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Protein

Probable G-protein coupled receptor 135

Gene

Gpr135

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 135
Gene namesi
Name:Gpr135
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2676315. Gpr135.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 6464ExtracellularSequence analysisAdd
BLAST
Transmembranei65 – 8521Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini86 – 10924CytoplasmicSequence analysisAdd
BLAST
Transmembranei110 – 13021Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini131 – 15626ExtracellularSequence analysisAdd
BLAST
Transmembranei157 – 17721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini178 – 18912CytoplasmicSequence analysisAdd
BLAST
Transmembranei190 – 21021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini211 – 23525ExtracellularSequence analysisAdd
BLAST
Transmembranei236 – 25621Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini257 – 29539CytoplasmicSequence analysisAdd
BLAST
Transmembranei296 – 31621Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini317 – 32913ExtracellularSequence analysisAdd
BLAST
Transmembranei330 – 35021Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini351 – 457107CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 457457Probable G-protein coupled receptor 135PRO_0000069613Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi47 – 471N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ7TQP2.
PRIDEiQ7TQP2.

PTM databases

PhosphoSiteiQ7TQP2.

Expressioni

Gene expression databases

BgeeiQ7TQP2.
CleanExiMM_GPR135.
ExpressionAtlasiQ7TQP2. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058762.

Structurei

3D structure databases

ProteinModelPortaliQ7TQP2.
SMRiQ7TQP2. Positions 78-353.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000008078.
HOGENOMiHOG000001555.
HOVERGENiHBG051780.
InParanoidiQ7TQP2.
KOiK08427.
OMAiLGNCAVM.
OrthoDBiEOG7HQN8R.
PhylomeDBiQ7TQP2.
TreeFamiTF333332.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TQP2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEQARPPGR PAASATLQGS AHPGGAASTA TAAALSFSSV ATVTLGNQSD
60 70 80 90 100
AGRPEAAGSR GPAPLLWHGA AVAAQALVLL LIFLLSSLGN CAVMGVIVKH
110 120 130 140 150
RQLRTVTNAF ILSLSLSDLL TALLCLPAAF LDLFAPPGDS GPWRSFCAAS
160 170 180 190 200
RFFSSCFGIV STFSVALISL DRYCAIVRPP RDKLGRRRAL QLLAGAWLAA
210 220 230 240 250
LGFSLPWDLL RAPREPPAPQ SFHRCLYRTS PDPAQLGVAY SVGLVVACYL
260 270 280 290 300
LPFLLMCFCR YHICKTVRLS DVRVRPMTTY ARVLRFFSEV RTATTVLIMI
310 320 330 340 350
IFVMCCWGPY CFLVLLAATR QGQATQAPSL LNVAAVWLTW ANGAINPVIY
360 370 380 390 400
AIRNPNISML LGRNREEGYR TRNMDAFLPS QGLGFQARSR NRLRNGCANR
410 420 430 440 450
LGACSRMPSS NPASGSGGEV VMWARKNPVV LFFREGPPDS VMEVGKLHNS

ETRDSSI
Length:457
Mass (Da):49,361
Last modified:October 1, 2003 - v1
Checksum:iD8555CD6EE4BDA14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288425 mRNA. Translation: AAP72134.1.
CCDSiCCDS25965.1.
RefSeqiNP_861417.1. NM_181752.1.
UniGeneiMm.390508.

Genome annotation databases

EnsembliENSMUST00000050649; ENSMUSP00000058762; ENSMUSG00000043398.
GeneIDi238252.
KEGGimmu:238252.
UCSCiuc007nvc.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288425 mRNA. Translation: AAP72134.1.
CCDSiCCDS25965.1.
RefSeqiNP_861417.1. NM_181752.1.
UniGeneiMm.390508.

3D structure databases

ProteinModelPortaliQ7TQP2.
SMRiQ7TQP2. Positions 78-353.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058762.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ7TQP2.

Proteomic databases

PaxDbiQ7TQP2.
PRIDEiQ7TQP2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050649; ENSMUSP00000058762; ENSMUSG00000043398.
GeneIDi238252.
KEGGimmu:238252.
UCSCiuc007nvc.1. mouse.

Organism-specific databases

CTDi64582.
MGIiMGI:2676315. Gpr135.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00390000008078.
HOGENOMiHOG000001555.
HOVERGENiHBG051780.
InParanoidiQ7TQP2.
KOiK08427.
OMAiLGNCAVM.
OrthoDBiEOG7HQN8R.
PhylomeDBiQ7TQP2.
TreeFamiTF333332.

Miscellaneous databases

NextBioi383701.
PROiQ7TQP2.
SOURCEiSearch...

Gene expression databases

BgeeiQ7TQP2.
CleanExiMM_GPR135.
ExpressionAtlasiQ7TQP2. baseline and differential.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives."
    Fredriksson R., Hoeglund P.J., Gloriam D.E.I., Lagerstroem M.C., Schioeth H.B.
    FEBS Lett. 554:381-388(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiGP135_MOUSE
AccessioniPrimary (citable) accession number: Q7TQP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 1, 2003
Last modified: December 9, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.