM_181752.1.
UniGeneiMm.390508.

Genome annotation databases

EnsembliENSMUST00000050649; ENSMUSP00000058762; ENSMUSG00000043398.
GeneIDi238252.
KEGGimmu:238252.
UCSCiuc007nvc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288425 mRNA. Translation: AAP72134.1.
CCDSiCCDS25965.1.
RefSeqiNP_861417.1. NM_181752.1.
UniGeneiMm.390508.

3D structure databases

ProteinModelPortaliQ7TQP2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058762.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ7TQP2.

Proteomic databases

PaxDbiQ7TQP2.
PRIDEiQ7TQP2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050649; ENSMUSP00000058762; ENSMUSG00000043398.
GeneIDi238252.
KEGGimmu:238252.
UCSCiuc007nvc.1. mouse.

Organism-specific databases

CTDi64582.
MGIiMGI:2676315. Gpr135.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000008078.
HOGENOMiHOG000001555.
HOVERGENiHBG051780.
InParanoidiQ7TQP2.
KOiK08427.
OMAiLGNCAVM.
OrthoDBiEOG091G0FMJ.
PhylomeDBiQ7TQP2.
TreeFamiTF333332.

Miscellaneous databases

PROiQ7TQP2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000043398.
CleanExiMM_GPR135.
ExpressionAtlasiQ7TQP2. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGP135_MOUSE
AccessioniPrimary (citable) accession number: Q7TQP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.